Cristina Uribe-Alvarez, Sandra Lucía Guerrero-Rodríguez, Jennifer Rhodes, Alexa Cannon, Jonathan Chernoff, Daniela Araiza-Olivera
Malignant melanoma is characterized by mutations in a number of driver genes, most notably BRAF and NRAS . Recent genomic analyses revealed that 4-9% of sun-exposed melanomas bear activating mutations in RAC1 , which encodes a small GTPase that is known to play key roles in cell proliferation, survival, and migration. The RAC1 protein activates several effector pathways, including Group A p21-activated kinases (PAKs), phosphoinositol-3-kinases (PI3Ks), in particular the beta isoform, and the serum-response factor/myocardin-related transcription factor (SRF/MRTF)...
February 11, 2020: Small GTPases