Journal of Population Therapeutics and Clinical Pharmacology

The purpose of this study is to improve the classification accuracy of the C4.5 Algorithm utilizing the forward selection technique. Breast Cancer from the UCI Machine Learning Repository is the dataset utilized. There are 286 records in the dataset with nine attributes and one class (label). The suggested model was evaluated with two existing classification models (C4.5 and Naïve Bayes) using the RapidMiner program. The procedure consists of multiple stages, the first of which consists of selecting the dominant trait using the feature selection technique (weight by information gain)...

Oral lichen planus (OLP) is a chronic inflammatory disease that commonly affects the skin and mucous membranes. There is a difference of opinion among clinicians about whether OLP has been associated with oral candidiasis. Nonetheless, in OLP patients, the oral candidiasis prevalence rate ranges from 7.7 to 16.6%, as established through biopsy findings, whereas 37-50% of the prevalence rate has been noticed in culture findings. Oral candidiasis has been linked to several local and systemic factors, including salivary gland dysfunction, dental prostheses, topical or inhaled corticosteroids, smoking, and the use of systemic medications...

BACKGROUND: Chronic Myeloid Leukemia (CML) is initiated in the bone marrow due to the chromosomal translocation t(9;22), resulting in the fusion oncogene BCR-ABL. Tyrosine kinase inhibitors (TKIs) targeting BCR-ABL have transformed fatal CML into an almost curable disease. However, TKIs lose efficacy during disease progression, and the mechanism of CML progression remains to be fully understood. Additionally, common molecular biomarkers for CML progression are lacking. Our studies previously detected ANKRD36 (c...

Anti-diabetic therapies possess many side effects; thus, searching for alternative strategies with low cost, minimal side effects, and high therapeutic value is very important. The present study aimed to explore the combined use of selenium yeast (SY) and standard anti-diabetic drug pioglitazone (PGZ) for diabetes mellitus (DM) treatment in streptozotocin (STZ)-induced DM. STZ was injected daily intraperitoneally with a low dose (40 mg/kg) into Sprague-Dawley rats to induce DM. The synergistic effect of the SY (0...

Asthma and Chronic obstructive pulmonary disease (COPD ) both are a common public health problem that affects a large portion of population. Nearly 20% of patients with obstructive lung disease have features of both asthma and COPD called ACOS that GOLD_GINA guidelines defines as persistent airflow limitation with several features of asthma and several features of COPD. Yet there is a little data available about diagnosis and treatment of this entity and current study aimed to compare therapeutic response between asthma, COPD and Asthma-COPD overlap syndrome (ACOS) subjects through spirometric data...

BACKGROUND: When rupture of membrane happens before onset of labor, the condition in obstetric practice is defined as "Prelabor rupture of membranes (PROM)" leading to leakage of amniotic fluid through ruptured chorioamniotic membranes and the conditions happens before 37 weeks of pregnancy the term "preterm PROM (PPROM)" is applied. Lack of vitamin C has been suggested as a predisposing factor and vitamin C supplementation has been suggested as a preventive measure. AIM OF THE STUDY: This study was aimed to determine the efficacy and safety of administration of vitamin C women with history of premature preterm rupture of membrane in prevention of such event in current pregnancy...

Data from the West Java Health Office in 2013 stated that the prevalence of non-communicable diseases (NCD), one of which is diabetes Mellitus, was 4.2% with pre-diabetes at 7.8% and 144 cases in the work area of the Singaparna Puskesmas.1 Empowerment of Posbindu cadres with NCD (PTM) ) to reduce cases of PTM. The purpose of this research is to develop a model of empowerment of Posbindu PTM by increasing the role and skills of the Posbindu PTM cadres. This study uses a combined or collaborative method approach, namely qualitative and quantitative...

BACKGROUND: Hypertension is a significant public health problem that affects people all over the world. Various epidemiologic researches have been conducted to reveal the relationship between hypertension and several biochemical markers. The goal of this project was to investigate the electrolytes, glucose, total protein, and lipid profile in people with normal and high blood pressure. MATERIALS AND METHODS: Between 2020 and 2022, a case-control study was done. Two hundred and eighteen males, age ranging from 30 to 70, took part in the study...

BACKGROUND: Hepcidin is a hormone that contributes to iron homeostasis, produced either through hepatic or extrahepatic pathways. Its production may be affected by proinflammatory mediators released by macrophages, which play a role in the development of peripheral insulin resistance. Insulin itself may increase the production of hepcidin hormone from pancreatic β-cells. OBJECTIVES: To evaluate the impact of induction of type 2 diabetes mellitus (T2DM) in albino wister rats on the level of hepcidin...

BACKGROUND: Postoperative nausea and vomiting occur in about 20-30% of women; however, some reports have estimated the rate at 70% in at-risk individuals. Gynecological and obstetrical operations are among the most frequent types of surgeries to be associated with nausea and vomiting postoperatively. Ondansetron and dexamethasone have been compared in a variety of studies for postoperative prophylaxis. AIM OF THE STUDY: This study was conducted in order to compare the efficacy and safety of dexamethasone and ondansetron, alone or in combination, for prevention of postoperative nausea and vomiting in a sample of Iraqi women undergoing gynecological surgeries...

The incidence of diabetes increased significantly around the world in accordance with lifestyle and change in eating behaviour. Streptozotocin-Nicotinamide (STZ-NA) is capable of inducing Diabetes Mellitus type 2 in experimental animals for insulin resistance. In this research, we inspect the therapeutic potential of Etlingera elatior ethanol extract (EEEE) on diabetes associated with diabetic nephropathy and hypertension complications in mice models. Diabetes and hypertension are induced in mice using STZ 45 mg/kgBB and NA 110 mg/kgBB, followed by unilateral ureter ligation (UUO) for 4 weeks after a week of STZ-NA induction...

Chronic renal failure is a deficiency and failure in the excretory function of the kidneys, which causes a general imbalance in the body by retaining and accumulating nitrogenous waste and harmful substances as a result of metabolic reactions. Other functions of the kidneys, such as the regulation of fluids and electrolytes, may also be affected. This study's primary purpose is to estimate some parameters in the serum of chronic renal failure patients. Data and blood samples were obtained from 90 patients with chronic renal failure and 50 healthy volunteers for this cross-sectional study, conducted between 11 April and 26 July 2022...

The awareness and utilization of psychological therapies for Alzheimer's disease have increased significantly in recent years. Limitations on the utilization of pharmacological therapy for Alzheimer's disease in China have corresponded with this surge in greater studies in the field. For individuals who have Alzheimer's disease, cognitive stimulation therapy (CST) is a quick self-help that is founded on the theories of quality and cognitive functioning. People with Alzheimer's disease often participate in cognitive behavioral programs; however, their expense has never been studied...

Alzheimer's disease (AD) is a neurodegenerative condition that disrupts neuropsychological activity and hinders the development of mental capacity. Efficient AD therapy is a major challenge in biological studies. Alzheimer's condition cannot be cured with any particular medication. The purpose of this study is to investigate the impact of multidisciplinary collaborative nursing and cognitive stimulation therapy (MCN- CST) on daily activities, quality of life, and cognitive performance in AD patients. The inclusion/exclusion method is initially used to gather information about AD patients...

Considering that breast cancer diagnosis affects a woman physically and emotionally, treatment during the therapy phase requires enthusiasm. Therefore, this study aims to explore breast cancer survivors' experiences with treatment. A qualitative methodology was used, while the data were collected with in-depth interviews and analyzed using interpretative phenomenological analysis. The study samples included up to five individuals who met the inclusion criteria of having stage III breast cancer for longer than 5 years without metastases and were obtained using the purposive sampling technique...

The force in the pencak silat jejag kick is called the moment of force or torque. The force moment is a measure of the force that can cause an object to rotate around the axis where the axis of rotation is located at the knee joint with the length of the calf as the length of the arm (the radius of the rotation axis). This research was conducted using laboratory biomechanical analysis. The research sample consisted of three male athletes of pencak silat. Previously, anthropometric measurements were carried out in the form of measuring calf length and calf muscle mass, then taking videos of athletes doing jejag kick movements in a static state with targets, which were then analyzed by kinovea...

In the era of technological trends, large statistics have been broadly carried out in diverse businesses, especially healthcare. An extensive amount of data has unfolded new gaps in fitness care. The immense facts in healthcare have the capability to improve healthcare to a higher level. Large records can correctly lessen healthcare problems such as the selection of the appropriate remedy, solution for healthcare, and enhancing the healthcare machine. There are six defining attributes in large data, namely, extent, range, speed, veracity, variability and complexity, and value...

Bone grafts are the most common techniques used in maxillofacial surgery in restoring any lost or defective bone. This novel surgical technique utilizes a new modified problast to restore the contour of the defected chin.

The aim of this research is to identify the strengths and weaknesses of organizational health in the Iraqi Central Handball Federation from the point of view of those who manage the implementation of the annual curriculum, and adopt a descriptive approach in the method of studying the case. This is based on a sample of administrators of the Iraqi Handball Federation curriculum [trainers, governors, members, president, the 138 members of the Central Federation's Administrative Authority, the President, members of the sub-federations of the sports market (2021/2022) selected deliberately by 100% and then divided into statistical analysis sample (30), reconnaissance sample (10), and application sample (98)]...

This review aims to report the current literature on the status of ferrule in root-filled teeth, classify the different types of ferrules, highlight the biomechanical failures due to inadequate ferrule effect, and discuss the current restorative concepts according to the ferrule design principles.