Guannan Zhao, Yuqi Guo, Zixuan Chen, Yinan Wang, Chuanhe Yang, Andrew Dudas, Ziyun Du, Wen Liu, Yanan Zou, Erzsebet Szabo, Sue-Chin Lee, Michelle Sims, Weiwang Gu, Todd Tillmanns, Lawrence M Pfeffer, Gabor Tigyi, Junming Yue
OBJECTIVE: Ovarian cancer is a gynecological malignancy that has a high mortality rate in women due to metastatic progression and recurrence. miRNAs are small, endogenous, noncoding RNAs that function as tumor suppressors or oncogenes in various human cancers by selectively suppressing the expression of target genes. The objective of this study is to investigate the role of miR-203 in ovarian cancer. METHODS: miR-203 was expressed in ovarian cancer SKOV3 and OVCAR3 cells using lentiviral vector and cell proliferation, migration, invasion were examined using MTT, transwell and Matrigel assays, respectively...
2015: Journal of Cancer Science & Therapy