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Nature Communications

Didac Carmona-Gutierrez, Andreas Zimmermann, Katharina Kainz, Federico Pietrocola, Guo Chen, Silvia Maglioni, Alfonso Schiavi, Jihoon Nah, Sara Mertel, Christine B Beuschel, Francesca Castoldi, Valentina Sica, Gert Trausinger, Reingard Raml, Cornelia Sommer, Sabrina Schroeder, Sebastian J Hofer, Maria A Bauer, Tobias Pendl, Jelena Tadic, Christopher Dammbrueck, Zehan Hu, Christoph Ruckenstuhl, Tobias Eisenberg, Sylvere Durand, Noélie Bossut, Fanny Aprahamian, Mahmoud Abdellatif, Simon Sedej, David P Enot, Heimo Wolinski, Jörn Dengjel, Oliver Kepp, Christoph Magnes, Frank Sinner, Thomas R Pieber, Junichi Sadoshima, Natascia Ventura, Stephan J Sigrist, Guido Kroemer, Frank Madeo
Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4'-dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC administration extends the lifespan of yeast, worms and flies, decelerates senescence of human cell cultures, and protects mice from prolonged myocardial ischaemia...
February 19, 2019: Nature Communications
Yufei Ding, Yang Qiu, Kefeng Cai, Qin Yao, Song Chen, Lidong Chen, Jiaqing He
Researches on flexible thermoelectric materials usually focus on conducting polymers and conducting polymer-based composites; however, it is a great challenge to obtain high thermoelectric properties comparable to inorganic counterparts. Here, we report an n-type Ag2 Se film on flexible nylon membrane with an ultrahigh power factor ~987.4 ± 104.1 μWm-1 K-2 at 300 K and an excellent flexibility (93% of the original electrical conductivity retention after 1000 bending cycles around a 8-mm diameter rod)...
February 19, 2019: Nature Communications
Shubo Wang, Bo Hou, Weixin Lu, Yuntian Chen, Z Q Zhang, C T Chan
Many novel properties of non-Hermitian systems are found at or near the exceptional points-branch points of complex energy surfaces at which eigenvalues and eigenvectors coalesce. In particular, higher-order exceptional points can result in optical structures that are ultrasensitive to external perturbations. Here we show that an arbitrary order exceptional point can be achieved in a simple system consisting of identical resonators placed near a waveguide. Unidirectional coupling between any two chiral dipolar states of the resonators mediated by the waveguide mode leads to the exceptional point, which is protected by the transverse spin-momentum locking of the guided wave and is independent of the positions of the resonators...
February 19, 2019: Nature Communications
Wenpeng Zhang, Donghui Zhang, Qinhua Chen, Junhan Wu, Zheng Ouyang, Yu Xia
The original version of this Article contained an error in Fig. 2f, in which the phospholipid was incorrectly labelled 'PE' rather than the correct 'PC'. This has now been corrected in the PDF and HTML versions of the Article.
February 19, 2019: Nature Communications
Chad B Stein, Pavol Genzor, Sanga Mitra, Alexandra R Elchert, Jonathan J Ipsaro, Leif Benner, Sushil Sobti, Yijun Su, Molly Hammell, Leemor Joshua-Tor, Astrid D Haase
PIWI-interacting RNAs (piRNAs) are at the center of a small RNA-based immune system that defends genomes against the deleterious action of mobile genetic elements (transposons). PiRNAs are highly variable in sequence with extensive targeting potential. Their diversity is restricted by their preference to start with a Uridine (U) at the 5' most position (1U-bias), a bias that remains poorly understood. Here we uncover that the 1U-bias of Piwi-piRNAs is established by consecutive discrimination against all nucleotides but U, first during piRNA biogenesis and then upon interaction with Piwi's specificity loop...
February 19, 2019: Nature Communications
Xingyi Ma, Sojin Song, Soohyun Kim, Mi-Sun Kwon, Hyunsook Lee, Wounjhang Park, Sang Jun Sim
Consensus ranking of protein affinity to identify point mutations has not been established. Therefore, analytical techniques that can detect subtle variations without interfering with native biomolecular interactions are required. Here we report a rapid method to identify point mutations by a single nanoparticle sensing system. DNA-directed gold crystallization forms rod-like nanoparticles with bridges based on structural design. The nanoparticles enhance Rayleigh light scattering, achieving high refractive-index sensitivity, and enable the system to monitor even a small number of protein-DNA binding events without interference...
February 19, 2019: Nature Communications
Weiyi Tang, Seaver Wang, Debany Fonseca-Batista, Frank Dehairs, Scott Gifford, Aridane G Gonzalez, Morgane Gallinari, Hélène Planquette, Géraldine Sarthou, Nicolas Cassar
Marine N2 fixation supports a significant portion of oceanic primary production by making N2 bioavailable to planktonic communities, in the process influencing atmosphere-ocean carbon fluxes and our global climate. However, the geographical distribution and controlling factors of marine N2 fixation remain elusive largely due to sparse observations. Here we present unprecedented high-resolution underway N2 fixation estimates across over 6000 kilometers of the western North Atlantic. Unexpectedly, we find increasing N2 fixation rates from the oligotrophic Sargasso Sea to North America coastal waters, driven primarily by cyanobacterial diazotrophs...
February 19, 2019: Nature Communications
A E Vasdekis, H Alanazi, A M Silverman, C J Williams, A J Canul, J B Cliff, A C Dohnalkova, G Stephanopoulos
Optimal metabolic trade-offs between growth and productivity are key constraints in strain optimization by metabolic engineering; however, how cellular noise impacts these trade-offs and drives the emergence of subpopulations with distinct resource allocation strategies, remains largely unknown. Here, we introduce a single-cell strategy for quantifying the trade-offs between triacylglycerol production and growth in the oleaginous microorganism Yarrowia lipolytica. The strategy relies on high-throughput quantitative-phase imaging and, enabled by nanoscale secondary ion mass spectrometry analyses and dedicated image processing, allows us to image how resources are partitioned between growth and productivity...
February 19, 2019: Nature Communications
Matthias Imboden, Etienne de Coulon, Alexandre Poulin, Christian Dellenbach, Samuel Rosset, Herbert Shea, Stephan Rohr
Systematic investigations of the effects of mechano-electric coupling (MEC) on cellular cardiac electrophysiology lack experimental systems suitable to subject tissues to in-vivo like strain patterns while simultaneously reporting changes in electrical activation. Here, we describe a self-contained motor-less device (mechano-active multielectrode-array, MaMEA) that permits the assessment of impulse conduction along bioengineered strands of cardiac tissue in response to dynamic strain cycles. The device is based on polydimethylsiloxane (PDMS) cell culture substrates patterned with dielectric actuators (DEAs) and compliant gold ion-implanted extracellular electrodes...
February 19, 2019: Nature Communications
Hend Alrasheed, Rong Jin, Joshua S Weitz
The original version of the Article contained a spelling error in the word 'piggyback'. This error has been corrected in both the PDF and HTML versions of the Article.
February 19, 2019: Nature Communications
Gang Huang, Arnout Voet, Giovanni Maglia
A high throughput single-molecule method for identifying peptides and sequencing proteins based on nanopores could reduce costs and increase speeds of sequencing, allow the fabrication of portable home-diagnostic devices, and permit the characterization of low abundance proteins and heterogeneity in post-translational modifications. Here we engineer the size of Fragaceatoxin C (FraC) biological nanopore to allow the analysis of a wide range of peptide lengths. Ionic blockades through engineered nanopores distinguish a variety of peptides, including two peptides differing only by the substitution of alanine with glutamate...
February 19, 2019: Nature Communications
Jiangqing Dong, Ximing Du, Huan Wang, Jue Wang, Chang Lu, Xiang Chen, Zhiwen Zhu, Zhipu Luo, Li Yu, Andrew J Brown, Hongyuan Yang, Jia-Wei Wu
Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs), and ORP1L specifically localizes to LELs. Here, we show in vitro that ORP1 is a PI(4,5)P2 - or PI(3,4)P2 -dependent cholesterol transporter, but cannot transport any PIPs. In cells, both ORP1L and PI(3,4)P2 are required for the efficient removal of cholesterol from LELs. Structures of the lipid-binding domain of ORP1 (ORP1-ORD) in complex with cholesterol or PI(4,5)P2 display open conformations essential for ORP function...
February 19, 2019: Nature Communications
Z Q Wang, K Nithyanandan, A Coillet, P Tchofo-Dinda, Ph Grelu
Ultrashort optical pulses propagating in a dissipative nonlinear system can interact and bind stably, forming optical soliton molecules. Soliton molecules in ultrafast lasers are under intense research focus and present striking analogies with their matter molecules counterparts. The recent development of real-time spectral measurements allows probing the internal dynamics of an optical soliton molecule, mapping the dynamics of the pulses' relative separations and phases that constitute the relevant internal degrees of freedom of the molecule...
February 19, 2019: Nature Communications
Oshan Wedage, Noel Amano, Michelle C Langley, Katerina Douka, James Blinkhorn, Alison Crowther, Siran Deraniyagala, Nikos Kourampas, Ian Simpson, Nimal Perera, Andrea Picin, Nicole Boivin, Michael Petraglia, Patrick Roberts
Defining the distinctive capacities of Homo sapiens relative to other hominins is a major focus for human evolutionary studies. It has been argued that the procurement of small, difficult-to-catch, agile prey is a hallmark of complex behavior unique to our species; however, most research in this regard has been limited to the last 20,000 years in Europe and the Levant. Here, we present detailed faunal assemblage and taphonomic data from Fa-Hien Lena Cave in Sri Lanka that demonstrates specialized, sophisticated hunting of semi-arboreal and arboreal monkey and squirrel populations from ca...
February 19, 2019: Nature Communications
Po Hu, Hongwei Zhao, Pei Zhu, Yongsheng Xiao, Weili Miao, Yinsheng Wang, Hailing Jin
Argonaute (AGO) proteins are core components of RNA interference (RNAi) but the mechanisms of their regulation, especially at the post-translational level, remain unclear. Among the ten AGOs in Arabidopsis, only AGO2 is induced by bacterial infection and is known to positively regulate immunity. Here we show that the N-terminal domain of AGO2 is enriched with arginine-glycine RG/GR repeats, which are methylated by protein arginine methyltransferase5 (PRMT5). Arginine methylation has dual functions in AGO2 regulation...
February 19, 2019: Nature Communications
Navaneetha K Ravichandran, David Broido
Recent experiments demonstrate that boron arsenide (BAs) is a showcase material to study the role of higher-order four-phonon interactions in affecting heat conduction in semiconductors. Here we use first-principles calculations to identify a phenomenon in BAs and a related material - boron antimonide, that has never been predicted or experimentally observed for any other material: competing responses of three-phonon and four-phonon interactions to pressure rise cause a non-monotonic pressure dependence of thermal conductivity, κ, which first increases similar to most materials and then decreases...
February 19, 2019: Nature Communications
Christine Insinna, Quanlong Lu, Isabella Teixeira, Adam Harned, Elizabeth M Semler, Jim Stauffer, Valentin Magidson, Ajit Tiwari, Anne K Kenworthy, Kedar Narayan, Christopher J Westlake
In the original version of this Article, the fifth sentence of the abstract incorrectly read 'Remarkably, we show that PACSIN1 and EHD1 assemble membrane t7ubules from the developing intracellular cilium that attach to the plasma membrane, creating an extracellular membrane channel (EMC) to the outside of the cell.', and should have read 'Remarkably, we show that PACSIN1 and EHD1 assemble membrane tubules from the developing intracellular cilium that attach to the plasma membrane, creating an extracellular membrane channel (EMC) to the outside of the cell...
February 19, 2019: Nature Communications
Natasja Wulff Pedersen, Anja Holm, Nikolaj Pagh Kristensen, Anne-Mette Bjerregaard, Amalie Kai Bentzen, Andrea Marion Marquard, Tripti Tamhane, Kristoffer Sølvsten Burgdorf, Henrik Ullum, Poul Jennum, Stine Knudsen, Sine Reker Hadrup, Birgitte Rahbek Kornum
Narcolepsy Type 1 (NT1) is a neurological sleep disorder, characterized by the loss of hypocretin/orexin signaling in the brain. Genetic, epidemiological and experimental data support the hypothesis that NT1 is a T-cell-mediated autoimmune disease targeting the hypocretin producing neurons. While autoreactive CD4+  T cells have been detected in patients, CD8+  T cells have only been examined to a minor extent. Here we detect CD8+  T cells specific toward narcolepsy-relevant peptides presented primarily by NT1-associated HLA types in the blood of 20 patients with NT1 as well as in 52 healthy controls, using peptide-MHC-I multimers labeled with DNA barcodes...
February 19, 2019: Nature Communications
Xin Liu, Yi Li, Jiandang Xue, Weikang Zhu, Junfeng Zhang, Yan Yin, Yanzhou Qin, Kui Jiao, Qing Du, Bowen Cheng, Xupin Zhuang, Jianxin Li, Michael D Guiver
Proton exchange membranes with short-pathway through-plane orientated proton conductivity are highly desirable for use in proton exchange membrane fuel cells. Magnetic field is utilized to create oriented structure in proton exchange membranes. Previously, this has only been carried out by proton nonconductive metal oxide-based fillers. Here, under a strong magnetic field, a proton-conducting paramagnetic complex based on ferrocyanide-coordinated polymer and phosphotungstic acid is used to prepare composite membranes with highly conductive through-plane-aligned proton channels...
February 19, 2019: Nature Communications
Yoo Hyung Kim, Jeongwoon Choi, Myung Jin Yang, Seon Pyo Hong, Choong-Kun Lee, Yoshiaki Kubota, Dae-Sik Lim, Gou Young Koh
Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1-FOXO1 cascade is essential for directional migration of tip cells towards hypoxic regions. In mice, endothelial-specific deletion of either MST1 or FOXO1 leads to the loss of tip cell polarity and subsequent impairment of sprouting angiogenesis. Mechanistically, MST1 is activated by reactive oxygen species (ROS) produced in mitochondria in response to hypoxia, and activated MST1 promotes the nuclear import of FOXO1, thus augmenting its transcriptional regulation of polarity and migration-associated genes...
February 19, 2019: Nature Communications
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