journal
https://read.qxmd.com/read/38615122/motility-induced-coexistence-of-a-hot-liquid-and-a-cold-gas
#1
JOURNAL ARTICLE
Lukas Hecht, Iris Dong, Benno Liebchen
If two phases exist at the same time, such as a gas and a liquid, they have the same temperature. This fundamental law of equilibrium physics is known to apply even to many non-equilibrium systems. However, recently, there has been much attention in the finding that inertial self-propelled particles like Janus colloids in a plasma or microflyers could self-organize into a hot gas-like phase that coexists with a colder liquid-like phase. Here, we show that a kinetic temperature difference across coexisting phases can occur even in equilibrium systems when adding generic (overdamped) self-propelled particles...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615115/double-walled-al-based-mof-with-large-microporous-specific-surface-area-for-trace-benzene-adsorption
#2
JOURNAL ARTICLE
Laigang Hu, Wenhao Wu, Min Hu, Ling Jiang, Daohui Lin, Jian Wu, Kun Yang
Double-walled metal-organic frameworks (MOFs), synthesized using Zn and Co, are potential porous materials for trace benzene adsorption. Aluminum is with low-toxicity and abundance in nature, in comparison with Zn and Co. Therefore, a double-walled Al-based MOF, named as ZJU-520(Al), with large microporous specific surface area of 2235 m2  g-1 , pore size distribution in the range of 9.26-12.99 Å and excellent chemical stability, was synthesized. ZJU-520(Al) is consisted by helical chain of AlO6 clusters and 4,6-Di(4-carboxyphenyl)pyrimidine ligands...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615096/dynamics-of-dna-damage-induced-nuclear-inclusions-are-regulated-by-sumoylation-of-btn2
#3
JOURNAL ARTICLE
Arun Kumar, Veena Mathew, Peter C Stirling
Spatial compartmentalization is a key facet of protein quality control that serves to store disassembled or non-native proteins until triage to the refolding or degradation machinery can occur in a regulated manner. Yeast cells sequester nuclear proteins at intranuclear quality control bodies (INQ) in response to various stresses, although the regulation of this process remains poorly understood. Here we reveal the SUMO modification of the small heat shock protein Btn2 under DNA damage and place Btn2 SUMOylation in a pathway promoting protein clearance from INQ structures...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615087/embedding-biocatalysts-in-a-redox-polymer-enhances-the-performance-of-dye-sensitized-photocathodes-in-bias-free-photoelectrochemical-water-splitting
#4
JOURNAL ARTICLE
Fangwen Cheng, Olha Pavliuk, Steffen Hardt, Leigh Anna Hunt, Bin Cai, Tomas Kubart, Leif Hammarström, Nicolas Plumeré, Gustav Berggren, Haining Tian
Dye-sensitized photoelectrodes consisting of photosensitizers and molecular catalysts with tunable structures and adjustable energy levels are attractive for low-cost and eco-friendly solar-assisted synthesis of energy rich products. Despite these advantages, dye-sensitized NiO photocathodes suffer from severe electron-hole recombination and facile molecule detachment, limiting photocurrent and stability in photoelectrochemical water-splitting devices. In this work, we develop an efficient and robust biohybrid dye-sensitized NiO photocathode, in which the intermolecular charge transfer is enhanced by a redox polymer...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615070/influenza-antibody-breadth-and-effector-functions-are-immune-correlates-from-acquisition-of-pandemic-infection-of-children
#5
JOURNAL ARTICLE
Janice Z Jia, Carolyn A Cohen, Haogao Gu, Milla R McLean, Raghavan Varadarajan, Nisha Bhandari, Malik Peiris, Gabriel M Leung, Leo L M Poon, Tim Tsang, Amy W Chung, Benjamin J Cowling, Nancy H L Leung, Sophie A Valkenburg
Cross-reactive antibodies with Fc receptor (FcR) effector functions may mitigate pandemic virus impact in the absence of neutralizing antibodies. In this exploratory study, we use serum from a randomized placebo-controlled trial of seasonal trivalent influenza vaccination in children (NCT00792051) conducted at the onset of the 2009 H1N1 pandemic (pH1N1) and monitored for infection. We found that seasonal vaccination increases pH1N1 specific antibodies and FcR effector functions. Furthermore, prospective baseline antibody profiles after seasonal vaccination, prior to pH1N1 infection, show that unvaccinated uninfected children have elevated ADCC effector function, FcγR3a and FcγR2a binding antibodies to multiple pH1N1 proteins, past seasonal and avian (H5, H7 and H9) strains...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615063/enhancing-photocatalytic-h-2-o-2-production-with-au-co-catalysts-through-electronic-structure-modification
#6
JOURNAL ARTICLE
Xidong Zhang, Duoduo Gao, Bicheng Zhu, Bei Cheng, Jiaguo Yu, Huogen Yu
Gold-based co-catalysts are a promising class of materials with potential applications in photocatalytic H2 O2 production. However, current approaches with Au co-catalysts show limited H2 O2 production due to intrinsically weak O2 adsorption at the Au site. We report an approach to strengthen O2 adsorption at Au sites, and to improve H2 O2 production, through the formation of electron-deficient Auδ+ sites by modifying the electronic structure. In this case, we report the synthesis of TiO2 /MoSx -Au, following selective deposition of Au onto a MoSx surface which is then further anchored onto TiO2 ...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615060/lipopolysaccharide-binding-protein-resists-hepatic-oxidative-stress-by-regulating-lipid-droplet-homeostasis
#7
JOURNAL ARTICLE
Qilun Zhang, Xuting Shen, Xin Yuan, Jing Huang, Yaling Zhu, Tengteng Zhu, Tao Zhang, Haibo Wu, Qian Wu, Yinguang Fan, Jing Ni, Leilei Meng, Anyuan He, Chaowei Shi, Hao Li, Qingsong Hu, Jian Wang, Cheng Chang, Fan Huang, Fang Li, Meng Chen, Anding Liu, Shandong Ye, Mao Zheng, Haoshu Fang
Oxidative stress-induced lipid accumulation is mediated by lipid droplets (LDs) homeostasis, which sequester vulnerable unsaturated triglycerides into LDs to prevent further peroxidation. Here we identify the upregulation of lipopolysaccharide-binding protein (LBP) and its trafficking through LDs as a mechanism for modulating LD homeostasis in response to oxidative stress. Our results suggest that LBP induces lipid accumulation by controlling lipid-redox homeostasis through its lipid-capture activity, sorting unsaturated triglycerides into LDs...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615046/highly-efficient-field-free-switching-of-perpendicular-yttrium-iron-garnet-with-collinear-spin-current
#8
JOURNAL ARTICLE
Man Yang, Liang Sun, Yulun Zeng, Jun Cheng, Kang He, Xi Yang, Ziqiang Wang, Longqian Yu, Heng Niu, Tongzhou Ji, Gong Chen, Bingfeng Miao, Xiangrong Wang, Haifeng Ding
Yttrium iron garnet, a material possessing ultralow magnetic damping and extraordinarily long magnon diffusion length, is the most widely studied magnetic insulator in spintronics and magnonics. Field-free electrical control of perpendicular yttrium iron garnet magnetization with considerable efficiency is highly desired for excellent device performance. Here, we demonstrate such an accomplishment with a collinear spin current, whose spin polarization and propagation direction are both perpendicular to the interface...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615045/stress-induced-ordering-evolution-of-1d-segmented-heteronanostructures-and-their-chemical-post-transformations
#9
JOURNAL ARTICLE
Qing-Xia Chen, Yu-Yang Lu, Yang Yang, Li-Ge Chang, Yi Li, Yuan Yang, Zhen He, Jian-Wei Liu, Yong Ni, Shu-Hong Yu
Investigations of one-dimensional segmented heteronanostructures (1D-SHs) have recently attracted much attention due to their potentials for applications resulting from their structure and synergistic effects between compositions and interfaces. Unfortunately, developing a simple, versatile and controlled synthetic method to fabricate 1D-SHs is still a challenge. Here we demonstrate a stress-induced axial ordering mechanism to describe the synthesis of 1D-SHs by a general under-stoichiometric reaction strategy...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615044/all-silicon-multidimensionally-encoded-optical-physical-unclonable-functions-for-integrated-circuit-anti-counterfeiting
#10
JOURNAL ARTICLE
Kun Wang, Jianwei Shi, Wenxuan Lai, Qiang He, Jun Xu, Zhenyi Ni, Xinfeng Liu, Xiaodong Pi, Deren Yang
Integrated circuit anti-counterfeiting based on optical physical unclonable functions (PUFs) plays a crucial role in guaranteeing secure identification and authentication for Internet of Things (IoT) devices. While considerable efforts have been devoted to exploring optical PUFs, two critical challenges remain: incompatibility with the complementary metal-oxide-semiconductor (CMOS) technology and limited information entropy. Here, we demonstrate all-silicon multidimensionally-encoded optical PUFs fabricated by integrating silicon (Si) metasurface and erbium-doped Si quantum dots (Er-Si QDs) with a CMOS-compatible procedure...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615042/deep-learning-predictions-of-tcr-epitope-interactions-reveal-epitope-specific-chains-in-dual-alpha-t-cells
#11
JOURNAL ARTICLE
Giancarlo Croce, Sara Bobisse, Dana Léa Moreno, Julien Schmidt, Philippe Guillame, Alexandre Harari, David Gfeller
T cells have the ability to eliminate infected and cancer cells and play an essential role in cancer immunotherapy. T cell activation is elicited by the binding of the T cell receptor (TCR) to epitopes displayed on MHC molecules, and the TCR specificity is determined by the sequence of its α and β chains. Here, we collect and curate a dataset of 17,715 αβTCRs interacting with dozens of class I and class II epitopes. We use this curated data to develop MixTCRpred, an epitope-specific TCR-epitope interaction predictor...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615033/dynamic-multicolor-emissions-of-multimodal-phosphors-by-mn-2-trace-doping-in-self-activated-caga-4-o-7
#12
JOURNAL ARTICLE
Yiqian Tang, Yiyu Cai, Kunpeng Dou, Jianqing Chang, Wei Li, Shanshan Wang, Mingzi Sun, Bolong Huang, Xiaofeng Liu, Jianrong Qiu, Lei Zhou, Mingmei Wu, Jun-Cheng Zhang
The manipulation of excitation modes and resultant emission colors in luminescent materials holds pivotal importance for encrypting information in anti-counterfeiting applications. Despite considerable achievements in multimodal and multicolor luminescent materials, existing options generally suffer from static monocolor emission under fixed external stimulation, rendering them vulnerability to replication. Achieving dynamic multimodal luminescence within a single material presents a promising yet challenging solution...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615031/positive-selection-underlies-repeated-knockout-of-orf8-in-sars-cov-2-evolution
#13
JOURNAL ARTICLE
Cassia Wagner, Kathryn E Kistler, Garrett A Perchetti, Noah Baker, Lauren A Frisbie, Laura Marcela Torres, Frank Aragona, Cory Yun, Marlin Figgins, Alexander L Greninger, Alex Cox, Hanna N Oltean, Pavitra Roychoudhury, Trevor Bedford
Knockout of the ORF8 protein has repeatedly spread through the global viral population during SARS-CoV-2 evolution. Here we use both regional and global pathogen sequencing to explore the selection pressures underlying its loss. In Washington State, we identified transmission clusters with ORF8 knockout throughout SARS-CoV-2 evolution, not just on novel, high fitness viral backbones. Indeed, ORF8 is truncated more frequently and knockouts circulate for longer than for any other gene. Using a global phylogeny, we find evidence of positive selection to explain this phenomenon: nonsense mutations resulting in shortened protein products occur more frequently and are associated with faster clade growth rates than synonymous mutations in ORF8...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615025/extreme-terahertz-magnon-multiplication-induced-by-resonant-magnetic-pulse-pairs
#14
JOURNAL ARTICLE
C Huang, L Luo, M Mootz, J Shang, P Man, L Su, I E Perakis, Y X Yao, A Wu, J Wang
Nonlinear interactions of spin-waves and their quanta, magnons, have emerged as prominent candidates for interference-based technology, ranging from quantum transduction to antiferromagnetic spintronics. Yet magnon multiplication in the terahertz (THz) spectral region represents a major challenge. Intense, resonant magnetic fields from THz pulse-pairs with controllable phases and amplitudes enable high order THz magnon multiplication, distinct from non-resonant nonlinearities such as the high harmonic generation by below-band gap electric fields...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615015/a-plant-nlr-receptor-employs-aba-central-regulator-pp2c-snrk2-to-activate-antiviral-immunity
#15
JOURNAL ARTICLE
Shen Huang, Chunli Wang, Zixuan Ding, Yaqian Zhao, Jing Dai, Jia Li, Haining Huang, Tongkai Wang, Min Zhu, Mingfeng Feng, Yinghua Ji, Zhongkai Zhang, Xiaorong Tao
Defence against pathogens relies on intracellular nucleotide-binding, leucine-rich repeat immune receptors (NLRs) in plants. Hormone signaling including abscisic acid (ABA) pathways are activated by NLRs and play pivotal roles in defence against different pathogens. However, little is known about how hormone signaling pathways are activated by plant immune receptors. Here, we report that a plant NLR Sw-5b mimics the behavior of the ABA receptor and directly employs the ABA central regulator PP2C-SnRK2 complex to activate an ABA-dependent defence against viral pathogens...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615014/inhibition-of-acss2-mediated-histone%C3%A2-crotonylation-alleviates-kidney-fibrosis-via-il-1%C3%AE-dependent-macrophage-activation-and-tubular-cell-senescence
#16
JOURNAL ARTICLE
Lingzhi Li, Ting Xiang, Jingjing Guo, Fan Guo, Yiting Wu, Han Feng, Jing Liu, Sibei Tao, Ping Fu, Liang Ma
Histone lysine crotonylation (Kcr), as a posttranslational modification, is widespread as acetylation (Kac); however, its roles are largely unknown in kidney fibrosis. In this study, we report that histone Kcr of tubular epithelial cells is abnormally elevated in fibrotic kidneys. By screening these crotonylated/acetylated factors, a crotonyl-CoA-producing enzyme ACSS2 (acyl-CoA synthetase short chain family member 2) is found to remarkably increase histone 3 lysine 9 crotonylation (H3K9cr) level without influencing H3K9ac in kidneys and tubular epithelial cells...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38615009/one-substrate-many-enzymes-virtual-screening-uncovers-missing-genes-of-carnitine-biosynthesis-in-human-and-mouse
#17
JOURNAL ARTICLE
Marco Malatesta, Emanuele Fornasier, Martino Luigi Di Salvo, Angela Tramonti, Erika Zangelmi, Alessio Peracchi, Andrea Secchi, Eugenia Polverini, Gabriele Giachin, Roberto Battistutta, Roberto Contestabile, Riccardo Percudani
The increasing availability of experimental and computational protein structures entices their use for function prediction. Here we develop an automated procedure to identify enzymes involved in metabolic reactions by assessing substrate conformations docked to a library of protein structures. By screening AlphaFold-modeled vitamin B6-dependent enzymes, we find that a metric based on catalytically favorable conformations at the enzyme active site performs best (AUROC Score=0.84) in identifying genes associated with known reactions...
April 13, 2024: Nature Communications
https://read.qxmd.com/read/38609408/integrated-proteogenomic-and-metabolomic-characterization-of-papillary-thyroid-cancer-with-different-recurrence-risks
#18
JOURNAL ARTICLE
Ning Qu, Di Chen, Ben Ma, Lijun Zhang, Qiuping Wang, Yuting Wang, Hongping Wang, Zhaoxian Ni, Wen Wang, Tian Liao, Jun Xiang, Yulong Wang, Shi Jin, Dixin Xue, Weili Wu, Yu Wang, Qinghai Ji, Hui He, Hai-Long Piao, Rongliang Shi
Although papillary thyroid cancer (PTC) has a good prognosis, its recurrence rate is high and remains a core concern in the clinic. Molecular factors contributing to different recurrence risks (RRs) remain poorly defined. Here, we perform an integrative proteogenomic and metabolomic characterization of 102 Chinese PTC patients with different RRs. Genomic profiling reveals that mutations in MUC16 and TERT promoter as well as multiple gene fusions like NCOA4-RET are enriched by the high RR. Integrative multi-omics analyses further describe the multi-dimensional characteristics of PTC, especially in metabolism pathways, and delineate dominated molecular patterns of different RRs...
April 12, 2024: Nature Communications
https://read.qxmd.com/read/38609402/a-modular-and-synthetic-biosynthesis-platform-for-de-novo-production-of-diverse-halogenated-tryptophan-derived-molecules
#19
JOURNAL ARTICLE
Kevin B Reed, Sierra M Brooks, Jordan Wells, Kristin J Blake, Minye Zhao, Kira Placido, Simon d'Oelsnitz, Adit Trivedi, Shruti Gadhiyar, Hal S Alper
Halogen-containing molecules are ubiquitous in modern society and present unique chemical possibilities. As a whole, de novo fermentation and synthetic pathway construction for these molecules remain relatively underexplored and could unlock molecules with exciting new applications in industries ranging from textiles to agrochemicals to pharmaceuticals. Here, we report a mix-and-match co-culture platform to de novo generate a large array of halogenated tryptophan derivatives in Escherichia coli from glucose...
April 12, 2024: Nature Communications
https://read.qxmd.com/read/38609401/author-correction-tgcrispri-efficient-gene-knock-down-using-truncated-grnas-and-catalytically-active-cas9
#20
Ankush Auradkar, Annabel Guichard, Saluja Kaduwal, Marketta Sneider, Ethan Bier
No abstract text is available yet for this article.
April 12, 2024: Nature Communications
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