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Protein & Cell

Chen Ling, Zunpeng Liu, Moshi Song, Weiqi Zhang, Si Wang, Xiaoqian Liu, Shuai Ma, Shuhui Sun, Lina Fu, Qun Chu, Juan Carlos Izpisua Belmonte, Zhaoxia Wang, Jing Qu, Yun Yuan, Guang-Hui Liu
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation. However, the underlying cellular and molecular mechanisms remain unidentified. Here, we generated non-integrative induced pluripotent stem cells (iPSCs) from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation (c.3226C>T, p.R1076C). Vascular smooth muscle cells (VSMCs) differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes, including activation of the NOTCH and NF-κB signaling pathway, cytoskeleton disorganization, and excessive cell proliferation...
February 18, 2019: Protein & Cell
Kun Jia, Zongyang Lu, Fei Zhou, Zhiqi Xiong, Rui Zhang, Zhiwei Liu, Yu'e Ma, Lei He, Cong Li, Zhen Zhu, Dejing Pan, Zhengxing Lian
No abstract text is available yet for this article.
February 14, 2019: Protein & Cell
Youqin Xu, Kaiyuan Ji, Meng Wu, Bingtao Hao, Kai-Tai Yao, Yang Xu
The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the roles of HERC4 in mammary tumorigenesis remain unclear. Here we demonstrate that the knockdown of HERC4 in human breast cancer cells dramatically suppressed their proliferation, survival, migration, and tumor growth in vivo, while the overexpression of HERC4 promoted their aggressive tumorigenic activities. HERC4 is a new E3 ligase for the tumor suppressor LATS1 and destabilizes LATS1 by promoting the ubiquitination of LATS1...
February 1, 2019: Protein & Cell
Lei Wang, Wei Wu, Qi Gu, Zengping Liu, Qiyou Li, Zhongwen Li, Jinhui Fang, Wenjing Liu, Jun Wu, Ying Zhang, Liu Wang, Haiwei Xu, Wei Li, Baoyang Hu, Qi Zhou, Zhengqin Yin, Jie Hao
No abstract text is available yet for this article.
January 23, 2019: Protein & Cell
Guangshun Zhang, Junyuan Cao, Yan Cai, Yang Liu, Yanli Li, Peilin Wang, Jiao Guo, Xiaoying Jia, Mengmeng Zhang, Gengfu Xiao, Yu Guo, Wei Wang
No abstract text is available yet for this article.
January 10, 2019: Protein & Cell
Wei Mu, Na Tang, Chen Cheng, Wen Sun, Xiaofei Wei, Haoyi Wang
No abstract text is available yet for this article.
January 7, 2019: Protein & Cell
Zixuan An, Wenxing Lv, Shang Su, Wei Wu, Yu Rao
No abstract text is available yet for this article.
January 2, 2019: Protein & Cell
Qiang Hong, Cong Li, Ruhong Ying, Heming Lin, Jingqiu Li, Yu Zhao, Hanhua Cheng, Rongjia Zhou
Folliculogenesis is essential for production of female gametes in vertebrates. However, the molecular mechanisms underlying follicle development, particularly apoptosis regulation in ovary, remain elusive. Here, we generated sox3 knockout zebrafish lines using CRISPR/Cas9. sox3 knockout led to follicle development retardation and a reduced fecundity in females. Comparative analysis of transcriptome between sox3-/- and wild-type ovaries revealed that Sox3 was involved in pathways of ovarian steroidogenesis and apoptosis...
December 26, 2018: Protein & Cell
Zheying Min, Yue Zhao, Jing Hang, Yun Ren, Tao Tan, Yong Fan, Yang Yu
No abstract text is available yet for this article.
December 10, 2018: Protein & Cell
Lin Dong, Tanping Fu, Junyi Pang, Zhiyong Liang, Wenli Duan
No abstract text is available yet for this article.
December 7, 2018: Protein & Cell
Yinan Jiang, Xinquan Wang
No abstract text is available yet for this article.
December 5, 2018: Protein & Cell
Xin Zhou, Yu He, Xiaofang Huang, Yuting Guo, Dong Li, Junjie Hu
Three-way junctions are characteristic structures of the tubular endoplasmic reticulum (ER) network. Junctions are formed through atlastin (ATL)-mediated membrane fusion and stabilized by lunapark (Lnp). However, how Lnp is preferentially enriched at three-way junctions remains elusive. Here, we showed that Lnp loses its junction localization when ATLs are deleted. Reintroduction of ATL1 R77A and ATL3, which have been shown to cluster at the junctions, but not wild-type ATL1, relocates Lnp to the junctions...
November 29, 2018: Protein & Cell
Jiaxing Cui, Hongfei Cui, Mingran Yang, Shiyu Du, Junfeng Li, Yingxue Li, Liyang Liu, Xuegong Zhang, Shao Li
The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progress. In this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrence and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients...
November 26, 2018: Protein & Cell
Fenjie Li, Junjun Ding
Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a biologically important modification that is involved in embryonic development, neurodevelopment, reprogramming, oncogenesis and immune responses. In this review, we have given a comprehensive overview of the current literature on the involvement of sialylation in cell fate decision during development, reprogramming and cancer progression. Sialylation is essential for early embryonic development and the deletion of UDP-GlcNAc 2-epimerase, a rate-limiting enzyme in sialic acid biosynthesis, is embryonically lethal...
November 26, 2018: Protein & Cell
Nan Zhou, Kaili Liu, Yue Sun, Ying Cao, Jing Yang
Microglial activation occurs in divergent neuropathological conditions. Such microglial event has the key involvement in the progression of CNS diseases. However, the transcriptional mechanism governing microglial activation remains poorly understood. Here, we investigate the microglial response to traumatic injury-induced neurodegeneration by the 3D fluorescence imaging technique. We show that transcription factors IRF8 and PU.1 are both indispensible for microglial activation, as their specific post-developmental deletion in microglia abolishes the process...
February 2019: Protein & Cell
Lijun Wang, Yanyan Qian, Yanjie Su
No abstract text is available yet for this article.
November 16, 2018: Protein & Cell
Jianxi Zhu, Mingyang Xu, Yi Liu, Lisha Zhuang, Kejun Ying, Feng Liu, Dan Liu, Wenbin Ma, Zhou Songyang
No abstract text is available yet for this article.
November 14, 2018: Protein & Cell
Yanni Li, Xiang Jin Kang, Jeremy Kah Sheng Pang, Boon Seng Soh, Yang Yu, Yong Fan
No abstract text is available yet for this article.
November 14, 2018: Protein & Cell
Da-Neng Wang, Lu-Chang Qin
No abstract text is available yet for this article.
November 13, 2018: Protein & Cell
Huanyin Tang, Anke Geng, Tengjiao Zhang, Chen Wang, Ying Jiang, Zhiyong Mao
No abstract text is available yet for this article.
November 12, 2018: Protein & Cell
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