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Experimental and Therapeutic Medicine

Zhao Hong Peng, Zhuang Xiong, Ben Sheng Zhao, Guo Bing Zhang, Wen Song, Long Xiang Tao, Xiu Ze Zhang
Postpartum hemorrhage is considered to be a serious complication in patients with pernicious placenta. Approaches employing abdominal aortic balloon occlusion to control hemorrhage are extremely effective for such patients. The present study analyzed 9 patients with pernicious placenta previa in a single hospital from June 2016 to November 2017. Prior to cesarean hysterectomy, an abdominal aortic balloon catheter was placed in all patients. The balloon was inflated and evacuated alternately using saline following delivery of the fetal head...
February 2019: Experimental and Therapeutic Medicine
Qing-Hua Ma, Jian-Hai Fang
Thus far, the target value for international normalized ratio (INR) has remained to be determined. The current study aimed to further explore the INR value of the anti-coagulation drug warfarin after cardiac valve replacement. The clinical data of 213 patients who underwent cardiac valve replacement at Linyi Central Hospital (Linyi, China) between January 2010 and May 2013 were retrospectively analyzed. The warfarin dosage, prothrombin time (PT) and INR were compared among patients with hemorrhage or embolism, and those with no complications...
February 2019: Experimental and Therapeutic Medicine
Lei Chen, Yongqi Long, Zhijun Han, Zhizhou Yuan, Wenjin Liu, Fan Yang, Tao Li, Linfei Shu, Yunying Zhong
Dysfunction of microRNAs (miRs) has been implicated in the development and progression of various human cancers. Our previous study demonstrated that miR-101 inhibited bladder cancer cell proliferation and invasion through inhibition of c-FOS expression. As an miR generally has many targets, other targets of miR-101 may also serve important roles in bladder cancer progression. Reverse transcription-quantitative polymerase chain reaction and western blot analyses were used to examine mRNA and protein expression, respectively...
February 2019: Experimental and Therapeutic Medicine
Jinrong Zhao, Jinguo Yu, Tiecheng Wang, Bertin Mban
The present study aimed to evaluate the safety and efficiency of ciliary sulcus implantation of intraocular lens (IOL) in patients that had undergone manual small incision cataract surgery (MSICS) complicated by large posterior capsule rupture (LPCR). A total of 11 eyes taken from 11 patients in Brazzaville, Republic of the Congo, that had experienced LPCR following MSICS were included in the current study. A rigid single-piece IOL (5.5 mm optic, 12.50 mm overall length) was implanted into the ciliary sulcus...
February 2019: Experimental and Therapeutic Medicine
Huiyu Yue, Bin Hu, Zhikai Luo, Mei Liu
The aim of the current study was to investigate whether metformin could counteract sevoflurane-induced neurotoxicity. In vitro experiments on the sevoflurane-induced nerve injury were performed using hippocampal neurons. Neuronal apoptosis was detected by an MTT assay. Protein expression levels of apoptosis-associated genes, including cleaved-caspase-3, apoptosis regulator BAX and apoptosis regulator Bcl-2 were detected by western blot analysis. The mechanism of the effect of metformin on sevoflurane-induced neuronal apoptosis was investigated using a sphingosine 1-phosphate receptor 1 (S1P1) antagonist (VPC23019) and mitogen-activated protein kinase kinase inhibitor (U0126)...
February 2019: Experimental and Therapeutic Medicine
Huili Zhang, Zhengde Tang, Zhihua Han, Lefeng Zeng, Changqian Wang
Catheter-based left atrial appendage closure (LAAC) has recently become an innovative strategy for preventing embolic events in patients with nonvalvular atrial fibrillation (AF). There is limited information on optimal sizing for LAAC with the recently developed LACBES® device. The aim of the present study was to assess the role of real time-three dimensional transesophageal echocardiography (RT-3D TEE) for LACBES® device selection during LAAC. A total of 22 patients with nonvalvular AF and indications for LAAC were enrolled in the study...
February 2019: Experimental and Therapeutic Medicine
Yifeng Zhao, Limin Zhang, Rui Han, Yonghua Si, Zigang Zhao
Post-hemorrhagic shock mesenteric lymph (PHSML) has an important role in the multiple organ injuries caused by severe shock. The current study investigated whether intravenous injection of PHSML induces organ injury in normal rats. Following the establishment of hemorrhagic shock in donor rats (40±2 mmHg, 3 h), PHSML was drained during hypotension at 1-3 h and then injected to normal rats through the femoral vein within 30 min. The mean arterial pressure (MAP) was measured, and samples were obtained for analysis of histology and biochemical indices at 2...
February 2019: Experimental and Therapeutic Medicine
Joji Tamaoka, Kazuki Takaoka, Hirokazu Hattori, Miho Ueta, Hanako Maeda, Michiyo Yamamura, Koji Yamanegi, Kazuma Noguchi, Hiromitsu Kishimoto
Aging is a significant risk factor for the development of bisphosphonate-related osteonecrosis of the jaws (BRONJ). Accumulating evidence suggests that bone aging is associated with oxidative stress (OS), and OS is associated with osteonecrosis. To elucidate the mechanisms of the onset of BRONJ, the present study focused on OS and the effects of treatment with the pro-oxidant DL-buthionine-(S,R)-sulfoximine (BSO), an oxidative stressor, on healing of a surgically induced penetrating injury of the palate. Six-week-old C57BL/6J mice were randomly divided into four groups (n=5 each) and treated with or without zoledronic acid (ZOL) and with or without BSO (experimental groups: ZOL, BSO, and ZOL+BSO; control group: saline solution)...
February 2019: Experimental and Therapeutic Medicine
Ming Zhu, Jian Xue, Shiliang Lu, Yi Yuan, Yunjun Liao, Jingjing Qiu, Cheng Liu, Qingting Liao
In previous studies, it has been demonstrated that the stromal vascular fraction (SVF) promoted the retention rate of grafts following fat transplantation through its angiogenic properties. However, the effect of SVF on inflammatory response subsequent to fat transplantation remains unclear. Fat from C57 mice were mixed with green fluorescent protein (GFP) SVF cells or phosphate-buffered saline and transplanted into C57BL/6 mice. The graft was harvested and immunofluorescent staining was performed on 1, 7, 14 and 30 days...
February 2019: Experimental and Therapeutic Medicine
Hongzhe Qi, Xinran Ji, Yalin Cui, Lizhen Wang, Hua Chen, Peifu Tang
The present study aimed to investigate the biomechanical comparison of channel-assisted minimally invasive restoration and three common Achilles tendon restoration techniques in an in vitro model via a progressive rehabilitation program. The 42 porcine tendons were randomly assigned to the following six groups of tendons (n=7/group): Achillon, percutaneous Achilles repair system (PARS), Krackow, channel-assisted minimally invasive repair (CAMIR), CAMIR augmentation (CAMIR+ ), CAMIR-5 (repair with No. 5 Ethibond suture)...
February 2019: Experimental and Therapeutic Medicine
Yosuke Nakazawa, Nana Ishimori, Jun Oguchi, Noriaki Nagai, Masaki Kimura, Megumi Funakoshi-Tago, Hiroomi Tamura
The lens has high concentrations of glutathione (GSH) and ascorbic acid (AsA) to maintain redox activity and prevent cataract formation, which is the leading cause of visual impairment worldwide. Metabolic syndrome is reported to be linked with a higher risk of age-associated cataract. As it was demonstrated previously that coffee consumption improved high-fat diet (HFD) -induced metabolic symptoms, it was hypothesized that coffee intake could delay the onset of obesity related-cataract; however, the effect of coffee consumption on this type of cataract remains unknown...
February 2019: Experimental and Therapeutic Medicine
Bin Cheng, Jin-Peng Zhong, Fu-Xia Wu, Guan-Lan Li, Qing-Xiao Ruan, Gang Luo, Hong Jiang
Ebselen is an organoselenium compound that has demonstrated potent antioxidant and anti-inflammatory effects in previous studies. The present study was conducted to evaluate the effect of ebselen on myocardial ischemia-reperfusion (I/R) injury in a rat model and to elucidate the related mechanisms. Myocardial infarct size was assessed using triphenyltetrazolium chloride staining. Myocardial injury was evaluated according to the histopathological and ultrastructural alterations of rat hearts and the serum activity levels of cardiac enzymes, including creatine kinase (CK), CK-MB isoenzyme and lactate dehydrogenase (LDH)...
February 2019: Experimental and Therapeutic Medicine
Hui Wang, Qingxia Yu, Lin Wang, Yongwei Li, Mao Xie, Youyi Lu, Yupeng Cui
Based on the important functions of phosphatase and tensin homolog (PTEN)-Long for renal diseases, the present study aimed to investigate the expression of PTEN-Long in patients and mice with nephritis and its effect on nephritis. Expression levels of PTEN-Long in serum of patients with nephritis, renal cell carcinoma (RCC) as well as normal controls, and in serum and renal tissues of mice were measured by western blotting. PTEN-Long knock-in and knock-out mice were constructed via the CRISPR-Cas9 technique...
February 2019: Experimental and Therapeutic Medicine
Feng Suo, Fei Jiang, Xiuhong Fang, Aihua Ma, Liping Ma
Diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis was evaluated. A total of 158 patients with suspected carotid artery stenosis in People's Hospital of Dongying from March 2014 to April 2017 were selected as the subjects. One hundred and two patients with carotid atherosclerosis were selected as the atherosclerosis group, the other 56 patients with no obvious carotid artery abnormalities were selected as the disease control group. In addition, there were 100 healthy subjects selected as the healthy control group...
February 2019: Experimental and Therapeutic Medicine
Xinxin Liu, Jiewen Zhang, Mingrong Xia, Junran Liu, Shan Jiang
Effect of donepezil on the homocysteine (Hcy) level in serum of Alzheimer's disease (AD) patients and correlation between Hcy and dyssomnia was investigated. A retrospective analysis of 124 AD patients in Zhengzhou University People's Hospital between January 2015 and October 2017 was performed, including 64 cases in the observation group and 60 cases in the control group. The control group was treated with folic acid, vitamin B12 and memantine hydrochloride tablet, and the observation group combined with donepezil on this basis, and both groups were treated for 4 months...
February 2019: Experimental and Therapeutic Medicine
Changhua Qu, Juan Zhang, Xiumei Zhang, Jiexin Du, Baifang Su, Hong Li
Combined detection of antinuclear antibody (ANA), anti-double-stranded DNA (ds-DNA) antibody and complements C3 and C4 in the diagnosis of systemic lupus erythematosus (SLE) was analyzed. One hundred and ninety-four patients with SLE admitted to Yantaishan Hospital of Yantai from January 2012 to December 2017 were selected as SLE group. A total of 106 patients with non-SLE rheumatic disease were selected as disease control group and 120 healthy subjects as healthy control group. The ANA and anti-ds-DNA antibodies were detected by ELISA and complement C3 and C4 were detected by rate nephelometry...
February 2019: Experimental and Therapeutic Medicine
Haldun Arpaci
The present study was designed to investigate the possible impact of hormonal and demographic parameters of patients with polycystic ovary syndrome (PCOS) on the circulating levels of myostatin. The study cohort comprised 46 patients with PCOS and 42 healthy female controls, and all subjects were of normal weight. Multiple regression analysis was applied to investigate the possible associations between serum myostatin levels and other laboratory parameters. Evaluation of the levels of myostatin revealed no significant differences between the PCOS and control groups (P>0...
February 2019: Experimental and Therapeutic Medicine
Ji-Hong Zhang, Mei Zhang, Ya-Nan Wang, Xiao-Ying Zhang
Correlation between interleukin-4 (IL-4) and interleukin-13 (IL-13) gene polymorphisms and bronchial asthma in Uygur children in Xinjiang, China, and the effects on serum total immunoglobulin E (IgE) were investigated. Thirty-seven child patients with asthma and 29 healthy children were screened. The gene polymorphisms of Arg130Gln in IL-13 and -590C/T in IL-4 gene promoter region were analyzed using the polymerase chain reaction (PCR) and direct gene sequencing; the asthma-related indexes were detected using the enzyme-linked immunosorbent assay, and the relevant indexes were analyzed; moreover, whether there was a synergistic effect between Arg130Gln in IL-13 and -590C/T in IL-4 gene promoter region in the pathogenesis of asthma in children was analyzed...
February 2019: Experimental and Therapeutic Medicine
Yang Li, Lei Cao, Jun Li, Zhongyi Sun, Chao Liu, He Liang, Deguo Wang, Jiwei Tian
Association of expression levels of tumor suppressor proteins p53 and p16 and inflammatory factors in simulated weightlessness with the degree of lumbar disc degeneration of rats was investigated. Magnetic resonance imaging (MRI) examination was performed for rats in control group and experimental group, and the intervertebral disc of rats in both groups was detected and analyzed using hematoxylin and eosin (H&E) histopathological staining. The mRNA expression levels of proinflammatory factors, interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) were detected, and p53 and p16 mRNA and protein expression levels were detected...
February 2019: Experimental and Therapeutic Medicine
Lili Lv, Longfei Yang, Honghua Cui, Tonghui Ma
The promyelocytic leukemia (PML)-retinoic acid receptor α (RARA) fusion is hypothesized to serve a vital role in the pathogenesis of acute promyelocytic leukemia (APL), which results from a reciprocal translocation between chromosomes 15 and 17, t(15;17)(q24;q21). A minority of APL cases lack the classical t(15;17) and have been identified to have cryptic or masked t(15;17) or complex translocations. The present study reports on a case of a 37-year-old male with APL harboring a complex three-way translocation t(1;17;15)(q21;q21;q24)...
February 2019: Experimental and Therapeutic Medicine
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