journal
https://read.qxmd.com/read/38638849/oncolytic-virotherapy-stimulates-anti%C3%A2-tumor-immune-response-and-demonstrates-activity-in-advanced-sarcoma-report-of-two-cases
#1
Yeting Qiu, Aijun Qin, Ronghua Zhao, Jun Ding, William Wei-Guo Jia, Manu Singh, Yanal Murad, Qian Tan, Ganessan Kichenadasse
Sarcoma is derived from mesenchymal neoplasms and has numerous subtypes, accounting for 1% of all adult malignancies and 15% of childhood malignancies. The prognosis of metastatic or recurrent sarcoma remains poor. The current study presents two cases of sarcoma enrolled in a phase I dose escalation trial for solid tumor, who had previously failed all standard therapies. These patients were treated with VG161, an immune-stimulating herpes simplex virus type 1 oncolytic virus with payloads of IL-12, IL-15 and IL-15 receptor α unit, and a programmed cell death 1 (PD-1)/PD-1 ligand 1 blocking peptide...
June 2024: Oncology Letters
https://read.qxmd.com/read/38638848/-retracted-tremella-polysaccharides-inhibit-cellular-apoptosis-and-autophagy-induced-by-pseudomonas-aeruginosa-lipopolysaccharide-in-a549-cells-through-sirtuin-1-activation
#2
Xiaolan Shi, Wenfeng Wei, Ning Wang
[This retracts the article DOI: 10.3892/ol.2018.8554.].
June 2024: Oncology Letters
https://read.qxmd.com/read/38638847/effects-of-combined-use-of-ribociclib-with-parp1-inhibitor-on-cell-kinetics-in-breast-cancer
#3
JOURNAL ARTICLE
Ercan Pulat, Mehmet R Topçul
In the present study, antiproliferative and anticancer effects of Valamor (VLM), which contains the active component ribociclib, and DPQ, a poly(ADP-ribose) polymerase 1 inhibitor, alone and in combination were evaluated in the MCF-7 and MDA-MB-231 breast cancer cell lines in vitro . VLM was applied at concentrations of 40, 80 and 160 µg/ml, and DPQ was used at concentrations of 3, 6 and 9 µg/ml. The proliferation rate, cell index obtained from the real-time cell analysis system, mitosis activity, bromodeoxyuridine cell proliferation and caspase activity parameters were determined...
June 2024: Oncology Letters
https://read.qxmd.com/read/38638846/erratum-corrigendum-mir%C3%A2-137-suppresses-proliferation-migration-and-invasion-of-colon-cancer-cell-lines-by-targeting-tcf4
#4
Wei-Ping Bi, Min Xia, Xin-Jian Wang
[This corrects the article DOI: 10.3892/ol.2018.8364.].
June 2024: Oncology Letters
https://read.qxmd.com/read/38638845/identification-and-validation-of-pcdhga12-and-prrx1-methylation-for-detecting-lung-cancer-in-bronchial-washing-sample
#5
JOURNAL ARTICLE
Tae Jeong Oh, Seunghyun Jang, Su Ji Kim, Min A Woo, Ji Woong Son, In Beom Jeong, Min Hyeok Lee, Sungwhan An
Bronchoscopy is a frequently used initial diagnostic procedure for patients with suspected lung cancer (LC). Cytological examinations of bronchial washing (BW) samples obtained during bronchoscopy often yield inconclusive results regarding LC diagnosis. The present study aimed to identify molecular biomarkers as a non-invasive method for LC diagnosis. Aberrant DNA methylation is used as a useful biomarker for LC. Therefore, microarray-based methylation profiling analyses on 13 patient-matched tumor tissues at stages I-III vs...
June 2024: Oncology Letters
https://read.qxmd.com/read/38638844/metastasis-to-the-bladder-from-primary-breast-cancer-a-case-report-and-literature-review
#6
Hanli Zhou, Danna Liu, Lu Chen, Yujie Zhang, Xiaoli Zhao, Yongchao Ge, Mengmeng Liu, Tiandong Kong
Breast cancer is the most prevalent malignant tumor affecting women and represents the leading cause of female cancer-related mortality worldwide. Although distant organ metastasis accounts for the majority of breast cancer-related deaths, reports on bladder metastasis are limited in the existing literature. The present study describes the case of a patient with bladder metastasis originating from breast cancer. In addition, the present study also provides a review of 54 cases of similar disease that have been documented in the currently available literature...
June 2024: Oncology Letters
https://read.qxmd.com/read/38638843/daratumumab%C3%A2-resistant-multiple-myeloma-with-extramedullary-disease-successfully-treated-with-combination-elotuzumab-pomalidomide-and-dexamethasone-a-case-report
#7
Masataka Sakashita, Naohi Sahara, Jun Aoki, Takashi Matsunaga, Seiichiro Kobayashi, Shinsuke Kitahara, Tomoki Fujii, Nobuhiro Ohno
Despite the emergence of monoclonal antibodies, the prognosis of patients with multiple myeloma (MM) with extramedullary disease remains poor. The present report describes a rare case of daratumumab-refractory MM that was successfully treated with elotuzumab, pomalidomide and dexamethasone. A 66-year-old male patient diagnosed with MM was treated with bortezomib, lenalidomide and dexamethasone, followed by high-dose chemotherapy and autologous stem cell transplantation. Thereafter, the patient was treated with lenalidomide and dexamethasone as maintenance therapy...
June 2024: Oncology Letters
https://read.qxmd.com/read/38638842/effects-of-espcs-mode-nursing-on-the-surgical-tolerance-gastrointestinal-tract-recovery-and-self%C3%A2-management-efficacy-of-patients-with-colon-cancer
#8
JOURNAL ARTICLE
Rui Yu, Meiling Sun, Shuli Xia, Li Zhang
Colon cancer is a common gastrointestinal malignant tumor. In addition to conventional treatment, thoughtful and comprehensive aftercare should be given to patients. The present study aimed to explore the effects of explain-simulate-practice-communication-support (ESPCS) model nursing on the surgical tolerance, gastrointestinal recovery and self-management efficacy of patients with colon cancer. The clinical data of 136 patients with colon cancer diagnosed and treated at the Second Affiliated Hospital of Harbin Medical University (Harbin, China) from June 2020 to April 2022 were retrospectively analyzed and a total of 84 patients met the inclusion criteria...
June 2024: Oncology Letters
https://read.qxmd.com/read/38638841/prognostic-value-of-serum-tartrate%C3%A2-resistant-acid-phosphatase%C3%A2-5b-for-bone-metastasis-in-patients-with-resectable-breast-cancer
#9
JOURNAL ARTICLE
Masafumi Shimoda, Yasufumi Sato, Kaori Abe, Nanae Masunaga, Masami Tsukabe, Tetsuhiro Yoshinami, Yoshiaki Sota, Tomohiro Miyake, Tomonori Tanei, Kenzo Shimazu
Bone metastasis significantly affects the quality of life of patients with metastatic breast cancer, and can shorten overall survival. Identifying patients with early-stage breast cancer at high risk for bone metastasis and preventing bone metastasis may lead to a better quality of life and prolonged survival. The present study investigated whether serum tartrate-resistant acid phosphatase-5b (TRACP-5b), a bone turnover marker, can be a prognostic factor for bone metastasis. Female patients who underwent resectable breast surgery between May 2002 and August 2006 were consecutively investigated...
June 2024: Oncology Letters
https://read.qxmd.com/read/38623571/-retracted-downregulation-of-long-non%C3%A2-coding-rna-gas5-promotes-cell-proliferation-migration-and-invasion-in-esophageal-squamous-cell-carcinoma
#10
Ke Ke, Zhanwen Sun, Zhengjun Wang
[This retracts the article DOI: 10.3892/ol.2018.8797.].
June 2024: Oncology Letters
https://read.qxmd.com/read/38623570/early-growth-response-1-regulates-dual%C3%A2-specificity-protein-phosphatase-1-and-inhibits-cell-migration-and-invasion-of-tongue-squamous-cell-carcinoma
#11
JOURNAL ARTICLE
Longxun Zhou, Yuqun Shan, Jun Li, Min Li, Zhen Meng, Na Guo
Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the head and neck, and among the OSCCs, tongue squamous cell carcinoma (TSCC) is one of the most common types. Although therapy strategies have recently advanced, the prognosis of TSCC has not substantially improved. Metastasis is one of the main causes of patient mortality in TSCC; therefore, it is necessary to elucidate the mechanism by which TSCC metastasis is regulated. In the present study, the early growth response 1 (Egr-1) expression in TSCC was analyzed based on GEO datasets and the effect of Egr-1 in TSCC tumor cell migration and invasion was measured using Transwell assay...
June 2024: Oncology Letters
https://read.qxmd.com/read/38618645/prognostic-significance-of-connective-tissue-growth-factor-expression-in-stromal-cells-in-patients-with-diffuse%C3%A2-type-gastric-cancer
#12
JOURNAL ARTICLE
Yuichiro Miki, Mami Yoshii, Ryoko Miyauchi, Hiroaki Kasashima, Tatsunari Fukuoka, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Shigeru Lee, Masakazu Yashiro, Kiyoshi Maeda
Connective tissue growth factor (CTGF) is a target gene of the Hippo signaling pathway. Its differential role in the histological types of gastric cancer (GC) remains unknown; therefore, the present study aimed to confirm the clinical significance of CTGF expression in cancer and stromal cells in patients with GC depending on the histological type. The present study enrolled 589 patients with GC. Immunohistochemistry was used to analyze CTGF expression in cancer and stromal cells. CTGF mRNA expression data and the corresponding clinical information of GC samples were collected from The Cancer Genome Atlas (TCGA) database...
June 2024: Oncology Letters
https://read.qxmd.com/read/38618644/efficacy-of-consolidation-of-immune-checkpoint-inhibitor-after-chemoradiation-for-unresectable-locally-advanced-pd%C3%A2-l1-negative-non%C3%A2-small-cell-lung-cancer-a-systematic-review-and-meta%C3%A2-analysis
#13
JOURNAL ARTICLE
Sunyin Rao, Li Min, Jie Zhao, Juan Su, Lianhua Ye
Chemoradiotherapy (CRT) followed by consolidation of immune checkpoint inhibitors (ICIs), such as durvalumab or pembrolizumab, for patients with unresectable, locally advanced non-small cell lung cancer (NSCLC) with tumor PD-L1 expression <1% remains a topic of controversy. Previous studies from PubMed, Cochrane Library and Embase databases were searched for a meta-analysis. A total of 16 studies were included in part one of the meta-analysis and it was observed that consolidation of ICIs after CRT improved overall survival (OS) [hazard ratio (HR) 1...
June 2024: Oncology Letters
https://read.qxmd.com/read/38601183/glycolysis%C3%A2-related-lncrna-may-be-associated-with-prognosis-and-immune-activity-in-grade-ii%C3%A2-iii-glioma
#14
JOURNAL ARTICLE
Tao Yang, Ruiguang Zhang, Zhenfen Cui, Bowen Zheng, Xiaowei Zhu, Xinyu Yang, Qiang Huang
Glucose metabolism, as a novel theory to explain tumor cell behavior, has been intensively studied in various tumors. The present study explored the long non-coding RNAs (lncRNAs) related to glycolysis in grade II-III glioma, aiming to provide a promising target for further research. Pearson correlation analysis was used to identify glycolysis-related lncRNAs. Univariate/multivariate Cox regression analysis and the Least Absolute Shrinkage and Selection Operator algorithm were applied to identify glycolysis-related lncRNAs to construct a prognosis prediction model...
May 2024: Oncology Letters
https://read.qxmd.com/read/38601182/postoperative-long%C3%A2-term-outcomes-of-acute-normovolemic-hemodilution-in-pancreatic-cancer-a-propensity-score-matching-analysis
#15
JOURNAL ARTICLE
Taiichi Wakiya, Keinosuke Ishido, Norihisa Kimura, Hayato Nagase, Taishu Kanda, Shunsuke Kubota, Hiroaki Fujita, Yoshiya Takahashi, Takeshi Yamamoto, Kohei Chida, Junichi Saito, Kazuyoshi Hirota, Kenichi Hakamada
Acute normovolemic hemodilution (ANH) is a useful intraoperative blood conservation technique. However, the impact on long-term outcomes in pancreatic ductal adenocarcinoma (PDAC) remains unclear. The present study investigated the impact of ANH on long-term outcomes in patients with PDAC undergoing radical surgery. Data from 155 resectable PDAC cases were collected. Patients were categorized according to whether or not they had received intraoperative allogeneic blood transfusion (ABT) or ANH. Postoperative complications, recurrence-free survival (RFS) and disease-specific survival (DSS), before and after propensity score matching (PSM), were compared among patients who did and did not receive ANH...
May 2024: Oncology Letters
https://read.qxmd.com/read/38601181/assessment-and-prognostic-significance-of-a-serum-cytokine-panel-in-diffuse-large-b%C3%A2-cell-lymphoma
#16
JOURNAL ARTICLE
Shufang Xie, Lifen Zhu, Lei Wang, Shibing Wang, Xiangmin Tong, Wanmao Ni
The objective of the present study was to assess the levels of circulating cytokines in patients with diffuse large B-cell lymphoma (DLBCL), and to examine the associations between the cytokine levels, clinicopathological manifestations and patient prognosis. The study enrolled 49 patients with DLBCL, 11 patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and 67 healthy controls from Zhejiang Provincial People's Hospital (Hangzhou, China) between January 2017 and January 2020. The serum levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor (TNF)-α and interferon (IFN)-γ were measured using flow cytometry...
May 2024: Oncology Letters
https://read.qxmd.com/read/38596264/fusobacteria-alterations-are-associated-with-colorectal-cancer-liver-metastasis-and-a-poor-prognosis
#17
JOURNAL ARTICLE
Min Jin, Qilin Fan, Fumei Shang, Tao Zhang, Shuji Ogino, Hongli Liu
Liver metastasis is a major cause of mortality in patients with advanced stages of colorectal cancer (CRC). The gut microbiota has been demonstrated to influence the progression of liver diseases, potentially providing novel perspectives for diagnosis, treatment and research. However, the gut microbial characteristics in CRC with liver metastasis (LM) and with no liver metastasis (NLM) have not yet been fully established. In the present study, high-throughput 16S RNA sequencing technology was employed, in order to examine the gut microbial richness and composition in patients with CRC with LM or NLM...
May 2024: Oncology Letters
https://read.qxmd.com/read/38596263/circulating-tumor-cells-help-differentiate-benign-ovarian-lesions-from-cancer-before-surgery-a-literature-review-and-proof-of-concept-study-using-flow-cytometry-with-fluorescence-imaging
#18
JOURNAL ARTICLE
Yung-Chia Kuo, Chi-Hsi Chuang, Hsuan-Chih Kuo, Cheng-Tao Lin, Angel Chao, Huei-Jean Huang, Hung-Ming Wang, Jason Chia-Hsun Hsieh, Hung-Hsueh Chou
Current tools are insufficient for distinguishing patients with ovarian cancer from those with benign ovarian lesions before extensive surgery. The present study utilized a readily accessible platform employing a negative selection strategy, followed by flow cytometry, to enumerate circulating tumor cells (CTCs) in patients with ovarian cancer. These counts were compared with those from patients with benign ovarian lesions. CTC counts at baseline, before and after anticancer therapy, and across various clinical scenarios involving ovarian lesions were assessed...
May 2024: Oncology Letters
https://read.qxmd.com/read/38590311/a-fully-validated-lc%C3%A2-ms-ms-method-for-quantifying%C3%A2-bevacizumab-in-plasma-samples-from-patients-with-nsclc-and-its-implications-in-therapeutic-drug-monitoring
#19
JOURNAL ARTICLE
Bo Li, Meng Yang, Xiaoxue Wang, Wenqian Chen, Hongkai Lu, Guan Wang, Liang Sun, Xiaoyang Liu, Xianbo Zuo, Pengmei Li, Lihong Liu, Xianglin Zhang
Given the increasing use of bevacizumab in combinatorial drug therapy for a multitude of different cancer types, there is a need for therapeutic drug monitoring to analyze the possible correlation between drug trough concentration, and therapeutic effect and adverse reactions. An ultra-performance liquid chromatography tandem-mass spectrometry method was then developed and validated to determine bevacizumab levels in human plasma samples. Chromatographic separation was achieved on a Shimadzu InertSustainBio C18 HP column, whereas subsequent mass spectrometric analysis was performed using a Shimadzu 8050CL triple quadrupole mass spectrometer equipped with an electro-spray ionization source in the positive ion mode...
May 2024: Oncology Letters
https://read.qxmd.com/read/38590310/successful-treatment-of-severe-splenic-lymphoma%C3%A2-associated-hemophagocytic-syndrome-by-splenectomy-and-subsequent-chemotherapy-a-case-report
#20
Hideyuki Masui, Maki Shindo, Yuta Inoue, Maki Sugiyama, Atsushi Ueda, Takero Shindo, Kae Okoshi, Koichi Kinoshita
Hemophagocytic lymphohistiocytosis (HLH) represents a fatal immunopathology derived from excessive inflammatory reactions. In particular, lymphoma-associated hemophagocytic syndrome (LAHS) is associated with a dismal prognosis. The current study presented a challenging case of splenic LAHS. A 71-year-old man presented with fatigue and anorexia. Laboratory test results revealed anemia, thrombocytopenia, lactate dehydrogenase elevation and markedly elevated levels of ferritin (6,210 ng/ml) and soluble interleukin 2 receptor (sIL-2R; 11,328 U/ml)...
May 2024: Oncology Letters
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