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Nuclear Medicine and Molecular Imaging

Ashwin Singh Parihar, Bhagwant Rai Mittal, Shelvin Kumar Vadi, Rajender Kumar, Kaniyappan Nambiyar, Bishan Radotra, Lileswar Kaman
We present the case of a 36-year-old woman who underwent 18 F-FDG PET/CT with suspicion of a primary breast malignancy. However, PET/CT detected an occult renal cell carcinoma with metastases to the thyroid, breast, lungs and lymph nodes. Thyroid and breast metastases are atypical metastatic sites of renal cell carcinoma. Breast metastases from extra mammary tissue are extremely rare, more so from renal cell carcinoma. Histopathologic confirmation of the breast lesions is imperative to avoid unnecessary mastectomy and imaging can help in raising the suspicion of metastatic involvement versus primary breast malignancy...
December 2018: Nuclear Medicine and Molecular Imaging
Ashwin Singh Parihar, Bhagwant Rai Mittal, Shelvin Kumar Vadi, Apurva Sood, Rajender Kumar, Usha Dutta
Groove pancreatitis is a rare form of chronic pancreatitis that affects the groove area adjacent to the second part of the duodenum. Clinical and biochemical features often overlap with other subsets of chronic pancreatitis, while the imaging features resemble that of carcinoma of the head of pancreas. We present a 38-year-old man with abdominal pain, nausea, vomiting, and loss of weight who underwent 18 F-FDG PET/CT to rule out a pancreatic malignancy. PET/CT imaging features of groove pancreatitis are distinct from the other subsets of chronic pancreatitis, such as alcoholic and autoimmune pancreatitis, and helpful in the diagnosis and planning further management of the patient...
December 2018: Nuclear Medicine and Molecular Imaging
Reeree Lee, Young So, Yoo Sung Song, Won Woo Lee
Planar scintigraphy using Tc-99m pertechnetate is useful for snapshot evaluation of hot thyroid nodules, which are pathologically follicular adenoma and seldom, if ever, malignant. The autonomy of the hot nodules has been demonstrated by the presence of thyroid-stimulating hormone-dependent extra-nodular thyroid tissue besides the hot nodules. Here, we present two cases of hot thyroid nodules in patients who underwent quantitative single-photon emission computed tomography/computed tomography (SPECT/CT). In addition to the nodules, contralateral normal thyroid parenchyma was evaluated based on standardized uptake values...
December 2018: Nuclear Medicine and Molecular Imaging
Sejin Ha, Sujin Park, Hyunji Kim, Heounjeong Go, Seung Hun Lee, Ji Yoon Choi, Jung Yong Hong, Jin-Sook Ryu
Diagnosing tumor-induced osteomalacia is often challenging because conventional imaging modalities may fail to locate the responsible tumor. This report describes the ability of 68 Ga-DOTATOC PET/CT to successfully distinguish between the responsible phosphaturic mesenchymal tumor and concurrent lymphoma lesions. A 52-year-old man with bone pain for several years was diagnosed with a vitamin D-resistant hypophosphatemic osteomalacia. Whole body 18 F-FDG PET/CT revealed multiple enlarged hypermetabolic lymph nodes in his bilateral cervical, axillary, mediastinal, abdominal, pelvic, and inguinal regions...
December 2018: Nuclear Medicine and Molecular Imaging
Sunju Choi, Hye Ryeong Kwon, Hee Young Cho, Kisoo Pahk, Sung-Ho Lee, Jae-Ho Chung, Hyun Woo Kwon, Sungeun Kim
Purpose: This study aimed to investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), which are volume-based PET parameters, using 18 F-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (18 F-FDG PET/CT) in patients with surgically resectable lung adenocarcinoma. Methods: We retrospectively evaluated 149 patients with lung adenocarcinoma who underwent 18 F-FDG PET/CT before surgical resection. Maximum standardized uptake value (SUVmax), MTV, and TLG of the primary tumor with threshold value of SUVmax 30, 40, and 50% were calculated, respectively...
December 2018: Nuclear Medicine and Molecular Imaging
Soyoung Kim, Young Tae Kim, Sunghoon Kim, Sang Wun Kim, Jung-Yun Lee, Won Jun Kang
Purpose: This study aimed to compare the diagnostic value of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and magnetic resonance imaging (MRI) in the preoperative evaluation of uterine carcinosarcoma. Methods: Fifty-four women with pathologically confirmed uterine carcinosarcoma who underwent preoperative FDG PET/CT and MRI from June 2006 to November 2016 were included. Pathologic findings from primary tumor lesions, para-aortic and pelvic lymph node (LN) areas, and peritoneal seeding lesions were compared with the FDG PET/CT and MRI findings...
December 2018: Nuclear Medicine and Molecular Imaging
Neslihan Cetin Avci, Filiz Hatipoglu, Ahmet Alacacıoglu, Emine Ebru Bayar, Gonca Gul Bural
Purpose: To compare the performance of fluorine-18 fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) with conventional imaging methods (CIM), including computed tomography (CT), magnetic resonance imaging (MRI), and mammography (MMG) in cancer of unknown primary (CUP). Methods: A total of 36 patients with CUP, who referred to our clinic for a FDG PET/CT scan, were enrolled in this study. Thirty of the patients were also examined through either diagnostic CT/MRI and/or MMG...
December 2018: Nuclear Medicine and Molecular Imaging
Soo Mee Kim, Young Soo Kim
Purpose: The double-scattering Compton camera (DSCC) is a radiation imaging system that can provide both unknown source energy spectra and 3D spatial source distributions. The energies and detection locations measured in coincidence with three CdZnTe (CZT) detectors contribute to reconstructing emission energies and a spatial image based on conical surface integrals. In this study, we developed a digital data acquisition (DAQ) board to support our research into coincidence detection in the DSCC...
December 2018: Nuclear Medicine and Molecular Imaging
Manoj Gupta, Partha Sarathi Choudhury, Sudhir Rawal, Harish Chandra Goel, S Avinash Rao
Purpose: The aim of the study was to compare response evaluation criteria in solid tumours 1.1 (RECIST 1.1), positron emission tomography response criteria in solid tumours (PERCIST), European organisation for research and treatment of cancer (EORTC), and MD Anderson (MDA) criteria for response assessment by Gallium 68-prostate-specific membrane antigen positron emission tomography-computed tomography (Ga68-PSMA PET-CT) in metastatic adenocarcinoma prostate cancer (mPCa) patients with biochemical progression...
December 2018: Nuclear Medicine and Molecular Imaging
Minseok Suh, Dong Soo Lee
Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease. However, several factors, such as lack of endophenotype classification, blood-brain barrier (BBB), target determination, ignorance of biodistribution after administration, and complex intercellular communication between brain cells, make brain theranostics application difficult, especially when it comes to clinical application...
December 2018: Nuclear Medicine and Molecular Imaging
Dong Soo Lee
No abstract text is available yet for this article.
December 2018: Nuclear Medicine and Molecular Imaging
Alyssa R Goldbach, Suzanne Pascarella, Simin Dadpravarar
We report a case of a 29-year-old female with a history of asthma, post-partum ARDS, and pulmonary hypertension who presents with severe shortness of breath. The patient describes her shortness of breath as progressive over the past 10 years. Chest radiography and CT angiography of the thorax showed findings consistent with fibrosing mediastinitis with severe stenosis of the left main pulmonary artery. This resulted in appearance of unilateral absent left lung perfusion on quantitative Tc-99-MAA perfusion and Xe-133 ventilation (V/Q) scan...
October 2018: Nuclear Medicine and Molecular Imaging
Fayçal Ben Bouallègue, Fabien Vauchot, Denis Mariano-Goulart
Baseline 18 F-FDG PET was performed in a 74-year-old patient with relapsing upper mediastinum lymphoma. Left subclavian thrombosis was suspected on prior contrast-enhanced CT. Dynamic PET imaging was achieved during 3 min after IV injection of 18 F-FDG to the left arm in order to further assess left subclavian vein permeability. The 20-s dynamic frame at 1 min after injection confirmed the absence of flow in the left subclavian vein and evidenced the derivation of 18 F-FDG through left axillary, then superficial, then right internal mammary collaterals to the superior vena cava, hence confirming the subclavian thrombosis...
October 2018: Nuclear Medicine and Molecular Imaging
Dharmender Malik, Rajender Kumar, Bhagwant Rai Mittal, Gaurav Parkash, Amanjit Bal, Anish Bhattacharya
We present a case of papillary thyroid cancer (post-thyroidectomy status) on regular treatment with suppressive Levothyroxine therapy. On follow-up at 6 months after radioactive iodine ablation for remnant thyroid tissue, her thyroglobulin, and anti-thyroglobulin levels were 0.06 ng/ml and 670 IU/ml, respectively. Low-dose whole-body I-131 scan was negative. To look for the cause of isolated increased anti-thyroglobulin level, a whole-body 18 F-FDG PET/CT was done which revealed multiple FDG-avid lytic skeletal lesions suggestive of metastases...
October 2018: Nuclear Medicine and Molecular Imaging
Meghana Prabhu, Deepali Jain, Siddhartha Datta Gupta, Chandrasekhar Bal, Rakesh Kumar
Thyroid carcinoma is the most common neoplasm of endocrine malignancies. Differentiated thyroid carcinoma (DTC) constitutes 90% of the thyroid carcinomas, rest being medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC). Distant metastases occur in up to 10% of patients with DTC. Metastases to axillary lymph nodes (ALN) are very rare. As per literature, only 25 cases have been reported. We report an unusual case of 47-year-old male with Hürthle cell carcinoma of the thyroid presenting with a solitary axillary lymph node metastasis 17 years after thyroidectomy, along with review of literature...
October 2018: Nuclear Medicine and Molecular Imaging
Young Jin Jeong, Kyung Won Park, Do-Young Kang
Primary progressive aphasia (PPA) is a heterogenous neurodegenerative disorder characterized by declining language and speech ability. Various underlying neuropathologies can induce PPA, and the disorder is divided into three subtypes-progressive non-fluent aphasia, semantic variant aphasia, and logopenic aphasia-according to clinical features. Accurate disease classification and prediction of underlying diseases are necessary for appropriate treatment, but proper use of imaging tests is important because clinical information alone often makes it difficult to make accurate decisions...
October 2018: Nuclear Medicine and Molecular Imaging
Sungwoo Bae, Ji-In Bang, Yoo Sung Song, Won Woo Lee
Respiratory-gated 18 F-fluorodeoxygluocse (18 F-FDG) PET/CT has been successfully used to better localize malignancies in the lung or upper abdominal organs. However, clinical usefulness of respiratory-gated 18 F-FDG PET/CT in detection of fever focus has not been reported yet. A 68-year-old male patient with a history of living donor liver transplantation and biliary stenting was referred for 18 F-FDG PET/CT due to fever of unknown origin (FUO). To find the accurate fever focus, respiratory-gated and non-gated 18 F-FDG PET/CT was performed...
October 2018: Nuclear Medicine and Molecular Imaging
Venkata Subramanian Krishnaraju, Dharmender Malik, Rajender Kumar, Giridhar S Bora, Bhagwant Rai Mittal, Anish Bhattacharya
Testicular torsion is a common differential diagnosis of acute scrotal pain along with acute epididymo-orchitis, which may lead to testicular non-viability. Doppler ultrasound and testicular scintigraphy are two routinely used modalities for the assessment of testicular viability. However, in some cases, these investigations may prove inadequate in differentiating between the two entities with widely differing management. Here, we present a case of a 52-year-old male with questionable viability of testis, who was investigated initially using testicular scintigraphy and was further subjected to a regional 18F-FDG PET/CT scan, in view of inconclusive findings with the conventional modalities...
October 2018: Nuclear Medicine and Molecular Imaging
Jihyun Kim, Hyunjong Lee, Hwanhee Lee, Ji-In Bang, Yeon-Koo Kang, Sungwoo Bae, Yoo Sung Song, Won Woo Lee
Purpose: The purpose of the study was to investigate the usefulness of quantitative salivary single-photon emission computed tomography/computed tomography (SPECT/CT) using Tc-99m pertechnetate in Sjögren's syndrome (SS). Methods: We retrospectively reviewed quantitative salivary SPECT/CT data from 95 xerostomic patients who were classified as either SS ( n  = 47, male:female = 0:47, age = 54.60 ± 13.16 y [mean ± SD]) or non-SS ( n  = 48, male:female = 5:43, age = 54...
October 2018: Nuclear Medicine and Molecular Imaging
Myoung Hyoun Kim, Seul-Gi Kim, Dae-Weung Kim
Purpose: We developed a Tc-99m and fluorescence-labeled peptide, Tc-99m TAMRA-GHEG-ECG-GNQWFI, to target tumor cells, and evaluated the diagnostic performance as a dual-modality imaging agent for tumor in a murine model. Methods: TAMRA-GHEG-ECG-GNQWFI was synthesized using Fmoc solid-phase peptide synthesis. Radiolabeling of TAMRA-GHEG-ECG-GNQWFI with Tc-99m was done using ligand exchange via tartrate. Binding affinity and in vitro cellular uptake studies were performed...
October 2018: Nuclear Medicine and Molecular Imaging
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