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Journals Clinical and Experimental Gast...

Clinical and Experimental Gastroenterology

https://read.qxmd.com/read/38434179/tchh-as-a-novel-prognostic-biomarker-for-patients-with-gastric-cancer-by-bioinformatics-analysis
#1
JOURNAL ARTICLE
Fu Yu, Li Xia Zhao, Shangqi Chu
BACKGROUND: This study aims to investigate the clinicopathological significance and prognostic value of Trichohyalin (TCHH) in gastric cancer patients through bioinformatics analysis. MATERIALS AND METHODS: Data on TCHH expression and clinicopathological information were sourced from The Cancer Genome Atlas (TCGA). The Wilcoxon signed-rank test was used for evaluating the correlation between TCHH mRNA expression levels and clinicopathological features. The predictive significance of TCHH mRNA expression for overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) in patients with gastric cancer was assessed using Cox regression models...
2024: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38434178/clinicopathological-characteristics-treatment-and-prognosis-in-duodenal-adenocarcinoma-with-liver-metastasis-a-seer-based-study
#2
JOURNAL ARTICLE
Zhengchun Zhu, Hong Liu, Fei Zhong
BACKGROUND AND OBJECTIVES: Duodenal adenocarcinoma (DAC) is a rare tumor that is often accompanied by liver metastasis in advanced stages. The aim of this study was to evaluate the correlation between clinicopathological characteristics and survival in DAC patients with liver metastasis, and to explore appropriate treatment options. METHODS: 482 DAC patients with liver metastasis were retrospectively identified from the Surveillance, Epidemiology and End Results (SEER) database (2011-2020)...
2024: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38404929/a-novel-rat-model-to-simulate-the-benign-esophageal-stricture-induced-by-endoscopic-submucosal-dissection
#3
JOURNAL ARTICLE
Yin-Gen Luo, Xiao-Wu Zhang, He Zhao, Jin-Gui Li, Jiay-Wei Tsauo, Tao Gong, Ai-Xin Ou, Tian-Hao Cong, Wen-Di Kang, Xiao Li
OBJECTIVE: This study aimed to establish a rat model that simulates benign esophageal strictures induced by endoscopic submucosal dissection (ESD). MATERIALS AND METHODS: Sixteen male Sprague-Dawley rats were randomly divided into mucosal resection (n = 8) and sham-operated groups (n = 8). The rats in the mucosal resection group underwent a 5-mm three-fourths mucosal resection by way of a 3-mm incision in the distal esophagus under direct visualization via laparotomy...
2024: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38352171/endoscopic-assisted-percutaneous-sigmoidopexy-new-highlights-on-technique-and-outcomes
#4
Abdel Rahman A Al Manasra, Tarik Alhmoud, Zaid Mesmar, Ahmad Hamaydeh
BACKGROUND: Sigmoid volvulus is primarily a disease of the elderly. CASE PRESENTATION: We describe a case of recurrent sigmoid volvulus in an elderly woman who refused surgery due to the high risk posed by general anesthesia and surgical intervention. She underwent endoscopic-assisted percutaneous sigmoidopexy using only three 2-shot anchor sets. No radiographic observation was necessary during the procedure. Some puncture sites were secured using endoscopic clips...
2024: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38352170/relevance-of-procalcitonin-levels-as-a-marker-of-severity-and-predictor-of-mortality-initiation-and-duration-of-antibiotics-in-patients-admitted-with-acute-pancreatitis-a-retrospective-cohort-study
#5
JOURNAL ARTICLE
Baldeep Kaur Mann, Janpreet Singh Bhandohal, Ishaan Kalha, Kasey Fox, Brian Jean
INTRODUCTION: Procalcitonin levels have been studied to predict the benefit of adding antibiotics in a patient with acute pancreatitis. Through this study, we are searching for any possible correlation between serum procalcitonin levels and the severity of acute pancreatitis (included acute on chronic cases) to determine whether procalcitonin levels can predict a benefit from antibiotic therapy in acute pancreatitis. METHODS: This is a retrospective cohort study involving patients with acute pancreatitis and acute on chronic pancreatitis...
2024: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38298861/magnetic-resonance-enterography-assessment-of-transmural-healing-with-vedolizumab-in-moderate-to-severe-crohn-s-disease-feasibility-in-the-versify-phase-3-clinical-trial
#6
JOURNAL ARTICLE
Jordi Rimola, Jean-Frédéric Colombel, Brian Bressler, Shashi Adsul, Jenifer Siegelman, Patricia E Cole, Dirk Lindner, Silvio Danese
PURPOSE: The VERSIFY phase 3 trial in patients with Crohn's disease (CD) treated with vedolizumab was the first to include a substudy that used a standardized magnetic resonance enterography (MRE) protocol to assess features of transmural inflammation (bowel edema and wall thickness) and extramural disease activity (enlarged lymph nodes). PATIENTS AND METHODS: Patients received intravenous vedolizumab (300 mg) at weeks 0 (baseline), 2, and 6, and then every 8 weeks for 26 or 52 weeks...
2024: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38205357/obstacles-to-early-diagnosis-of-acute-hepatic-porphyria-current-perspectives-on-improving-early-diagnosis-and-clinical-management
#7
REVIEW
Manish Thapar, Akash Singh, Kevin M Robinson, Herbert L Bonkovsky
Porphyrias are, for the most part, inherited disorders of the heme biosynthetic pathway which lead to accumulation of specific intermediates responsible for most of the symptoms and signs of biochemically active disease. Acute hepatic porphyrias usually come to clinical attention primarily in women in their reproductive years who present with episodic, severe, generalized abdominal pain. Such acute attacks may also be associated with tachycardia, systemic arterial hypertension, hyponatremia, recent history of dark reddish to brownish urine, and anxiety, delirium, and sensory or motor neuropathies...
2024: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38143515/development-of-a-pharmacokinetic-model-that-accounts-for-the-plasma-concentrations-of-conjugated-and-unconjugated-bilirubin-observed-in-a-variety-of-disease-states
#8
JOURNAL ARTICLE
David G Levitt, Michael D Levitt
INTRODUCTION: For a large variety of liver pathologies, the plasma unconjugated (UB) and conjugated (CB) bilirubin concentrations appear to be coupled. For example, in alcoholic cirrhosis, UB and CB are roughly the same over a large range of total bilirubin, requiring an initial massive increase (about 40-fold) in plasma CB to reach the level of UB and then similar increases in UB and CB as the disease progresses. This coupling has been either unrecognized or ignored and this paper is the first attempt to try to explain it quantitatively in terms of known hepatic cell metabolic and membrane transport properties...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38111516/personalized-treatment-for-crohn-s-disease-current-approaches-and-future-directions
#9
REVIEW
Joseph William Clinton, Raymond Keith Cross
Crohn's disease is a complex, relapsing and remitting inflammatory disorder of the gastrointestinal tract with a variable disease course. While the treatment options for Crohn's disease have dramatically increased over the past two decades, predicting individual patient response to treatment remains a challenge. As a result, patients often cycle through multiple different therapies before finding an effective treatment which can lead to disease complications, increased costs, and decreased quality of life. Recently, there has been increased emphasis on personalized medicine in Crohn's disease to identify individual patients who require early advanced therapy to prevent complications of their disease...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38090679/psma-targeted-pet-radiotracer-18-f-dcfpyl-as-an-imaging-biomarker-in-inflammatory-bowel-disease
#10
Mohamed Saleh Ismail, Diane E Peters, Steven P Rowe, Ali Salavati, Sowmya Sharma, Robert A Anders, Martin Pomper, Barbara S Slusher, Florin M Selaru
BACKGROUND: Prostate-specific membrane antigen (PSMA) is highly and specifically upregulated in active-inflamed mucosa of patients with inflammatory bowel disease (IBD). We hypothesized that this upregulation would be detectable using a PSMA-targeted positron emission tomography/computed tomography (PET/CT) imaging agent, [18 F]DCFPyL, enabling non-invasive visualization of inflammation. A noninvasive means of detecting active inflammation would have high clinical value in localization and management of IBD...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38090678/gardenia-iridoid-glucosides-protect-against-%C3%AE-naphthalene-isothiocya-nate-induced-cholestatic-rats-through-activation-of-the-fxr-shp-signaling-pathway
#11
JOURNAL ARTICLE
Meng Xu, Ke Che, Cong Wang, Ya-Ru Chen, Meng-Yuan Chen, Guang-Lei Zhang, Hao Yu, Hao-Nan Xu, Ya-Bao Li, Ping Sheng, Hao Chen
INTRODUCTION: Cholestasis is a common liver disorder that currently has limited treatment options. Gardenia Iridoid Glucosides (GIG) have been found to possess various physiological activities, such as cholagogic, hypoglycemic, antibacterial, and anti-inflammatory effects. The objective of this study was to investigate the effects of GIG on bile acid enterohepatic circulation and explore the underlying mechanism in cholestatic rats. METHODS: In order to identify key pathways associated with cholestasis, we conducted Gene Ontology (GO) Enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/38023814/body-mass-index-profile-of-adult-patients-with-inflammatory-bowel-disease-in-a-multicenter-study-in-northeastern-brazil
#12
JOURNAL ARTICLE
Jones Silva Lima, Carlos Alexandre Antunes de Brito, Lívia Medeiros Soares Celani, Marcelo Vicente Toledo de Araújo, Maurilio Toscano de Lucena, Graciana Bandeira Salgado Vasconcelos, Gustavo André Silva Lima, Fernando Jorge Firmino Nóbrega, George Tadeu Nunes Diniz, Norma Lucena-Silva, Regiane Maio, Valéria Ferreira Martinelli
PURPOSE: Inflammatory bowel disease (IBD) is a disease of increasing prevalence in developing countries. Obesity has emerged as a potential risk for IBD; however, the data in the literature are conflicting, and relevant studies in Brazil are limited. Here, we report body mass index profile (BMI) of patients with IBD treated at reference centers in three states of northeastern Brazil. PATIENTS AND METHODS: Observational descriptive study conducted from January 2021 through December 2021 in patient with IBD...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/37954129/dumping-syndrome-pragmatic-treatment-options-and-experimental-approaches-for-improving-clinical-outcomes
#13
REVIEW
Gwen M C Masclee, Ad A M Masclee
Dumping syndrome is a common complication after esophageal, gastric and bariatric surgery and has a significant negative impact on the quality of life of patients. This narrative review describes the clinical syndrome, pathophysiology, diagnosis and reports on standard and pragmatic therapeutical treatment options in order to improve the clinical outcome of patients with dumping syndrome. Dumping syndrome consists of early and late dumping symptoms and can be diagnosed using clinical parameters with the help of the Sigstad's score, questionnaires or by provocative testing...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/37920418/indications-and-findings-of-upper-gastrointestinal-endoscopy-at-a-tertiary-hospital-in-ethiopia-a-cross-sectional-study
#14
JOURNAL ARTICLE
Abel Mureja Argaw, Samrawit Solomon Ethiopia, Geda Lelisa, Henok Fisseha, Biruk Mulugeta
BACKGROUND: Gastrointestinal disease is a significant global health problem. Symptoms related to digestive system diseases negatively affect quality of life and impose a significant economic impact. Upper gastrointestinal symptoms are common in the Ethiopian population, and the associated pathologies are diverse. Real-time endoscopic visualization of the upper gastrointestinal tract is crucial for diagnosis. However, local data on the indications for endoscopic evaluation and the common underlying pathologies are limited...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/37904894/wandering-spleen-and-acute-gastric-volvulus-in-an-elderly-woman-with-acute-abdomen-a-case-report
#15
Somprakas Basu, Arvind Pratap, Satyanam Kumar Bhartiya, Vijay Kumar Shukla
Gastric volvulus is an uncommon clinical condition with the potentially life-threatening complication of acute gastric necrosis. A wandering spleen may also be associated with gastric volvulus and can produce a diagnostic dilemma as the cause of an acute abdomen. We present a case of an elderly woman who presented with acute abdominal symptoms. She did not have the classical Borchardt triad to diagnose gastric volvulus and had a coexisting wandering spleen. Although torsion and ischemia of the wandering spleen were initially thought to be the cause of acute abdomen, a subsequent contrast-enhanced CT (CECT) scan confirmed a coexistent mesenteric-axial gastric volvulus with gangrenous changes...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/37753185/prevalence-of-oral-helicobacter-pylori-infection-in-an-indigenous-community-in-southwest-mexico
#16
JOURNAL ARTICLE
Victor Hugo Urrutia-Baca, Karen Ivonne Gonzalez Brosig, Alina Abigail Salazar-Garza, Ricardo Gomez-Flores, Patricia Tamez-Guerra, Myriam Angelica De La Garza-Ramos
PURPOSE: Epidemiological studies have been conducted to improve the health and economic quality of life of indigenous communities in Mexico. These studies have found that infections cause frequent health problems. Helicobacter pylori are responsible for conditions ranging from gastritis to stomach cancer. This study determined the prevalence of H. pylori in families from Siltepec, Chiapas, Mexico. PATIENT AND METHODS: Ninety-nine dental plaque samples from 36 families were studied...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/37614978/a-multicenter-randomized-phase-ii-trial-investigating-the-effect-of-polyglycolic-acid-sheet-on-the-prevention-of-pancreatic-fistula-after-gastrectomy-with-prophylactic-lymph-node-dissection
#17
JOURNAL ARTICLE
Dai Shimizu, Chie Tanaka, Mitsuro Kanda, Koki Nakanishi, Seiji Ito, Yachiyo Kuwatsuka, Masahiko Ando, Kenta Murotani, Michitaka Fujiwara, Yasuhiro Kodera
Pancreatic fistula after gastrectomy with lymph node dissection is associated with prolonged hospital stay and critical complications such as intra-abdominal bleeding and sepsis. Polyglycolic acid (PGA) sheets are absorbable suture reinforcement materials. A randomized Phase II trial has been planned to evaluate the effect of PGA sheets on preventing postoperative pancreatic fistula. A total of 320 patients will be recruited from thirteen institutions. Patients who are scheduled to undergo distal or total gastrectomy will be randomly allocated into the PGA group or control group, and the dissected area around the pancreas will be covered by the PGA sheet in the PGA group...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/37609124/emerging-therapies-for-ulcerative-colitis-updates-from-recent-clinical-trials
#18
REVIEW
Turki AlAmeel, Abdulelah AlMutairdi, Badr Al-Bawardy
Ulcerative colitis (UC) is a chronic and progressive inflammatory disorder that affects the colon. The advent of advanced therapies such as biologic agents and small molecules has revolutionized the management of UC. Despite the expanding therapeutic armamentarium of advanced therapies to treat UC, the overall net remission rates and durability of currently available agents are relatively low. This highlights the need for further drug development and more innovative clinical trial design. There are currently multiple emerging agents in the pipeline for the management of UC...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/37605644/relationship-of-serum-bile-acids-with-fat-deposition-in-the-pancreas-liver-and-skeletal-muscle
#19
JOURNAL ARTICLE
Zena Al-Ani, Juyeon Ko, Maxim S Petrov
INTRODUCTION: Ectopic fat deposition is well appreciated as a key contributor to digestive and liver diseases. Bile acids have emerged as pleiotropic signalling molecules involved in numerous metabolic pathways. The aim was to study the associations of bile acids with ectopic fat deposition and lipid panel. METHODS: A single 3.0 Tesla magnetic resonance imaging scanner was employed to measure fat deposition in the pancreas, liver, and skeletal muscle in 76 adults...
2023: Clinical and Experimental Gastroenterology
https://read.qxmd.com/read/37601009/hypertension-and-histopathology-severity-of-non-alcoholic-fatty-liver-disease-among-adults-with-obesity-a-cross-sectional-study
#20
JOURNAL ARTICLE
Diego Chambergo-Michilot, Paola K Rodrigo-Gallardo, Mariella R Huaman, Angie Z Vasquez-Chavesta, Gustavo Salinas-Sedo, Carlos J Toro-Huamanchumo
BACKGROUND: Cardiovascular diseases are responsible for the majority of deaths resulting from non-alcoholic fatty liver disease (NAFLD). NAFLD is associated with hypertension and this is a key predictor of severe liver outcomes and an indicator of nonspecific portal fibrosis. AIM: To assess the association between hypertension and NAFLD severity. METHODS: We conducted a secondary analysis of data from Peruvian adults with obesity and NAFLD who attended a Peruvian bariatric center...
2023: Clinical and Experimental Gastroenterology
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