journal
Journals Therapeutic Advances in Chroni...

Therapeutic Advances in Chronic Disease

https://read.qxmd.com/read/38827348/golimumab-and-certolizumab-pegol-for-the-treatment-of-hidradenitis-suppurativa-a-literature-review-and-future-perspective
#1
REVIEW
Amirhossein Heidari, Yekta Ghane, Nazila Heidari, Seyedayin Hosseini, Azadeh Goodarzi
Hidradenitis suppurativa (HS) is an inflammatory skin condition with an underlying inflammatory process. Due to the limited efficacy of available treatments, HS remains a therapeutic challenge. The safety and efficacy of tumor necrosis factor-α (TNF-α) inhibitors, adalimumab, infliximab, and etanercept, are well studied in this patient population, and in some cases, HS was unresponsive to them. In recent years, evidence has been growing regarding the application of other anti-TNFs, including certolizumab pegol (CPZ) and golimumab...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38764445/real-world-non-interventional-post-authorization-safety-study-of-long-term-use-of-burosumab-in-children-and-adolescents-with-x-linked-hypophosphatemia-first-interim-analysis
#2
JOURNAL ARTICLE
Annemieke M Boot, Gema Ariceta, Signe Sparre Beck-Nielsen, Maria Luisa Brandi, Karine Briot, Carmen de Lucas Collantes, Sandro Giannini, Dieter Haffner, Richard Keen, Elena Levtchenko, M Zulf Mughal, Outi Makitie, Ola Nilsson, Dirk Schnabel, Liana Tripto-Shkolnik, M Carola Zillikens, Jonathan Liu, Alina Tudor, Francesco Emma
BACKGROUND: X-linked hypophosphatemia (XLH) is a rare, progressive disorder characterized by excess fibroblast growth factor 23 (FGF23), causing renal phosphate-wasting and impaired active vitamin D synthesis. Burosumab is a recombinant human monoclonal antibody that inhibits FGF23, restoring patient serum phosphate levels. Safety data on long-term burosumab treatment are currently limited. OBJECTIVES: This post-authorization safety study (PASS) aims to monitor long-term safety outcomes in children and adolescents (1-17 years) treated with burosumab for XLH...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38726235/take-vedolizumab-home-transition-from-intravenous-to-subcutaneous-treatment
#3
REVIEW
Kaituo Huang, Lingya Yao, Jing Liu, Qian Cao
In 2020, the European Medicines Agency approved subcutaneous (SC) vedolizumab (VDZ) for the maintenance treatment of adult patients with moderate to severe inflammatory bowel disease (IBD). This article reviews the efficacy, safety, persistence, pharmacology, patient satisfaction, and economic implications of transitioning to SC VDZ treatment and explores whether SC formulations can be recommended by the same guidelines as intravenous (IV) formulations. Clinical trials and real-world evidence indicate that transitioning from IV to SC VDZ in patients with IBD maintains clinical, biochemical, and patient-reported clinical remission and is well-tolerated, with no new safety issues identified, except for injection site reactions...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38665975/willingness-to-start-insulin-therapy-among-insulin-na%C3%A3-ve-persons-with-type-2-diabetes-mellitus-at-gulu-regional-referral-hospital-gulu-city-uganda
#4
JOURNAL ARTICLE
Brenda Nakitto, Moses Opedo, Federes Nansubuga, Edward Omondi, Emmanuel Musinguzi, Edwin Cleopas Otile, Steven Ekak, Christine Nannungi, Paska Apiyo, Pebalo Francis Pebolo, Felix Bongomin
BACKGROUND: Most patients with type 2 diabetes mellitus (DM2) will require insulin for glycemic control during their disease. OBJECTIVES: We evaluated the willingness to start insulin therapy among insulin-naïve persons with DM2 in urban Northern Uganda. DESIGN: A facility-based, quantitative, cross-sectional study was conducted between June and August 2023 recruiting insulin-naïve type 2 diabetes mellitus patients attending routine health care at Gulu Regional Referral Hospital, Gulu, Uganda...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38645893/untimely-surgery-for-stent-fracture-related-death-after-transjugular-intrahepatic-portosystemic-shunt-a-case-report
#5
Yunjiang Li, Junhui Sun, Tanyang Zhou, Weiwei Wang, Guowei Wang, Qingming Hou, Zuhua Chen, Qiang Wang, Keyang Xu, Yunfeng Ye, Jianfeng Bao
Transjugular intrahepatic portosystemic shunt (TIPS) is a life-saving procedure for patients with severe portal hypertension and persistent variceal bleeding. Stent fracture is a rare and severe complication; however, its cause and mechanisms remain poorly defined. This case helps understand the factors contributing to its occurrence, complications, and subsequent poor outcomes. A 63-year-old male was presented with ruptured bare stent after a TIPS procedure. The upper edge of the bare stent was ruptured, and its fraction subsequently migrated to the entrance of the right atrium...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38560721/impact-of-cytomegalovirus-on-outcomes-in-acute-severe-ulcerative-colitis-a-retrospective-observational-study
#6
JOURNAL ARTICLE
Dazhong Huang, Michael Rennie, Alicia Krasovec, Shyam Nagubandi, Sichang Liu, Edward Ge, Barinder Khehra, Michael Au, Shobini Sivagnanam, Vu Kwan, Claudia Rogge, Nikola Mitrev, Viraj Kariyawasam
BACKGROUND: Concomitant cytomegalovirus (CMV) is highly prevalent in acute severe ulcerative colitis (ASUC) but data for outcomes of CMV positivity in ASUC and the benefit of antiviral therapy remain unclear. OBJECTIVES: We aim to determine the impact of CMV positivity, and antiviral therapy, on outcomes such as colectomy-free survival, length of hospital stay and readmission rate, among hospitalized patients with ASUC. DESIGN: This is a retrospective, multicentre study of patients admitted with ASUC...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38560720/dynamic-shifts-in-lung-cytokine-patterns-in-post-covid-19-interstitial-lung-disease-patients-a-pilot-study
#7
JOURNAL ARTICLE
Daniela Oatis, Hildegard Herman, Cornel Balta, Alina Ciceu, Erika Simon-Repolski, Alin Gabriel Mihu, Caterina Claudia Lepre, Marina Russo, Maria Consiglia Trotta, Antonietta Gerarda Gravina, Michele D'Amico, Anca Hermenean
INTRODUCTION: The pathogenesis of post-COVID interstitial lung disease, marked by lung tissue scarring and functional decline, remains largely unknown. OBJECTIVES: We aimed to elucidate the temporal cytokine/chemokine changes in bronchoalveolar lavage (BAL) from patients with post-COVID interstitial lung disease to uncover potential immune drivers of pulmonary complications. DESIGN: We evaluated 16 females diagnosed with post-COVID interstitial lung disease, originating from moderate to severe cases during the second epidemic wave in the Autumn of 2020, treated at the Pneumology Department of the Arad County Clinical Hospital, Romania...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38560719/brain-functional-and-structural-changes-in-diabetic-children-how-can-intellectual-development-be-optimized-in-type-1-diabetes
#8
REVIEW
Maia Stanisławska-Kubiak, Katarzyna Anna Majewska, Agata Krasińska, Paulina Wais, Dominik Majewski, Ewa Mojs, Andrzej Kȩdzia
The neuropsychological functioning of people with type 1 diabetes (T1D) is of key importance to the effectiveness of the therapy, which, in its complexity, requires a great deal of knowledge, attention, and commitment. Intellectual limitations make it difficult to achieve the optimal metabolic balance, and a lack of this alignment can contribute to the further deterioration of cognitive functions. The aim of this study was to provide a narrative review of the current state of knowledge regarding the influence of diabetes on brain structure and functions during childhood and also to present possible actions to optimize intellectual development in children with T1D...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38544906/patient-preferences-for-active-ulcerative-colitis-treatments-and-fecal-microbiota-transplantation
#9
JOURNAL ARTICLE
Deborah A Marshall, Karen V MacDonald, Dina Kao, Charles N Bernstein, Gilaad G Kaplan, Humberto Jijon, Glen Hazlewood, Remo Panaccione, Yasmin Nasser, Maitreyi Raman, Paul Moayyedi
BACKGROUND: Fecal microbiota transplantation (FMT) is a promising treatment for active ulcerative colitis (UC). Understanding patient preferences can identify treatment features that may impact treatment decisions, improve shared decision-making, and contribute to patient-centered care, which is especially important in the context of novel treatments like FMT. OBJECTIVES: We aimed to quantify preferences for active UC treatments, specifically FMT and biologics, and identify patient characteristics associated with different preference patterns...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38511069/comparison-of-different-medical-treatments-for-primary-hyperaldosteronism-a-systematic-review-and-network-meta-analysis
#10
JOURNAL ARTICLE
Wen-Yu Ho, Ching-Chung Hsiao, Ping-Hsun Wu, Jui-Yi Chen, Yu-Kang Tu, Vin-Cent Wu, Jia-Jin Chen
BACKGROUND: The effectiveness and side effects between different medical treatments in patients with primary hyperaldosteronism have not been systematically studied. OBJECTIVE: To analyze the efficacy between different mineralocorticoid receptor antagonists (MRAs) and epithelial sodium channel (ENaC) inhibitors in a network meta-analysis (NMA) framework, while also evaluating adverse events. DESIGN: Systematic review and NMA. DATA SOURCES AND METHODS: The systematic review and NMA was reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38496233/predictors-of-seizure-outcomes-in-stereo-electroencephalography-guided-radio-frequency-thermocoagulation-for-mri-negative-epilepsy
#11
JOURNAL ARTICLE
Qi Huang, Pandeng Xie, Jian Zhou, Haoran Ding, Zhao Liu, Tianfu Li, Yuguang Guan, Mengyang Wang, Jing Wang, Pengfei Teng, Mingwang Zhu, Kaiqiang Ma, Han Wu, Guoming Luan, Feng Zhai
BACKGROUND: One-third of intractable epilepsy patients have no visually identifiable focus for neurosurgery based on imaging tests [magnetic resonance imaging (MRI)-negative cases]. Stereo-electroencephalography-guided radio-frequency thermocoagulation (SEEG-guided RF-TC) is utilized in the clinical treatment of epilepsy to lower the incidence of complications post-open surgery. OBJECTIVE: This study aimed to identify prognostic factors and long-term seizure outcomes in SEEG-guided RF-TC for patients with MRI-negative epilepsy...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38440782/photodynamic-therapy-of-cervical-cancer-a-scoping-review-on-the-efficacy-of-various-molecules
#12
JOURNAL ARTICLE
Nasrulla Abdullaevich Shanazarov, Afshin Zare, Nadiar Maratovich Mussin, Rustam Kuanyshbekovich Albayev, Asset Askerovich Kaliyev, Yerbolat Maratovich Iztleuov, Sandugash Bakhytbekovna Smailova, Amin Tamadon
BACKGROUND: Cervical cancer poses a considerable worldwide health issue, where infection with the human papillomavirus (HPV) plays a vital role as a risk factor. Photodynamic therapy (PDT) is a minimally invasive treatment for HPV-related cervical lesions, which uses photosensitizers and light to selectively destroy abnormal cells. OBJECTIVES: Our objective is to present a comprehensive overview of the different types of molecules employed in PDT to reduce the occurrence and fatality rates associated with cervical cancer...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38415046/real-world-safety-and-effectiveness-of-secukinumab-in-adult-patients-with-moderate-to-severe-plaque-psoriasis-results-from-postmarketing-surveillance-in-korea
#13
JOURNAL ARTICLE
Byung Soo Kim, Dong Hyun Kim, Bong Seok Shin, Eun-So Lee, Seong Jin Jo, Chul Hwan Bang, Yeojun Yun, Yong Beom Choe
BACKGROUND: Secukinumab, a fully human monoclonal antibody, was approved in Korea for the treatment of moderate to severe psoriasis in September 2015. OBJECTIVES: To assess the safety and effectiveness of secukinumab in patients with moderate to severe psoriasis in Korea. DESIGN: Multicenter, real-world, noninterventional study conducted over 6 years. METHODS: Adults with moderate to severe psoriasis were enrolled...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38380226/clinical-and-imaging-findings-in-enteropathic-spondyloarthritis-with-special-emphasize-in-diagnostic-delay-a-cross-sectional-study
#14
JOURNAL ARTICLE
Paola Conigliaro, Arianna D'Antonio, Andrea Wlderk, Federico Sabuzi, Mario Ferraioli, Leonardo Sichi, Valerio Da Ros, Livia Biancone, Alberto Bergamini, Maria Sole Chimenti
BACKGROUND: Enteropathic spondyloarthritides (eSpAs) are chronic inflammatory joint diseases associated with inflammatory bowel disease (IBD). Limited data are available on the prevalence since arthritis in IBD patients may be underestimated because medications may hide disease activity with a possible diagnostic delay. OBJECTIVES: We aimed to evaluate diagnostic delay in eSpA and explore associated demographic, clinical, and radiographic characteristics. DESIGN: Single-centre cross-sectional study conducted on consecutive out-patients referred to the combined Gi-Rhe clinic (November 2018-October 2019)...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38362254/prevalence-of-major-non-communicable-diseases-and-their-associated-risk-factors-in-afghanistan-a-systematic-review-and-meta-analysis
#15
REVIEW
Ahmad Siyar Noormal, Volker Winkler, Sneha Bansi Bhusari, Olaf Horstick, Valérie R Louis, Andreas Deckert, Khatia Antia, Zahia Wasko, Pratima Rai, Aline Frare Mocruha, Peter Dambach
BACKGROUND: Non-communicable diseases (NCDs) are the leading cause of mortality worldwide, and increasingly so in low- and middle-income countries. Afghanistan is dealing with a double burden of diseases, yet there has been no evidence synthesis on the prevalence of major NCDs and their risk factors. OBJECTIVE: This study aims to provide a comprehensive synthesis of the existing data on the prevalence of major NCDs and the common related risk factors in Afghanistan...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38299013/epidemiological-characteristics-etiological-spectrum-and-outcomes-of-adult-patients-with-pericardial-effusion-at-a-teaching-hospital-in-somalia
#16
JOURNAL ARTICLE
Mohamed Farah Yusuf Mohamud, Ishak Ahmed Abdi, Muzeyyen Uzel, Selim Turfan, Said Abdirahman Ahmed, Hussein Hassan Mohamed, Hassan Adan Ali Adan, Mohamed A M Ahmed
BACKGROUND: Pericardial effusion (PE) is an abnormal fluid volume in the pericardial space and is a common clinical entity. The incidence of PE is estimated diversely and depends on risk factors, etiologies, and geographic locations. OBJECTIVES: This study aimed to assess the clinical characteristics, etiologic spectrum, echocardiographic features, and outcomes among patients with different types of PE. METHOD: This retrospective observational study included 93 patients with confirmed PE...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38250743/the-totality-of-evidence-approach-in-the-development-of-avt02-adalimumab-a-biosimilar-to-humira
#17
REVIEW
Joseph E McClellan, Sesselja Ómarsdóttir, Nivedita Roy, Verena Berger, Cecilia Michel, Fausto Berti
The development of a biosimilar is based on comparative structural, physicochemical, functional and clinical assessments. The sum of these analyses encompasses the 'totality of evidence', which demonstrates no clinically meaningful differences between the biosimilar and the reference product (RP). Once biosimilarity has been established, provided there is suitable scientific justification, clinical data may be extrapolated to other indications of the RP. AVT02 has been developed as a biosimilar to high-concentration, low-volume Humira (adalimumab), an anti-tumour necrosis factor-alpha monoclonal antibody approved for various chronic inflammatory indications...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38250742/effect-of-short-term-cardiac-function-changes-after-cardiac-resynchronization-therapy-on-long-term-prognosis-in-heart-failure-patients-with-and-without-diabetes
#18
JOURNAL ARTICLE
Yu Yu, Ligang Ding, Hao Huang, Sijing Cheng, Yu Deng, Chi Cai, Min Gu, Xuhua Chen, Hongxia Niu, Wei Hua
BACKGROUND: The relationship between short-term cardiac function changes and long-term outcomes in heart failure (HF) patients undergoing cardiac resynchronization therapy (CRT) remains uncertain, especially when stratified by diabetes status. OBJECTIVES: This study aims to assess the association between short-term cardiac function changes and outcomes such as all-cause mortality and HF hospitalization in patients undergoing CRT, stratified by diabetes status. DESIGN: This is a cohort longitudinal retrospective study...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38223905/tafamidis-improves-myocardial-longitudinal-strain-in-a97s-transthyretin-cardiac-amyloidosis
#19
JOURNAL ARTICLE
Yuan-Kun Aden Wu, An-Li Yu, Mei-Fang Cheng, Lung-Chun Lin, Ming-Jen Lee, Chia-Hung Chou, Chia-Tung Shun, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Ping-Huei Tseng, Siao-Ping Lin, Mao-Yuan Su, Chi-Chao Chao, Sung-Tsang Hsieh, Cheng-Hsuan Tsai, Yen-Hung Lin
BACKGROUND: Transthyretin cardiomyopathy (ATTR-CM) is a debilitating disease that has received much attention since the emergence of novel treatments. The Transthyretin Cardiomyopathy Clinical Trial showed that tafamidis, a transthyretin tetramer stabilizer, effectively reduced the declines in functional capacity and quality of life. However, Ala97Ser (A97S) hereditary ATTR-CM is underrepresented in major ATTR-CM tafamidis trials. OBJECTIVES: We aim to investigate the change in global longitudinal strain (GLS) of A97S ATTR-CM patients after 12 months of tafamidis treatment...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38213832/aortic-arch-calcification-increases-major-adverse-cardiac-event-risk-modifiable-by-echocardiographic-left-ventricular-hypertrophy-in-end-stage-kidney-disease-patients
#20
JOURNAL ARTICLE
Chia-Ter Chao, Min-Tser Liao, Chung-Kuan Wu
BACKGROUND: The factors affecting cardiovascular risk associated with vascular calcification in patients with chronic kidney disease are less well addressed. Distinct risk factors may contribute synergistically to this elevated cardiovascular risk in this population. OBJECTIVES: We aimed to determine whether echocardiographic left ventricular hypertrophy (LVH) affects the risk of major adverse cardiac events (MACE) associated with vascular calcification in end-stage kidney disease (ESKD) patients...
2024: Therapeutic Advances in Chronic Disease
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