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Mediterranean Journal of Hematology and Infectious Diseases

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https://read.qxmd.com/read/30671219/bone-mineral-density-and-vitamin-d-receptor-genetic-variants-in-egyptian-children-with-beta-thalassemia-major-on-vitamin-d-supplementation
#1
Hadeer A Abbassy, Reham A Abo Elwafa, Omneya M Omar
Background: Low bone mineral density (BMD) is a characteristic feature of Beta thalassemia major (βTM) patients. Vitamin D is important for bone mineralization. Vitamin D receptors (VDR) genetic variants may be related to vitamin D status and BMD. Objectives: To evaluate the effect of VDR genetic variants on vitamin D levels and BMD in βTM Egyptian patients supplemented with vitamin D. Methods: This study was conducted on forty children with βTM and seventeen unrelated healthy sex and age-matched controls...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671218/increase-in-candida-parapsilosis-candidemia-in-cancer-patients
#2
Mingyue Sun, Chunguang Chen, Weiqiang Xiao, Yanmin Chang, Cailin Liu, Qingxia Xu
This study aimed to identify the risk factors of candidemia and asses possible clinically significant differences between Candida parapsilosis and other Candida species in a Chinese tertiary cancer center over six years. A total of 323 cancer patients were enrolled and analyzed from 2012 to 2018. Among the isolates, the species most frequently isolated was C. parapsilosis (37.15%, 120/323), and C. albicans only accounted for 34.37%. Based on statistical analysis, when candidemia patients who had C. parapsilosis were compared with other Candida spp ...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671217/high-prevalence-of-hepatitis-c-virus-among-b-cell-non-hodgkin-lymphoma-patients-in-mansoura-region-egypt-anrs-12263-study
#3
Layla M Saleh, Danielle Canioni, Sameh Shamaa, Maha El-Zaafarany, Ziad Emarah, Sherin Abdel-Aziz, Entsar Eladle, Alsaeed Abdelaziz, Olivier Hermine, Caroline Besson, Hasan Abdel-Ghaffar
Background: The prevalence of Hepatitis C virus in Egypt reaches 15%, which is considered the highest in the world. Genotype 4 represents 93 % of Egyptian HCV infections. Non-Hodgkin lymphoma (NHL) is the 5th most common cancer in Egypt. The association between HCV infection and occurrence of B-cell NHL is well known while data are scarce in Eastern countries. Objectives: We aimed to evaluate the prevalence of HCV infection among patients with B-cell NHL and the clinical characteristics of HCV associated B-cell NHL in the Delta region (Mansoura-Egypt)...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671216/chronic-kidney-disease-amongst-sickle-cell-anaemia-patients-at-the-university-of-maiduguri-teaching-hospital-northeastern-nigeria-a-study-of-prevalence-and-risk-factors
#4
A A Bukar, M M Sulaiman, A I Ladu, A M Abba, M K Ahmed, G T Marama, U M Abjah
Background: Involvement of the kidneys in patients with sickle cell anaemia is a well recognised chronic complication. This study seeks to determine the prevalence of chronic kidney disease in patients with homozygous sickle cell disease (HbSS) and to identify risk factors associated with its development. Methodology: The subjects consisted of adolescents and adults with HbSS recruited sequentially from the adult haematology outpatient clinic and Daycare ward of the unit...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671215/detection-of-calr-mutations-using-high-resolution-melting-curve-analysis-hrm-a-application-on-a-large-cohort-of-greek-et-and-mf-patients
#5
Andreas Giannopoulos, Niki Rougkala, Theodoros Loupis, Marina Mantzourani, Nora-Athina Viniou, Eleni Variami, Theodoros P Vassilakopoulos, George Dryllis, Ioannis Kotsianidis, Theodora Gougopoulou, Marianna Politou, Kostas Konstantopoulos, George Vassilopoulos
Background and Objectives: Somatic mutations in the calreticulin gene ( CALR ) are detected in approximately 70% of patients with essential thrombocythemia (ET) and primary or secondary myelofibrosis (MF), lacking the JAK2 and MPL mutations. To determine the prevalence of CALR frameshift mutations in a population of MPN patients of Greek origin, we developed a rapid low-budget PCR-based assay and screened samples from 5 tertiary Haematology units. This is a first of its kind report of the Greek patient population that also disclosed novel CALR mutants...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671214/soluble-st2-and-cd163-as-potential-biomarkers-to-differentiate-primary-hemophagocytic-lymphohistiocytosis-from-macrophage-activation-syndrome
#6
Zhuo Gao, Yini Wang, Jingshi Wang, Jia Zhang, Zhao Wang
The differentiation of primary hemophagocytic lymphohistiocytosis (pHLH) and macrophage activation syndrome (MAS) poses a challenge to hematologists. The aim of this study was (1) to compare the levels of soluble ST2 (sST2), sCD163, IFN-γ, IL-10, IL-18, TNF-α and Serum soluble interleukin-2 receptor (sCD25) in patients with pHLH and MAS and (2) to investigate whether they can help differentiate the two diseases. A total of 52 participants were recruited in this study, including 12 pHLH patients, 20 MAS patients, and 20 healthy subjects...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671213/bortezomib-maintenance-for-the-treatment-of-monoclonal-gammopathy-of-renal-significance
#7
Holly Lee, Peter Duggan, Paola Neri, Jason Tay, Victor H Jimenez-Zepeda
Monoclonal gammopathy of renal significance (MGRS) defines renal diseases resulting from the nephrotoxic effects of monoclonal proteins secreted from non-malignant clonal B cells or plasma cells, that do not meet criteria for multiple myeloma, Waldenstrom's macroglobulinemia, chronic lymphocytic leukemia, or lymphomas. Renal disease in MGRS can result from monoclonal immunoglobulin deposition to different parts of the kidney and includes a wide spectrum of glomerular, tubulointerstitial and vascular renal diseases...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671212/respiratory-viral-infections-in-children-and-adolescents-with-hematological-malignancies
#8
Seung Beom Han, Ju Ae Shin, Seong Koo Kim, Jae Wook Lee, Dong-Gun Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang
Background: Despite the introduction of a polymerase chain reaction (PCR) test for the diagnosis of respiratory viral infection (RVI), guidance on the application of this test and the management of RVI in immunocompromised children is lacking. This study evaluated the clinical characteristics of RVI and established strategies for the PCR test in children and adolescents with hematological malignancies. Methods: This study included children and adolescents with underlying hematological malignancies and respiratory symptoms, in whom a multiplex PCR test was performed...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671211/the-use-of-hplc-as-a-tool-for-neonatal-cord-blood-screening-of-haemoglobinopathy-a-validation-study
#9
A Al-Madhani, A Pathare, S Al Zadjali, M Al Rawahi, I Al-Nabhani, S Alkindi
Background: Newborn cord blood screening identifies infants with underlying haemoglobinopathies before they develop the characteristic symptoms or sequelae. Aims: This study was performed to validate the interpretation high-performance chromatography (HPLC) along with complete blood count (CBC) results as a tool for universal neonatal screening of hemoglobin disorders in Oman. Methods: HPLC and CBC data on subjects who participated in the National Neonatal screening program at birth were obtained from archival records...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671210/hiv-and-lymphoma-from-epidemiology-to-clinical-management
#10
REVIEW
Alessandro Re, Chiara Cattaneo, Giuseppe Rossi
Patients infected with human immunodeficiency virus (HIV) are at increased risk for developing both non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). Even if this risk has decreased for NHL after the introduction of combination antiretroviral therapy (cART), they remain the most common acquired immune deficiency syndrome (AIDS)-related cancer in the developed world. They are almost always of B-cell origin, and some specific lymphoma types are more common than others. Some of these lymphoma types can occur in both HIV-uninfected and infected patients, while others preferentially develop in the context of AIDS...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671209/international-multicenter-experience-in-the-treatment-outcome-of-invasive-aspergillosis-in-immunocompromised-cancer-patients
#11
Ray Hachem, Marjorie V Batista, Souha S Kanj, Saeed El Zein, Sara Haddad, Ying Jiang, Nobuyoshi Mori, Rocha Vanderson, Anne-Marie Chaftari, Issam Raad
Background: Invasive aspergillosis (IA) is a life-threatening infection in immunocompromised patients. In this study, we compared the efficacy of voriconazole containing regimen vs non-voriconazole containing regimen in patients with IA. Methods: In this retrospective study, we reviewed the medical records of all immunocompromised cancer patients diagnosed with proven or probable IA between February 2012 and March 2018. This trial included 26 patients from the American University of Beirut, Lebanon, 20 patients from Hospital das Clinicas da Faculdade de Medicina, Universidade de São Paulo, Brazil, and 10 patients from St...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671208/new-therapeutic-options-for-the-treatment-of-sickle-cell-disease
#12
REVIEW
Alessandro Matte, Francesco Zorzi, Filippo Mazzi, Enrica Federti, Oliviero Olivieri, Lucia De Franceschi
Sickle cell disease (SCD; ORPHA232; OMIM # 603903) is a chronic and invalidating disorder distributed worldwide, with high morbidity and mortality. Given the disease complexity and the multiplicity of pathophysiological targets, development of new therapeutic options is critical, despite the positive effects of hydroxyurea (HU), for many years the only approved drug for SCD. New therapeutic strategies might be divided into (1) pathophysiology-related novel therapies and (2) innovations in curative therapeutic options such as hematopoietic stem cell transplantation and gene therapy...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30671207/in-vivo-emergence-of-ul56-c325y-cytomegalovirus-resistance-to-letermovir-in-a-patient-with-acute-myeloid-leukemia-after-hematopoietic-cell-transplantation
#13
Jochen J Frietsch, Detlef Michel, Thomas Stamminger, Friederike Hunstig, Sebastian Birndt, Ulf Schnetzke, Sebastian Scholl, Andreas Hochhaus, Inken Hilgendorf
CMV associated tissue-invasive disease is associated with a considerable risk of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Recently, the terminase inhibitor letermovir (LMV) has been approved for prophylaxis of CMV infection in HSCT. We hereby report a 60-year-old female experiencing CMV reactivation after HSCT in a CMV seronegative donor-constellation. Due to ongoing elevated CMV viral load and drug-associated myelosuppression, which prevented ganciclovir therapy, treatment was replaced by foscarnet...
2019: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30416702/phenotyping-of-rh-kell-duffy-and-kidd-blood-group-antigens-among-non-tribal-and-tribal-population-of-south-gujarat-and-its-implication-in-preventing-alloimmunization-in-multitransfused-patients
#14
Avani Shah, Kanjaksha Ghosh, Preeti Sharma, Kanchan Mishra
No abstract text is available yet for this article.
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30416701/cardiac-toxicity-associated-with-hcv-direct-antiviral-agents
#15
Claudio Ucciferri, Alessandro Occhionero, Jacopo Vecchiet, Katia Falasca
No abstract text is available yet for this article.
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30416700/megakaryocyte-contribution-to-bone-marrow-fibrosis-many-arrows-in-the-quiver
#16
REVIEW
Alessandro Malara, Vittorio Abbonante, Maria Zingariello, Annarita Migliaccio, Alessandra Balduini
In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30416699/the-broad-ranging-panorama-of-systemic-autoinflammatory-disorders-with-specific-focus-on-acute-painful-symptoms-and-hematologic-manifestations-in-children
#17
REVIEW
Donato Rigante
Systemic autoinflammatory disorders (SAIDs) are inherited defects of innate immunity characterized by recurrent sterile inflammatory attacks involving skin, joints, serosal membranes, gastrointestinal tube, and other tissues, which recur with variable rhythmicity and display reactive amyloidosis as a potential long-term complication. Dysregulated inflammasome activity leading to overproduction of many proinflammatory cytokines, such as interleukin-1 (IL-1), and delayed shutdown of inflammation are considered crucial pathogenic keys in the vast majority of SAIDs...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30416698/deferasirox-over-a-decade-of-experience-in-thalassemia
#18
REVIEW
Nour M Moukalled, Rayan Bou-Fakhredin, Ali T Taher
Thalassemia incorporates a broad clinical spectrum characterized by decreased or absent production of normal hemoglobin leading to decreased red blood cell survival and ineffective erythropoiesis. Chronic iron overload remains an inevitable complication resulting from regular blood transfusions (transfusion-dependent) and/or increased iron absorption (mainly non-transfusion-dependent thalassemia), requiring adequate treatment to prevent the significant associated morbidity and mortality. Iron chelation therapy has become a cornerstone in the management of thalassemia patients, leading to improvements in their outcome and quality of life...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30416697/cutaneous-manifestations-of-primary-immunodeficiency-diseases-in-tunisian-children
#19
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Imen Ben-Mustapha, Ridha Kouki, Habib Besbes, Mohamed Ridha Barbouche, Fethi Mellouli, Mohamed Bejaoui
Skin manifestations are frequent among patients with primary immunodeficiency diseases (PIDs). Their prevalence varies according to the type of immunodeficiency. This review provides the reader with an up-to-date summary of the common dermatologic manifestations of PIDs among Tunisian children. We conducted a prospective study on two hundred and ninety children with immune deficiency. Demographic details (including age, sex, and consanguinity) with personal and family history were recorded. Special attention was paid to cutaneous manifestations...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/30416696/jadenu-%C3%A2-substituting-exjade-%C3%A2-in-iron-overloaded-%C3%AE-thalassemia-major-btm-patients-a-preliminary-report-of-the-effects-on-the-tolerability-serum-ferritin-level-liver-iron-concentration-and-biochemical-profiles
#20
Mohamed A Yassin, Ashraf T Soliman, Vincenzo De Sanctis, Radwa M Hussein, Randa Al-Okka, Nancy Kassem, Rula Ghasoub, Ahmed Basha, Abdulqadir J Nashwan, Ahmad M Adel
Introduction: Due to the chronic nature of chelation therapy and the adverse consequences of iron overload, patient adherence to therapy is an important issue. Jadenu ® is a new oral formulation of deferasirox (Exjade ® ) tablets for oral suspension. While Exjade® is a dispersible tablet that must be mixed in liquid and taken on an empty stomach, Jadenu ® can be taken in a single step, with or without a light meal, simplifying administration for the treatment of patients with chronic iron overload...
2018: Mediterranean Journal of Hematology and Infectious Diseases
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