journal
https://read.qxmd.com/read/38803081/characteristics-of-norovirus-capsid-protein-specific-cd8-t-cell-responses-in-previously-infected-individuals
#1
JOURNAL ARTICLE
Taojun He, Yilin Deng, Fang Zhang, Jin Zhang, Luhong Zhu, Qinjin Wang, Jie Ning, Hui Wu, Hanmei Yuan, Bin Li, Chao Wu
Norovirus (NV) infection causes acute gastroenteritis in children and adults. Upon infection with NV, specific CD8+ T cells, which play an important role in anti-infective immunity, are activated in the host. Owing to the NV's wide genotypic variability, it is challenging to develop vaccines with cross-protective abilities against infection. To aid effective vaccine development, we examined specific CD8+ T-cell responses towards viral-structural protein (VP) epitopes, which enable binding to host susceptibility receptors...
May 27, 2024: Virulence
https://read.qxmd.com/read/38803076/maternal-and-neonatal-outcomes-and-clinical-laboratory-testing-of-pregnant-women-with-covid-19-during-the-ba-5-2-bf-7-surge
#2
JOURNAL ARTICLE
Jiali Cao, Zehong Huang, Jing Zeng, Jumei Liu, Weilun Zuo, Zhiying Su, Yujuan Chen, Weiwei Yu, Huiming Ye
The impact of COVID-19 on pregnant women and newborns continues to be a critical societal concern. However, the majority of research focuses on the disease resulting from the early pandemic variants, without sufficient study on the more recent BA.5.2/BF.7. We retrospectively recruited pregnant women giving birth during the surge of the BA.5.2/BF.7 and analysed the risk impact of COVID-19 on maternal and neonatal outcomes. Furthermore, subjects matched through propensity scores were used for the analysis of clinical laboratory tests...
May 27, 2024: Virulence
https://read.qxmd.com/read/38745468/m1-type-polarized-macrophage-contributes-to-brain-damage-through-cxcr3-2-cxcl11-pathways-after-rgnnv-infection-in-grouper
#3
JOURNAL ARTICLE
Kaishan Liang, Minlin Zhang, Jiantao Liang, Xiaoling Zuo, Xianze Jia, Jinhong Shan, Zongyang Li, Jie Yu, Zijie Xuan, Liyuan Luo, Huihong Zhao, Songyong Gan, Ding Liu, Qiwei Qin, Qing Wang
The vertebrate central nervous system (CNS) is the most complex system of the body. The CNS, especially the brain, is generally regarded as immune-privileged. However, the specialized immune strategies in the brain and how immune cells, specifically macrophages in the brain, respond to virus invasion remain poorly understood. Therefore, this study aimed to examine the potential immune response of macrophages in the brain of orange-spotted groupers ( Epinephelus coioides ) following red-spotted grouper nervous necrosis virus (RGNNV) infection...
May 15, 2024: Virulence
https://read.qxmd.com/read/38680083/molecular-mechanism-of-infectious-spleen-and-kidney-necrosis-virus-in-manipulating-the-hypoxia-inducible-factor-pathway-to-augment-virus-replication
#4
JOURNAL ARTICLE
Jian He, Yang Yu, Wenhui Liu, Zhimin Li, Zhang Qi, Shaoping Weng, Changjun Guo, Jianguo He
Infectious spleen and kidney necrosis virus (ISKNV), a member of the genus Megalocytivirus in the family Iridoviridae , can infect over fifty fish species and cause significant economic losses in Asia. Our previous study showed that hypoxia triggers the hypoxia-inducible factor pathway (HIF-pathway), leading to increased replication of ISKNV through promoting the upregulation of viral hypoxic response genes like orf077r . This study delved into the molecular mechanism behind how ISKNV manipulates the HIF-pathway to enhance its replication...
April 29, 2024: Virulence
https://read.qxmd.com/read/38576396/antibiotics-daptomycin-interacts-with-s-protein-of-sars-cov-2-to-promote-cell-invasion-of-omicron-b1-1-529-pseudovirus
#5
JOURNAL ARTICLE
Xu Cao, Lan Huang, Min Tang, Yue Liang, Xinpeng Liu, Huijin Hou, Shufang Liang
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has posed enormous challenges to global public health. The use of antibiotics has greatly increased during the SARS-CoV-2 epidemic owing to the presence of bacterial co-infection and secondary bacterial infections. The antibiotics daptomycin (DAP) is widely used in the treatment of infectious diseases caused by gram-positive bacteria owing to its highly efficient antibacterial activity. It is pivotal to study the antibiotics usage options for patients of coronavirus infectious disease (COVID-19) with pneumonia those need admission to receive antibiotics treatment for bacterial co-infection in managing COVID-19 disease...
April 5, 2024: Virulence
https://read.qxmd.com/read/38528779/the-long-noncoding-rna-loc107053557-acts-as-a-gga-mir-3530-5p-sponge-to-suppress-the-replication-of-vvibdv-through-regulating-stat1-expression
#6
JOURNAL ARTICLE
Xuewei Huang, Yue Li, Jiaxuan Li, Yanping Jiang, Wen Cui, Han Zhou, Lijie Tang
Infectious bursal disease virus (IBDV) causes immunosuppression and high mortality in young chickens. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are important regulators during viral infection. However, detailed the regulatory mechanisms of lncRNA-miRNA-mRNA have not yet been described in IBDV infection. Here, we analysed the role of lncRNA53557/gga-miR-3530-5p/STAT1 axis in very virulent IBDV (vvIBDV) infection. Evidently upregulated expression of lncRNA53557 was observed in bursa of Fabricius and DT40 cells...
March 25, 2024: Virulence
https://read.qxmd.com/read/38515339/-staphylococcus-pseudintermedius-induces-pyroptosis-of-canine-corneal-epithelial-cells-by-activating-the-ros-nlrp3-signaling-pathway
#7
JOURNAL ARTICLE
Zhihao Wang, Long Guo, Changning Yuan, Chengcheng Zhu, Jun Li, Haoran Zhong, Peng Mao, Jianji Li, Luying Cui, Junsheng Dong, Kangjun Liu, Xia Meng, Guoqiang Zhu, Heng Wang
Staphylococcus pseudintermedius ( S. pseudintermedius ) is a common pathogen that causes canine corneal ulcers. However, the pathogenesis remained unclear. In this study, it has been demonstrated that S. pseudintermedius invaded canine corneal epithelial cells (CCECs) intracellularly, mediating oxidative damage and pyroptosis by promoting the accumulation of intracellular reactive oxygen species (ROS) and activating the NLRP3 inflammasome. The canine corneal stroma was infected with S. pseudintermedius to establish the canine corneal ulcer model in vivo...
March 22, 2024: Virulence
https://read.qxmd.com/read/38515333/alpha1-antitrypsin-impacts-innate-host-pathogen-interactions-with-candida-albicans-by-stimulating-fungal-filamentation
#8
JOURNAL ARTICLE
Martin Jaeger, Axel Dietschmann, Sophie Austermeier, Sude Dinçer, Pauline Porschitz, Larsen Vornholz, Ralph J A Maas, Evelien G G Sprenkeler, Jürgen Ruland, Stefan Wirtz, Tania Azam, Leo A B Joosten, Bernhard Hube, Mihai G Netea, Charles A Dinarello, Mark S Gresnigt
Our immune system possesses sophisticatedmechanisms to cope with invading microorganisms, while pathogensevolve strategies to deal with threats imposed by host immunity. Thehuman plasma protein α1-antitrypsin (AAT) exhibits pleiotropicimmune-modulating properties by both preventing immunopathology andimproving antimicrobial host defence. Genetic associations suggesteda role for AAT in candidemia, the most frequent fungal bloodstreaminfection in the ICU, yet little is known about how AAT influencesinteractions between Candidaalbicans and the immunesystem...
March 22, 2024: Virulence
https://read.qxmd.com/read/38869140/recombination-and-amino-acid-point-mutations-in-vp3-exhibit-a-synergistic-effect-on-increased-virulence-of-rmdpv
#9
JOURNAL ARTICLE
Jianye Wang, Wanmei Li, Xiaoyan Gong, Zhixian Wang, Yu Wang, Jueyi Ling, Zhiwei Jiang, Guoqiang Zhu, Yufeng Li
Recombinant Muscovy duck parvovirus (rMDPV) is a product of genetic recombination between classical Muscovy duck parvovirus (MDPV) and goose parvovirus (GPV). The recombination event took place within a 1.1-kb DNA segment located in the middle of the VP3 gene, and a 187-bp sequence extending from the P9 promoter to the 5' initiation region of the Rep1 ORF. This resulted in the alteration of five amino acids within VP3. Despite these genetic changes, the precise influence of recombination and amino acid mutations on the pathogenicity of rMDPV remains ambiguous...
December 2024: Virulence
https://read.qxmd.com/read/38868991/the-pathogenicity-and-virulence-of-the-opportunistic-pathogen-staphylococcus-epidermidis
#10
REVIEW
Órla Burke, Merve S Zeden, James P O'Gara
The pervasive presence of Staphylococcus epidermidis and other coagulase-negative staphylococci on the skin and mucous membranes has long underpinned a casual disregard for the infection risk that these organisms pose to vulnerable patients in healthcare settings. Prior to the recognition of biofilm as an important virulence determinant in S. epidermidis , isolation of this microorganism in diagnostic specimens was often overlooked as clinically insignificant with potential delays in diagnosis and onset of appropriate treatment, contributing to the establishment of chronic infection and increased morbidity or mortality...
December 2024: Virulence
https://read.qxmd.com/read/38860453/essential-roles-of-rad6-in-conidial-property-stress-tolerance-and-pathogenicity-of-beauveria-bassiana
#11
JOURNAL ARTICLE
Yi Guan, Haomin He, Yuhan Guo, Longbin Zhang
Rad6 functions as a ubiquitin-conjugating protein that regulates cellular processes in many fungal species. However, its role in filamentous entomopathogenic fungi remains poorly understood. This study characterizes Rad6 in Beauveria bassiana , a filamentous fungus widely employed as a critical fungicide globally. The results demonstrate a significant association between Rad6 and conidial properties, heat shock response, and UV-B tolerance. Concurrently, the mutant strain exhibited heightened sensitivity to oxidative stress, cell wall interfering agents, DNA damage stress, and prolonged heat shock...
December 2024: Virulence
https://read.qxmd.com/read/38853365/correction
#12
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 2024: Virulence
https://read.qxmd.com/read/38808732/integrative-and-conjugative-elements-of-pasteurella-multocida-prevalence-and-signatures-in-population-evolution
#13
JOURNAL ARTICLE
Jiao He, Zhishuang Yang, Mingshu Wang, Renyong Jia, Shun Chen, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Yu He, Zhen Wu, Anchun Cheng, Dekang Zhu
Pasteurella multocida ( P. multocida ) is a bacterial pathogen responsible for a range of infections in humans and various animal hosts, causing significant economic losses in farming. Integrative and conjugative elements (ICEs) are important horizontal gene transfer elements, potentially enabling host bacteria to enhance adaptability by acquiring multiple functional genes. However, the understanding of ICEs in P. multocida and their impact on the transmission of this pathogen remains limited. In this study, 42 poultry-sourced P...
December 2024: Virulence
https://read.qxmd.com/read/38804638/the-salmonella-virulence-protein-pagn-contributes-to-the-advent-of-a-hyper-replicating-cytosolic-bacterial-population
#14
JOURNAL ARTICLE
Sébastien Holbert, Emilie Barilleau, Jin Yan, Jérôme Trotereau, Michael Koczerka, Mégane Charton, Yves Le Vern, Julien Pichon, Guntram A Grassl, Philippe Velge, Agnès Wiedemann
Salmonella enterica subspecies enterica serovar Typhimurium is an intracellular pathogen that invades and colonizes the intestinal epithelium. Following bacterial invasion, Salmonella is enclosed within a membrane-bound vacuole known as a Salmonella -containing vacuole (SCV). However, a subset of Salmonella has the capability to prematurely rupture the SCV and escape, resulting in Salmonella hyper-replication within the cytosol of epithelial cells. A recently published RNA-seq study provides an overview of cytosolic and vacuolar upregulated genes and highlights pagN vacuolar upregulation...
December 2024: Virulence
https://read.qxmd.com/read/38797966/tobramycin-resistant-small-colony-variant-mutant-of-salmonella-enterica-serovar-typhimurium-shows-collateral-sensitivity-to-nitrofurantoin
#15
JOURNAL ARTICLE
Chang-Zhen Wang, Yue-Jun Zhang, Yue-Fei Chu, Long-Gen Zhong, Jin-Peng Xu, Liu-Yan Liang, Teng-Fei Long, Liang-Xing Fang, Jian Sun, Xiao-Ping Liao, Yu-Feng Zhou
The increasing antibiotic resistance poses a significant global health challenge, threatening our ability to combat infectious diseases. The phenomenon of collateral sensitivity, whereby resistance to one antibiotic is accompanied by increased sensitivity to another, offers potential avenues for novel therapeutic interventions against infections unresponsive to classical treatments. In this study, we elucidate the emergence of tobramycin (TOB)-resistant small colony variants (SCVs) due to mutations in the hemL gene, which render S ...
December 2024: Virulence
https://read.qxmd.com/read/38797948/pathogenicity-and-virulence-of-o-nyong-nyong-virus-a-less-studied-togaviridae-with-pandemic-potential
#16
REVIEW
Samuel Tong Jia Ming, Katrina Tan Yi Jun, Guillaume Carissimo
O'nyong-nyong virus (ONNV) is a neglected mosquito-borne alphavirus belonging to the Togaviridae family. ONNV is known to be responsible for sporadic outbreaks of acute febrile disease and polyarthralgia in Africa. As climate change increases the geographical range of known and potential new vectors, recent data indicate a possibility for ONNV to spread outside of the African continent and grow into a greater public health concern. In this review, we summarise the current knowledge on ONNV epidemiology, host-pathogen interactions, vector-virus responses, and insights into possible avenues to control risk of further epidemics...
December 2024: Virulence
https://read.qxmd.com/read/38773735/hijacking-host-cell-vesicular-transport-new-insights-into-the-nutrient-acquisition-mechanism-of-chlamydia
#17
REVIEW
Lei Wenbo, Yang Yewei, Zhou Hui, Li Zhongyu
Chlamydia infection is an important cause of public health diseases, and no effective vaccine is currently available. Owing to its unique intracellular lifestyle, Chlamydia requires a variety of nutrients and substrates from host cells, particularly sphingomyelin, cholesterol, iron, amino acids, and the mannose-6-phosphate receptor, which are essential for inclusion development. Here, we summarize the recent advances in Chlamydia nutrient acquisition mechanism by hijacking host cell vesicular transport, which plays an important role in chlamydial growth and development...
December 2024: Virulence
https://read.qxmd.com/read/38767562/clinical-features-and-risk-factors-for-pyogenic-liver-abscess-caused-by-multidrug-resistant-organisms-a-retrospective-study
#18
JOURNAL ARTICLE
Qin Long, Xiaoyu Zhao, Chang Chen, Min Hao, Xiaohua Qin
The incidence rate of pyogenic liver abscess caused by multidrug-resistant bacteria has increased in recent years. This study aimed to identify the clinical characteristics and risk factors for pyogenic liver abscess caused by multidrug-resistant bacteria. We conducted a retrospective analysis of the clinical features, laboratory test results, and causes of pyogenic liver abscesses in 239 patients admitted to a tertiary hospital. Multivariable logistic regression was used to identify risk factors for multidrug resistance...
December 2024: Virulence
https://read.qxmd.com/read/38745370/platelet-derived-major-histocompatibility-complex-class-i-coating-on-treponema-pallidum-attenuates-natural-killer-cell-lethality
#19
JOURNAL ARTICLE
Qiu-Yan Xu, Xin-Qi Zheng, Wei-Ming Ye, Dong-Yu Yi, Ze Li, Qing-Qi Meng, Man-Li Tong, Dan Liu, Tian-Ci Yang
The evasive tactics of Treponema pallidum pose a major challenge in combating and eradicating syphilis. Natural killer (NK) cells mediate important effector functions in the control of pathogenic infection, preferentially eliminating targets with low or no expression of major histocompatibility complex (MHC) class I. To clarify T. pallidum's mechanisms in evading NK-mediated immunosurveillance, experiments were performed to explore the cross-talk relations among T. pallidum , NK cells, and platelets. T. pallidum adhered to, activated, and promoted particle secretion of platelets...
December 2024: Virulence
https://read.qxmd.com/read/38741276/glms-plays-a-key-role-in-the-virulence-factor-expression-and-biofilm-formation-ability-of-staphylococcus-aureus-promoted-by-advanced-glycation-end-products
#20
JOURNAL ARTICLE
Lijia Ni, Rui Shen, Hua Luo, Xuexue Li, Xiaofan Zhang, Lisi Huang, Yawen Deng, Xiaoyan Liao, Yonglin Wu, Chaohui Duan, Xiaoying Xie
Staphylococcus aureus (S. aureus) is well known for its biofilm formation ability and is responsible for serious, chronic refractory infections worldwide. We previously demonstrated that advanced glycation end products (AGEs), a hallmark of chronic hyperglycaemia in diabetic tissues, enhanced biofilm formation by promoting eDNA release via sigB upregulation in S. aureus , contributing to the high morbidity and mortality of patients presenting a diabetic foot ulcer infection. However, the exact regulatory network has not been completely described...
December 2024: Virulence
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