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Journals World Journal of Gastrointesti...

World Journal of Gastrointestinal Oncology

https://read.qxmd.com/read/38994174/fine-needle-aspiration-technique-under-endoscopic-ultrasound-guidance-a-technical-approach-for-rna-profiling-of-pancreatic-neoplasms
#1
JOURNAL ARTICLE
Sabina Sherafedinovna Seyfedinova, Olga Aleksandrovna Freylikhman, Polina Sergeevna Sokolnikova, Konstantin Aleksandrovich Samochernykh, Anna Aleksandrovna Kostareva, Olga Viktorovna Kalinina, Evgeniy Gennadievich Solonitsyn
BACKGROUND: Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) has been a longstanding challenge. The prognosis of patients with PDAC depends on the stage at diagnosis. It is necessary to identify biomarkers for the detection and differentiation of pancreatic tumors and optimize PDAC sample preparation procedures for DNA and RNA analysis. Most molecular studies are done using paraffin-embedded blocks; however, the integrity of DNA and RNA is often compromised in this format. Moreover, RNA isolated from human pancreatic tissue samples is generally of low quality, in part, because of the high concentration of endogenous pancreatic RNAse activity present...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994173/n-glycosylation-of-wnt3-regulates-the-progression-of-hepatocellular-carcinoma-by-affecting-wnt-%C3%AE-catenin-signal-pathway
#2
JOURNAL ARTICLE
Xin-Zhan Zhang, Xiao-Chuan Mo, Zhu-Ting Wang, Rong Sun, Da-Quan Sun
BACKGROUND: Wnt/FZD-mediated signaling pathways are activated in more than 90% of hepatocellular carcinoma (HCC) cell lines. As a well-known secretory glycoprotein, Wnt3 can interact with FZD receptors on the cell surface, thereby activating the Wnt/β-catenin signaling pathway. However, the N-glycosylation modification site of Wnt3 and the effect of this modification on the biological function of the protein are still unclear. AIM: To investigate the effect of Wnt3 N-glycosylation on the biological function of HCC cells...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994172/unraveling-colorectal-cancer-prevention-the-vitamin-d-gut-flora-immune-system-nexus
#3
REVIEW
Zhi-Song Zhan, Zu-Shun Zheng, Jing Shi, Juan Chen, Si-Yi Wu, Shi-Yan Zhang
Colorectal cancer (CRC) is one of the most common cancers diagnosed in the world. Although environmental and genetic factors play a major role in the pathogenesis of CRC, extensive research has suggested that vitamin D may play a pivotal role in the development of CRC. Vitamin D, primarily obtained through sunlight exposure, dietary sources, and supplements, has long been recognized for its essential functions in maintaining health, including immune regulation. This article delves into the intricate relationship between vitamin D, the immune system, gut flora, and the prevention of CRC...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994171/sm-like-5-knockdown-inhibits-proliferation-and-promotes-apoptosis-of-colon-cancer-cells-by-upregulating-p53-cdkn1a-and-tnfrsf10b
#4
JOURNAL ARTICLE
Cai-Jing Mo, Xiao-Yuan Deng, Ru-Lan Ma, Kun Zhu, Lei Shi, Kang Li
BACKGROUND: The role of Sm-like 5 (LSM5) in colon cancer has not been determined. In this study, we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism involved. AIM: To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism involved. METHODS: The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis analysis...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994170/application-of-fusobacterium-nucleatum-as-a-biomarker-in-gastrointestinal-malignancies
#5
EDITORIAL
Long-Chen Yu, Ya-Ping Li, Yue-Ming Xin, Mai Mao, Ya-Xin Pan, Yi-Xuan Qu, Zheng-Dong Luo, Yi Zhang, Xin Zhang
The morbidity and mortality of gastrointestinal (GI) malignancies are among the highest in the world, posing a serious threat to human health. Because of the insidious onset of the cancer, it is difficult for patients to be diagnosed at an early stage, and it rapidly progresses to an advanced stage, resulting in poor treatment and prognosis. Fusobacterium nucleatum ( F. nucleatum ) is a gram-negative, spore-free anaerobic bacterium that primarily colonizes the oral cavity and is implicated in the development of colorectal, esophageal, gastric, and pancreatic cancers via various intricate mechanisms...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994169/development-of-a-diagnostic-nomogram-for-alpha-fetoprotein-negative-hepatocellular-carcinoma-based-on-serological-biomarkers
#6
JOURNAL ARTICLE
Li He, Cui Zhang, Lan-Lan Liu, Li-Ping Huang, Wen-Jing Lu, Yuan-Yuan Zhang, De-Yong Zou, Yu-Fei Wang, Qing Zhang, Xiao-Li Yang
BACKGROUND: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Serum biomarkers play an important role in the early diagnosis and prognosis of HCC. Because a certain percentage of HCC patients are negative for alpha-fetoprotein (AFP) , the diagnosis of AFP-negative HCC is essential to improve the detection rate of HCC. AIM: To establish an effective model for diagnosing AFP-negative HCC based on serum tumour biomarkers. METHODS: A total of 180 HCC patients were enrolled in this study...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994168/epidemiology-and-prognostic-nomogram-for-locally-advanced-gastric-signet-ring-cell-carcinoma-a-population-based-study
#7
JOURNAL ARTICLE
Ze-Hao Yu, Lei-Ming Zhang, Zhi-Qi Dai, Meng-Na Zhang, Si-Ming Zheng
BACKGROUND: Gastric signet ring cell carcinoma (GSRC) represents a specific subtype of gastric cancer renowned for its contentious epidemiological features, treatment principles, and prognostic factors. AIM: To investigate the epidemiology of GSRC and establish an improved model for predicting the prognosis of patients with locally advanced GSRC (LAGSRC) after surgery. METHODS: The annual rates of GSRC incidence and mortality, covering the years 1975 to 2019, were extracted from the Surveillance, Epidemiology, and End Results (SEER) database to explore the temporal trends in both disease incidence and mortality rates using Joinpoint software...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994167/t1-colorectal-cancer-management-in-the-era-of-minimally-invasive-endoscopic-resection
#8
EDITORIAL
Shirley Xue Jiang, Aein Zarrin, Neal Shahidi
T1 colorectal cancer (CRC), defined by tumor invasion confined to the submucosa, has historically been managed by surgery. Improved understanding of recurrence and lymph node metastases risk, coupled with advances in endoscopic resection techniques, have led to an increasing capacity for organ-sparing local excision. Minimally invasive management of T1 CRC begins with optical evaluation of the lesion to diagnose invasive disease and quantify depth of invasion, which informs therapeutic decision making. Modality selection between various available endoscopic resection techniques depends upon lesion characteristics, technique risk-benefit profiles, and location-specific implications...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994166/mixed-neuroendocrine-and-adenocarcinoma-of-gastrointestinal-tract-a-complex-diagnosis-and-therapeutic-challenge
#9
EDITORIAL
Santosh Shenoy
In this editorial we comment on the manuscript describing a case of adenocarcinoma mixed with a neuroendocrine carcinoma of the gastroesophageal junction. Mixed neuroendocrine and non-neuroendocrine neoplasms of the gastrointestinal system are rare heterogeneous group of tumors characterized by a high malignant potential, rapid growth, and poor prognosis. Due to the rarity of these cancers, the standard therapy is poorly defined. The diagnosis of these tumors is based on combination of morphological features, immunohistochemical and neuroendocrine and epithelial cell markers...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994165/meta-analysis-of-transarterial-chemoembolization-combined-with-cryoablation-vs-transarterial-chemoembolization-alone-for-%C3%A2-5-cm-hepatocellular-carcinoma
#10
JOURNAL ARTICLE
Jie-Fei Cheng, Qiu-Lian Sun, Ling Tang, Xin-Jian Xu, Xiang-Zhong Huang
BACKGROUND: Hepatocellular carcinoma (HCC) ranks sixth globally in cancer incidence and third in mortality rates. Unfortunately, over 70% of HCC patients forego the opportunity for curative surgery or liver transplantation due to inadequate physical examinations, poor physical condition, and limited organ availability upon diagnosis. Clinical guidelines endorse transarterial chemoembolization (TACE) as the frontline treatment for intermediate to advanced-stage HCC. Cryoablation (CRA) is an emerging local ablative therapy increasingly used in HCC management...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994164/drug-eluting-bead-transarterial-chemoembolization-as-neoadjuvant-therapy-pre-liver-transplantation-for-advanced-stage-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
Zhao-Dan Ye, Li Zhuang, Meng-Chen Song, Zhe Yang, Wu Zhang, Jing-Feng Zhang, Guo-Hong Cao
BACKGROUND: The objectives of this study were to assess the safety and efficacy of drug-eluting bead transarterial chemoembolization (DEB-TACE) as neoadjuvant therapy before liver transplantation (LT) for advanced-stage hepatocellular carcinoma (HCC) and to analyze the prognostic factors. AIM: To determine whether DEB-TACE before LT is superior to LT for advanced-stage HCC. METHODS: A total of 99 individuals diagnosed with advanced HCC were studied retrospectively...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994163/retraction-note-to-rna-binding-protein-cpsf6-regulates-ibsp-to-affect-pyroptosis-in-gastric-cancer
#12
Xue-Jun Wang, Yong Liu, Bin Ke, Li Zhang, Han Liang
[This retracts the article on p. 1531 in vol. 15, PMID: 37746647.].
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994162/circ_0004592-an-auxiliary-diagnostic-biomarker-for-gastric-cancer
#13
JOURNAL ARTICLE
Shan Kong, Yan-Hua Xu, Ming Zheng, Shao-Qing Ju, Heng-Chuan Shi
BACKGROUND: Gastric cancer (GC) has a high mortality rate, and robust diagnostic biomarkers are currently lacking. However, the clinical relevance of circular RNAs (circRNAs) as GC biomarkers remains largely unexplored. AIM: To evaluate the potential of novel circRNA circ_0004592 in the early screening and prognosis of GC. METHODS: High-throughput sequencing of circRNAs was performed to screen for potential target molecules. Circ_0004592 expression was examined in GC tissues, cells, and plasma...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994161/association-between-helicobacter-pylori-infection-mismatch-repair-her2-and-tumor-infiltrating-lymphocytes-in-gastric-cancer
#14
JOURNAL ARTICLE
Carlos A Castaneda, Miluska Castillo, Luis A Bernabe, Joselyn Sanchez, Matteo Fassan, Katherine Tello, Ignacio Ivan Wistuba, Ivan Chavez Passiuri, Eloy Ruiz, Juvenal Sanchez, Fernando Barreda, Daniel Valdivia, Yaqueline Bazan, Milagros Abad-Licham, Claudio Mengoa, Hugo Fuentes, Paola Montenegro, Ebert Poquioma, Raul Alatrista, Claudio J Flores, Luis Taxa
BACKGROUND: The influence of Helicobacter-pylori ( H. pylori ) infection and the characteristics of gastric cancer (GC) on tumor-infiltrating lymphocyte (TIL) levels has not been extensively studied. Analysis of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive information. AIM: To determine the rates of deficient mismatch-repair (dMMR), HER2-status and H. pylori infection and their association with TIL levels in GC. METHODS: Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral (IT), stromal (ST) and invasive-border (IB) compartments...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994160/impact-of-baseline-hepatitis-b-virus-viral-load-on-the-long-term-prognosis-of-advanced-hepatocellular-carcinoma-treated-with-immunotherapy
#15
JOURNAL ARTICLE
Di Pan, Hao-Nan Liu, Zhi-Yuan Yao, Xiao-Xiao Chen, Yu-Qi Li, Jing-Jing Zhu, Zheng-Xiang Han, Xiao-Bing Qin
BACKGROUND: Although the combination of lenvatinib and PD-1 inhibitors has become the standard regimen for the treatment of advanced hepatocellular carcinoma (HCC), real data on the impact of baseline hepatitis B virus (HBV)-DNA levels on the clinical efficacy of this regimen is still limited. AIM: To evaluate the effectiveness of camrelizumab combined with lenvatinib in patients with HCC at varying levels of HBV-DNA. METHODS: One hundred and twenty patients with HCC who received camrelizumab and lenvatinib treatment were categorized into two cohorts: HBV-DNA ≤ 2000 ( n = 66) and HBV-DNA > 2000 ( n = 54)...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994159/bidirectional-effects-of-the-tryptophan-metabolite-indole-3-acetaldehyde-on-colorectal-cancer
#16
JOURNAL ARTICLE
Ze Dai, Kai-Li Deng, Xiao-Mei Wang, Dong-Xue Yang, Chun-Lan Tang, Yu-Ping Zhou
BACKGROUND: Colorectal cancer (CRC) has a high incidence and mortality. Recent studies have shown that indole derivatives involved in gut microbiota metabolism can impact the tumorigenesis, progression, and metastasis of CRC. AIM: To investigate the effect of indole-3-acetaldehyde (IAAD) on CRC. METHODS: The effect of IAAD was evaluated in a syngeneic mouse model of CRC and CRC cell lines (HCT116 and DLD-1). Cell proliferation was assessed by Ki-67 fluorescence staining and cytotoxicity tests...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994158/predictive-value-of-preoperative-routine-examination-for-the-prognosis-of-patients-with-pt2n0m0-or-pt3n0m0-colorectal-cancer
#17
JOURNAL ARTICLE
Peng-Fei Jing, Jin Chen, En-Da Yu, Chao-Yu Miao
BACKGROUND: In recent years, the incidence of colorectal cancer (CRC) has been increasing. With the popularization of endoscopic technology, a number of early CRC has been diagnosed. However, despite current treatment methods, some patients with early CRC still experience postoperative recurrence and metastasis. AIM: To search for indicators associated with early CRC recurrence and metastasis to identify high-risk populations. METHODS: A total of 513 patients with pT2N0M0 or pT3N0M0 CRC were retrospectively enrolled in this study...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994157/complement-factor-i-knockdown-inhibits-colon-cancer-development-by-affecting-wnt-%C3%AE-catenin-c-myc-signaling-pathway-and-glycolysis
#18
JOURNAL ARTICLE
Yong-Jun Du, Yue Jiang, Yan-Mei Hou, Yong-Bo Shi
BACKGROUND: Colon cancer (CC) occurrence and progression are considerably influenced by the tumor microenvironment. However, the exact underlying regulatory mechanisms remain unclear. AIM: To investigate immune infiltration-related differentially expressed genes (DEGs) in CC and specifically explored the role and potential molecular mechanisms of complement factor I (CFI). METHODS: Immune infiltration-associated DEGs were screened for CC using bioinformatics...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994156/extrahepatic-cholestasis-associated-with-paracoccidioidomycosis-challenges-in-the-differential-diagnosis-of-biliopancreatic-neoplasia
#19
JOURNAL ARTICLE
José Sebastião Dos Santos, Vitor de Moura Arrais, William José Rosseto Ferreira, Ricardo Ribeiro Correa Filho, Mariângela Ottoboni Brunaldi, Rafael Kemp, Ajith Kumar Sankanrakutty, Jorge Elias Junior, Fernando Bellissimo-Rodrigues, Roberto Martinez, Edson Zangiacomi Martinez, José Celso Ardengh
BACKGROUND: Paracoccidioidomycosis (PCM) may involve the hepatic pedicle and peripancreatic lymph nodes, cause damage to the bile duct and manifest, exceptionally, in combination with extrahepatic cholestasis (EHC), making investigation and treatment challenging. AIM: To investigate the management of patients with visceral PCM admitted with EHC. METHODS: All patients diagnosed with PCM treated in a public, tertiary teaching hospital between 1982 and 2020 were retrospectively evaluated...
June 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38994155/comprehensive-analysis-of-clinical-and-biological-value-of-ing-family-genes-in-liver-cancer
#20
JOURNAL ARTICLE
Shi-Cai Liu
BACKGROUND: Liver cancer (LIHC) is a malignant tumor that occurs in the liver and has a high mortality in cancer. The ING family genes were identified as tumor suppressor genes. Dysregulated expression of these genes can lead to cell cycle arrest, senescence and/or apoptosis. ING family genes are promising targets for anticancer therapy. However, their role in LIHC is still not well understood. AIM: To have a better understanding of the important roles of ING family members in LIHC...
June 15, 2024: World Journal of Gastrointestinal Oncology
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