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Clinical and Translational Gastroenterology

Caroline Weeks
Although commercial enteral formulas have been available on the market for several decades, a cultural shift toward consuming unprocessed foods with minimally added sugar has sparked interest in the preparation of home blenderized tube feedings for enteral feeding-dependent patients. Recent surveys, however, indicate lack of clinical awareness or familiarity in the management of this method of nutrition support. This article aims to equip the gastroenterologist with a guide for initiation, monitoring, and evaluation of a blenderized tube feedings regimen, and provides insights into an opportunity for greater partnership between the gastrointestinal provider and registered dietitian...
February 1, 2019: Clinical and Translational Gastroenterology
Marta Herreros-Villanueva, Saray Duran-Sanchon, Ana Carmen Martín, Rosa Pérez-Palacios, Elena Vila-Navarro, María Marcuello, Mireia Diaz-Centeno, Joaquín Cubiella, Maria Soledad Diez, Luis Bujanda, Angel Lanas, Rodrigo Jover, Vicent Hernández, Enrique Quintero, Juan José Lozano, Marta García-Cougil, Ibon Martínez-Arranz, Antoni Castells, Meritxell Gironella, Rocio Arroyo
OBJECTIVES: Specific microRNA (miRNA) signatures in biological fluids can facilitate earlier detection of the tumors being then minimally invasive diagnostic biomarkers. Circulating miRNAs have also emerged as promising diagnostic biomarkers for colorectal cancer (CRC) screening. In this study, we investigated the performance of a specific signature of miRNA in plasma samples to design a robust predictive model that can distinguish healthy individuals from those with CRC or advanced adenomas (AA) diseases...
January 2019: Clinical and Translational Gastroenterology
Matthias Christian Reichert, Cristina Ripoll, Markus Casper, Robin Greinert, Edith Vandieken, Frank Grünhage, Beate Appenrodt, Alexander Zipprich, Frank Lammert
OBJECTIVES: Common nucleotide-binding oligomerization domain containing 2 (NOD2) gene variants have been associated with bacterial infections (BIs) in cirrhosis, in particular, spontaneous bacterial peritonitis, and mortality. Our aim was to evaluate the independent association of NOD2 variants with BI according to the decompensation stage. METHODS: Consecutive patients with cirrhosis in 2 academic medical centers were included and genotyped for the NOD2 variants p...
January 2019: Clinical and Translational Gastroenterology
Jin Dai, Zhe-Xuan Li, Yang Zhang, Jun-Ling Ma, Tong Zhou, Wei-Cheng You, Wen-Qing Li, Kai-Feng Pan
OBJECTIVES: Molecular prognostic biomarkers for gastric cancer (GC) are still limited. We aimed to identify potential messenger RNAs (mRNAs) associated with GC prognosis and further establish an mRNA signature to predict the survival of GC based on the publicly accessible databases. METHODS: Discovery of potential mRNAs associated with GC survival was undertaken for 441 patients with GC based on the Cancer Genome Atlas (TCGA), with information on clinical characteristics and vital status...
January 2019: Clinical and Translational Gastroenterology
Bin Yan, Zhongsheng Lu, Zhizheng Ge, Side Liu, Xuegang Guo, Dean Tian, Yuxiu Yang, Xiaobo Li, Wei Gong, Zhiguo Liu, Mei Liu, Bingxi Zhou, Kabing Zhao, Fei Pan, Jing Yang, Yunsheng Yang
OBJECTIVES: To evaluate the healing efficacy of rebamipide and lansoprazole combination therapy with lansoprazole alone for endoscopic submucosal dissection (ESD)-induced ulcers and clarify the ulcer healing-associated factors. METHODS: Three hundred patients were randomized into control and experimental groups after they underwent ESD. The patients received intravenous pantoprazole (30 mg) every 12 hours and oral rebamipide (100 mg, experimental group) or placebo (control group) 3 times daily on days 1-3...
January 2019: Clinical and Translational Gastroenterology
Irina Gîrleanu, Anca Trifan, Cătălin Sfarti
No abstract text is available yet for this article.
December 7, 2018: Clinical and Translational Gastroenterology
M J Linares-Gil, J Valls, P Hereu-Boher, F J Nebot, B De-Ramón, E Diaz-Munió, R Sanzol, J De-Oca, P Pérez-Lozano, J M Suñé-Negre, E García-Montoya
OBJECTIVE: The aim of this study is to evaluate the efficacy and safety of a topical formulation containing lidocaine plus diclofenac (CLIFE1) compared to lidocaine (CLIFE2), to decrease pain in benign anorectal surgery (BARS) to date not evaluated. More than 50% of patients undergoing BARS, especially hemorrhoidectomy, suffer from moderate and severe postoperative pain. This remains an unresolved problem that could be addressed with the new CLIFE1 topical treatment. METHODS: A multicenter, randomized double-blind, active-controlled parallel-group superiority trial, was conducted in two Spanish hospitals...
November 23, 2018: Clinical and Translational Gastroenterology
Amy Y Xiao, Marianne L Tan, Maria N Plana, Dhiraj Yadav, Javier Zamora, Maxim S Petrov
The original version of this Article presented incorrect information for citation 50. This has now been corrected in both the PDF and HTML versions of the Article. Petrov, M. S. Predicting the severity of acute pancreatitis: choose the right horse before hitching the cart. Dig. Dis. Sci. 56, 3402-3404 (2011).Parikh, R. et al. Understanding and using sensitivity, specificity and predictive values Indian J. Ophthalmol. 56, 45-50 (2008).
November 21, 2018: Clinical and Translational Gastroenterology
Janette Furuzawa-Carballeda, Lise Boon, Gonzalo Torres-Villalobos, Fernanda Romero-Hernández, Estefania Ugarte-Berzal, Erik Martens, Jennifer Vandooren, Vasily Rybakin, Enrique Coss-Adame, Miguel Valdovinos, David Velazquez-Fernández, Ghislain Opdenakker
OBJECTIVES: Achalasia is a primary esophageal motility disorder resulting from selective loss of inhibitory neurons in the esophageal myenteric plexus, likely due to an autoimmune response with involvement of the adaptive immune system. Innate immune processes of the host constitute the bridge between environmental etiological factors and the adaptive immune system. Although these remain poorly investigated, they might be of diagnostic and therapeutic relevance. In view of the role of extracellular proteolysis in organ-specific autoimmunity, we studied gelatinases of the matrix metalloproteinase (MMP) family in achalasia patients...
November 19, 2018: Clinical and Translational Gastroenterology
Satish S C Rao, Siegfried Yu, Eula P Tetangco, Yun Yan
No abstract text is available yet for this article.
November 19, 2018: Clinical and Translational Gastroenterology
Haritha G Reddy, Bryan J Schneider, Andrew W Tai
The original version of this Article contained an error in the spelling of colitis in the article title. It was incorrectly spelt as "colits". This has now been corrected in both the PDF and HTML versions of the Article.
November 14, 2018: Clinical and Translational Gastroenterology
Takayuki Yamamoto, Takayuki Iida, Kentaro Ikeya, Masaichi Kato, Ai Matsuura, Satoshi Tamura, Ryosuke Takano, Shinya Tani, Satoshi Osawa, Ken Sugimoto, Takahiro Shimoyama, Hiroyuki Hanai
This Article was originally published under Nature Research's License to Publish, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the Article have been modified accordingly.
November 14, 2018: Clinical and Translational Gastroenterology
Song Gao, Zhi-Ying Zhao, Zhen-Yong Zhang, Yue Zhang, Rong Wu
BACKGROUND: Numerous articles have reported that abnormal expression levels of microRNAs (miRNAs) are related to the survival times of esophageal carcinoma (EC) patients, which contains esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Nevertheless, there has not been a comprehensive meta-analysis to assess the accurate prognostic value of miRNAs in EC. METHODS: Studies published in English up to April 12, 2018 that evaluated the correlation of the expression levels of miRNAs with overall survival (OS) in EC were identified by online searches in PubMed, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews performed by two independent authors...
November 13, 2018: Clinical and Translational Gastroenterology
Wen-Bin Zou, Xin-Ying Tang, Dai-Zhan Zhou, Yang-Yang Qian, Liang-Hao Hu, Fei-Fei Yu, Dong Yu, Hao Wu, Shun-Jiang Deng, Jin-Huan Lin, An-Jing Zhao, Zhen-Hua Zhao, Hong-Yu Wu, Jia-Hui Zhu, Wei Qian, Lei Wang, Lei Xin, Min-Jun Wang, Li-Juan Wang, Xue Fang, Lin He, Emmanuelle Masson, David N Cooper, Claude Férec, Zhao-Shen Li, Jian-Min Chen, Zhuan Liao
OBJECTIVES: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on the age of disease onset and clinical outcomes, as well as their potential interactions with environmental risk factors, remain unclear. These issues are addressed here in a large Chinese CP cohort. METHODS: We performed targeted next-generation sequencing of the four CP-associated genes in 1061 Han Chinese CP patients and 1196 controls...
November 12, 2018: Clinical and Translational Gastroenterology
Yue-Meng Wan, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Xi-Nan Wu, Ying Xu
BACKGROUND: Acute-on-chronic liver failure (ACLF) can be caused by reactivation of chronic hepatitis B virus (HBV) infection (HBV-ACLF). It's unclear whether HBV genotypes affect the clinical and therapeutical outcomes of patients with HBV-ACLF. This study was to investigate the short-term antiviral response and overall survival in HBV-ACLF patients treated by tenofovir or entecavir. METHODS: Seventy-three consecutive patients with HBV-ACLF were stratified into genotype B group (n = 33) and C group (n = 40)...
November 12, 2018: Clinical and Translational Gastroenterology
R Duclaux-Loras, F Charbit-Henrion, B Neven, J Nowak, S Collardeau-Frachon, C Malcus, P F Ray, D Moshous, J Beltrand, O Goulet, N Cerf-Bensussan, A Lachaux, F Rieux-Laucat, F M Ruemmele
OBJECTIVE: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is an autoimmune disease caused by mutations in the forkhead box protein 3 gene (FOXP3), which encodes a key regulator of immune tolerance. The aim of this study was to describe the clinical heterogeneity of the disease in a national French cohort. METHODS: Multicenter retrospective study of patients diagnosed with IPEX syndrome caused by mutations in FOXP3. RESULTS: Thirty children from 26 families were included...
November 2, 2018: Clinical and Translational Gastroenterology
Kyle Staller, Mingyang Song, Francine Grodstein, Catherine A Matthews, William E Whitehead, Braden Kuo, Andrew T Chan, Mary K Townsend
BACKGROUND: Higher body mass index (BMI) and low physical activity have been associated with increased prevalence of fecal incontinence (FI) in cross-sectional studies, but prospective studies examining the role of these factors are lacking. We sought to determine whether BMI and/or physical activity are associated with risk of FI among older women. METHODS: We prospectively examined the association between BMI and physical activity and risk of FI in the Nurses' Health Study among 51,708 women who were free of FI in 2008...
October 25, 2018: Clinical and Translational Gastroenterology
Yael R Nobel, Erik J Snider, Griselda Compres, Daniel E Freedberg, Hossein Khiabanian, Charles J Lightdale, Nora C Toussaint, Julian A Abrams
INTRODUCTION: There is increasing evidence that the microbiome contributes to esophageal disease. Diet, especially fiber and fat intake, is a known potent modifier of the colonic microbiome, but its impact on the esophageal microbiome is not well described. We hypothesized that dietary fiber and fat intake would be associated with a distinct esophageal microbiome. METHODS: We collected esophageal samples from 47 ambulatory patients scheduled to undergo endoscopy who completed a validated food frequency questionnaire quantifying dietary fiber and fat intake...
October 25, 2018: Clinical and Translational Gastroenterology
Thiruvengadam Muniraj, Harry R Aslanian
No abstract text is available yet for this article.
October 24, 2018: Clinical and Translational Gastroenterology
Serena Stigliano, Alexander Waldthaler, Emma Martinez-Moneo, Luana Lionetto, Stuart Robinson, Marko Malvik, Aleksandra Hedstrom, Aleksandra Kaczka, Marius Scholdei, Stephan Haas, Maurizio Simmaco, Gianfranco Delle Fave, Matthias Lohr, Peter Simon, Gabriele Capurso
BACKGROUND: Osteopathy is common in patients with chronic pancreatitis (CP), but previous studies carry several limitations. Vitamin K is essential for bone metabolism, but its role in this setting has never been investigated. Our aim is to assess the prevalence of osteoporosis and osteopenia in CP patients, and to investigate the association between osteopathy and CP features and nutritional parameters, especially vitamin D and K levels. METHODS: Multicentre cross-sectional study on CP patients diagnosed according to M-ANNHEIM criteria...
October 15, 2018: Clinical and Translational Gastroenterology
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