journal
https://read.qxmd.com/read/38058983/immunization-with-embryonic-stem-cells-induced-pluripotent-stem-cells-induces-effective-immunity-against-ovarian-tumor-initiating-cells-in-mice
#41
JOURNAL ARTICLE
Fengsheng Yu, Zujuan Zhang, Xiaohong Chang, Xue Ye, Hongyan Cheng, Yi Li, Heng Cui
Cancer stem cells (CSCs) express pluripotent markers and share many features with normal pluripotent stem cells. It is possible that immunity induced by embryonic stem cells (ESCs) and induced pluripotent stem cells- (IPSCs-) based vaccines may selectively target CSCs. In our study, cells expressing the pluripotent marker CD133 in the murine ovarian cancer cell-line ID8 were isolated and identified as CSCs. We investigated the preventive efficacy of ESCs and IPSCs-based vaccines against the development of ovarian cancer in vivo and evaluated the humoral and cellular immunities targeting CSCs in vitro ...
2023: Stem Cells International
https://read.qxmd.com/read/38034060/mechanisms-and-optimization-strategies-of-paracrine-exosomes-from-mesenchymal-stem-cells-in-ischemic-heart-disease
#42
REVIEW
Xiaorong Yin, Lizhi Lin, Fang Fang, Bin Zhang, Cheng Shen
The morbidity and mortality of myocardial infarction (MI) are increasing worldwide. Mesenchymal stem cells (MSCs) are multipotent stem cells with self-renewal and differentiation capabilities that are essential in tissue healing and regenerative medicine. However, the low implantation and survival rates of transplanted cells hinder the widespread clinical use of stem cells. Exosomes are naturally occurring nanovesicles that are secreted by cells and promote the repair of cardiac function by transporting noncoding RNA and protein...
2023: Stem Cells International
https://read.qxmd.com/read/38020206/adipose-derived-mesenchymal-stem-cell-facilitate-hematopoietic-stem-cell-proliferation-via-the-jagged-1-notch-1-hes-signaling-pathway
#43
JOURNAL ARTICLE
Hongbo Wang, Xiaojuan Bi, Rongyao Zhang, Hailong Yuan, Jianli Xu, Kaile Zhang, Songqing Qi, Xue Zhang, Ming Jiang
BACKGROUND: Poor graft function (PGF) is a life-threatening complication following hematopoietic stem cell transplantation (HSCT). Current therapies, such as CD34+ cell infusion, have shown limited effectiveness. Conversely, mesenchymal stem cells (MSCs) show potential in addressing PGF. Adipose-derived mesenchymal stem cells (ADSCs) effectively support long-term hematopoietic stem cell proliferation. Therefore, this study aimed to investigate the mechanisms underlying the long-term hematopoietic support provided by ADSCs...
2023: Stem Cells International
https://read.qxmd.com/read/38020205/photobiomodulation-can-enhance-stem-cell-viability-in-cochlea-with-auditory-neuropathy-but-does-not-restore-hearing
#44
JOURNAL ARTICLE
So-Young Chang, Eunjeong Kim, Nathaniel T Carpena, Jae-Hun Lee, Doo Hee Kim, Min Young Lee
Sensorineural hearing loss is very difficult to treat. Currently, one of the techniques used for hearing rehabilitation is a cochlear implant that can transform sound into electrical signals instead of inner ear hair cells. However, the prognosis remains very poor if sufficient auditory nerve cells are not secured. In this study, the effect of mouse embryonic stem cells (mESC) and photobiomodulation (PBM) combined treatment on auditory function and auditory nerve cells in a secondary neuropathy animal model was investigated...
2023: Stem Cells International
https://read.qxmd.com/read/38020204/crispr-cas9-genome-editing-in-lgmd2a-r1-patient-derived-induced-pluripotent-stem-and-skeletal-muscle-progenitor-cells
#45
JOURNAL ARTICLE
Lampros Mavrommatis, Abdul Zaben, Urs Kindler, Marie-Cécile Kienitz, Julienne Dietz, Hyun-Woo Jeong, Pierre Böhme, Beate Brand-Saberi, Matthias Vorgerd, Holm Zaehres
Large numbers of Calpain 3 (CAPN3) mutations cause recessive forms of limb-girdle muscular dystrophy (LGMD2A/LGMDR1) with selective atrophy of the proximal limb muscles. We have generated induced pluripotent stem cells (iPSC) from a patient with two mutations in exon 3 and exon 4 at the calpain 3 locus (W130C, 550delA). Two different strategies to rescue these mutations are devised: (i) on the level of LGMD2A-iPSC, we combined CRISPR/Cas9 genome targeting with a FACS and Tet transactivator-based biallelic selection strategy, which resulted in a new functional chimeric exon 3-4 without the two CAPN3 mutations...
2023: Stem Cells International
https://read.qxmd.com/read/38020203/umbilical-cord-mesenchymal-stem-cells-overexpressing-heme-oxygenase-1-promotes-symptoms-recovery-in-cystitis-rats-by-alleviating-neuroinflammation
#46
JOURNAL ARTICLE
Qiongqiong Gao, Zhentao Gao, Minzhi Su, Yong Huang, Chi Zhang, Cuiping Li, Hailun Zhan, Bolong Liu, Xiangfu Zhou
Interstitial cystitis/bladder pain syndrome (IC/BPS) seriously reduces the patient's quality of life, yet current therapies only provide partial relief. In the spinal dorsal horn (SDH), neuroinflammation plays a pivotal role in the development of IC. Injection of human umbilical cord mesenchymal stem cells (hUMSCs) to reduce inflammation is an effective strategy, and heme oxygenase-1 (HO-1) exhibits anti-nociceptive effect in neuroinflammatory pain. This study aimed to test the therapeutic effects of hUMSCs overexpressing HO-1 on cyclophosphamide-induced cystitis rat model...
2023: Stem Cells International
https://read.qxmd.com/read/37964984/establishing-and-validating-an-aging-related-prognostic-signature-in-osteosarcoma
#47
JOURNAL ARTICLE
Yibo Ma, Shuo Zheng, Mingjun Xu, Changjian Chen, Hongtao He
Aging is an inevitable process that biological changes accumulate with time and results in increased susceptibility to different tumors. But currently, aging-related genes (ARGs) in osteosarcoma were not clear. We investigated the potential prognostic role of ARGs and established an ARG-based prognostic signature for osteosarcoma. The transcriptome data and corresponding clinicopathological information of patients with osteosarcoma were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases...
2023: Stem Cells International
https://read.qxmd.com/read/37964983/a-novel-molecular-classification-method-for-glioblastoma-based-on-tumor-cell-differentiation-trajectories
#48
JOURNAL ARTICLE
Guanghao Zhang, Xiaolong Xu, Luojiang Zhu, Sisi Li, Rundong Chen, Nan Lv, Zifu Li, Jing Wang, Qiang Li, Wang Zhou, Pengfei Yang, Jianmin Liu
The latest 2021 WHO classification redefines glioblastoma (GBM) as the hierarchical reporting standard by eliminating glioblastoma, IDH-mutant and only retaining the tumor entity of "glioblastoma, IDH-wild type." Knowing that subclassification of tumors based on molecular features is supposed to facilitate the therapeutic choice and increase the response rate in cancer patients, it is necessary to carry out molecular classification of the newly defined GBM. Although differentiation trajectory inference based on single-cell sequencing (scRNA-seq) data holds great promise for identifying cell heterogeneity, it has not been used in the study of GBM molecular classification...
2023: Stem Cells International
https://read.qxmd.com/read/37954462/stem-cell-based-therapy-and-cell-free-therapy-as-an-alternative-approach-for-cardiac-regeneration
#49
REVIEW
Iwona Deszcz
The World Health Organization reports that cardiovascular diseases (CVDs) represent 32% of all global deaths. The ineffectiveness of conventional therapies in CVDs encourages the development of novel, minimally invasive therapeutic strategies for the healing and regeneration of damaged tissue. The self-renewal capacity, multilineage differentiation, lack of immunogenicity, and immunosuppressive properties of mesenchymal stem cells (MSCs) make them a promising option for CVDs. However, growing evidence suggests that myocardial regeneration occurs through paracrine factors and extracellular vesicle (EV) secretion, rather than through differentiation into cardiomyocytes...
2023: Stem Cells International
https://read.qxmd.com/read/37908315/curative-effect-of-ad-mscs-against-cisplatin-induced-hepatotoxicity-in-rats-is-potentiated-by-azilsartan-targeting-oxidative-stress-mapk-and-apoptosis-signaling-pathways
#50
JOURNAL ARTICLE
Amany Abdlrehim Bekhit, Olivia N Beshay, Michael A Fawzy, Sara Mohamed Naguib Abdel-Hafez, Gaber El-Saber Batiha, Farid S Ataya, Moustafa Fathy
Despite its clinical value, cisplatin (CISP) is complicated by marked hepatotoxicity via inducing oxidative stress, inflammatory, and apoptotic pathways. This study aims to explore the protective impact of azilsartan (AZIL), an antihypertensive drug, in addition to adipose tissue-derived mesenchymal stem cells (AD-MSCs) on CISP-induced hepatotoxicity. After characterization and labeling of AD-MSCs by PKH26 dye, 54 Wistar male albino rats were randomly divided into nine groups: I (CONT), II (AZIL.H), III (CISP), IV (CISP + AZIL...
2023: Stem Cells International
https://read.qxmd.com/read/37900967/transglutaminase-2-prevents-premature-senescence-and-promotes-osteoblastic-differentiation-of-mesenchymal-stem-cells-through-nrf2-activation
#51
JOURNAL ARTICLE
Soo-Jin Lee, Ji-Woong Shin, Mee-Ae Kwon, Ki Baek Lee, Hyo-Jun Kim, Jin-Haeng Lee, Heun-Soo Kang, Jong Kwan Jun, Sung-Yup Cho, In-Gyu Kim
Transglutaminase 2 (TG2) is a multifunctional enzyme that exhibits transamidase, GTPase, kinase, and protein disulfide isomerase (PDI) activities. Of these, transamidase-mediated modification of proteins regulates apoptosis, differentiation, inflammation, and fibrosis. TG2 is highly expressed in mesenchymal stem cells (MSCs) compared with differentiated cells, suggesting a role of TG2 specific for MSC characteristics. In this study, we report a new function of TG2 in the regulation of MSC redox homeostasis...
2023: Stem Cells International
https://read.qxmd.com/read/37881518/umbilical-cord-derived-mesenchymal-stem-cells-attenuate-s100-induced-autoimmune-hepatitis-via-modulating-th1-and-th17-cell-responses-in-mice
#52
JOURNAL ARTICLE
Xiaofeng Wei, Xinhong Cheng, Yang Luo, Xun Li
Currently, the first-line treatment for autoimmune hepatitis (AIH) is still the combination of glucocorticoids or immunosuppressants. However, hormone and immunosuppressive therapy can cause serious side effects, such as Cushing syndrome and bone marrow suppression. Previous studies reported on the applicability and safety of mesenchymal stem cells (MSCs) to ameliorate liver inflammation and fibrosis. However, the characteristics of MSCs sources directly contribute to the different conclusions on the mechanisms underlying MSC-mediated immunoregulation...
2023: Stem Cells International
https://read.qxmd.com/read/37868704/dental-pulp-stem-cells-for-bone-tissue-engineering-a-literature-review
#53
REVIEW
Xiaolei Bai, Ruijue Cao, Danni Wu, Huicong Zhang, Fan Yang, Linhong Wang
Bone tissue engineering (BTE) is a promising approach for repairing and regenerating damaged bone tissue, using stem cells and scaffold structures. Among various stem cell sources, dental pulp stem cells (DPSCs) have emerged as a potential candidate due to their multipotential capabilities, ability to undergo osteogenic differentiation, low immunogenicity, and ease of isolation. This article reviews the biological characteristics of DPSCs, their potential for BTE, and the underlying transcription factors and signaling pathways involved in osteogenic differentiation; it also highlights the application of DPSCs in inducing scaffold tissues for bone regeneration and summarizes animal and clinical studies conducted in this field...
2023: Stem Cells International
https://read.qxmd.com/read/37868703/vcam-1-promotes-angiogenesis-of-bone-marrow-mesenchymal-stem-cells-derived-from-patients-with-trauma-induced-osteonecrosis-of-the-femoral-head-by-regulating-the-apelin-ccn2-pathway
#54
JOURNAL ARTICLE
Yiming Shao, Lei Sun, Baodong Ma, Ranran Jin, Yueyao Ban, Ruibo Li, Jianfa Wang, Hongkai Lian, Han Yue
Trauma-induced osteonecrosis of the femoral head (TI-ONFH) is a pathological process in which the destruction of blood vessels supplying blood to the femoral head causes the death of bone tissue cells. Vascular cell adhesion molecule 1 (VCAM-1) has been shown to have potent proangiogenic activity, but the role in angiogenesis of TI-ONFH is unclear. In this work, we discovered that VCAM-1 was significantly downregulated in the bone marrow mesenchymal stem cells (BMSCs) derived from patients with TI-ONFH. Subsequently, we constructed BMSCs overexpressing VCAM-1 using a lentiviral vector...
2023: Stem Cells International
https://read.qxmd.com/read/37829611/retracted-lncrna-hottip-recruits-ezh2-to-inhibit-pten-expression-and-participates-in-im-resistance-in-chronic-myeloid-leukemia
#55
Stem Cells International
[This retracts the article DOI: 10.1155/2022/9993393.].
2023: Stem Cells International
https://read.qxmd.com/read/37810631/production-of-highly-uniform-midbrain-organoids-from-human-pluripotent-stem-cells
#56
JOURNAL ARTICLE
Xuerui Yao, Ji Hyun Kang, Kee-Pyo Kim, Hyogeun Shin, Zhe-Long Jin, Hao Guo, Yong-Nan Xu, Ying-Hua Li, Sai Hali, Jeongwoo Kwon, Hyeonwoo La, Chanhyeok Park, Yong-June Kim, Lin Wang, Kwonho Hong, Qilong Cao, Il-Joo Cho, Nam-Hyung Kim, Dong Wook Han
Brain organoids have been considered as an advanced platform for in vitro disease modeling and drug screening, but numerous roadblocks exist, such as lack of large-scale production technology and lengthy protocols with multiple manipulation steps, impeding the industrial translation of brain organoid technology. Here, we describe the high-speed and large-scale production of midbrain organoids using a high-throughput screening-compatible platform within 30 days. Micro midbrain organoids ( µ MOs) exhibit a highly uniform morphology and gene expression pattern with minimal variability...
2023: Stem Cells International
https://read.qxmd.com/read/37810630/adipose-derived-stem-cell-exosomes-antagonize-the-inhibitory-effect-of-dihydrotestosterone-on-hair-follicle-growth-by-activating-wnt-%C3%AE-catenin-pathway
#57
JOURNAL ARTICLE
Xin Tang, Cuixiang Cao, Yunxiao Liang, Le Han, Bin Tu, Miao Yu, Miaojian Wan
The most prevalent type of alopecia is androgenetic alopecia (AGA), which has a high prevalence but no effective treatment. Elevated dihydrotestosterone (DHT) level in the balding area was usually thought to be critical in the pathophysiology of AGA. The canonical Wnt/ β -catenin signaling pathway plays a key role in promoting hair follicle development and sustaining the hair follicle cycle. Adipose-derived stem cell exosomes (ADSC-Exos) are widely used in the field of regenerative medicine due to the advantages of being cell free and immune privileged...
2023: Stem Cells International
https://read.qxmd.com/read/37771550/human-mesenchymal-stem-cells-derived-exosome-mimetic-vesicles-regulation-of-the-mapk-pathway-and-ros-levels-inhibits-glucocorticoid-induced-apoptosis-in-osteoblasts
#58
JOURNAL ARTICLE
Hongxu Lu, Zhaoxia Zhang, Zhaoying Wang, Jinkui Wang, Tao Mi, Liming Jin, Xin Wu, Junyi Luo, Yimeng Liu, Junhong Liu, Wenquan Cai, Peng Guo, Dawei He
BACKGROUND: Long-term extensive use of glucocorticoids will lead to hormonal necrosis of the femoral head, and osteoblasts play an important role in the prevention of osteonecrosis. However, there is no complete cure for necrosis of the femoral head. Mesenchymal stem cell- (MSCs-) derived exosomes are widely used for the repair of various tissue lesions. Therefore, the aim of this study was to investigate the mechanism of dexamethasone- (DEX-) induced osteoblast apoptosis and the therapeutic effect of human umbilical cord MSC- (hucMSC-) derived exosome mimetic vesicles (EMVs) on osteoblast-induced apoptosis by DEX...
2023: Stem Cells International
https://read.qxmd.com/read/37771549/promising-markers-in-the-context-of-mesenchymal-stem-stromal-cells-subpopulations-with-unique-properties
#59
REVIEW
Agnieszka Smolinska, Aleksandra Bzinkowska, Paulina Rybkowska, Magdalena Chodkowska, Anna Sarnowska
The heterogeneity of the mesenchymal stem/stromal cells (MSCs) population poses a challenge to researchers and clinicians, especially those observed at the population level. What is more, the lack of precise evidences regarding MSCs developmental origin even further complicate this issue. As the available evidences indicate several possible pathways of MSCs formation, this diverse origin may be reflected in the unique subsets of cells found within the MSCs population. Such populations differ in specialization degree, proliferation, and immunomodulatory properties or exhibit other additional properties such as increased angiogenesis capacity...
2023: Stem Cells International
https://read.qxmd.com/read/37744638/retracted-the-mechanism-of-oxidative-stress-in-cells-isolation-identification-and-genome-wide-sequence-analysis-of-nitrite-amylolytic-bacillus
#60
Stem Cells International
[This retracts the article DOI: 10.1155/2022/9521900.].
2023: Stem Cells International
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