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Journals Therapeutic Advances in Endocr...

Therapeutic Advances in Endocrinology and Metabolism

https://read.qxmd.com/read/38379780/insulin-therapy-among-diabetic-patients-in-rural-communities-of-sub-saharan-africa-a-perspective-review
#1
REVIEW
Ritah Kiconco, Sylvia Achieng Lumumba, Charles Nkubi Bagenda, Raymond Atwine, Joseph Ndarubweine, Simon Peter Rugera
In this perspective review, we describe a brief background on the status quo of diabetes mellitus-related therapies and glycemic control among patients in rural communities in sub-Saharan Africa. The article discusses insulin therapy as well as the difficulties in obtaining insulin and oral hypoglycemic medications for diabetic patients living in sub-Saharan Africa. We wrap up our discussion with suggestions on solutions and opportunities for future research to tackle this health challenge in these impoverished communities...
2024: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38322111/liver-biopsy-handling-of-metabolic-associated-fatty-liver-disease-mafld-the-children-s-hospital-of-eastern-ontario-grossing-protocol
#2
REVIEW
Consolato M Sergi, Mohit Kehar, Carolina Jimenez-Rivera
Metabolic-(non-alcoholic) associated fatty liver disease (MAFLD/NAFLD) has increasingly become a worldwide epidemic. It has been suggested that renaming NAFLD to MAFLD is critical in identifying patients with advanced fibrosis and poor cardiovascular outcomes. There are concerns that the progression to non-alcoholic steatohepatitis (NASH) may become a constant drive in the future healthcare of children and adolescents. There is a necessity to tackle the emerging risk factors for NASH-associated hepatocellular carcinoma (HCC)...
2024: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38288136/anti-inflammatory-role-of-glucagon-like-peptide-1-receptor-agonists-and-its-clinical-implications
#3
REVIEW
Saleh Hadi Alharbi
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as promising therapeutic agents with potent anti-inflammatory properties and diverse clinical implications. This in-depth review article explores the mechanisms behind the anti-inflammatory actions of GLP-1RAs and assesses their prospective applicability in a wide range of disease scenarios. The current review establishes the significance of comprehending the anti-inflammatory role of GLP-1RAs and identifies pertinent research gaps. A concise overview of inflammation and its clinical consequences underscores the critical need for effective anti-inflammatory interventions...
2024: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38250316/therapeutic-potential-of-adiponectin-in-prediabetes-strategies-challenges-and-future-directions
#4
REVIEW
Mona Mohamed Ibrahim Abdalla
Adiponectin, an adipose-derived hormone, plays a pivotal role in glucose regulation and lipid metabolism, with a decrease in circulating adiponectin levels being linked to insulin resistance and prediabetes. This review examines the therapeutic potential of adiponectin in managing prediabetes, elucidating on multiple aspects including its role in glucose and lipid metabolism, influence on insulin sensitivity, and anti-inflammatory properties. Moreover, the paper highlights the latest strategies to augment adiponectin levels, such as gene therapy, pharmacological interventions, dietary modifications, and lifestyle changes...
2024: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38196773/glycogen-storage-disease-type-iii-a-mixed-methods-study-to-assess-the-burden-of-disease
#5
JOURNAL ARTICLE
Ayla Evins, Jill Mayhew, Tricia Cimms, Julie Whyte, Kathy Vong, Elizabeth Hribal, Christopher J Evans, Andrew Grimm
BACKGROUND: Glycogen storage disease type III (GSD III) is a rare inherited disorder that results from a glycogen debranching enzyme deficiency. OBJECTIVES: The purpose of this research was to collect data on the signs, symptoms, and impacts of GSD III from the perspective of adult patients and caregivers of individuals with GSD III. DESIGN: Online survey and qualitative interviews. METHODS: Following institutional review board approval, adult patients and caregivers of children with GSD III were recruited through advocacy networks and clinical sites...
2024: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38188532/semaglutide-in-the-spotlight-weighing-benefits-against-rising-concerns
#6
JOURNAL ARTICLE
Patrick Ashinze, Toufik Abdul-Rahman, Andrew Awuah Wireko
No abstract text is available yet for this article.
2024: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38152659/hippo-yap-signaling-pathway-a-new-therapeutic-target-for-diabetes-mellitus-and-vascular-complications
#7
REVIEW
Lan Wei, Jingjing Gao, Liangzhi Wang, Qianru Tao, Chao Tu
Diabetic angiopathy, which includes diabetic kidney disease (DKD), cardio-cerebrovascular disease, and diabetic retinopathy (DR) among other diseases, is one of the most common complications affecting diabetic patients. Among these, DKD, which is a major cause of morbidity and mortality, affects about 40% of diabetic patients. Similarly, DR involves retinal neovascularization and neurodegeneration as a result of chronic hyperglycemia and is the main cause of visual impairment and blindness. In addition, inflammation also promotes atherosclerosis and diabetes, with atherosclerosis-related cardiovascular diseases being often a main cause of disability or death in diabetic patients...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38152658/dual-basal-insulin-regimen-for-the-management-of-dawn-phenomenon-in-children-with-type-1-diabetes-a-retrospective-cohort-study
#8
JOURNAL ARTICLE
Nur Berna Celik, Dicle Canoruc Emet, Merve Canturk, Z Alev Ozon, E Nazli Gonc
BACKGROUND: Handling of the dawn phenomenon (DP) with multiple daily insulin injection (MDII) regimen is a real challenge. OBJECTIVE: We aimed to demonstrate the effectiveness of a dual-basal-insulin (a long-acting glargine and an intermediate-acting neutral protamine Hagedorn (NPH)) regimen for the management of DP in children with type 1 diabetes mellitus (T1DM). The primary efficacy outcome was to overcome morning hyperglycemia without causing hypoglycemia during the non-DP period of the night...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38152657/assessing-the-prediction-of-type-2-diabetes-risk-using-polygenic-and-clinical-risk-scores-in-south-asian-study-populations
#9
JOURNAL ARTICLE
Madhusmita Rout, Gurpreet S Wander, Sarju Ralhan, Jai Rup Singh, Christopher E Aston, Piers R Blackett, Steven Chernausek, Dharambir K Sanghera
BACKGROUND: Genome-wide polygenic risk scores (PRS) have shown high specificity and sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However, the PRS-driven information and its clinical significance in non-Europeans are underrepresented. We examined the predictive efficacy and transferability of PRS models using variant information derived from genome-wide studies of Asian Indians (AIs) (PRSAI ) and Europeans (PRSEU ) using 13,974 AI individuals. METHODS: Weighted PRS models were constructed and analyzed on 4602 individuals from the Asian Indian Diabetes Heart Study/Sikh Diabetes Study (AIDHS/SDS) as discovery/training and test/validation datasets...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38028332/hypovitaminosis-d-masking-hypercalcemia-in-primary-hyperparathyroidism-case-report
#10
Tamer Mohamed Elsherbiny
Hyperparathyroidism (HPTH) is the third most common endocrine disorder. Hypovitaminosis D affects up to 40% of the general population and about a third of hyperparathyroid patients. Such a combination may alter the classic presentation of HPTH. This report presents a premenopausal female with long history of osteoporosis, normocalcemia, and hypovitaminosis D who was initially diagnosed as secondary HPTH. After restoring vitamin D to normal using parenteral loading doses, the patient developed persistent mild to moderate hypercalcemia with persistent parathormone elevation consistent with primary HPTH associated with hypercalciuria and complicated with nephrocalcinosis...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/38028331/zoledronic-acid-sequential-to-teriparatide-may-promote-greater-inhibition-of-bone-resorption-than-zoledronic-acid-alone
#11
JOURNAL ARTICLE
Sharon Giveon, Galia Zacay, Iris Vered, A Joseph Foldes, Liana Tripto-Shkolnik
BACKGROUND: Teriparatide (TPTD) should be followed by an antiresorptive to maximize bone mineral density gain and anti-fracture protection. Infrequent zoledronic acid (ZOL) administration has demonstrated effectiveness. The duration of ZOL effect following TPTD is unknown. OBJECTIVE: To evaluate the effect of ZOL on bone resorption marker in a post-TPTD versus ZOL-alone scenario in osteoporotic patients. DESIGN: Retrospective cohort study...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37916029/soluble-tumor-necrosis-factor-receptor-type-1-predicts-cardiorenal-outcomes-and-better-associated-with-distinct-cardiovascular-or-renal-outcomes-than-precedential-renal-or-cardiovascular-events-in-type-2-diabetes-mellitus
#12
JOURNAL ARTICLE
Li-Hsin Chang, Chia-Huei Chu, Chin-Chou Huang, Liang-Yu Lin
BACKGROUND: Inflammations are the crucial pathogenesis of chronic complications of type 2 diabetes mellitus (T2DM). OBJECTIVES: The timeline of cardiovascular and renal complications of T2DM and whether soluble tumor necrosis factor receptor type 1 (sTNFR1) levels predict cardiorenal outcomes were still elusive. DESIGN: Prospectively observational study. METHODS: Chinese patients with T2DM were enrolled. Cardiorenal composite events defined by either cardiovascular composite events (all-cause mortality, acute coronary syndrome, or non-fatal stroke) or renal composite events (a decline of >30% of renal function or worsening status of albuminuria) were followed...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37916028/design-and-rationale-for-the-sib-trial-a-randomized-parallel-comparison-of-semaglutide-versus-placebo-on-intestinal-barrier-function-in-type-2-diabetes-mellitus
#13
JOURNAL ARTICLE
Steven Rella, Joseph Onyiah, Chelsea Baker, Vatsala Singh, Andrew Her, Neda Rasouli
OBJECTIVE: To describe the rationale and design of the SIB trial, an interventional clinical trial testing the hypothesis that subcutaneous (s.c.) once-weekly semaglutide can improve intestinal permeability and reduce systemic inflammation in participants with type 2 diabetes (T2D) and obesity. METHODS: SIB (NCT04979130) is an investigator-initiated, single-center randomized, double-blinded, placebo-controlled clinical study being conducted at the University of Colorado Anschutz Medical Campus...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37916027/pheochromocytoma-a-changing-perspective-and-current-concepts
#14
REVIEW
Andreas Kiriakopoulos, Periklis Giannakis, Evangelos Menenakos
This article aims to review current concepts in diagnosing and managing pheochromocytoma and paraganglioma (PPGL). Personalized genetic testing is vital, as 40-60% of tumors are linked to a known mutation. Tumor DNA should be sampled first. Next-generation sequencing is the best and most cost-effective choice and also helps with the expansion of current knowledge. Recent advancements have also led to the increased incorporation of regulatory RNA, metabolome markers, and the NETest in PPGL workup. PPGL presentation is highly volatile and nonspecific due to its multifactorial etiology...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37873516/efficacy-of-zoledronate-denosumab-or-teriparatide-in-postmenopausal-women-with-type-2-diabetes-mellitus-at-high-risk-of-fragility-fractures-protocol-of-an-open-blinded-endpoint-randomized-controlled-pilot-trial
#15
JOURNAL ARTICLE
Trupti Nagendra Prasad, Sanjay Kumar Bhadada, Veenu Singla, Neelam Aggarwal, Sant Ram, Uttam Chand Saini, Ashok Kumar, Rimesh Pal
BACKGROUND: People with type 2 diabetes (T2D) are at high risk of fragility fractures; however, there are no randomized controlled trials evaluating the efficacy of anti-osteoporosis drugs as a primary pre-specified endpoint in T2D. OBJECTIVES: To compare the efficacy of anti-osteoporotic drugs in postmenopausal women with T2D. DESIGN: Prospective, randomized, open, blinded endpoint clinical pilot trial. METHODS: Postmenopausal women (⩾50 years) with T2D (duration ⩾5 years), HbA1c 7-10%, eGFR ⩾45 mL/min/1...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37811525/response-to-a-low-energy-meal-replacement-plan-on-glycometabolic-profile-and-reverse-cardiac-remodelling-in-type-2-diabetes-a-comparison-between-south-asians-and-white-europeans
#16
JOURNAL ARTICLE
Lavanya Athithan, Gaurav S Gulsin, Joseph Henson, Loai Althagafi, Emma Redman, Stavroula Argyridou, Kelly S Parke, Jian Yeo, Thomas Yates, Kamlesh Khunti, Melanie J Davies, Gerry P McCann, Emer M Brady
BACKGROUND: South Asians (SA) constitute a quarter of the global population and are disproportionally affected by both type 2 diabetes (T2D) and heart failure. There remains limited data of the acceptability and efficacy of low-energy meal replacement plans to induce remission of T2D in SA. OBJECTIVES: The objective of this exploratory secondary analysis of the DIASTOLIC study was to determine if there was a differential uptake, glycometabolic and cardiovascular response to a low-energy meal replacement plan (MRP) between SA and White European (WE) people with T2D...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37780174/exploring-the-mechanism-of-metformin-action-in-alzheimer-s-disease-and-type-2-diabetes-based-on-network-pharmacology-molecular-docking-and-molecular-dynamic-simulation
#17
JOURNAL ARTICLE
Xin Shi, Lingling Li, Zhiyao Liu, Fangqi Wang, Hailiang Huang
BACKGROUND: Metformin, which has been shown to be highly effective in treating type 2 diabetes (T2D), is also believed to be valuable for Alzheimer's disease (AD). Computer simulation techniques have emerged as an innovative approach to explore mechanisms. OBJECTIVE: To study the potential mechanism of metformin action in AD and T2D. METHODS: The chemical structure of metformin was obtained from PubChem. The targets of metformin were obtained from PubChem, Pharm Mapper, Batman, SwissTargetPrediction, DrugBank, and PubMed...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37736657/association-of-hyponatremia-with-bone-mineral-density-and-fractures-a-narrative-review
#18
REVIEW
Ploutarchos Tzoulis, Maria P Yavropoulou
Recent studies suggest a possible association of hyponatremia with osteoporosis, falls and bone fractures. The objectives of this narrative review were to further explore this association and the related pathophysiological mechanisms and to suggest a practical approach to patients with osteoporosis or chronic hyponatremia in clinical practice. We conducted an extensive PubMed search until October 2022 with the combination of the following keywords: 'hyponatremia' or 'sodium' or 'SIADH' and 'fractures' or 'bone' or 'osteoporosis', as MeSH Terms...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37719790/prevalence-and-associated-factors-of-hyperuricemia-among-chinese-patients-with-diabetes-a-cross-sectional-study
#19
JOURNAL ARTICLE
Shiyi Sun, Lihong Chen, Dawei Chen, Yan Li, Guanjian Liu, Lin Ma, Jun Li, Fangwei Cao, Xingwu Ran
BACKGROUND: As a part of metabolic syndrome, hyperuricemia has a higher incidence in patients with diabetes than in the general population owing to various underlying factors. OBJECTIVES: The objective of the present study was to investigate the prevalence of hyperuricemia among patients with diabetes and identify associated factors. DESIGN: A cross-sectional study. METHODS: Herein, we included patients with diabetes managed at nine healthcare centers in Chenghua District, Chengdu, from February 2021 to November 2021...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37719789/role-of-estrogen-in-the-regulation-of-central-and-peripheral-energy-homeostasis-from-a-menopausal-perspective
#20
REVIEW
Jing Zhu, Yier Zhou, Bihui Jin, Jing Shu
Estrogen plays a prominent role in regulating and coordinating energy homeostasis throughout the growth, development, reproduction, and aging of women. Estrogen receptors (ERs) are widely expressed in the brain and nearly all tissues of the body. Within the brain, central estrogen via ER regulates appetite and energy expenditure and maintains cell glucose metabolism, including glucose transport, aerobic glycolysis, and mitochondrial function. In the whole body, estrogen has shown beneficial effects on weight control, fat distribution, glucose and insulin resistance, and adipokine secretion...
2023: Therapeutic Advances in Endocrinology and Metabolism
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