journal
https://read.qxmd.com/read/38794352/correction-zaman-et-al-synthesis-and-evaluation-of-thiol-conjugated-poloxamer-and-its-pharmaceutical-applications-pharmaceutics-2021-13-693
#1
Muhammad Zaman, Sadaf Saeed, Rabia Imtiaz Bajwa, Muhammad Shafeeq Ur Rahman, Saeed Ur Rahman, Muhammad Jamshaid, Muhammad F Rasool, Abdul Majeed, Imran Imran, Faleh Alqahtani, Sultan Alshehri, Abdullah F AlAsmari, Nemat Ali, Mohammed S Alasmari
In the original publication, there was a mistake in one author name, Mohammed Alasmari should be Mohammed S [...].
May 20, 2024: Pharmaceutics
https://read.qxmd.com/read/38794351/development-of-a-web-application-for-simulating-plasma-drug-concentrations-in-patients-with-zolpidem-intoxication
#2
JOURNAL ARTICLE
Hwa Jun Cha, Sungpil Han, Kwan Cheol Pak, Hyungsub Kim
Zolpidem is a widely prescribed hypnotic Z-drug used to treat short-term insomnia. However, a growing number of individuals intentionally overdose on these drugs. This study aimed to develop a predictive tool for physicians to assess patients with zolpidem overdose. A population pharmacokinetic (PK) model was established using digitized data obtained from twenty-three healthy volunteers after a single oral administration of zolpidem. Based on the final PK model, a web application was developed using open-source R packages such as rxode2, nonmem2rx, and shiny...
May 20, 2024: Pharmaceutics
https://read.qxmd.com/read/38794350/polymer-matrix-and-manufacturing-methods-in-solid-dispersion-system-for-enhancing-andrographolide-solubility-and-absorption-a-systematic-review
#3
REVIEW
Pratchaya Tipduangta, Sunee Chansakaow, Pimpimon Tansakul, Rungarun Meungjai, Piyameth Dilokthornsakul
Background: Andrographolide (ADG) has poor aqueous solubility and low bioavailability. This study systematically reviews the use of solid dispersion (SD) techniques to enhance the solubility and absorption of ADG, with a focus on the methods and polymers utilized. Methodology: We searched electronic databases including PubMed, Web of Science, Scopus® , Embase and ScienceDirect Elsevier® up to November 2023 for studies on the solubility or absorption of ADG in SD formulations. Two reviewers independently reviewed the retrieved articles and extracted data using a standardized form and synthesized the data qualitatively...
May 20, 2024: Pharmaceutics
https://read.qxmd.com/read/38794349/formulation-of-ascorbic-acid-and-betaine-based-therapeutic-deep-eutectic-system-for-enhanced-transdermal-delivery-of-ascorbic-acid
#4
JOURNAL ARTICLE
Ji-Eun Song, Seung-Hyun Jun, Joo-Yeon Ryoo, Nae-Gyu Kang
L-ascorbic acid (AA), a potent antioxidant, is commonly used topically in the pharmaceutical and cosmetic fields. However, the incorporation of AA into topical formulations is difficult because of its highly unstable nature and relatively poor skin permeability. In this study, we propose an alternative strategy for improving the solubility and topical delivery of AA through its conversion to a therapeutic deep eutectic system (THEDES). AA and betaine (Bet)-based THEDESs were prepared at certain molar ratios and characterized using polarized optical microscopy, Fourier transform infrared spectroscopy, and differential scanning calorimetry...
May 20, 2024: Pharmaceutics
https://read.qxmd.com/read/38794348/integrating-clopidogrel-s-first-pass-effect-in-a-joint-semi-physiological-population-pharmacokinetic-model-of-the-drug-and-its-inactive-carboxylic-acid-metabolite
#5
JOURNAL ARTICLE
Zorica Pejčić, Valentina Topić Vučenović, Branislava Miljković, Katarina M Vučićević
Clopidogrel (CLO), a pro-drug for preventing thrombotic events, undergoes rapid absorption and extensive metabolism, with approximately 85-90% converted to an inactive carboxylic acid metabolite (CLO-CA) and the remaining to an active thiol (CLO-TH). Few pharmacokinetic models for the drug and its metabolites exist, with most focusing on CLO-TH. Although CLO-CA is inactive, its predominant (compared to its parent drug and metabolites) presence in plasma underscores the importance of characterizing its formation and pharmacokinetic profile...
May 20, 2024: Pharmaceutics
https://read.qxmd.com/read/38794347/comparative-study-of-5-aminolevulinic-acid-mediated-photodynamic-therapy-and-the-loop-electrosurgical-excision-procedure-for-the-treatment-of-cervical-high-grade-squamous-intraepithelial-lesions
#6
JOURNAL ARTICLE
Xiaoyun Wang, Xiaoming Xu, Yaxi Ma, Yixin Tang, Zheng Huang
The loop electrosurgical excision procedure (LEEP) is a common treatment for cervical intraepithelial neoplasia (CIN). Photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) is a non-invasive modality that has been used for treating precancerous diseases and HPV infections. This comparative study evaluated the efficacy and safety of ALA PDT and the LEEP in the treatment of cervical high-grade squamous intraepithelial lesions (HSILs). Patient records were reviewed and HSIL patients with HPV infections (24-51 years old) who underwent PDT or LEEP treatment were selected...
May 20, 2024: Pharmaceutics
https://read.qxmd.com/read/38794346/novel-efficient-lipid-based-delivery-systems-enable-a-delayed-uptake-and-sustained-expression-of-mrna-in-human-cells-and-mouse-tissues
#7
JOURNAL ARTICLE
Artem G Fedorovskiy, Denis N Antropov, Anton S Dome, Pavel A Puchkov, Daria M Makarova, Maria V Konopleva, Anastasiya M Matveeva, Eugenia A Panova, Elena V Shmendel, Mikhail A Maslov, Sergey E Dmitriev, Grigory A Stepanov, Oleg V Markov
Over the past decade, mRNA-based therapy has displayed significant promise in a wide range of clinical applications. The most striking example of the leap in the development of mRNA technologies was the mass vaccination against COVID-19 during the pandemic. The emergence of large-scale technology and positive experience of mRNA immunization sparked the development of antiviral and anti-cancer mRNA vaccines as well as therapeutic mRNA agents for genetic and other diseases. To facilitate mRNA delivery, lipid nanoparticles (LNPs) have been successfully employed...
May 19, 2024: Pharmaceutics
https://read.qxmd.com/read/38794345/effects-of-nozzle-retraction-elimination-on-spray-distribution-in-middle-posterior-turbinate-regions-a-comparative-study
#8
JOURNAL ARTICLE
Amr Seifelnasr, Xiuhua Si, Jinxiang Xi
The standard multi-dose nasal spray pump features an integrated actuator and nozzle, which inevitably causes a retraction of the nozzle tip during application. The retraction stroke is around 5.5 mm and drastically reduces the nozzle's insertion depth, which further affects the initial nasal spray deposition and subsequent translocation, potentially increasing drug wastes and dosimetry variability. To address this issue, we designed a new spray pump that separated the nozzle from the actuator and connected them with a flexible tube, thereby eliminating nozzle retraction during application...
May 19, 2024: Pharmaceutics
https://read.qxmd.com/read/38794344/investigation-of-hydrocolloid-plant-polysaccharides-as-potential-candidates-to-mimic-the-functions-of-muc5b-in-saliva
#9
JOURNAL ARTICLE
Christina Winter, Carolin Tetyczka, Duy Toan Pham, Dagmar Kolb, Gerd Leitinger, Sandra Schönfelder, Olaf Kunert, Tanja Gerlza, Andreas Kungl, Franz Bucar, Eva Roblegg
The successful substitution of complex physiological fluids, such as human saliva, remains a major challenge in drug development. Although there are a large number of saliva substitutes on the market, their efficacy is often inadequate due to short residence time in the mouth, unpleasant mouthfeel, or insufficient protection of the teeth. Therefore, systems need to be identified that mimic the functions of saliva, in particular the salivary mucin MUC5B and the unique physiological properties of saliva. To this end, plant extracts known to contain hydrocolloid polysaccharides and to have mucus-forming properties were studied to evaluate their suitability as saliva substitutes...
May 18, 2024: Pharmaceutics
https://read.qxmd.com/read/38794343/a-sensitive-liquid-chromatography-tandem-mass-spectrometry-method-for-measuring-fosfomycin-concentrations-in-human-prostatic-tissue
#10
JOURNAL ARTICLE
Matteo Conti, Beatrice Giorgi, Rossella Barone, Milo Gatti, Pier Giorgio Cojutti, Federico Pea
The aim of this study was to develop and validate a fast and sensitive bioanalytical method for the accurate quantification of fosfomycin concentrations in human prostatic tissue. The sample preparation method only required milligrams of tissue sample. Each sample was mixed with two times its weight of water and homogenized. A methanol solution that was three times the volume of the internal standard (fosfomycin-13C3) was added, followed by vortex mixing and centrifugation. After its extraction from the homogenized prostatic tissue, fosfomycin was quantified by means of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) triple quadrupole system operating in negative electrospray ionization and multiple reaction monitoring detection mode...
May 17, 2024: Pharmaceutics
https://read.qxmd.com/read/38794342/spray-dried-nanolipid-powders-for-pulmonary-drug-delivery-a-comprehensive-mini-review
#11
REVIEW
Mahmoud H Abu Elella, Arwa Omar Al Khatib, Hisham Al-Obaidi
Lung diseases have received great attention in the past years because they contribute approximately one-third of the total global mortality. Pulmonary drug delivery is regarded as one of the most appealing routes to treat lung diseases. It addresses numerous drawbacks linked to traditional dosage forms. It presents notable features, such as, for example, a non-invasive route, localized lung drug delivery, low enzymatic activity, low drug degradation, higher patient compliance, and avoiding first-pass metabolism...
May 17, 2024: Pharmaceutics
https://read.qxmd.com/read/38794341/suitable-promoter-for-dna-vaccination-using-a-pdna-ternary-complex
#12
JOURNAL ARTICLE
Tomoaki Kurosaki, Hiroki Nakamura, Hitoshi Sasaki, Yukinobu Kodama
In this study, we evaluated the effect of several promoters on the transfection activity and immune-induction efficiency of a plasmid DNA (pDNA)/polyethylenimine/γ-polyglutamic acid complex (pDNA ternary complex). Model pDNAs encoding firefly luciferase (Luc) were constructed with several promoters, such as simian virus 40 (SV40), eukaryotic elongation factor 1 alpha (EF1), cytomegalovirus (CMV), and chicken beta actin hybrid (CBh) (pSV40-Luc, pEF1-Luc, pCMV-Luc, and pCBh-Luc, respectively). Four types of pDNA ternary complexes, each with approximately 145-nm particle size and -30-mV ζ-potential, were stably constructed...
May 17, 2024: Pharmaceutics
https://read.qxmd.com/read/38794340/automated-non-sterile-pharmacy-compounding-a-multi-site-study-in-european-hospital-and-community-pharmacies-with-pediatric-immediate-release-propranolol-hydrochloride-tablets
#13
JOURNAL ARTICLE
Niklas Sandler Topelius, Farnaz Shokraneh, Mahsa Bahman, Julius Lahtinen, Niko Hassinen, Sari Airaksinen, Soumya Verma, Ludmila Hrizanovska, Jana Lass, Urve Paaver, Janika Tähnas, Catharina Kern, Frederic Lagarce, Dominic Fenske, Julia Malik, Holger Scherliess, Sara P Cruz, Mattias Paulsson, Jan Dekker, Katja Kammonen, Maria Rautamo, Hendrik Lück, Antoine Pierrot, Stephanie Stareprawo, Marija Tubic-Grozdanis, Stefanie Zibolka, Uli Lösch, Martina Jeske, Ulrich Griesser, Karin Hummer, Andreas Thalmeier, Anna Harjans, Alexander Kruse, Ralph Heimke-Brinck, Karim Khoukh, Fabien Bruno
Pharmacy compounding, the art and science of preparing customized medications to meet individual patient needs, is on the verge of transformation. Traditional methods of compounding often involve manual and time-consuming processes, presenting challenges in terms of consistency, dosage accuracy, quality control, contamination, and scalability. However, the emergence of cutting-edge technologies has paved a way for a new era for pharmacy compounding, promising to redefine the way medications are prepared and delivered as pharmacy-tailored personalized medicines...
May 17, 2024: Pharmaceutics
https://read.qxmd.com/read/38794339/poly-acrylic-acid-poly-vinyl-alcohol-microarray-patches-for-continuous-transdermal-delivery-of-levodopa-and-carbidopa-in-vitro-and-in-vivo-studies
#14
JOURNAL ARTICLE
Yaocun Li, Lalitkumar K Vora, Jiawen Wang, Akmal Hidayat Bin Sabri, Andrew Graham, Helen O McCarthy, Ryan F Donnelly
Levodopa (LD) has been the most efficacious medication and the gold standard therapy for Parkinson's disease (PD) for decades. However, its long-term administration is usually associated with motor complications, which are believed to be the result of the fluctuating pharmacokinetics of LD following oral administration. Duodopa® is the current option to offer a continuous delivery of LD and its decarboxylase inhibitor carbidopa (CD); however, its administration involves invasive surgical procedures, which could potentially lead to lifelong complications, such as infection...
May 17, 2024: Pharmaceutics
https://read.qxmd.com/read/38794338/therapeutic-drug-monitoring-and-biomarkers-towards-better-dosing-of-antimicrobial-therapy
#15
JOURNAL ARTICLE
Eman Wehbe, Asad E Patanwala, Christine Y Lu, Hannah Yejin Kim, Sophie L Stocker, Jan-Willem C Alffenaar
Due to variability in pharmacokinetics and pharmacodynamics, clinical outcomes of antimicrobial drug therapy vary between patients. As such, personalised medication management, considering both pharmacokinetics and pharmacodynamics, is a growing concept of interest in the field of infectious diseases. Therapeutic drug monitoring is used to adjust and individualise drug regimens until predefined pharmacokinetic exposure targets are achieved. Minimum inhibitory concentration (drug susceptibility) is the best available pharmacodynamic parameter but is associated with many limitations...
May 17, 2024: Pharmaceutics
https://read.qxmd.com/read/38794337/strategies-to-improve-the-transdermal-delivery-of-poorly-water-soluble-non-steroidal-anti-inflammatory-drugs
#16
REVIEW
Alexandra Balmanno, James R Falconer, Halley G Ravuri, Paul C Mills
The transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has the potential to overcome some of the major disadvantages relating to oral NSAID usage, such as gastrointestinal adverse events and compliance. However, the poor solubility of many of the newer NSAIDs creates challenges in incorporating the drugs into formulations suitable for application to skin and may limit transdermal permeation, particularly if the goal is therapeutic systemic drug concentrations. This review is an overview of the various strategies used to increase the solubility of poorly soluble NSAIDs and enhance their permeation through skin, such as the modification of the vehicle, the modification of or bypassing the barrier function of the skin, and using advanced nano-sized formulations...
May 16, 2024: Pharmaceutics
https://read.qxmd.com/read/38794336/novel-drug-delivery-systems-an-important-direction-for-drug-innovation-research-and-development
#17
REVIEW
Qian Chen, Zhen Yang, Haoyu Liu, Jingyuan Man, Ayodele Olaolu Oladejo, Sally Ibrahim, Shengyi Wang, Baocheng Hao
The escalating demand for enhanced therapeutic efficacy and reduced adverse effects in the pharmaceutical domain has catalyzed a new frontier of innovation and research in the field of pharmacy: novel drug delivery systems. These systems are designed to address the limitations of conventional drug administration, such as abbreviated half-life, inadequate targeting, low solubility, and bioavailability. As the disciplines of pharmacy, materials science, and biomedicine continue to advance and converge, the development of efficient and safe drug delivery systems, including biopharmaceutical formulations, has garnered significant attention both domestically and internationally...
May 16, 2024: Pharmaceutics
https://read.qxmd.com/read/38794335/deep-learning-insights-into-the-dynamic-effects-of-photodynamic-therapy-on-cancer-cells
#18
JOURNAL ARTICLE
Md Atiqur Rahman, Feihong Yan, Ruiyuan Li, Yu Wang, Lu Huang, Rongcheng Han, Yuqiang Jiang
Photodynamic therapy (PDT) shows promise in tumor treatment, particularly when combined with nanotechnology. This study examines the impact of deep learning, particularly the Cellpose algorithm, on the comprehension of cancer cell responses to PDT. The Cellpose algorithm enables robust morphological analysis of cancer cells, while logistic growth modelling predicts cellular behavior post-PDT. Rigorous model validation ensures the accuracy of the findings. Cellpose demonstrates significant morphological changes after PDT, affecting cellular proliferation and survival...
May 16, 2024: Pharmaceutics
https://read.qxmd.com/read/38794334/the-proteasome-inhibitor-cep-18770-induces-cell-death-in-medulloblastoma
#19
JOURNAL ARTICLE
Swastina Nath Varma, Shany Ye, Sara Ferlin, Charley Comer, Kian Cotton, Maria Victoria Niklison-Chirou
Medulloblastomas (MBs) represent the most prevalent malignant solid tumors in kids. The conventional treatment regimen for MBs includes surgical removal of the tumor, followed by radiation and chemotherapy. However, this approach is associated with significant morbidity and detrimental side effects. Consequently, there is a critical demand for more precise and less harmful treatments to enhance the quality of life for survivors. CEP-18770, a novel proteasome inhibitor that targets the 20S subunit, has emerged as a promising candidate, due to its anticancer activity in metastatic solid tumors and multiple myeloma, coupled with an acceptable safety profile...
May 16, 2024: Pharmaceutics
https://read.qxmd.com/read/38794333/synergistic-enhancement-of-targeted-wound-healing-by-near-infrared-photodynamic-therapy-and-silver-metal-organic-frameworks-combined-with-s-or-n-doped-carbon-dots
#20
JOURNAL ARTICLE
Maja D Nešić, Iva A Popović, Jelena Žakula, Lela Korićanac, Jelena Filipović Tričković, Ana Valenta Šobot, Maria Victoria Jiménez, Manuel Algarra, Tanja Dučić, Milutin Stepić
The literature data emphasize that nanoparticles might improve the beneficial effects of near-infrared light (NIR) on wound healing. This study investigates the mechanisms of the synergistic wound healing potential of NIR light and silver metal-organic frameworks combined with nitrogen- and sulfur-doped carbon dots (AgMOFsN-CDs and AgMOFsS-CDs, respectively), which was conducted by testing the fibroblasts viability, scratch assays, biochemical analysis, and synchrotron-based Fourier transform infrared (SR-FTIR) cell spectroscopy and imaging...
May 16, 2024: Pharmaceutics
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