journal
https://read.qxmd.com/read/38577541/retrospective-study-of-the-incidence-risk-factors-treatment-outcomes-of-bacterial-infections-at-uncommon-sites-in-cirrhotic-patients
#1
JOURNAL ARTICLE
Sophie Schneitler, Christina Schneider, Markus Casper, Frank Lammert, Marcin Krawczyk, Sören L Becker, Matthias Christian Reichert
BACKGROUND: Bacterial infections (BI) negatively affect the natural course of cirrhosis. The most frequent BI are urinary tract infections (UTI), pneumonia, and spontaneous-bacterial peritonitis (SBP). AIM: To assess the relevance of bacterial infections beyond the commonly recognized types in patients with cirrhosis and to investigate their relationship with other clinical variables. METHODS: We retrospectively analyzed patients with cirrhosis and BI treated between 2015 and 2018 at our tertiary care center...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577540/prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-end-stage-liver-disease-a-meta-analysis
#2
JOURNAL ARTICLE
Xiang-Hao Cai, Yun-Ming Tang, Shu-Ru Chen, Jia-Hui Pang, Yu-Tian Chong, Hong Cao, Xin-Hua Li
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is commonly utilized as a prognostic indicator in end-stage liver disease (ESLD), encompassing conditions like liver failure and decompensated cirrhosis. Nevertheless, some studies have contested the prognostic value of NLR in ESLD. AIM: To investigate the ability of NLR to predict ESLD. METHODS: Databases, such as Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Weipu, and Wanfang, were comprehensively searched to identify studies published before October 2022 assessing the prognostic ability of NLR to predict mortality in patients with ESLD...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577539/update-in-lean-metabolic-dysfunction-associated-steatotic-liver-disease
#3
JOURNAL ARTICLE
Karina Sato-Espinoza, Perapa Chotiprasidhi, Mariella R Huaman, Javier Díaz-Ferrer
BACKGROUND: A new nomenclature consensus has emerged for liver diseases that were previously known as non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD). They are now defined as metabolic dysfunction-associated steatotic liver disease (MASLD), which includes cardiometabolic criteria in adults. This condition, extensively studied in obese or overweight patients, constitutes around 30% of the population, with a steady increase worldwide...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577538/comparison-of-fungal-vs-bacterial-infections-in-the-medical-intensive-liver-unit-cause-or-corollary-for-high-mortality
#4
JOURNAL ARTICLE
Sarah Khan, Hanna Hong, Stephanie Bass, Yifan Wang, Xiao-Feng Wang, Omar T Sims, Christine E Koval, Aanchal Kapoor, Christina C Lindenmeyer
BACKGROUND: Due to development of an immune-dysregulated phenotype, advanced liver disease in all forms predisposes patients to sepsis acquisition, including by opportunistic pathogens such as fungi. Little data exists on fungal infection within a medical intensive liver unit (MILU), particularly in relation to acute on chronic liver failure. AIM: To investigate the impact of fungal infections among critically ill patients with advanced liver disease, and compare outcomes to those of patients with bacterial infections...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577537/advances-in-discovery-of-novel-investigational-agents-for-functional-cure-of-chronic-hepatitis-b-a-comprehensive-review-of-phases-ii-and-iii-therapeutic-agents
#5
REVIEW
Robert Lam, Joseph K Lim
Chronic hepatitis B virus (HBV) infection affects over 295 million people globally and an estimated 1.6 million people in the United States. It is associated with significant morbidity and mortality due to cirrhosis, liver failure, and liver cancer. Antiviral therapy with oral nucleos(t)ide analogues is associated with high rates of virologic suppression, which in turn has been associated with a decreased risk of liver complications. However, current antiviral regimens are limited by concerns with adverse effects, adherence, resistance, long-term treatment, and ongoing risk for liver events...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577536/palliative-long-term-abdominal-drains-vs-large-volume-paracenteses-for-the-management-of-refractory-ascites-in-end-stage-liver-disease
#6
JOURNAL ARTICLE
Senamjit Kaur, Rodrigo V Motta, Bryony Chapman, Victoria Wharton, Jane D Collier, Francesca Saffioti
BACKGROUND: Long-term abdominal drains (LTAD) are a cost-effective palliative measure to manage malignant ascites in the community, but their use in patients with end-stage chronic liver disease and refractory ascites is not routine practice. The safety and cost-effectiveness of LTAD are currently being studied in this setting, with preliminary positive results. We hypothesised that palliative LTAD are as effective and safe as repeat palliative large volume paracentesis (LVP) in patients with cirrhosis and refractory ascites and may offer advantages in patients' quality of life...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577535/hepatocellular-carcinoma-immune-microenvironment-and-check-point-inhibitors-current-status
#7
REVIEW
Tarana Gupta, Nikhil Sai Jarpula
Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and has a high mortality rate. The Barcelona Clinic Liver Cancer staging system in addition to tumor staging also links the modality of treatment available to a particular stage. The recent description of the tumor microenvironment (TME) in HCC has provided a new concept of immunogenicity within the HCC. Virus-related HCC has been shown to be more immunogenic with higher expression of cytotoxic T lymphocytes and decreased elements for immunosuppression such as regulatory T cells...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577534/lean-body-mass-index-is-a-marker-of-advanced-tumor-features-in-patients-with-hepatocellular-carcinoma
#8
JOURNAL ARTICLE
Andrew Scott deLemos, Jing Zhao, Milin Patel, Banks Kooken, Karan Mathur, Hieu Minh Nguyen, Areej Mazhar, Maggie McCarter, Heather Burney, Carla Kettler, Naga Chalasani, Samer Gawrieh
BACKGROUND: Obesity is an independent risk factor for the development of hepatocellular carcinoma (HCC) and may influence its outcomes. However, after diagnosis of HCC, like other malignancies, the obesity paradox may exist where higher body mass index (BMI) may in fact confer a survival benefit. This is frequently observed in patients with advanced HCC and cirrhosis, who often present late with advanced tumor features and cancer related weight loss. AIM: To explore the relationship between BMI and survival in patients with cirrhosis and HCC...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577533/non-alcoholic-fatty-liver-disease-and-sleep-disorders
#9
REVIEW
Lu-Fang Bu, Chong-Yu Xiong, Jie-Yi Zhong, Yan Xiong, Dong-Ming Li, Fen-Fang Hong, Shu-Long Yang
Studies have shown that non-alcoholic fatty liver disease (NAFLD) may be associated with sleep disorders. In order to explore the explicit relationship between the two, we systematically reviewed the effects of sleep disorders, especially obstructive sleep apnea (OSA), on the incidence of NAFLD, and analyzed the possible mechanisms after adjusting for confounding factors. NAFLD is independently associated with sleep disorders. Different sleep disorders may be the cause of the onset and aggravation of NAFLD...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577532/is-there-a-need-for-universal-double-reflex-testing-of-hbsag-positive-individuals-for-hepatitis-d-infection
#10
EDITORIAL
Zaigham Abbas, Minaam Abbas
Hepatitis D virus (HDV) can infect HBsAg-positive individuals, causing rapid fibrosis progression, early decompensation, increased hepatocellular carcinoma risk, and higher mortality than hepatitis B virus (HBV) mono-infection. Most countries lack high-quality HDV prevalence data, and the collection techniques employed often bias published data. In recent meta-analyses, HDV prevalence in HBsAg-positive patients reaches 5%-15% and is even significantly higher in endemic areas. Since HBV vaccination programs were implemented, HDV prevalence has decreased among younger populations...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577531/associations-of-pnpla3-and-lep-genetic-polymorphisms-with-metabolic-associated-fatty-liver-disease-in-thai-people-living-with-human-immunodeficiency-virus
#11
JOURNAL ARTICLE
Kanuengnit Choochuay, Punna Kunhapan, Apichaya Puangpetch, Sissades Tongsima, Pornpen Srisawasdi, Abhasnee Sobhonslidsuk, Somnuek Sungkanuparph, Mohitosh Biswas, Chonlaphat Sukasem
BACKGROUND: The prevalence of metabolic-associated fatty liver disease (MAFLD) is a growing public health issue in people living with human immunodeficiency virus (PLWH). However, the pathophysiology of MAFLD is still unknown, and the role of genetic variables is only now becoming evident. AIM: To evaluate the associations of gene-polymorphism-related MAFLD in PLWH. METHODS: The study employed transient elastography with a controlled attenuation parameter ≥ 248 dB/m to identify MAFLD in patients from a Super Tertiary Hospital in central Thailand...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577530/prediction-model-for-hepatitis-b-e-antigen-seroconversion-in-chronic-hepatitis-b-with-peginterferon-alfa-treated-based-on-a-response-guided-therapy-strategy
#12
JOURNAL ARTICLE
Pei-Xin Zhang, Xiao-Wei Zheng, Ya-Fei Zhang, Jun Ye, Wei Li, Qian-Qian Tang, Jie Zhu, Gui-Zhou Zou, Zhen-Hua Zhang
BACKGROUND: Models for predicting hepatitis B e antigen (HBeAg) seroconversion in patients with HBeAg-positive chronic hepatitis B (CHB) after nucleos(t)ide analog treatment are rare. AIM: To establish a simple scoring model based on a response-guided therapy (RGT) strategy for predicting HBeAg seroconversion and hepatitis B surface antigen (HBsAg) clearance. METHODS: In this study, 75 previously treated patients with HBeAg-positive CHB underwent a 52-week peginterferon-alfa (PEG-IFNα) treatment and a 24-wk follow-up...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577529/comprehensive-prognostic-and-immune-analysis-of-sterol-o-acyltransferase-1-in-patients-with-hepatocellular-carcinoma
#13
JOURNAL ARTICLE
Chang-Jiao Gan, Yue Zheng, Bin Yang, Li-Min Cao
BACKGROUND: Sterol O-acyltransferase 1 (SOAT1) is an important target in the diagnosis and treatment of liver cancer. However, the prognostic value of SOAT1 in patients with hepatocellular carcinoma (HCC) is still not clear. AIM: To investigate the correlation of SOAT1 expression with HCC, using RNA-seq and gene expression data of The Cancer Genome Atlas (TCGA)-liver hepatocellular carcinoma (LIHC) and pan-cancer. METHODS: The correlation between SOAT1 expression and HCC was analyzed...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577528/amebic-liver-abscess-an-update
#14
REVIEW
Ramesh Kumar, Rishabh Patel, Rajeev Nayan Priyadarshi, Ruchika Narayan, Tanmoy Maji, Utpal Anand, Jinit R Soni
Amebic liver abscess (ALA) is still a common problem in the tropical world, where it affects over three-quarters of patients with liver abscess. It is caused by an anaerobic protozoan Entamoeba hystolytica , which primarily colonises the cecum. It is a non-suppurative infection of the liver consisting primarily of dead hepatocytes and cellular debris. People of the male gender, during their reproductive years, are most prone to ALA, and this appears to be due to a poorly mounted immune response linked to serum testosterone levels...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577527/protein-succinylation-hepatic-metabolism-and-liver-diseases
#15
REVIEW
Shuang Liu, Rui Li, Ya-Wen Sun, Hai Lin, Hai-Fang Li
Succinylation is a highly conserved post-translational modification that is processed via enzymatic and non-enzymatic mechanisms. Succinylation exhibits strong effects on protein stability, enzyme activity, and transcriptional regulation. Protein succinylation is extensively present in the liver, and increasing evidence has demonstrated that succinylation is closely related to hepatic metabolism. For instance, histone acetyltransferase 1 promotes liver glycolysis, and the sirtuin 5-induced desuccinylation is involved in the regulation of the hepatic urea cycle and lipid metabolism...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38577526/influence-of-nonalcoholic-fatty-liver-disease-on-response-to-antiviral-treatment-in-patients-with-chronic-hepatitis-b-a-meta-analysis
#16
JOURNAL ARTICLE
Shi-Yi Liu, Dian Wang, Jing Liu, Lu-Ping Yang, Gong-Ying Chen
BACKGROUND: Although hepatitis B virus infection is the leading cause of chronic liver injury globally, nonalcoholic fatty liver disease (NAFLD) is gradually gaining attention as another major chronic liver disease. The number of patients having chronic hepatitis B (CHB) with concomitant hepatic steatosis has increased. AIM: To analyze the effect of NAFLD on the response to antiviral treatment in patients with CHB. METHODS: Relevant English studies were systematically searched across PubMed, EMBASE, Web of Science, and Cochrane Library until October 2023...
March 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38495288/predicting-major-adverse-cardiovascular-events-after-orthotopic-liver-transplantation-using-a-supervised-machine-learning-model-a-cohort-study
#17
JOURNAL ARTICLE
Jonathan Soldera, Leandro Luis Corso, Matheus Machado Rech, Vinícius Remus Ballotin, Lucas Goldmann Bigarella, Fernanda Tomé, Nathalia Moraes, Rafael Sartori Balbinot, Santiago Rodriguez, Ajacio Bandeira de Mello Brandão, Bruno Hochhegger
BACKGROUND: Liver transplant (LT) patients have become older and sicker. The rate of post-LT major adverse cardiovascular events (MACE) has increased, and this in turn raises 30-d post-LT mortality. Noninvasive cardiac stress testing loses accuracy when applied to pre-LT cirrhotic patients. AIM: To assess the feasibility and accuracy of a machine learning model used to predict post-LT MACE in a regional cohort. METHODS: This retrospective cohort study involved 575 LT patients from a Southern Brazilian academic center...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38495287/metabolic-associated-fatty-liver-disease-and-sarcopenia-a-double-whammy
#18
REVIEW
Aditya Viswanath, Sherouk Fouda, Cornelius James Fernandez, Joseph M Pappachan
The prevalence of metabolic-associated fatty liver disease (MAFLD) has increased substantially in recent years because of the global obesity pandemic. MAFLD, now recognized as the number one cause of chronic liver disease in the world, not only increases liver-related morbidity and mortality among sufferers but also worsens the complications associated with other comorbid conditions such as cardiovascular disease, type 2 diabetes mellitus, obstructive sleep apnoea, lipid disorders and sarcopenia. Understanding the interplay between MAFLD and these comorbidities is important to design optimal therapeutic strategies...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38495286/contemporary-concepts-of-prevention-and-management-of-gastroesophageal-variceal-bleeding-in-liver-cirrhosis-patients
#19
EDITORIAL
Dmitry Victorovich Garbuzenko
This editorial describes the contemporary concepts of prevention and management of gastroesophageal variceal bleeding in liver cirrhosis (LC) patients according to the current guidelines. Gastroesophageal variceal bleeding is the most dangerous complication of portal hypertension in LC patients. Risk stratification and determination of an individual approach to the choice of therapeutic measures aimed at their prevention and management has emerged as one of the top concerns in modern hepatology. According to the current guidelines, in the absence of clinically significant portal hypertension, etiological and non-etiological therapies of LC is advisable for the primary preventing gastroesophageal variceal bleeding, whereas its presence serves as an indication for the administration of non-selective β-blockers, among which carvedilol is the drug of choice...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38495285/interleukins-in-liver-disease-treatment
#20
EDITORIAL
Ming Yang, Chun-Ye Zhang
Cytokines play pleiotropic roles in human health and disease by regulating both innate and adaptive immune responses. Interleukins (ILs), a large group of cytokines, can be divided into seven families, including IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, and IL-17 families. Here, we review the functions of ILs in the pathogenesis and resolution of liver diseases, such as liver inflammation ( e.g. , IL-35), alcohol-related liver disease ( e.g. , IL-11), non-alcoholic steatohepatitis ( e.g. , IL-22), liver fibrosis ( e...
February 27, 2024: World Journal of Hepatology
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