Takuto Shimizu, Makito Miyake, Kota Iida, Sayuri Onishi, Tomomi Fujii, Yusuke Iemura, Kazuki Ichikawa, Chihiro Omori, Fumisato Maesaka, Mitsuru Tomizawa, Tatsuki Miyamoto, Nobumichi Tanaka, Kiyohide Fujimoto
The process and molecular mechanisms underlying the formation and destruction of a pseudo-capsule (PC) in clear cell renal cell carcinoma (ccRCC) are poorly understood. In the present study, the PCs of surgical specimens from primary tumors and metastatic lesions in 169 patients with ccRCC, and carcinogen-induced ccRCC rat models were semi-quantified using the invasion of PC (i-Cap) score system. This was based on the relationship among the tumor, PC and adjacent normal tissue (NT) as follows: i-Cap 0, tumor has no PC and does not invade NT; i-Cap 1, tumor has a complete PC and does not invade into the PC; i-Cap 2, tumor with focal absences in the PC, which partially invades the PC but not completely through the PC; i-Cap 3, tumor crosses the PC and invades the NT; i-Cap 4, tumor directly invades the NT without a PC...
May 2024: Oncology Letters