Kazuo Kamaike, Mutsumi Sano, Daisuke Sakata, Yu Nishihara, Hiroaki Amino, Akihiro Ohtsuki, Yui Okada, Takafumi Miyakawa, Makoto Kogawara, Mai Tsutsumi, Misato Takahashi, Etsuko Kawashima, Koichiro Ota, Hiroaki Miyaoka
MGB polyamide-oligonucleotide conjugates ON 1 - 4 with linked MGB polyamides at the 2-exocyclic amino group of a guanine base using aminoalkyl linkers were synthesized and evaluated in terms of binding affinity for complementary DNA containing the MGB polyamide binding sequence using T m and CD analyses. The MGB polyamides comprised pyrrole polyamides (Py4 - and Py3 -), which possess binding affinity for A-T base pairs, and imidazole (Im3 -) and pyrrole- γ -imidazole (Py3 - γ -Im3 -) polyamide hairpin motifs, which possess binding affinity for C-G base pairs...
2023: Journal of Nucleic Acids