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Journal of Biomedical Semantics

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https://read.qxmd.com/read/31118102/similarity-corpus-on-microbial-transcriptional-regulation
#1
Oscar Lithgow-Serrano, Socorro Gama-Castro, Cecilia Ishida-Gutiérrez, Citlalli Mejía-Almonte, Víctor H Tierrafría, Sara Martínez-Luna, Alberto Santos-Zavaleta, David Velázquez-Ramírez, Julio Collado-Vides
BACKGROUND: The ability to express the same meaning in different ways is a well-known property of natural language. This amazing property is the source of major difficulties in natural language processing. Given the constant increase in published literature, its curation and information extraction would strongly benefit from efficient automatic processes, for which corpora of sentences evaluated by experts are a valuable resource. RESULTS: Given our interest in applying such approaches to the benefit of curation of the biomedical literature, specifically that about gene regulation in microbial organisms, we decided to build a corpus with graded textual similarity evaluated by curators and that was designed specifically oriented to our purposes...
May 22, 2019: Journal of Biomedical Semantics
https://read.qxmd.com/read/31014403/integrating-terminologies-into-standard-sql-a-new-approach-for-research-on-routine-data
#2
André Sander, Roland Wauer
BACKGROUND: Most electronic medical records still contain large amounts of free-text data. Semantic evaluation of such data requires the data to be encoded with sufficient classifications or transformed into a knowledge-based database. METHODS: We present an approach that allows databases accessible via SQL (Structured Query Language) to be searched directly through semantic queries without the need for further transformations. Therefore, we developed I) an extension to SQL named Ontology-SQL (O-SQL) that allows to use semantic expressions, II) a framework that uses a standard terminology server to annotate free-text containing database tables and III) a parser that rewrites O-SQL to SQL, so that such queries can be passed to the database server...
April 24, 2019: Journal of Biomedical Semantics
https://read.qxmd.com/read/30975223/moonstone-a-novel-natural-language-processing-system-for-inferring-social-risk-from-clinical-narratives
#3
Mike Conway, Salomeh Keyhani, Lee Christensen, Brett R South, Marzieh Vali, Louise C Walter, Danielle L Mowery, Samir Abdelrahman, Wendy W Chapman
BACKGROUND: Social risk factors are important dimensions of health and are linked to access to care, quality of life, health outcomes and life expectancy. However, in the Electronic Health Record, data related to many social risk factors are primarily recorded in free-text clinical notes, rather than as more readily computable structured data, and hence cannot currently be easily incorporated into automated assessments of health. In this paper, we present Moonstone, a new, highly configurable rule-based clinical natural language processing system designed to automatically extract information that requires inferencing from clinical notes...
April 11, 2019: Journal of Biomedical Semantics
https://read.qxmd.com/read/30832727/seeing-the-whole-picture-integrated-pre-surgery-reports-with-preoptique
#4
Guillermo Vega-Gorgojo, Laura Slaughter, Martin Giese
BACKGROUND: Information technology has transformed the way healthcare is conducted. There is a deluge of patient data dispersed in different systems that are commonly not interoperable. As a result, access to patient data has become a major bottleneck for healthcare professionals that struggle to find the relevant information in a timely way and without missing critical clinical information. RESULTS: We implemented PreOptique, a novel hybrid semantic and text-based system that was commissioned by a large hospital in Norway for providing integrated access to patient health records scattered over several databases and document repositories...
March 4, 2019: Journal of Biomedical Semantics
https://read.qxmd.com/read/30691505/levels-and-building-blocks-toward-a-domain-granularity-framework-for-the-life-sciences
#5
Lars Vogt
BACKGROUND: With the emergence of high-throughput technologies, Big Data and eScience, the use of online data repositories and the establishment of new data standards that require data to be computer-parsable become increasingly important. As a consequence, there is an increasing need for an integrated system of hierarchies of levels of different types of material entities that helps with organizing, structuring and integrating data from disparate sources to facilitate data exploration, data comparison and analysis...
January 28, 2019: Journal of Biomedical Semantics
https://read.qxmd.com/read/30658707/a-neural-classification-method-for-supporting-the-creation-of-bioverbnet
#6
Billy Chiu, Olga Majewska, Sampo Pyysalo, Laura Wey, Ulla Stenius, Anna Korhonen, Martha Palmer
BACKGROUND: VerbNet, an extensive computational verb lexicon for English, has proved useful for supporting a wide range of Natural Language Processing tasks requiring information about the behaviour and meaning of verbs. Biomedical text processing and mining could benefit from a similar resource. We take the first step towards the development of BioVerbNet: A VerbNet specifically aimed at describing verbs in the area of biomedicine. Because VerbNet-style classification is extremely time consuming, we start from a small manual classification of biomedical verbs and apply a state-of-the-art neural representation model, specifically developed for class-based optimization, to expand the classification with new verbs, using all the PubMed abstracts and the full articles in the PubMed Central Open Access subset as data...
January 18, 2019: Journal of Biomedical Semantics
https://read.qxmd.com/read/30658684/development-of-a-cardiac-centered-frailty-ontology
#7
Kristina Doing-Harris, Bruce E Bray, Anne Thackeray, Rashmee U Shah, Yijun Shao, Yan Cheng, Qing Zeng-Treitler, Jennifer H Garvin, Charlene Weir
BACKGROUND: A Cardiac-centered Frailty Ontology can be an important foundation for using NLP to assess patient frailty. Frailty is an important consideration when making patient treatment decisions, particularly in older adults, those with a cardiac diagnosis, or when major surgery is a consideration. Clinicians often report patient's frailty in progress notes and other documentation. Frailty is recorded in many different ways in patient records and many different validated frailty-measuring instruments are available, with little consistency across instruments...
January 18, 2019: Journal of Biomedical Semantics
https://read.qxmd.com/read/30616688/identification-of-conclusive-association-entities-in-biomedical-articles
#8
Rey-Long Liu
BACKGROUND: Conclusive association entities (CAEs) in a biomedical article a are those biomedical entities (e.g., genes, diseases, and chemicals) that are specifically involved in the associations concluded in a. Identification of CAEs among candidate entities in the title and the abstract of an article is essential for curation and exploration of conclusive findings in biomedical literature. However, the identification is challenging, as it is difficult to conduct semantic analysis to determine whether an entity is a specific target on which the reported findings are conclusive enough...
January 7, 2019: Journal of Biomedical Semantics
https://read.qxmd.com/read/30587224/investigating-the-role-of-interleukin-1-beta-and-glutamate-in-inflammatory-bowel-disease-and-epilepsy-using-discovery-browsing
#9
Thomas C Rindflesch, Catherine L Blake, Michael J Cairelli, Marcelo Fiszman, Caroline J Zeiss, Halil Kilicoglu
BACKGROUND: Structured electronic health records are a rich resource for identifying novel correlations, such as co-morbidities and adverse drug reactions. For drug development and better understanding of biomedical phenomena, such correlations need to be supported by viable hypotheses about the mechanisms involved, which can then form the basis of experimental investigations. METHODS: In this study, we demonstrate the use of discovery browsing, a literature-based discovery method, to generate plausible hypotheses elucidating correlations identified from structured clinical data...
December 27, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/30223897/ontoserver-a-syndicated-terminology-server
#10
Alejandro Metke-Jimenez, Jim Steel, David Hansen, Michael Lawley
BACKGROUND: Even though several high-quality clinical terminologies, such as SNOMED CT and LOINC, are readily available, uptake in clinical systems has been slow and many continue to capture information in plain text or using custom terminologies. This paper discusses some of the challenges behind this slow uptake and describes a clinical terminology server implementation that aims to overcome these obstacles and contribute to the widespread adoption of standardised clinical terminologies...
September 17, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/30189889/using-predicate-and-provenance-information-from-a-knowledge-graph-for-drug-efficacy-screening
#11
Wytze J Vlietstra, Rein Vos, Anneke M Sijbers, Erik M van Mulligen, Jan A Kors
BACKGROUND: Biomedical knowledge graphs have become important tools to computationally analyse the comprehensive body of biomedical knowledge. They represent knowledge as subject-predicate-object triples, in which the predicate indicates the relationship between subject and object. A triple can also contain provenance information, which consists of references to the sources of the triple (e.g. scientific publications or database entries). Knowledge graphs have been used to classify drug-disease pairs for drug efficacy screening, but existing computational methods have often ignored predicate and provenance information...
September 6, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/30170633/representing-vaccine-misinformation-using-ontologies
#12
Muhammad Amith, Cui Tao
BACKGROUND: In this paper, we discuss the design and development of a formal ontology to describe misinformation about vaccines. Vaccine misinformation is one of the drivers leading to vaccine hesitancy in patients. While there are various levels of vaccine hesitancy to combat and specific interventions to address those levels, it is important to have tools that help researchers understand this problem. With an ontology, not only can we collect and analyze varied misunderstandings about vaccines, but we can also develop tools that can provide informatics solutions...
August 31, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/30111369/biomedical-ontology-alignment-an-approach-based-on-representation-learning
#13
Prodromos Kolyvakis, Alexandros Kalousis, Barry Smith, Dimitris Kiritsis
BACKGROUND: While representation learning techniques have shown great promise in application to a number of different NLP tasks, they have had little impact on the problem of ontology matching. Unlike past work that has focused on feature engineering, we present a novel representation learning approach that is tailored to the ontology matching task. Our approach is based on embedding ontological terms in a high-dimensional Euclidean space. This embedding is derived on the basis of a novel phrase retrofitting strategy through which semantic similarity information becomes inscribed onto fields of pre-trained word vectors...
August 15, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/30097014/eapb-entropy-aware-path-based-metric-for-ontology-quality
#14
Ying Shen, Daoyuan Chen, Buzhou Tang, Min Yang, Kai Lei
BACKGROUND: Entropy has become increasingly popular in computer science and information theory because it can be used to measure the predictability and redundancy of knowledge bases, especially ontologies. However, current entropy applications that evaluate ontologies consider only single-point connectivity rather than path connectivity, and they assign equal weights to each entity and path. RESULTS: We propose an Entropy-Aware Path-Based (EAPB) metric for ontology quality by considering the path information between different vertices and textual information included in the path to calculate the connectivity path of the whole network and dynamic weights between different nodes...
August 10, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/29925405/adverse-event-detection-by-integrating-twitter-data-and-vaers
#15
Junxiang Wang, Liang Zhao, Yanfang Ye, Yuji Zhang
BACKGROUND: Vaccine has been one of the most successful public health interventions to date. However, vaccines are pharmaceutical products that carry risks so that many adverse events (AEs) are reported after receiving vaccines. Traditional adverse event reporting systems suffer from several crucial challenges including poor timeliness. This motivates increasing social media-based detection systems, which demonstrate successful capability to capture timely and prevalent disease information...
June 20, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/29895320/disease-mentions-in-airport-and-hospital-geolocations-expose-dominance-of-news-events-for-disease-concerns
#16
Joana M Barros, Jim Duggan, Dietrich Rebholz-Schuhmann
BACKGROUND: In recent years, Twitter has been applied to monitor diseases through its facility to monitor users' comments and concerns in real-time. The analysis of tweets for disease mentions should reflect not only user specific concerns but also disease outbreaks. This requires the use of standard terminological resources and can be focused on selected geographic locations. In our study, we differentiate between hospital and airport locations to better distinguish disease outbreaks from background mentions of disease concerns...
June 12, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/29880031/ontology-based-literature-mining-and-class-effect-analysis-of-adverse-drug-reactions-associated-with-neuropathy-inducing-drugs
#17
Junguk Hur, Arzucan Özgür, Yongqun He
BACKGROUND: Adverse drug reactions (ADRs), also called as drug adverse events (AEs), are reported in the FDA drug labels; however, it is a big challenge to properly retrieve and analyze the ADRs and their potential relationships from textual data. Previously, we identified and ontologically modeled over 240 drugs that can induce peripheral neuropathy through mining public drug-related databases and drug labels. However, the ADR mechanisms of these drugs are still unclear. In this study, we aimed to develop an ontology-based literature mining system to identify ADRs from drug labels and to elucidate potential mechanisms of the neuropathy-inducing drugs (NIDs)...
June 7, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/29751829/querying-archetype-based-ehrs-by-search-ontology-based-xpath-engineering
#18
Stefan Kropf, Alexandr Uciteli, Katrin Schierle, Peter Krücken, Kerstin Denecke, Heinrich Herre
BACKGROUND: Legacy data and new structured data can be stored in a standardized format as XML-based EHRs on XML databases. Querying documents on these databases is crucial for answering research questions. Instead of using free text searches, that lead to false positive results, the precision can be increased by constraining the search to certain parts of documents. METHODS: A search ontology-based specification of queries on XML documents defines search concepts and relates them to parts in the XML document structure...
May 11, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/29743102/extending-the-dideo-ontology-to-include-entities-from-the-natural-product-drug-interaction-domain-of-discourse
#19
John Judkins, Jessica Tay-Sontheimer, Richard D Boyce, Mathias Brochhausen
BACKGROUND: Prompted by the frequency of concomitant use of prescription drugs with natural products, and the lack of knowledge regarding the impact of pharmacokinetic-based natural product-drug interactions (PK-NPDIs), the United States National Center for Complementary and Integrative Health has established a center of excellence for PK-NPDI. The Center is creating a public database to help researchers (primarly pharmacologists and medicinal chemists) to share and access data, results, and methods from PK-NPDI studies...
May 9, 2018: Journal of Biomedical Semantics
https://read.qxmd.com/read/29669592/ggdonto-ontology-as-a-knowledge-base-for-genetic-diseases-and-disorders-of-glycan-metabolism-and-their-causative-genes
#20
Elena Solovieva, Toshihide Shikanai, Noriaki Fujita, Hisashi Narimatsu
BACKGROUND: Inherited mutations in glyco-related genes can affect the biosynthesis and degradation of glycans and result in severe genetic diseases and disorders. The Glyco-Disease Genes Database (GDGDB), which provides information about these diseases and disorders as well as their causative genes, has been developed by the Research Center for Medical Glycoscience (RCMG) and released in April 2010. GDGDB currently provides information on about 80 genetic diseases and disorders caused by single-gene mutations in glyco-related genes...
April 18, 2018: Journal of Biomedical Semantics
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