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Oncotarget

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https://read.qxmd.com/read/30774782/correction-the-role-of-ap-1-in-self-sufficient-proliferation-and-migration-of-cancer-cells-and-its-potential-impact-on-an-autocrine-paracrine-loop
#1
Sherif Abd El-Fattah Ibrahim, Aierken Abudu, Eugenia Johnson, Neelum Aftab, Susan Conrad, Michele Fluck
[This corrects the article DOI: 10.18632/oncotarget.26047.].
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774781/correction-long-non-coding-rnas-could-act-as-vectors-for-paternal-heredity-of-high-fat-diet-induced-obesity
#2
Tian An, Teng Zhang, Fei Teng, Jia-Cheng Zuo, Yan-Yun Pan, Yu-Fei Liu, Jia-Nan Miao, Yu-Jie Gu, Na Yu, Dan-Dan Zhao, Fang-Fang Mo, Si-Hua Gao, Guangjian Jiang
[This corrects the article DOI: 10.18632/oncotarget.18138.].
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774780/emerging-approaches-to-study-cell-cell-interactions-in-tumor-microenvironment
#3
REVIEW
Nao Nishida-Aoki, Taranjit S Gujral
Cell-cell interactions are of crucial importance for tissue formation, homeostasis, regeneration processes, and immune response. Recent studies underlined contribution of cell-cell interaction in tumor microenvironment (TME) for tumor progression and metastasis. Cancer cells modify the host cells to tumor-supportive traits, and the modified host cells contribute to tumor progression by interacting with cancer cells and further modifying other normal cells. However, the complex interaction networks of cancer cells and host cells remained largely unknown...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774779/alt-cancer-cells-are-specifically-sensitive-to-lysine-acetyl-transferase-inhibition
#4
Dalal Bakhos-Douaihy, Chantal Desmaze, Maya Jeitany, Laurent R Gauthier, Denis Biard, Marie-Pierre Junier, Hervé Chneiweiss, François D Boussin
Some cancer cells elongate their telomeres through the ALT (alternative lengthening of telomeres) pathway, which is based on homologous recombination for the addition of telomere repeats without telomerase activity. General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF), two homologous lysine acetyltransferases, exert opposite effects on the ALT pathway, inhibiting or favoring it respectively. Here we show that ALT cells are particularly sensitive to the inhibition of acetyltransferases activities using Anacardic Acid (AA)...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774778/immunonutritional-consequences-of-different-serine-type-protease-inhibitors-in-a-c57bl-6-hepatocarcinoma-model
#5
Jose Laparra, Bartosz Fotschki, Claudia Haros
Imbalances in innate immunity and the activity of innate immune cells are implicated in the development of hepatocellular carcinoma (HCC). Plant seeds are good sources of protease inhibitors, which can have a significant influence on human health disorders, especially in the field of cancer prevention. To elucidate the impact and preventive effects of immunonutritional serine-type protease inhibitors (STPIs) on HCC, it was used an established model of chemically induced liver injury. Injured livers induced Akt as well as hepatic infiltration of NKG2D + and CD74 + cells...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774777/ampk-activation-by-aicar-sensitizes-prostate-cancer-cells-to-radiotherapy
#6
Colin Rae, Robert J Mairs
Although radiotherapy is often used to treat localized disease and for palliative care in prostate cancer patients, novel methods are required to improve the sensitivity of aggressive disease to ionizing radiation. AMP-activated protein kinase (AMPK) is an energy sensor which regulates proliferation, aggressiveness and survival of cancer cells. We assessed the ability of the AMPK activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) to sensitize prostate cancer cells to radiation. Prostate cancer cell lines LNCaP and PC3 were treated with X-rays and AICAR then assessed for clonogenic survival, spheroid growth delay, cell cycle progression, and AMPK and p53 activity...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774776/contribution-of-msmb-promoter-region-gene-polymorphism-to-early-onset-prostate-cancer-risk-in-mexican-males
#7
Silvia Juliana Trujillo-Cáceres, Luisa Torres-Sánchez, Ana I Burguete-García, Yaneth Citlalli Orbe Orihuela, Ruth Argelia Vázquez-Salas, Esmeralda Álvarez-Topete, Rocío Gómez
Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. MSMB gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Herein, socio-demographic features, sexually transmitted infections records, the reproductive backgrounds, and the genetic characterisation were analysed in 322 incident PC cases and 628 population healthy controls from Mexico City...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774775/poor-overall-survival-in-hyperhaploid-multiple-myeloma-is-defined-by-double-hit-bi-allelic-inactivation-of-tp53
#8
Cody Ashby, Ruslana G Tytarenko, Yan Wang, Niels Weinhold, Sarah K Johnson, Michael Bauer, Christopher P Wardell, Carolina Schinke, Sharmilan Thanendrarajan, Mauricio Zangari, Frits van Rhee, Faith E Davies, Jeffrey R Sawyer, Gareth J Morgan, Brian A Walker
Hyperhaploid multiple myeloma is a rare numerical aberration group defined by a range of 24-34 chromosomes, which is associated with a poor prognosis with a 5-year survival rate of 23%. Hyperhaploid patient samples (n=8) were sequenced and copy number and mutations identified. Samples had a median of 13 monosomies (range 12-14), which in general were those not associated with trisomies in hyperdiploid samples. The chromosomes traditionally trisomic in hyperdiploid myeloma were disomic in hyperhaploid myeloma with retention of heterodisomy...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774774/high-cxcr4-expression-impairs-rituximab-response-and-the-prognosis-of-r-chop-treated-diffuse-large-b-cell-lymphoma-patients
#9
Maria Bach Laursen, Linn Reinholdt, Anna Amanda Schönherz, Hanne Due, Ditte Starberg Jespersen, Lykke Grubach, Marianne Schmidt Ettrup, Rasmus Røge, Steffen Falgreen, Suzette Sørensen, Julie Støve Bødker, Alexander Schmitz, Hans E Johnsen, Martin Bøgsted, Karen Dybkær
Survival of diffuse large B-cell lymphoma (DLBCL) patients has improved by inclusion of rituximab. Refractory/recurrent disease caused by treatment resistance is, however, a major problem. Determinants of rituximab sensitivity are not fully understood, but effect of rituximab are enhanced by antagonizing cell surface receptor CXCR4. In a two-step strategy, we tested the hypothesis that prognostic value of CXCR4 in DLBCL relates to rituximab treatment, due to a hampering effect of CXCR4 on the response of DLBCL cells to rituximab...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774773/prostate-specific-loss-of-uxt-promotes-cancer-progression
#10
Yu Wang, Eric D Schafler, Phillip A Thomas, Susan Ha, Gregory David, Emily Adney, Michael J Garabedian, Peng Lee, Susan K Logan
Ubiquitously-expressed, prefoldin-like chaperone (UXT) also called Androgen Receptor Trapped clone-27 (ART-27) is widely expressed in human tissues. Our previous studies showed that UXT regulates transcription repression including androgen receptor (AR) signaling in prostate cancer. Here we analyzed a tissue microarray consisting of normal prostate, benign prostatic hyperplasia, high grade prostatic intraepithelial neoplasia (HGPIN) and primary prostate cancer cases for UXT protein expression. We found that HGPIN and malignant tumors have significantly decreased UXT expression compared to the normal prostate...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774772/can-we-predict-long-term-survival-in-resectable-pancreatic-ductal-adenocarcinoma
#11
Tamara M H Gall, Gareth Gerrard, Adam E Frampton, Leandro Castellano, Raida Ahmad, Nagy Habib, Duncan Spalding, Madhava Pai, Letizia Foroni, Long R Jiao
Objective: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumour associated with poor 5-year survival. We aimed to determine factors which differentiate short and long-term survivors and identify a prognostic biomarker. Methods: Over a ten-year period, patients with resected PDAC who developed disease recurrence within 12 months (Group I) and those who had no disease recurrence for 24 months (Group II) were identified. Clinicopathological data was analysed...
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774771/personalised-surveillance-after-treatment-for-high-risk-cancer
#12
EDITORIAL
Christina Guo, Jeremy Lewin, Mark Shackleton
No abstract text is available yet for this article.
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774770/systems-proteogenomics-for-precision-oncology
#13
EDITORIAL
Frederick Klauschen
No abstract text is available yet for this article.
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774769/parp6-inhibition-as-a-strategy-to-exploit-centrosome-clustering-in-cancer-cells
#14
EDITORIAL
Zebin Wang, Shaun E Grosskurth, Huawei Chen
No abstract text is available yet for this article.
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774768/pro-tumorigenic-non-pump-function-of-sodium-iodide-symporter-a-reimagined-trojan-horse
#15
EDITORIAL
Fang Feng, Lamis Yehia, Charis Eng
No abstract text is available yet for this article.
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774767/a-novel-combined-targeted-therapy-with-bromodomain-antagonist-and-mek-inhibitor-in-anaplastic-thyroid-cancer
#16
COMMENT
Carmelo Nucera
No abstract text is available yet for this article.
January 22, 2019: Oncotarget
https://read.qxmd.com/read/30774766/correction-the-nrf2-inhibitor-brusatol-is-a-potent-antitumour-agent-in-an-orthotopic-mouse-model-of-colorectal-cancer
#17
Jonathan P Evans, Boleslaw K Winiarski, Paul A Sutton, Robert P Jones, Lorenzo Ressel, Carrie A Duckworth, D Mark Pritchard, Zhi-Xiu Lin, Vicky L Fretwell, Elizabeth M Tweedle, Eithne Costello, Christopher E Goldring, Ian M Copple, B Kevin Park, Daniel H Palmer, Neil R Kitteringham
[This corrects the article DOI: 10.18632/oncotarget.25497.].
January 18, 2019: Oncotarget
https://read.qxmd.com/read/30774765/correction-up-regulation-of-p16-by-mir-877-3p-inhibits-proliferation-of-bladder-cancer
#18
Shiqi Li, Yi Zhu, Zhen Liang, Xiao Wang, Shuai Meng, Xin Xu, Xianglai Xu, Jian Wu, Alin Ji, Zhenghui Hu, Yiwei Lin, Hong Chen, Yeqing Mao, Wei Wang, Xiangyi Zheng, Ben Liu, Liping Xie
[This corrects the article DOI: 10.18632/oncotarget.10575.].
January 18, 2019: Oncotarget
https://read.qxmd.com/read/30774764/downregulation-of-mir-194-5p-induces-paclitaxel-resistance-in-ovarian-cancer-cells-by-altering-mdm2-expression
#19
Koji Nakamura, Kenjiro Sawada, Mayuko Miyamoto, Yasuto Kinose, Akihiko Yoshimura, Kyoso Ishida, Masaki Kobayashi, Aasa Shimizu, Erika Nakatsuka, Kae Hashimoto, Seiji Mabuchi, Tadashi Kimura
Paclitaxel is a first-line drug for treating epithelial ovarian cancer (EOC). However, prognosis for patients with advanced stage cancer remains poor due to primary or acquired drug resistance. Therefore, overcoming chemoresistance is one of the greatest challenges in treating EOC. In this study, we identified microRNAs (miRNA) that regulate paclitaxel resistance and tested their potential utility as therapeutic targets. Paclitaxel-resistant cell lines were established using two EOC cell lines: SKVO3ip1 and HeyA8...
January 18, 2019: Oncotarget
https://read.qxmd.com/read/30774763/preoperative-mri-radiomics-features-improve-prediction-of-survival-in-glioblastoma-patients-over-mgmt-methylation-status-alone
#20
Florent Tixier, Hyemin Um, Dalton Bermudez, Aditi Iyer, Aditya Apte, Maya S Graham, Kathryn S Nevel, Joseph O Deasy, Robert J Young, Harini Veeraraghavan
Background: Glioblastoma (GBM) is the most common malignant central nervous system tumor, and MGMT promoter hypermethylation in this tumor has been shown to be associated with better prognosis. We evaluated the capacity of radiomics features to add complementary information to MGMT status, to improve the ability to predict prognosis. Methods: 159 patients with untreated GBM were included in this study and divided into training and independent test sets. 286 radiomics features were extracted from the magnetic resonance images acquired prior to any treatments...
January 18, 2019: Oncotarget
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