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Therapeutic Advances in Endocrinology and Metabolism

Alina Oprea, Nicolas C G Bonnet, Olivier Pollé, Philippe A Lysy
Adrenal insufficiency is defined as impaired adrenocortical hormone synthesis. According to its source, the deficit is classified as primary (adrenal steroidogenesis impairment), secondary (pituitary adrenocorticotropic hormone deficit) or tertiary (hypothalamic corticotropin-releasing hormone deficit). The management of adrenal insufficiency resides primarily in physiological replacement of glucocorticoid secretion. Standard glucocorticoid therapy is shrouded in several controversies. Along the difficulties arising from the inability to accurately replicate the pulsatile circadian cortisol rhythm, come the uncertainties of dose adjustment and treatment monitoring (absence of reliable biomarkers)...
2019: Therapeutic Advances in Endocrinology and Metabolism
Basma Salameh, Hiba Salem, Jihad M Abdallah, Ahmad Batran, Ehab Omar Naerat
Background: This research study investigates the degree of medication-related satisfaction experienced by Palestinian patients with diabetes. In addition, this study further assesses the association between certain clinical and socio-demographic factors and the degree of satisfaction among the patients. Methods: This cross-sectional, descriptive study design consisted of 415 randomly selected patients from the Palestine Medical Complex (PMC), the Palestinian Ministry of Health Clinics, and from the Palestinian Diabetes Institute (also known as: Al-Bireh Medical Center)...
2019: Therapeutic Advances in Endocrinology and Metabolism
Valeria Alcántara-Aragón
Diabetes technologies are an unstoppable phenomenon. They offer opportunities to improve patient self-care through empowerment. However, they can be a challenge for both patients and clinicians. Thus, the use of technology may empower or burden. To understand and benefit from the use of diabetes technologies, one must understand the currently unmet needs in diabetes management. These unmet needs call for perspectives beyond glycated hemoglobin and an evaluation of technology solutions. Optimal use of these technologies is necessary to obtain benefits and achieve cost-effectiveness; this process depends on diabetes education and training...
2019: Therapeutic Advances in Endocrinology and Metabolism
Zohar Landau, Galit Kowen-Sandbank, Daniela Jakubowicz, Asnat Raziel, Nasser Sakran, Inna Zaslavsky-Paltiel, Liat Lerner-Geva, Orit Pinhas-Hamiel
Objective: We examined short and long-term outcomes of bariatric surgery in patients with obesity and type 1 diabetes mellitus (T1DM). Methods: We reviewed the records of all adults insured by Maccabi Healthcare Services during 2010 -2015, with body mass index (BMI) ⩾30 kg/m2 and T1DM; and compared weight reduction and glucose control according to the performance of bariatric surgery. BMI and glycated hemoglobin (HbA1c) levels were extracted for baseline and every 6 months, for a mean 3...
2019: Therapeutic Advances in Endocrinology and Metabolism
Ruo-Qiang Wang, Yu-Long Lan, Jia-Cheng Lou, Yi-Zhu Lyu, Yu-Chao Hao, Qian-Fei Su, Bin-Bin Ma, Zhong-Bo Yuan, Zhi-Kuan Yu, Hong-Qiang Zhang, Dong-Sheng Wang, Ting-Zhun Zhu, Yan Ding, Ning Zhang, Bo Zhang
The laminin subunit alpha 2 (LAMA2) gene encodes an alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). In the current study, we investigated the relationship between LAMA2 promoter methylation status and the invasiveness of clinically nonfunctioning pituitary adenomas (PitNETs). Specimens from patients with nonfunctioning PitNET were classified into three groups according to preoperative computed tomography (CT)/magnetic resonance imaging findings: a normal group ( n = 6), non-invasive group ( n = 11) and invasive group ( n = 6)...
2019: Therapeutic Advances in Endocrinology and Metabolism
Violet Kasabri, Esraa Shawakri, Amal Akour, Randa Naffa, Nahla Khawaja, Ibrahim Al-Sarraf, Jameel Bzour
Background: Oxytocin (OXT), fetuin-A and interleukin-18 (IL-18) are involved in the development and progression of metabolic syndrome (MetS) and prediabetes (pre/T2DM). Aims participants and methods: This study aimed to compare and correlate the plasma levels of OXT, fetuin-A and IL-18 with clinical parameters, haematological indices and adiposity indices in Jordanian MetS subjects. In a cross-sectional study, 30 normoglycaemic lean study participants (control), 30 MetS study participants, and 29 MetS pre/T2DM study participants were recruited...
December 2018: Therapeutic Advances in Endocrinology and Metabolism
Hussam Abusahmin, John Geen, Gautam Das
No abstract text is available yet for this article.
November 2018: Therapeutic Advances in Endocrinology and Metabolism
Rawan Mohammad Al Saudi, Violet Kasabri, Randa Naffa, Nailya Bulatova, Yasser Bustanji
Background: The aim of the study was to compare and correlate glycated high-density lipoprotein (GHDL-C) and glycated low-density lipoprotein (GLDL-C) plasma levels with adiposity indices [weight/hip ratio (WHR) and body adiposity index (BAI)], lipid ratios and hematological indices [platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR)]. Methods: This was a cross-sectional study of 30 nondiabetic metabolic syndrome (MetS) patients, 30 prediabetic or type 2 diabetes mellitus (T2DM) patients and 30 normoglycemic controls...
October 2018: Therapeutic Advances in Endocrinology and Metabolism
Qutaiba Qusay Al-Heety, Violet Kasabri, Amal Akour, Randa Naffa, Samar Abu Rkhaya
Background: Paraoxonase 1 (PON1) and soluble intercellular adhesion molecule-1(sICAM-1) are intricately involved in metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) pathophysiology. This study aimed to investigate PON1 and sICAM-1 plasma levels in addition to correlating them with adiposity, atherogenicity and hematological indices in T2DM and MetS. Methods: This cross-sectional study composed of 28 healthy lean subjects (control), 29 normoglycemic MetS subjects and 30 MetS-Pre/T2DM...
October 2018: Therapeutic Advances in Endocrinology and Metabolism
Mustafa Tosur, Mary L Brandt, Ioanna D Athanassaki, Surya P Rednam
Individuals with PTEN Hamartoma Tumor Syndrome (PHTS) are at greatly increased risk for developing well-differentiated thyroid cancer. Specific circumstances in which total thyroidectomies should be considered have not been defined. A 14-year-old macrocephalic female with history of developmental delay and lipoma over her left flank presented with neck swelling and was found have multinodular goiter and auto-immune thyroiditis. Asymptomatic tracheal narrowing was also detected on her initial diagnostic imaging...
September 2018: Therapeutic Advances in Endocrinology and Metabolism
Nagi I Ali, Abdullah O Alamoudi, Ishag Adam
Background: Thyroid-stimulating hormone (TSH), thyroxin (T4) and T3 levels are varied in the different settings with disorders of thyroid homeostasis. It is recommended that every setting has to establish its own reference intervals (RIs) for these hormones. Methods: A multi-stage stratified sampling method was used to select a representative sample of a Sudanese adult (>20 years of age) in Nyala in western Sudan in the Darfur region during the period between January and June 2016 to establish RIs of thyroid-related hormones (TSH, T4 and T3)...
September 2018: Therapeutic Advances in Endocrinology and Metabolism
Reem Sami Alquoqa, Violet Kasabri, Randa Naffa, Amal Akour, Yasser Bustanji
Background: Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are associated with obesity, which triggers the release of inflammatory substances. Myeloperoxidase (MPO), a peroxidase enzyme, and alpha-1-acid glycoprotein (AGP), an acute-phase protein, are known to be released in patients with inflammatory conditions and cardiovascular disease (CVD). Methods: In this study, we investigated the correlation between MPO and AGP levels in pre/diabetic and MetS patients by conducting a cross-sectional study at The University of Jordan Hospital (UoJH) at the diabetes and endocrinology outpatient clinics...
September 2018: Therapeutic Advances in Endocrinology and Metabolism
Suresh Rama Chandran, Jaydutt Bhalshankar, Rashida Farhad Vasanwala, Yi Zhao, Katharine R Owen, Daphne Su-Lyn Gardner
Background: Young adults with diabetes in Asia represent a heterogeneous group. Using traditional clinical criteria to preselect individuals for testing for maturity-onset diabetes of the young (MODY) may exclude a large proportion from testing. High-sensitivity C-reactive protein (hs-CRP) has shown promise as a biomarker to differentiate hepatic nuclear factor 1 alpha ( HNF1A )-MODY from type 2 diabetes. We aimed to compare the use of hs-CRP as a biomarker versus traditional criteria, to guide testing for HNF1A -MODY among a cohort of young adults with diabetes in Singapore...
September 2018: Therapeutic Advances in Endocrinology and Metabolism
Grzegorz M Rdzak, Laura M Whitman, Silvio E Inzucchi
Persistent elevation of thyroid stimulating hormone (TSH) is a common clinical problem in outpatient clinics treating patients with primary hypothyroidism. One challenge to practitioners involves predicaments where patients have an inadequate response to a seemingly appropriate dose of levothyroxine (L-T4). A patient's self-assessed compliance to hormone replacement therapy or verification refill history at the patient's pharmacy might not be a reliable form of confirmation of non-adherence to the drug by the patient, which has been referred to as "L-T4 pseudo-malabsorption...
July 2018: Therapeutic Advances in Endocrinology and Metabolism
Samira Kahnamouyi, Mohammad Nouri, Laya Farzadi, Masoud Darabi, Vahid Hosseini, Amir Mehdizadeh
Mammalian reproduction systems are largely regulated by the secretion of two gonadotropins, that is, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The main action of LH and FSH on the ovary is to stimulate secretion of estradiol and progesterone, which play an important role in the ovarian function and reproductive cycle control. FSH and LH secretions are strictly controlled by the gonadotropin-releasing hormone (GnRH), which is secreted from the hypothalamus into the pituitary vascular system...
July 2018: Therapeutic Advances in Endocrinology and Metabolism
Mabrouk Bahloul, Olfa Turki, Anis Chaari, Mounir Bouaziz
Hyperglycaemia is often observed in severe scorpion-envenomed patients. It is due to a severe autonomic storm with a massive release of catecholamines, increased glucagon levels, cortisol levels, and either decreased insulin levels or insulin resistance. The presence of hyperglycaemia is an indicator of severity in this specific condition. Indeed, hyperglycaemia was associated with the severity of clinical manifestations of severe scorpion envenomation requiring intensive care unit (ICU) admission. In fact, the presence of hyperglycaemia was associated with the presence of respiratory failure, pulmonary oedema, haemodynamic instability, neurological failure, multisystem organ failure, and an increased mortality and ICU length of stay...
July 2018: Therapeutic Advances in Endocrinology and Metabolism
Lalantha Leelarathna, Donna Ashley, Carrie Fidler, Witesh Parekh
Background: Fast-acting insulin aspart is a new formulation of the rapid-acting insulin analogue insulin aspart and represents an advancement over current rapid-acting insulin analogues in terms of onset of action and postprandial glucose control. The objective of the current analysis was to demonstrate the cost impact of prescribing fast-acting insulin aspart instead of insulin aspart, to highlight the value of fast-acting insulin aspart for the treatment of people with diabetes requiring mealtime insulin...
July 2018: Therapeutic Advances in Endocrinology and Metabolism
Francesco Freni, Bruno Galletti, Francesco Galletti, Gianlorenzo Dionigi
No abstract text is available yet for this article.
July 2018: Therapeutic Advances in Endocrinology and Metabolism
Sait Sager, Esra Hatipoglu, Burcak Gunes, Sertac Asa, Lebriz Uslu, Kerim Sönmezoğlu
Background: It is necessary to stimulate serum thyroid-stimulating hormone (TSH) levels either endogenously by thyroid hormone withdrawal (THW) or exogenously by administration of recombinant human TSH (rhTSH) for radioactive iodine (RAI) therapy. Thyrotropin alfa (Thyrogen) has many advantages over THW. Radiation dose to laboratory staff while drawing blood for tests on the day 5 is one of the disadvantages of preferring Thyrogen. Our aim was to compare day 3 and day 5 blood test results after Thyrogen injections...
June 2018: Therapeutic Advances in Endocrinology and Metabolism
Patrick Timpel, Fernando Henpin Yue Cesena, Christiane da Silva Costa, Matheus Dorigatti Soldatelli, Emanuel Gois, Eduardo Castrillon, Lina Johana Jaime Díaz, Gabriela M Repetto, Fanah Hagos, Raul E Castillo Yermenos, Kevin Pacheco-Barrios, Wafaa Musallam, Zilda Braid, Nesreen Khidir, Marcela Romo Guardado, Roberta Muriel Longo Roepke
Background: Overweight and obesity are significant public health concerns that are prevalent in younger age cohorts. Preventive or therapeutic interventions are difficult to implement and maintain over time. On the other hand, the majority of adolescents in the United States have a smartphone, representing a huge potential for innovative digitized interventions, such as weight loss programs delivered via smartphone applications. Although the number of available smartphone applications is increasing, evidence for their effectiveness in weight loss is insufficient...
June 2018: Therapeutic Advances in Endocrinology and Metabolism
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