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Journals World Journal of Gastrointesti...

World Journal of Gastrointestinal Oncology

https://read.qxmd.com/read/38425409/global-research-trends-and-prospects-of-cellular-metabolism-in-colorectal-cancer
#1
JOURNAL ARTICLE
Yan-Chen Liu, Zhi-Cheng Gong, Chao-Qun Li, Peng Teng, Yan-Yan Chen, Zhao-Hui Huang
BACKGROUND: An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer (CRC). However, no work is currently available to synthesize the field through bibliometrics. AIM: To analyze the development in the field of "glucose metabolism" (GM), "amino acid metabolism" (AM), "lipid metabolism" (LM), and "nucleotide metabolism" (NM) in CRC by visualization. METHODS: Articles within the abovementioned areas of GM, AM, LM and NM in CRC, which were published from January 1, 1991, to December 31, 2022, are retrieved from the Web of Science Core Collection and analyzed by CiteSpace 6...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425408/expression-of-cyclin-dependent-kinase-9-is-positively-correlated-with-the-autophagy-level-in-colon-cancer
#2
JOURNAL ARTICLE
Lei Zheng, Jia Lu, Da-Lu Kong
BACKGROUND: Cyclin-dependent kinase 9 (CDK9) expression and autophagy in colorectal cancer (CRC) tissues has not been widely studied. CDK9, a key regulator of transcription, may influence the occurrence and progression of CRC. The expression of autophagy-related genes BECN1 and drug resistance factor ABCG2 may also play a role in CRC. Under normal physiological conditions, autophagy can inhibit tumorigenesis, but once a tumor forms, autophagy may promote tumor growth. Therefore, understanding the relationship between autophagy and cancer, particularly how autophagy promotes tumor growth after its formation, is a key motivation for this research...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425407/progress-in-the-treatment-of-advanced-hepatocellular-carcinoma-with-immune-combination-therapy
#3
REVIEW
Di Pan, Hao-Nan Liu, Peng-Fei Qu, Xiao Ma, Lu-Yao Ma, Xiao-Xiao Chen, Yu-Qin Wang, Xiao-Bing Qin, Zheng-Xiang Han
Advanced hepatocellular carcinoma (HCC) is a severe malignancy that poses a serious threat to human health. Owing to challenges in early diagnosis, most patients lose the opportunity for radical treatment when diagnosed. Nonetheless, recent advancements in cancer immunotherapy provide new directions for the treatment of HCC. For instance, monoclonal antibodies against immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with HCC...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425406/anti-egfr-antibody-monotherapy-for-colorectal-cancer-with-severe-hyperbilirubinemia-a-case-report
#4
Toshiaki Tsurui, Yuya Hirasawa, Yutaro Kubota, Kiyoshi Yoshimura, Takuya Tsunoda
BACKGROUND: Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer (CRC). Effective drainage is often impossible before initiating systemic chemotherapy, owing to the liver's diffuse metastatic involvement. Moreover, an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently unavailable. CASE SUMMARY: The patient, a man in his 50s, presented with progressive fatigue and severe jaundice...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425405/prognostic-value-of-circulating-tumor-cells-combined-with-neutrophil-lymphocyte-ratio-in-patients-with-hepatocellular-carcinoma
#5
JOURNAL ARTICLE
Jia-Li Chen, Lu Guo, Zhen-Ying Wu, Kun He, Han Li, Chi Yang, Yun-Wei Han
BACKGROUND: Circulating tumor cell (CTC) count and neutrophil-to-lymphocyte ratio (NLR) are both closely associated with the prognosis of hepatocellular carcinoma (HCC). AIM: To investigate the prognostic value of combining these two indicators in HCC. METHODS: Clinical data were collected from patients with advanced HCC who received immune therapy combined with targeted therapy at the Department of Oncology, the Affiliated Hospital of Southwest Medical University, Sichuan, China, from 2021 to 2023...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425404/comprehensive-analysis-of-the-protein-phosphatase-2a-regulatory-subunit-b56%C3%AE%C2%B5-in-pan-cancer-and-its-role-and-mechanism-in-hepatocellular-carcinoma
#6
JOURNAL ARTICLE
Hong-Mei Wu, Yuan-Yuan Huang, Yu-Qiu Xu, Wei-Lai Xiang, Chang Yang, Ru-Yuan Liu, Di Li, Xue-Feng Guo, Zheng-Bao Zhang, Chun-Hua Bei, Sheng-Kui Tan, Xiao-Nian Zhu
BACKGROUND: B56ε is a regulatory subunit of the serine/threonine protein phosphatase 2A, which is abnormally expressed in tumors and regulates various tumor cell functions. At present, the application of B56ε in pan-cancer lacks a comprehensive analysis, and its role and mechanism in hepatocellular carcinoma (HCC) are still unclear. AIM: To analyze B56ε in pan-cancer, and explore its role and mechanism in HCC. METHODS: The Cancer Genome Atlas, Genotype-Tissue Expression, Gene Expression Profiling Interactive Analysis, and Tumor Immune Estimation Resource databases were used to analyze B56ε expression, prognostic mutations, somatic copy number alterations, and tumor immune characteristics in 33 tumors...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425403/prohibitin-1-inhibits-cell-proliferation-and-induces-apoptosis-via-the-p53-mediated-mitochondrial-pathway-in-vitro
#7
JOURNAL ARTICLE
Juan-Juan Shi, Yi-Kai Wang, Mu-Qi Wang, Jiang Deng, Ning Gao, Mei Li, Ya-Ping Li, Xin Zhang, Xiao-Li Jia, Xiong-Tao Liu, Shuang-Suo Dang, Wen-Jun Wang
BACKGROUND: Prohibitin 1 (PHB1) has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed, and it participates in a variety of essential cellular functions, including apoptosis, cell cycle regulation, proliferation, and survival. Emerging evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma (HCC). However, the role of PHB1 in HCC is controversial. AIM: To investigate the effects of PHB1 on the proliferation and apoptosis of human HCC cells and the relevant mechanisms in vitro ...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425402/multifaceted-role-of-micrornas-in-gastric-cancer-stem-cells-mechanisms-and-potential-biomarkers
#8
REVIEW
Qian-Hui Sun, Zi-Yu Kuang, Guang-Hui Zhu, Bao-Yi Ni, Jie Li
MicroRNAs (miRNAs) have received much attention in the past decade as potential key epigenomic regulators of tumors and cancer stem cells (CSCs). The abnormal expression of miRNAs is responsible for different phenotypes of gastric cancer stem cells (GCSCs). Some specific miRNAs could be used as promising biomarkers and therapeutic targets for the identification of GCSCs. This review summarizes the coding process and biological functions of miRNAs and demonstrates their role and efficacy in gastric cancer (GC) metastasis, drug resistance, and apoptosis, especially in the regulatory mechanism of GCSCs...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425401/early-adenocarcinoma-mixed-with-a-neuroendocrine-carcinoma-component-arising-in-the-gastroesophageal-junction-a-case-report
#9
Yu-Qing Cheng, Geng-Fang Wang, Xiao-Li Zhou, Min Lin, Xin-Wen Zhang, Qin Huang
BACKGROUND: Early adenocarcinoma mixed with a neuroendocrine carcinoma (NEC) component arising in the gastroesophageal junctional (GEJ) region is rare and even rarer in young patients. Here, we report such a case in a 29-year-old Chinese man. CASE SUMMARY: This patient presented to our hospital with a 3-mo history of dysphagia and regurgitation. Upper endoscopy revealed an elevated nodule in the distal esophagus 1.6 cm above the GEJ line, without Barrett's esophagus or involvement of the gastric cardia...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425400/immune-related-long-noncoding-rna-zinc-finger-protein-710-as1-201-promotes-the-metastasis-and-invasion-of-gastric-cancer-cells
#10
JOURNAL ARTICLE
Wei Ding, Wei-Wei Chen, Yi-Qin Wang, Xue-Zhong Xu, Yi-Bo Wang, Yong-Min Yan, Yu-Lin Tan
BACKGROUND: Gastric cancer (GC) is a prevalent malignant tumor of the gastrointestinal system. ZNF710 is a transcription factor (TF), and zinc finger protein 710 (ZNF710)-AS1-201 is an immune-related long noncoding RNA (lncRNA) that is upregulated in GC cells. AIM: To assess the correlation between ZNF710-AS1-201 and immune microenvironment features and to investigate the roles of ZNF710-AS1-201 in the invasion and metastasis processes of GC cells. METHODS: We obtained data from The Cancer Genome Atlas and Wujin Hospital...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425399/early-results-of-the-integrative-epigenomic-transcriptomic-landscape-of-colorectal-adenoma-and-cancer
#11
JOURNAL ARTICLE
You-Wang Lu, Zhao-Li Ding, Rui Mao, Gui-Gang Zhao, Yu-Qi He, Xiao-Lu Li, Jiang Liu
BACKGROUND: Aberrant methylation is common during the initiation and progression of colorectal cancer (CRC), and detecting these changes that occur during early adenoma (ADE) formation and CRC progression has clinical value. AIM: To identify potential DNA methylation markers specific to ADE and CRC. METHODS: Here, we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic landscape...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425398/cardiotoxicity-induced-by-fluoropyrimidine-drugs-in-the-treatment-of-gastrointestinal-tumors
#12
EDITORIAL
Mo-Wei Kong, Feng-Di Sun, Zhen-Ying Pei, Li Xu, Ze-Bi Wang, Yan Chen, Shu-Qing Tang, Ting-Fang Yang, Guo-Xiang He
In this editorial, we review the article published in World J Gastrointest Oncol 2019, 11: 1031-1042. We specifically focus on the occurrence, clinical characteristics, and risk factors of fluoropyrimidine drug-related cardiotoxicity in patients with gastrointestinal tumors. Despite significant advancements in diagnostic and therapeutic techniques that have reduced mortality rates associated with digestive system tumors, the incidence and mortality rates of treatment-related cardiotoxicity have been increasing, severely impacting the survival and prognosis of cancer patients...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425397/does-enhanced-recovery-after-surgery-programs-improve-clinical-outcomes-in-liver-cancer-surgery
#13
EDITORIAL
Belinda Sánchez-Pérez, José M Ramia
Enhanced recovery after surgery (ERAS) programs have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recommendations in 2022. Liver surgery is usually performed in oncological patients (liver metastasis, hepatocellular carcinoma, cholangiocarcinoma, etc. ), but the real impact of liver surgery ERAS programs in oncological outcomes is not clearly defined. Theoretical advantages of ERAS programs are: ERAS decreases postoperative complication rates and has been demonstrated a clear relationship between complications and oncological outcomes; a better and faster postoperative recovery should let oncologic teams begin chemotherapeutic regimens on time; prehabilitation and nutrition actions before surgery should also improve the performance status of the patients receiving chemotherapy...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425396/systemic-inflammation-response-index-and-weight-loss-as-prognostic-factors-in-metastatic-pancreatic-cancer-a-concept-study-from-the-pantheia-seom-trial
#14
JOURNAL ARTICLE
Vilma Pacheco-Barcia, Sara Custodio-Cabello, Fatima Carrasco-Valero, Magda Palka-Kotlowska, Axel Mariño-Mendez, Alberto Carmona-Bayonas, Javier Gallego, A J Muñoz Martín, Paula Jimenez-Fonseca, Luis Cabezon-Gutierrez
BACKGROUND: The prognostic value of the Systemic Inflammation Response Index (SIRI) in advanced pancreatic cancer is recognized, but its correlation with patients´ nutritional status and outcomes remains unexplored. AIM: To study the prognostic significance of SIRI and weight loss in metastatic pancreatic cancer. METHODS: The PANTHEIA-Spanish Society of Medical Oncology (SEOM) study is a multicentric (16 Spanish hospitals), observational, longitudinal, non-interventional initiative, promoted by the SEOM Real World-Evidence work group...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425395/effect-of-screening-colonoscopy-frequency-on-colorectal-cancer-mortality-in-patients-with-a-family-history-of-colorectal-cancer
#15
JOURNAL ARTICLE
Li Zheng, Bin Li, Ling Lei, Li-Jia Wang, Zhi-Ping Zeng, Jian-Dong Yang
BACKGROUND: Colorectal cancer is a common malignant tumor in China, and its incidence in the elderly is increasing annually. Inflammatory bowel disease is a group of chronic non-specific intestinal inflammatory diseases, including ulcerative colitis and Crohn's disease. AIM: To assess the effect of screening colonoscopy frequency on colorectal cancer mortality. METHODS: We included the clinicopathological and follow-up data of patients with colorectal cancer who underwent laparoscopic colectomy or open colectomy at our Gastrointestinal Department between January 2019 and December 2022...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425394/preoperative-controlling-nutritional-status-as-an-optimal-prognostic-nutritional-index-to-predict-the-outcome-for-colorectal-cancer
#16
JOURNAL ARTICLE
Li-Xiang Liu, Hao Wang, Bo Gao, Ting-Ting Xu, Qing-Gang Yuan, Shi-Zhen Zhou, Chao Ding, Ji Miao, Wen-Xian Guan
BACKGROUND: The controlling nutritional status (CONUT) score effectively reflects a patient's nutritional status, which is closely related to cancer prognosis. This study investigated the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer, and compared the predictive ability of the CONUT score with other indexes. AIM: To analyze the predictive performance of the CONUT score for the survival rate of colorectal cancer patients who underwent potentially curative resection...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425393/targeting-oxidative-stress-with-natural-products-a-novel-strategy-for-esophageal-cancer-therapy
#17
REVIEW
Fang Cao, Han-Ling Zhang, Cui Guo, Xue-Liang Xu, Qiang Yuan
Esophageal cancer (ESC) is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract. Although the exact pathogenesis of ESC has not been fully elucidated, excessive oxidative stress is an important characteristic that leads to the development of many cancers. Abnormal expression of several proteins and transcription factors contributes to oxidative stress in ESCs, which alters the growth and proliferation of ESCs and promotes their metastasis. Natural compounds, including alkaloids, terpenes, polyphenols, and xanthine compounds, can inhibit reactive oxygen species production in ESCs...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425392/identification-of-anti-gastric-cancer-effects-and-molecular-mechanisms-of-resveratrol-from-network-pharmacology-and-bioinformatics-to-experimental-validation
#18
JOURNAL ARTICLE
Ying-Qian Ma, Ming Zhang, Zhen-Hua Sun, Hong-Yue Tang, Ying Wang, Jiang-Xue Liu, Zhan-Xue Zhang, Chao Wang
BACKGROUND: Gastric cancer (GC) is one of the most aggressive malignancies with limited therapeutic options and a poor prognosis. Resveratrol, a non-flavonoid polyphenolic compound found in a variety of Chinese medicinal materials, has shown excellent anti-GC effect. However, its exact mechanisms of action in GC have not been clarified. AIM: To identify the effects of resveratrol on GC progression and explore the related molecular mechanisms. METHODS: Action targets of resveratrol and GC-related targets were screened from public databases...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425391/biological-factors-driving-colorectal-cancer-metastasis
#19
REVIEW
Shuai-Xing An, Zhao-Jin Yu, Chen Fu, Min-Jie Wei, Long-Hai Shen
Approximately 20% of colorectal cancer (CRC) patients present with metastasis at diagnosis. Among Stage I-III CRC patients who undergo surgical resection, 18% typically suffer from distal metastasis within the first three years following initial treatment. The median survival duration after the diagnosis of metastatic CRC (mCRC) is only 9 mo. mCRC is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue, allowing cancer cells to spread from primary to distant organs; however, increasing evidence suggests that the mCRC process can begin early in tumor development...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38425390/prognostic-nutritional-index-in-predicting-survival-of-patients-with-gastric-or-gastroesophageal-junction-adenocarcinoma-a-systematic-review
#20
JOURNAL ARTICLE
Stylianos Fiflis, Grigorios Christodoulidis, Menelaos Papakonstantinou, Alexandros Giakoustidis, Stergos Koukias, Paraskevi Roussos, Marina Nektaria Kouliou, Konstantinos Eleftherios Koumarelas, Dimitrios Giakoustidis
BACKGROUND: Gastric cancer is the third most common cause of cancer related death worldwide. Surgery with or without chemotherapy is the most common approach with curative intent; however, the prognosis is poor as mortality rates remain high. Several indexes have been proposed in the past few years in order to estimate the survival of patients undergoing gastrectomy. The preoperative nutritional status of gastric cancer patients has recently gained attention as a factor that could affect the postoperative course and various indexes have been developed...
February 15, 2024: World Journal of Gastrointestinal Oncology
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