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Clinical and Experimental Gastroenterology

George Uchenna Eleje, Henrietta Aritetsoma Ogbunugafor, Chiemelu Dickson Emegoakor, Ebere Innocent Okoye, Ogochukwu Ifeanyi Ezejiofor, Shirley Nneka Chukwurah, Joseph Ifeanyichukwu Ikechebelu, Godwin W Nchinda, Chidozie Godwin Ugochukwu, Lucy Ijeoma Nnaji-Ihedinmah, Festus Basden C Okoye, Frank Uchenna Eneh, Michael Emeka Onwukamuche, Charles Okechukwu Esimone
Background: To our knowledge, there is no prior randomized study on the utility of Syferol-IHP (blend of virgin coconut oil and Ocimum sanctum oil) when coadministered with a triple therapy schedule. Aim: This study determined the efficacy and safety of Syferol-IHP as adjunct to conventional triple therapy for the treatment of peptic ulcer disease (PUD). Methods: A pilot double-blind randomized trial was conducted in patients with confirmed diagnosis (endoscopy-guided biopsy) of PUD...
2019: Clinical and Experimental Gastroenterology
Byron P Vaughn, Thomas Kaiser, Christopher Staley, Matthew J Hamilton, Jon Reich, Carolyn Graiziger, Stephanie Singroy, Amanda J Kabage, Michael J Sadowsky, Alexander Khoruts
Introduction: Inflammatory bowel disease (IBD) is thought to arise from an abnormal immune response to the gut microbiota. IBD is associated with altered intestinal microbial community structure and functionality, which may contribute to inflammation and complications such as colon cancer and liver disease. Primary sclerosing cholangitis (PSC) is associated with IBD and markedly increases the risk of colon cancer. We hypothesized that secondary bile acids, which are products of microbial metabolism, are increased in PSC patients...
2019: Clinical and Experimental Gastroenterology
Mamoon H Al-Omari, Khaleel Qararha, Mohammed Garaleh, Mahmoud M Smadi, Mohammed Bani Hani, Mwaffaq Elheis
Purpose: The aim was to compare computed tomography (CT) findings between patients with mesenteric panniculitis (MP) with and without known malignancy. Patients and methods: We retrospectively analyzed 116 consecutive patients who were diagnosed with MP on the basis of CT findings and categorized them according to the absence (Group 1: 73 patients) or presence (Group 2: 43 patients) of malignancy. Patient age and sex, diameter, size, mass effect, location, and fat density of the MP mass, presence of a pseudocapsule and/or halo sign, and lymph node status were compared between the two groups...
2019: Clinical and Experimental Gastroenterology
Jonathan P Segal, Matteo Rottoli, Richard K Felwick, Guy Ht Worley, Simon D McLaughlin, Carlo Vallicelli, Paul Bassett, Omar D Faiz, Ailsa L Hart, Susan K Clark
Aim: Prepouch ileitis (PPI) is inflammation of the ileum proximal to an ileoanal pouch, usually associated with pouchitis. The treatment of PPI as a specific entity has been poorly studied, but it is generally treated concurrently with pouchitis. This to our knowledge is the largest study to explore the efficacy of biologics for the specific treatment of PPI. Methods: This was a retrospective observational study reporting outcomes following biological treatment in patients with PPI across three centers...
2018: Clinical and Experimental Gastroenterology
Udo Rudloff
Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a recently described, rare gastric polyposis syndrome. It is characterized by extensive involvement of the fundus and body of the stomach with fundic gland polyps sparing the antrum and lesser curvature, an autosomal dominant inheritance pattern with incomplete penetrance, and a significant predisposition for the development of gastric adenocarcinoma. Due to the recent discovery of APC promotor IB mutations (c.-191T>C, c.-192A>G, and c...
2018: Clinical and Experimental Gastroenterology
Vicki K Wing, Yan Song, Cheryl Xiang, Xinyue Liu, Dendy Macaulay, Maria Ponsillo, William A Blumentals
Purpose: Short bowel syndrome (SBS) is a serious rare disorder that is usually managed with parenteral nutrition. Central venous catheter (CVC)-related complications are known to occur, but their incidence rates (IRs) in Japan are unknown. The aim of this study was to estimate the incidence of complications in Japanese patients with CVCs, including patients with SBS using CVCs. Patients and methods: A retrospective cohort study in 64,817 patients with CVCs, including 81 patients with SBS, between April 2008 and October 2016 using a claims database in Japan was conducted...
2018: Clinical and Experimental Gastroenterology
Naomi C Sacks, Abhishek Sharma, Philip L Cyr, Gerald Bertiger, David N Dahdal, Stuart P Brogadir
Background and aims: Proper bowel cleansing is necessary prior to colonoscopy, but poor tolerability to bowel preparation agents may increase the odds of poor cleansing and incomplete screenings. The aim of this study was to evaluate the real-world effectiveness and safety of bowel preparation agents. Methods: Claims data were extracted for individuals who had a screening colonoscopy from July 1, 2012, to June 30, 2015, were ≥18 years of age, and who could be observed ≥6 months before and ≥3 months after the screening...
2018: Clinical and Experimental Gastroenterology
Anas A Youssef, Hisham A Issa, Maha Z Omar, Eman G Behiry, Asmaa A Elfallah, Ali Hasaneen, Mohamed Darwish, Dalia B Ibrahim
Objectives: The aim of this study was to assess serum levels of endocan & VEGF in patients with hepatitis C virus-related HCC and their diagnostic and predictive value of mortality. Methods: A total of 195 patients with CHC were subdivided into the following two groups: 105 HCV cirrhotic patients with HCC and 90 HCV cirrhotic patients without HCC. Sixty apparently healthy subjects served as the control group. The serum VEGF and endocan were assessed by ELISA...
2018: Clinical and Experimental Gastroenterology
Rodrigo Galhardi Gasparini, Ligia Yukie Sassaki, Rogerio Saad-Hossne
Purpose: This study aimed to estimate the incidence and prevalence of inflammatory bowel disease (IBD) in São Paulo, Brazil, for 2012-2015. Patients and methods: This observational, descriptive, and cross-sectional study included 22,638 IBD patients out of 43,046,555 inhabitants, who had initiated their treatment through the Governmental Program of the Brazilian Unified National Health System between the years of 2012 and 2015. The onset of the disease (used to determine incidence) was established as the date of the patient's initial registration in the Governmental Program with a diagnosis for Crohn's disease (CD) or ulcerative colitis (UC)...
2018: Clinical and Experimental Gastroenterology
Ghada M El Sagheer, Asmaa K Ahmad, Aliaa S Abd-ElFattah, Zienab M Saad, Lamia Hamdi
Background: Fibroblast growth factor (FGF) 21 was reported to be induced by different injurious agents, including chronic hepatitis C (CHC) virus, affecting the liver. The aims of this study were to evaluate the FGF21 levels in CHC patients before and after the treatment with direct-acting antiviral agents (DAAs) in comparison to that in control subjects and to correlate these levels with insulin resistance (IR), lipid profile, and fibrosis stages. Patients and methods: We studied 75 naive CHC patients and 40 age- and gender-matched healthy control subjects...
2018: Clinical and Experimental Gastroenterology
Jihan Harki, Mustafa Suker, M Sherezade Tovar-Doncel, Louisa Jd van Dijk, Désirée van Noord, Casper Hj van Eijck, Marco J Bruno, Ernst J Kuipers, Can Ince
Background: Little is known about the microcirculatory alterations in patients with chronic mesenteric ischemia (CMI). We hypothesized that patients with CMI have an impaired microcirculatory function and show an oral microcirculatory response after caloric challenge compared to healthy controls. Methods: All patients and controls received the standard workup for CMI. Sublingual micro-circulation was evaluated before (T0) and 20 minutes after (T1) feeding. The total vessel density (TVD; mm/mm2 ), perfused vessel density (PVD; mm/mm2 ), proportion of perfused vessels (PPV; %) and microvascular flow index (MFI; AU) were assessed...
2018: Clinical and Experimental Gastroenterology
Stephen Inns, Jeffrey Wong, Dena McPhedran, Gladys De Guzman, Katherine Broome, Dalice Sim, Rosemarie Sandford
Introduction: Efficient and accurate triage of endoscopy referrals is essential. Many of the decisions made are based on national and local triage criteria. Standardizing this approach for nurse use could maintain quality, address clinical risk and significantly improve resource utilization. Aims: This study aimed to compare gastroenterologist and nurse triage of unselected gastroenterology referrals in order to evaluate the proportion of referrals felt able to be triaged to endoscopy and the inter-rater agreement between a triage gastroenterologist and endoscopy nurses for clinical triage decisions regarding the urgency of gastroscopy and colonoscopy...
2018: Clinical and Experimental Gastroenterology
Spencer D Dorn, Holly O Cirri, Audrey O Chang, Seth D Crockett, Joseph A Galanko, John A Baron
Purpose: Managing and communicating colonoscopy-generated pathology results and appropriate follow-up recommendations can be challenging. To improve this process, we developed and implemented a standardized electronic health record-based intervention with built-in decision support. Methods: Fourteen attending endoscopists performed enough colonoscopies to qualify for the study. For each, we randomly sampled and abstracted data from 35 colonoscopies that met prespecified inclusion criteria during both the pre-intervention and also post-intervention periods...
2018: Clinical and Experimental Gastroenterology
Michael Kukulka, Sai Nudurupati, Maria Claudia Perez
Objective: To assess the effect of route of administration on the bioavailability of dexlansoprazole 60 mg delayed-release capsule granules. Methods: One open-label, Phase I, single-dose, 3-period crossover study was conducted in healthy adults. The bioavailability of Dexilant® (dexlansoprazole) after dexlansoprazole capsule granules were mixed with water and administered via 16 French nasogastric tube or orally via syringe was compared to administration of the intact capsule in the fasted state, swallowed with water...
2018: Clinical and Experimental Gastroenterology
Michele Malaguarnera, Saverio Latteri, Gaetano Bertino, Roberto Madeddu, Vito Emanuele Catania, Giuseppe Currò, Antonio Maria Borzì, Filippo Drago, Giulia Malaguarnera
Purpose: Portal vein thrombosis (PVT) is one of the severe complications of hepatocellular carcinoma (HCC). PVT deteriorates the liver, and its dysfunction increases the risk of bleeding, influencing the prognosis of patients with liver cirrhosis and HCC. The aim of our study was to investigate whether D-dimer testing could be a sensitive marker for the diagnosis and prognosis of HCC patients with PVT. Patients and methods: Between June 2010 and December 2015, 118 HCC patients were admitted to Cannizzaro Hospital, Catania, and 50 controls were recruited from their relatives for health examinations...
2018: Clinical and Experimental Gastroenterology
Silvana Bonilla, Samuel Nurko
Chronic abdominal pain is frequently encountered in pediatric practice. A large proportion of cases meet Rome criteria for abdominal pain-functional gastrointestinal disorders (AP-FGIDs). These disorders are costly and, in some cases, lead to impairment of daily functioning and overall quality of life. Pathophysiologic mechanisms include early stressful events, visceral hypersensitivity, dysmotility, changes in intestinal microbiota, and altered central nervous system processing. They are considered disorders of the brain-gut interaction...
2018: Clinical and Experimental Gastroenterology
Danny J Avalos, Irene Sarosiek, Priyadarshini Loganathan, Richard W McCallum
Diabetic gastroparesis (DMGP) is a condition of delayed gastric emptying after gastric outlet obstruction has been excluded. Symptoms of nausea, vomiting, early satiety, bloating, and abdominal pain are associated with DMGP. Uncontrolled symptoms can lead to overall poor quality of life and financial burdens on the healthcare system. A combination of antiemetics and prokinetics is used in symptom control; metoclopramide is the main prokinetic available for clinical use and is the only U.S. Food and Drug Administration-approved agent in the United States...
2018: Clinical and Experimental Gastroenterology
Christopher Chang
Irritable bowel syndrome (IBS) is a common gastrointestinal (GI) disorder characterized by abdominal pain that occurs with defecation or alterations in bowel habits. Further classification is based on the predominant bowel habit: constipation-predominant IBS, diarrhea-predominant IBS (IBS-D), or mixed IBS. The pathogenesis of IBS is unclear and is considered multifactorial in nature. GI dysbiosis, thought to play a role in IBS pathophysiology, has been observed in patients with IBS. Alterations in the gut microbiota are observed in patients with small intestinal bacterial overgrowth, and overgrowth may occur in a subset of patients with IBS...
2018: Clinical and Experimental Gastroenterology
Vanessa Mateus, João Rocha, Hélder Mota-Filipe, Bruno Sepodes, Rui Pinto
Purpose: Hemin is a heme-oxygenase inducer, which can confer anti-inflammatory, cytoprotective, and antiapoptotic effects. These properties are beneficial therapeutical effects to inflammatory bowel disease (IBD). IBD is a worldwide health problem characterized by chronic inflammation of intestinal epithelium, which promotes intestinal and extraintestinal symptomatology. Current treatment only induces and maintains the patient in remission and results in many side effects. The research of other pharmacologic approaches is crucial to the treatment of IBD...
2018: Clinical and Experimental Gastroenterology
Kamesh Gupta, Pooja Rani, Anurag Rohatgi, Mukesh Verma, Shivani Handa, Keemi Dalal, Anand Jain
Objective: To evaluate the effectiveness of noradrenaline for the treatment of hepatorenal syndrome (HRS). Background: HRS represents the development of renal failure in cirrhotic patients. The standard treatment for HRS is terlipressin, which, as opposed to noradrenaline, is more expensive and less accessible in most tertiary care centers. Patients and methods: Thirty consecutive patients with HRS type 1 received noradrenaline (1-4.0 mg/hour) and albumin for 14 days...
2018: Clinical and Experimental Gastroenterology
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