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World Journal of Gastrointestinal Oncology

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https://read.qxmd.com/read/31040898/significance-of-her2-protein-expression-and-her2-gene-amplification-in-colorectal-adenocarcinomas
#1
Xin-Yu Wang, Zhi-Xue Zheng, Yu Sun, Yan-Hua Bai, Yun-Fei Shi, Li-Xin Zhou, Yun-Feng Yao, Ai-Wen Wu, Deng-Feng Cao
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver, and a well-established therapeutic target in breast and gastric cancers. While the role of HER2 as a prognostic biomarker in colorectal adenocarcinomas (CRCs) remains uncertain, its relevance as a therapeutic target has been established. We undertook the present study to evaluate the frequency of HER2 expression in CRC and to correlate it with various clinicopathological variables. AIM: To correlate HER2 protein expression and HER2 gene amplification with clinicopathological features and survival in surgically resected CRC...
April 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/31040897/validated-model-for-prediction-of-recurrent-hepatocellular-carcinoma-after-liver-transplantation-in-asian-population
#2
Ka Wing Ma, Wong Hoi She, Albert Chi Yan Chan, Tan To Cheung, James Yan Yue Fung, Wing Chiu Dai, Chung Mau Lo, Kenneth Siu Ho Chok
BACKGROUND: Liver transplantation (LT) is regarded as the best treatment for both primary and recurrent hepatocellular carcinoma (HCC). Post-transplant HCC recurrence rate is relatively low but significant, ranging from 10%-30% according to different series. When recurrence happens, it is usually extrahepatic and associated with poor prognosis. A predictive model that allows patient stratification according to recurrence risk can help to individualize post-transplant surveillance protocol and guidance of the use of anti-tumor immunosuppressive agents...
April 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/31040896/iodine-125-implantation-with-transjugular-intrahepatic-portosystemic-shunt-for-main-portal-vein-tumor-thrombus
#3
Yue Zhang, Yi-Fan Wu, Zhen-Dong Yue, Hong-Wei Zhao, Lei Wang, Zhen-Hua Fan, Fu-Liang He, Tao Wang, Fu-Quan Liu
BACKGROUND: Main portal vein tumor thrombus (MPVTT), which has a high incidence, is the major complication of terminal liver cancer. The occurrence of MPVTT is always a negative prognostic factor for patients with hepatocellular carcinoma (HCC). Therefore, attention should be paid to the treatment of MPVTT and its complications. AIM: To evaluate the efficacy of transarterial chemoembolization/transarterial embolization (TACE/TAE)+125 I seeds implantation with transjugular intrahepatic portosystemic shunt (TIPS) in treating MPVTT and its complications...
April 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/31040895/predictive-factors-of-histological-response-of-colorectal-liver-metastases-after-neoadjuvant-chemotherapy
#4
Chloé Serayssol, Charlotte Maulat, Florence Breibach, Fatima-Zohra Mokrane, Janick Selves, Rosine Guimbaud, Philippe Otal, Bertrand Suc, Emilie Berard, Fabrice Muscari
BACKGROUND: Colorectal cancer is the third most common cancer in men and the second most common in women worldwide. Almost a third of the patients has or will develop liver metastases. Neoadjuvant chemotherapy (NAC) has recently become nearly systematic prior to surgery of colorectal livers metastases (CRLMs). The response to NAC is evaluated by radiological imaging according to morphological criteria. More recently, the response to NAC has been evaluated based on histological criteria of the resected specimen...
April 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/31040894/up-regulation-of-tumor-necrosis-factor-%C3%AE-pathway-survival-genes-and-of-the-receptor-tnfr2-in-gastric-cancer
#5
Ana Flávia Teixeira Rossi, Júlia Cocenzo Contiero, Fernanda da Silva Manoel-Caetano, Fábio Eduardo Severino, Ana Elizabete Silva
BACKGROUND: Gastric carcinogenesis can be induced by chronic inflammation triggered by Helicobacter pylori ( H. pylori ) infection. Tumor necrosis factor (TNF)-α and its receptors (TNFR1 and TNFR2) regulate important cellular processes, such as apoptosis and cell survival, and the disruption of which can lead to cancer. This signaling pathway is also modulated by microRNAs (miRNAs), altering gene expression. AIM: To evaluate the mRNA and miRNAs expression involved in the TNF-α signaling pathway in gastric cancer (GC) tissues and its relationship...
April 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/31040893/identification-of-genomic-features-associated-with-immunotherapy-response-in-gastrointestinal-cancers
#6
REVIEW
Yin He, Zhi-Xian Liu, Ze-Hang Jiang, Xiao-Sheng Wang
Gastrointestinal (GI) cancers prevail and account for an extremely high number of cancer deaths worldwide. The traditional treatment strategies, including surgery, chemotherapy, radiotherapy, and targeted therapy, have a limited therapeutic effect for advanced GI cancers. Recently, immunotherapy has shown promise in treating various refractory malignancies, including the GI cancers with mismatch repair deficiency (dMMR) or microsatellite instability (MSI). Thus, immunotherapy could be a promising treatment approach for GI cancers...
April 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30918598/stent-placement-followed-by-preoperative-chemotherapy-and-elective-surgery-for-acute-malignant-colorectal-obstruction-six-cases-of-report
#7
Jun-Jie Liu, Teng-Hui Ma, Qi-Yuan Qin, Lei Wang
BACKGROUND: The self-expandable metal stent is used as a bridge to surgery in the treatment of acute malignant colorectal obstruction (AMCO). However, recent studies have shown inferior long-term outcomes and increased risk of tumor dissemination after stent placement. In addition, the optimal interval between stent placement and surgery is not clear. The aim of the current study was to present a new strategy for AMCO: stent placement followed by preoperative chemotherapy and elective surgery...
March 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30918597/near-infrared-fluorescence-guided-esophageal-reconstructive-surgery-a-systematic-review
#8
Elke Van Daele, Yves Van Nieuwenhove, Wim Ceelen, Christian Vanhove, Bart P Braeckman, Anne Hoorens, Jurgen Van Limmen, Oswald Varin, Dirk Van de Putte, Wouter Willaert, Piet Pattyn
BACKGROUND: After an esophagectomy, the stomach is most commonly used to restore continuity of the upper gastrointestinal tract. These esophago-gastric anastomoses are prone to serious complications such as leakage associated with high morbidity and mortality. Graft perfusion is considered to be an important predictor for anastomotic integrity. Based on the current literature we believe Indocyanine green fluorescence angiography (ICGA) is an easy assessment tool for gastric tube (GT) perfusion, and it might predict anastomotic leakage (AL)...
March 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30918596/risk-of-cholangiocarcinoma-in-patients-undergoing-therapeutic-endoscopic-retrograde-cholangiopancreatography-or-cholecystectomy-a-population-based-study
#9
Chi-Chih Wang, Ming-Chang Tsai, Wen-Wei Sung, Tzu-Wei Yang, Hsuan-Yi Chen, Yao-Tung Wang, Chang-Cheng Su, Ming-Hseng Tseng, Chun-Che Lin
BACKGROUND: Cholangiocarcinoma is a highly lethal disease that had been underestimated in the past two decades. Many risk factors are well documented for in cholangiocarcinoma, but the impacts of advanced biliary interventions, like endoscopic sphincterotomy (ES), endoscopic papillary balloon dilatation (EPBD), and cholecystectomy, are inconsistent in the previous literature. AIM: To clarify the risks of cholangiocarcinoma after ES/EPBD, cholecystectomy or no intervention for cholelithiasis using the National Health Insurance Research Database (NHIRD)...
March 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30918595/hepatic-resection-vs-percutaneous-radiofrequency-ablation-of-hepatocellular-carcinoma-abutting-right-diaphragm
#10
Kyoung Doo Song, Hyo Keun Lim, Hyunchul Rhim, Min Woo Lee, Tae Wook Kang, Yong Han Paik, Jong Man Kim, Jae-Won Joh
BACKGROUND: It is usually difficult to adequately conduct percutaneous ultrasound-guided radiofrequency (RF) ablation for hepatocellular carcinomas (HCCs) abutting the diaphragm. Our hypothesis was that the subphrenic location of HCC could have an effect on the long-term therapeutic outcomes after hepatic resection and RF ablation. AIM: To compare the long-term therapeutic outcomes of hepatic resection and percutaneous RF ablation for HCCs abutting the diaphragm...
March 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30918594/post-operative-computed-tomography-scan-reliable-tool-for-quality-assessment-of-complete-mesocolic-excision
#11
Cristian Livadaru, Stefan Morarasu, Tudor Cristian Frunza, Florina A Ghitun, Elena Florina Paiu-Spiridon, Florina Sava, Cristina Terinte, Dan Ferariu, Sorinel Lunca, Gabriel Mihail Dimofte
BACKGROUND: Quality control in colon cancer surgery is an ongoing debate ever since standardization proved to be highly efficient in improving survival in rectal cancer. Complete mesocolic excision (CME) is widely acclaimed as the new gold-standard in colon cancer resections, thus it is imperative to establish quality criteria of CME in order to make it easily understood and verified by surgeons worldwide. One simple and reproducible tool could be the measurement of arterial stumps postoperatively and a straightforward way to test its reliability is to test it in a comparative study between CME and non-CME surgery...
March 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30918593/human-colorectal-cancer-cells-frequently-express-igg-and-display-unique-ig-repertoire
#12
Zi-Han Geng, Chun-Xiang Ye, Yan Huang, Hong-Peng Jiang, Ying-Jiang Ye, Shan Wang, Yuan Zhou, Zhan-Long Shen, Xiao-Yan Qiu
BACKGROUND: There is growing evidence proving that many human carcinomas, including colon cancer, can overexpress immunoglobulin (Ig); the non B cancer cell-derived Ig usually displayed unique V(D)J rearrangement pattern that are distinct from B cell-derived Ig. Especially, the cancer-derived Ig plays important roles in cancer initiation, progression, and metastasis. However, it still remains unclear if the colon cancer-derived Ig can display unique V(D)J pattern and sequencing, which can be used as novel target for colon cancer therapy...
March 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30918592/glycerophospholipids-pathways-and-chromosomal-instability-in-gastric-cancer-global-lipidomics-analysis
#13
Cheng-Yu Hung, Ta-Sen Yeh, Cheng-Kun Tsai, Ren-Chin Wu, Ying-Chieh Lai, Meng-Han Chiang, Kuan-Ying Lu, Chia-Ni Lin, Mei-Ling Cheng, Gigin Lin
BACKGROUND: Based on the breakthrough of genomics analysis, The Cancer Genome Atlas Research Group recently proposed an integrative genomic analysis, dividing gastric cancer (GC) into four subtypes, characterized by the chromosomal instability (CIN) status. However, the CIN status of GC is still vaguely characterized and lacking the valuable easy-to-use CIN markers to diagnosis in molecular and histological detection. AIM: To explore the associations of CIN with downstream lipidomics profiles...
March 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30788043/anal-carcinoma-in-giant-anal-condyloma-multidisciplinary-approach-necessary-for-optimal-outcome-two-case-reports-and-review-of-literature
#14
Santosh Shenoy, Murali Nittala, Yazen Assaf
BACKGROUND: Anal cancers are caused by human papilloma virus (HPV). Buschke-Lowenstein tumor also known as giant anal condyloma (GCA) is a variant of giant neglected anal tumors arising from warts caused by HPV infection. HPV are a family of double-stranded DNA viruses and primarily cause sexually transmitted disease of the genitalia and oropharyngeal mucosa. These tumors are slow growing; locally destructive large verrucous masses. CASE SUMMARY: We present a series of two cases with large anal tumors harboring invasive cancers and highlight their presentation and management...
February 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30788042/comparison-of-endoscopic-submucosal-dissection-with-surgical-gastrectomy-for-early-gastric-cancer-an-updated-meta-analysis
#15
Hua Li, Li-Qian Feng, Yao-Yao Bian, Li-Li Yang, Deng-Xiang Liu, Zhi-Bin Huo, Li Zeng
BACKGROUND: There are several surgical options for treating early gastric cancers (EGCs), such as endoscopic resection, laparoscopic or open gastrectomy with D1 or D2 lymphadenectomy. Endoscopic resection for EGC with low risk of lymph node metastasis has been widely accepted as a therapeutic alternative. The role of endoscopic submucosal dissection (ESD) in treating EGC is not well established, especially when compared with resection surgery cases in a long-term follow-up scope. AIM: To compare the safety and efficacy of the short- and long-term outcomes between ESD and resection surgery...
February 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30788041/feasibility-of-terahertz-imaging-for-discrimination-of-human-hepatocellular-carcinoma
#16
Feng Duan, Yu-Ye Wang, De-Gang Xu, Jia Shi, Lin-Yu Chen, Li Cui, Yan-Hua Bai, Yong Xu, Jing Yuan, Chao Chang
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, and novel methods for early/rapid diagnosis of HCC are needed. Terahertz (THz) spectroscopy is considered to have the potential to distinguish between normal liver tissue and HCC tissue; however, there are few reports on it. We conduct this observational study to explore the feasibility of THz imaging for the diagnosis of HCC. AIM: To evaluate the feasibility of THz for discriminating between HCC and normal liver tissues using fresh tissue specimens obtained from HCC patients who had undergone surgery...
February 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30788040/c-reactive-protein-may-be-a-prognostic-factor-for-the-whole-gastroenteropancreatic-neuroendocrine-tumor-group
#17
Ömer Komaç, Göksel Bengi, Özgül Sağol, Mesut Akarsu
BACKGROUND: Long non-coding RNAs (lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer (GC). Considering the crucial functions of lncRNAs, the identification and exploration of novel lncRNAs in GC is necessary. AIM: To identify independent prognostic markers for the whole gastroenteropancreatic neuroendocrine tumor (GEP-NET) group...
February 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30788039/redox-immune-and-genetic-biomarker-system-for-personalized-treatments-in-colorectal-cancer
#18
Anna Maria Berghella, Anna Aureli, Angelica Canossi, Tiziana Del Beato, Alessia Colanardi, Patrizia Pellegrini
BACKGROUND: Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer (CRC) onset that could improve clinical strategies. AIM: To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer treatment. METHODS: A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumor-node-metastasis classification...
February 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30788038/identification-of-patients-with-pancreatic-adenocarcinoma-due-to-inheritable-mutation-challenges-of-daily-clinical-practice
#19
Alexander Jp Fulton, Angela Lamarca, Christina Nuttall, Lynne McCallum, Rille Pihlak, Derek O'Reilly, Fiona Lalloo, Mairéad G McNamara, Richard A Hubner, Tara Clancy, Juan W Valle
BACKGROUND: Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. AIM: To assess the referral pathways for genetic consultations in PDAC. METHODS: Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria...
February 15, 2019: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30788037/novel-long-non-coding-rna-linc02532-promotes-gastric-cancer-cell-proliferation-migration-and-invasion-in-vitro
#20
Cheng Zhang, Ming-Hui Ma, Yu Liang, Kun-Zhe Wu, Dong-Qiu Dai
BACKGROUND: Long non-coding RNAs (lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer (GC). Considering the crucial functions of lncRNAs, the identification and exploration of novel lncRNAs in GC is necessary. AIM: To explore the role of novel lncRNA LINC02532 in GC...
February 15, 2019: World Journal of Gastrointestinal Oncology
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