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Journals Experimental and Therapeutic M...

Experimental and Therapeutic Medicine

https://read.qxmd.com/read/38873049/evaluation-of-birth-outcomes-congenital-anomalies-and-neonatal-complications-of-singletons-born-to-infertile-women-treated-with-letrozole-a-retrospective-cohort-study
#1
JOURNAL ARTICLE
Bin Wang, Hong Lin, Rubin Xia, Shuiqin Lin, Zhiling Li
At present, safety of letrozole administration as an ovulation-inducing drug still remains controversial. Investigation of the safety of letrozole use for the induction of ovulation in the Chinese population is scant. The present study aimed to fill this gap. Data concerning mothers using letrozole and birth outcomes of their singleton offspring were collected as the letrozole group (n=194), equivalent data from mothers using non-letrozole drugs and their singleton offspring were included as the non-letrozole group (control, n=154)...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873048/-retracted-molecular-hydrogen-improves-type-2-diabetes-through-inhibiting-oxidative-stress
#2
Yi Ming, Qi-Hang Ma, Xin-Li Han, Hong-Yan Li
[This retracts the article DOI: 10.3892/etm.2020.8708.].
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873047/chest-non%C3%A2-contrasted-computed-tomography-in-detecting-acute-pulmonary-thromboembolism-a-single%C3%A2-center-retrospective-study
#3
JOURNAL ARTICLE
Runcai Guo, Mei Deng, Linfeng Xi, Shuai Zhang, Wenqing Xu, Min Liu
The object of the study was to evaluate comprehensively the value of chest non-contrasted CT (NC-CT) in detecting acute pulmonary thromboembolism (APE). All patients were categorized into two groups: i) With APE; and ii) without APE based on clinical diagnosis. Using the clot distribution on computed tomography pulmonary angiography (CTPA), APE was divided into central and peripheral APE. Imaging features including hyperdense lumen sign and peripheral wedge-shaped opacity on chest NC-CT were evaluated. The attenuation value of peripheral wedge-shaped opacity on NC-CT was compared between patients with and without APE...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873046/increased-serum-il%C3%A2-41-associated-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#4
JOURNAL ARTICLE
Tiantian Cen, Minxuan Huang, Mingcai Li, Jie Jin, Qunli Ding, Dan Lv, Lin Fei, Shanshan Wang, Hongying Ma
Interleukin (IL)-41 is a novel immunomodulatory cytokine involved in the pathogenesis of several inflammatory and metabolic illnesses. However, it remains unclear how IL-41 contributes to the pathogenesis of chronic obstructive pulmonary disease (COPD). Therefore, the aim of the present study was to explore the correlation between the expression level of IL-41 and acute exacerbation of COPD (AECOPD). In total, 107 patients with COPD and 56 healthy controls were recruited from the First Affiliated Hospital of Ningbo University (Ningbo, China)...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873045/fastkd1-as-a-diagnostic-and-prognostic-biomarker-for-stad-insights-into-m6a-modification-and-immune-infiltration
#5
JOURNAL ARTICLE
Yi Yang, Yan Gao, Xu-Sheng Liu, Zhong-Min Huang, Yu Zhang, Yao-Hua Zhang, Zi-Yue Liu, Yu-Xuan Chen, Zhi-Jun Pei
Fas-activated serine/threonine kinase domain 1 (FASTKD1), a known modulator of mitochondrial-mediated cell death and survival processes, has garnered attention for its potential role in various biological contexts. However, its involvement in gastric cancer remains unclear. Thus, the present study aimed to investigate the relationship between FASTKD1 expression and key factors, including clinicopathological characteristics, immune infiltration and m6A modification in stomach adenocarcinoma (STAD). The expression of FASTKD1 was analyzed in STAD and normal adjacent tissues to assess its association with clinicopathological characteristics and survival prognosis...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873044/-retracted-paclitaxel-inhibits-breast-cancer-metastasis-via-suppression-of-aurora-kinase%C3%A2-mediated-cofilin%C3%A2-1-activity
#6
Yue Zhang, Yaoyi Wang, Jun Xue
[This retracts the article DOI: 10.3892/etm.2017.5588.].
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873043/altered-gut-microbe-metabolites-in-patients-with-alcohol%C3%A2-induced-osteonecrosis-of-the-femoral-head-an-integrated-omics-analysis
#7
JOURNAL ARTICLE
Chen Yue, Maoxiao Ma, Jiayi Guo, Hongjun Li, Yuxia Yang, Youwen Liu, Bin Xu
Excessive alcohol consumption is considered to be a major risk factor of alcohol-induced osteonecrosis of the femoral head (AONFH). The gut microbiota (GM) has been reported to aid in the regulation of human physiology and its composition can be altered by alcohol consumption. The aim of the present study was to improve the understanding of the GM and its metabolites in patients with AONFH. Metabolomic sequencing and 16S rDNA analysis of fecal samples were performed using liquid chromatography-mass spectrometry to characterize the GM of patients with AONFH and healthy normal controls (NCs)...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873042/squamous-papilloma-involving-the-mandible-a-case-report-and-descriptive-literature-review
#8
JOURNAL ARTICLE
Xin Zheng, Lianlian Liu, Congyuan Cao, Shuojin Huang, Dongxiao Tang, Shuai Li, Qianting He
Squamous papilloma is a benign neoplasm that originates from the stratified squamous epithelium of the mucous membrane. Its principal etiological factor is human papillomavirus infection, with a predilection for manifesting within the oral cavity. Squamous papilloma predominantly affects regions on the palate, cheeks, lips and tongue. However, to the best of our knowledge, the occurrence of squamous papilloma within the confines of the mandible remains unreported hitherto. The present report documents a case of squamous papilloma involving the mandible who was managed at the First Affiliated Hospital of Sun Yat-sen University (Guangzhou, China) in January 2023...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873041/comparison-of-the-protective-effects-of-chitosan-oligosaccharides-and-chitin-oligosaccharide-on-apoptosis-inflammation-and-oxidative-stress
#9
JOURNAL ARTICLE
Qiongyu Li, Wan-Rong Shi, Yun-Lin Huang
Chitin degradation products, especially chitosan oligosaccharides (COSs), are highly valued in various industrial fields, such as food, medicine, cosmetics and agriculture, for their rich resources and high cost-effectiveness. However, little is known about the impact of acetylation on COS cellular bioactivity. The present study aimed to compare the differential effects of COS and highly N-acetylated COS (NACOS), known as chitin oligosaccharide, on H2 O2 -induced cell stress. MTT assay showed that pretreatment with NACOS and COS markedly inhibited H2 O2 -induced RAW264...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873040/association-between-lipid-accumulation-product-index-and-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Feixiang Wu, Chenmin Cui, Junping Wu, Yunqing Wang
Diabetes mellitus and lipid metabolism disorders are increasingly recognized as key contributors to the development of chronic kidney disease (CKD). The lipid accumulation product (LAP) index, a novel marker of lipid accumulation, has potential implications for CKD risk assessment. The present meta-analysis aimed to assess the association between LAP index and CKD, with an emphasis on varying impacts in diabetic and non-diabetic populations. A comprehensive search for relevant publications was performed using PubMed/MEDLINE, Scopus, Cochrane Library, ScienceDirect and Google Scholar databases, and a meta-analysis of 17 studies was performed to investigate the relationship between LAP index and CKD...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873039/efficacy-and-safety-of-transanal-opening-of-intersphincteric-space-in-the-treatment-of-high-complex-anal-fistula-a-meta%C3%A2-analysis
#11
JOURNAL ARTICLE
Chunqiang Wang, Tianye Huang, Xuebing Wang
The best treatment of high complex anal fistula (HCAF) is to avoid anal incontinence while improving the cure rate. On this basis, several surgical procedures for preserving the anal sphincter have been proposed. The purpose of the present study was to evaluate the efficacy and safety of transanal opening of intersphincteric space for treating HCAF. PubMed, Cochrane Library, China National Knowledge Infrastructure and the Wanfang databases were searched to collate all the articles on transanal opening of intersphincteric space for treating HCAF...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38873038/potential-clinical-applications-of-current-and-future-oral-forms-of-desmopressin-review
#12
REVIEW
Karel Everaert, Tove Holm-Larsen, George Bou Kheir, Sylvie Rottey, Jeffrey P Weiss, Johan Vande Walle, Abdo E Kabarriti, Lien Dossche, François Hervé, Anne-Françoise Spinoit, Jens Peter Nørgaard, Kristian Vinter Juul
Desmopressin is a synthetic analogue of vasopressin and a selective vasopressin receptor 2 agonist. It was first synthesised in 1967 and utilised for its antidiuretic properties. It is also used in bleeding disorders to enhance clotting. Other potential uses of the drug have been reported. The present review aims to provide a broad overview of the literature on potential further uses of oral forms of desmopressin. Key therapeutic areas of interest were identified based on known physiological activities/targets of desmopressin or reports of an effect of desmopressin in the literature...
August 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38868614/exaggerated-placental-site-in-a-cesarean-scar-misdiagnosed-as-gestational-trophoblastic-neoplasia-a-case-report
#13
JOURNAL ARTICLE
Zongbin Chen, Minghua Wang, Ping Yang, Bo Yao, Hanlin Shuai, Ping Li
The present study reports a rare case of an exaggerated placental site (EPS) in a caesarean scar that was misdiagnosed as gestational trophoblastic neoplasia (GTN) by imaging, resulting in unnecessary surgical treatment. A 38-year-old woman underwent hysteroscopic resection of a cesarean scar pregnancy (CSP). The patient's serum β-human chorionic gonadotropin (β-hCG) level was elevated (76,196 mIU/ml) at the 24-day postoperative follow-up visit. On postoperative day 51, the patient experienced vaginal bleeding for three days and β-hCG levels were 2,799 mIU/ml...
July 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38868613/epileptic-seizures-as-an-initial-symptom-for-sturge%C3%A2-weber-syndrome-type-iii-a-report-of-two-cases
#14
JOURNAL ARTICLE
Yaping Wang, Guifu Geng, Wandong Hu, Huan Zhang, Yong Liu, Zaifen Gao, Hongwei Zhang, Jianguo Shi
Sturge-Weber syndrome (SWS) type III, a rare neurocutaneous disorder, presents diagnostic challenges due to its variable clinical manifestations. The present study focuses on enhancing the understanding of this syndrome by conducting a detailed analysis of two pediatric cases and providing a comprehensive review of the existing literature. The cases, managed at the Children's Hospital Affiliated to Shandong University (Jinan, China), highlight the diverse clinical presentations and successful management strategies for SWS type III...
July 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38868612/18%C3%A2-%C3%AE-%C3%A2-glycyrrhetinic-acid-induces-apoptosis-in-gingival-fibroblasts-exposed-to-phenytoin
#15
JOURNAL ARTICLE
Reiri Takeuchi, Takatoshi Nomura, Manabu Yaguchi, Chieko Taguchi, Itaru Suzuki, Haruka Suzuki, Hiroko Matsumoto, Yuichiro Okada, Kazumune Arikawa, Takato Nomoto, Koichi Hiratsuka
Phenytoin (PHT)-induced gingival overgrowth is caused by the increased proliferation and reduced apoptosis of gingival fibroblasts in inflammatory gingiva. Licorice has long been used as a component of therapeutic preparations. It inhibits cell proliferation, induces cell apoptosis and has anti-inflammatory effects. 18-α-glycyrrhetinic acid (18α-GA), the active compound in licorice, promotes apoptosis in various types of cells. The present study determined whether 18α-GA affects apoptosis in gingival fibroblasts exposed to PHT...
July 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38868611/impact-of-premorbid-use-of-beta%C3%A2-blockers-on-survival-outcomes-of-patients-with-sepsis-a-systematic-review-and-meta%C3%A2-analysis
#16
JOURNAL ARTICLE
Huan Chu, Fengmin Fei, Yao Su, Huifei Zhou
It is unclear if premorbid use of beta-blockers affects sepsis outcomes. The present systematic review aimed to assess the impact of premorbid beta-blocker use on mortality and the need for mechanical ventilation in patients with sepsis. Embase, Scopus, PubMed and Web of Science were searched for studies comparing outcomes of patients with sepsis based on the premorbid use of beta-blockers. The primary outcome was mortality, and the secondary outcome was the need for mechanical ventilation. The results were reported as odds ratios (ORs) with 95% confidence intervals (CIs)...
July 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38827477/sirtuin-5-alleviates-apoptosis-and-autophagy-stimulated-by-ammonium-chloride-in-bovine-mammary-epithelial-cells
#17
JOURNAL ARTICLE
Junhui He, Luping Feng, Hanlin Yang, Shikai Gao, Jinru Dong, Guangyang Lu, Luya Liu, Xinyi Zhang, Kai Zhong, Shuang Guo, Guangming Zha, Liqiang Han, Heping Li, Yueying Wang
Ammonia (NH3 ) is an irritating and harmful gas that affects cell apoptosis and autophagy. Sirtuin 5 (SIRT5) has multiple enzymatic activities and regulates NH3 -induced autophagy in tumor cells. In order to determine whether SIRT5 regulates NH3 -induced bovine mammary epithelial cell apoptosis and autophagy, cells with SIRT5 overexpression or knockdown were generated and in addition, bovine mammary epithelial cells were treated with SIRT5 inhibitors. The results showed that SIRT5 overexpression reduced the content of NH3 and glutamate in cells by inhibiting glutaminase activity in glutamine metabolism, and reduced the ratio of ADP/ATP...
July 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38827476/meteorin%C3%A2-like-meteorin%C3%A2-%C3%AE-protects-against-cardiac-dysfunction-after-myocardial-infarction-in-mice-by-inhibiting-autophagy
#18
JOURNAL ARTICLE
Jiahong Shangguan, Gangqiong Liu, Lili Xiao, Wenjing Zhang, Xiaodan Zhu, Ling Li
Meteorin-β (Metrnβ) is a protein that is secreted by skeletal muscle and adipose tissue, and participates in cardiovascular diseases. However, its role in myocardial infarction (MI) has not been fully elucidated to date. The aim of the present study was to investigate the role and underlying mechanism of Metrnβ in MI. In the present study, mice were subjected to left coronary ligation to induce a MI model before being injected with adeno-associated virus 9 (AAV9)-Metrnβ to overexpress Metrnβ...
July 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38827475/-retracted-microrna%C3%A2-379-suppresses-cell-proliferation-migration-and-invasion-in-nasopharyngeal-carcinoma-by-targeting-tumor-protein-d52
#19
Xiaojun Zhao, Jiusheng Chu
[This retracts the article DOI: 10.3892/etm.2018.6302.].
July 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38827474/groove-pancreatitis-presenting-with-upper-gastrointestinal-obstruction-and-abnormal-renal-function-a-case-report-and-literature-review
#20
Xiaoyuan Fan, Chihong Shi, Dewen Lu
Groove pancreatitis (GP) is a rare type of chronic pancreatitis characterized by fibrotic lesions localized to the groove between the pancreatic head, duodenum, and common bile duct. We present a case of a 59-year-old male alcoholic with vomiting and renal dysfunction found to have duodenal obstruction and low-density pancreatic head lesions on computed tomography concerning for GP. The patient underwent pancreaticoduodenectomy and pathology confirmed the diagnosis postoperatively. The patient recovered well without complications or relapse at follow-up...
July 2024: Experimental and Therapeutic Medicine
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