journal
https://read.qxmd.com/read/37686699/a-real-world-comparative-analysis-of-atezolizumab-plus-bevacizumab-and-transarterial-chemoembolization-plus-radiotherapy-in-hepatocellular-carcinoma-patients-with-portal-vein-tumor-thrombosis
#1
JOURNAL ARTICLE
Soon Kyu Lee, Jung Hyun Kwon, Sung Won Lee, Hae Lim Lee, Hee Yeon Kim, Chang Wook Kim, Do Seon Song, U Im Chang, Jin Mo Yang, Soon Woo Nam, Seok-Hwan Kim, Myeong Jun Song, Ji Hoon Kim, Ahlim Lee, Hyun Yang, Si Hyun Bae, Ji Won Han, Heechul Nam, Pil Soo Sung, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Dong Jae Shim, Doyoung Kim, Myungsoo Kim
This study aimed to compare the treatment outcomes of atezolizumab-plus-bevacizumab (Ate/Bev) therapy with those of transarterial chemoembolization plus radiotherapy (TACE + RT) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) and without metastasis. Between June 2016 and October 2022, we consecutively enrolled 855 HCC patients with PVTT. After excluding 758 patients, 97 patients (n = 37 in the Ate/Bev group; n = 60 in the TACE + RT group) were analyzed. The two groups showed no significant differences in baseline characteristics and had similar objective response and disease control rates...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686698/novel-function-of-cancer-stem-cell-marker-aldh1a3-in-glioblastoma-pro-angiogenesis-through-paracrine-pai-1-and-il-8
#2
JOURNAL ARTICLE
Zhen Chen, Rainer Will, Su Na Kim, Maike Anna Busch, Nicole Dünker, Philipp Dammann, Ulrich Sure, Yuan Zhu
Hyper-angiogenesis is a typical feature of glioblastoma (GBM), the most aggressive brain tumor. We have reported the expression of aldehyde dehydrogenase 1A3 (ALDH1A3) in proliferating vasculature in GBM patients. We hypothesized that ALDH1A3 may act as an angiogenesis promoter in GBM. Two GBM cell lines were lentivirally transduced with either ALDH1A3 (ox) or an empty vector (ev). The angiogenesis phenotype was studied in indirect and direct co-culture of endothelial cells (ECs) with oxGBM cells (oxGBMs) and in an angiogenesis model in vivo...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686697/mab14-a-monoclonal-antibody-against-cell-surface-pcna-a-potential-tool-for-sezary-syndrome-diagnosis-and-targeted-immunotherapy
#3
JOURNAL ARTICLE
Jamal Knaneh, Emmilia Hodak, Shlomit Fedida-Metula, Avishay Edri, Rachel Eren, Yael Yoffe, Iris Amitay-Laish, Hadas Prag Naveh, Ido Lubin, Angel Porgador, Lilach Moyal
Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common types of primary cutaneous T-cell lymphoma (CTCL). Proliferating cell nuclear antigen (PCNA) is expressed on the cell surface of cancer cells (csPCNA), but not on normal cells. It functions as an immune checkpoint ligand by interacting with natural killer (NK) cells through the NK inhibitory receptor NKp44, leading to the inhibition of NK cytotoxicity. A monoclonal antibody (mAb14) was established to detect csPCNA on cancer cells and block their interaction with NKp44...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686696/differentially-expressed-genes-mirnas-and-network-models-a-strategy-to-shed-light-on-molecular-interactions-driving-hnscc-tumorigenesis
#4
JOURNAL ARTICLE
Saniya Arfin, Dhruv Kumar, Andrea Lomagno, Pietro Luigi Mauri, Dario Di Silvestre
Head and neck squamous cell carcinoma (HNSCC) is among the most common cancer worldwide, accounting for hundreds thousands deaths annually. Unfortunately, most patients are diagnosed in an advanced stage and only a percentage respond favorably to therapies. To help fill this gap, we hereby propose a retrospective in silico study to shed light on gene-miRNA interactions driving the development of HNSCC. Moreover, to identify topological biomarkers as a source for designing new drugs. To achieve this, gene and miRNA profiles from patients and controls are holistically reevaluated using protein-protein interaction (PPI) and bipartite miRNA-target networks...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686695/primary-colorectal-tumor-displays-differential-genomic-expression-profiles-associated-with-hepatic-and-peritoneal-metastases
#5
JOURNAL ARTICLE
Maximiliano Gelli, Christophe Desterke, Mohamed Amine Bani, Valérie Boige, Charles Ferté, Peggy Dartigues, Bastien Job, Geraldine Perkins, Pierre Laurent-Puig, Diane Goéré, Jacques R R Mathieu, Jerome Cartry, Michel Ducreux, Fanny Jaulin
BACKGROUND: Despite improvements in characterization of CRC heterogeneity, appropriate risk stratification tools are still lacking in clinical practice. This study aimed to elucidate the primary tumor transcriptomic signatures associated with distinct metastatic routes. METHODS: Primary tumor specimens obtained from CRC patients with either isolated LM (CRC-Liver) or PM (CRC-Peritoneum) were analyzed by transcriptomic mRNA sequencing, gene set enrichment analyses (GSEA) and immunohistochemistry...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686694/human-aldehyde-dehydrogenases-a-superfamily-of-similar-yet-different-proteins-highly-related-to-cancer
#6
REVIEW
Vasileios Xanthis, Theodora Mantso, Anna Dimtsi, Aglaia Pappa, Vasiliki E Fadouloglou
The superfamily of human aldehyde dehydrogenases (hALDHs) consists of 19 isoenzymes which are critical for several physiological and biosynthetic processes and play a major role in the organism's detoxification via the NAD(P) dependent oxidation of numerous endogenous and exogenous aldehyde substrates to their corresponding carboxylic acids. Over the last decades, ALDHs have been the subject of several studies as it was revealed that their differential expression patterns in various cancer types are associated either with carcinogenesis or promotion of cell survival...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686693/genomic-alterations-associated-with-estrogen-receptor-pathway-activity-in-metastatic-breast-cancer-have-a-differential-impact-on-downstream-er-signaling
#7
JOURNAL ARTICLE
Lindsay Angus, Marcel Smid, Saskia M Wilting, Manouk K Bos, Neeltje Steeghs, Inge R H M Konings, Vivianne C G Tjan-Heijnen, Johanna M G H van Riel, Agnes J van de Wouw, Cpct Consortium, Edwin Cuppen, Martijn P Lolkema, Agnes Jager, Stefan Sleijfer, John W M Martens
Mutations in the estrogen receptor gene ( ESR1 ), its transcriptional regulators, and the mitogen-activated protein kinase (MAPK) pathway are enriched in patients with endocrine-resistant metastatic breast cancer (MBC). Here, we integrated whole genome sequencing with RNA sequencing data from the same samples of 101 ER-positive/HER2-negative MBC patients who underwent a tumor biopsy prior to the start of a new line of treatment for MBC (CPCT-02 study, NCT01855477) to analyze the downstream effects of DNA alterations previously linked to endocrine resistance, thereby gaining a better understanding of the associated mechanisms...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686692/improving-prediction-of-cervical-cancer-using-knn-imputed-smote-features-and-multi-model-ensemble-learning-approach
#8
JOURNAL ARTICLE
Hanen Karamti, Raed Alharthi, Amira Al Anizi, Reemah M Alhebshi, Ala' Abdulmajid Eshmawi, Shtwai Alsubai, Muhammad Umer
Objective: Cervical cancer ranks among the top causes of death among females in developing countries. The most important procedures that should be followed to guarantee the minimizing of cervical cancer's aftereffects are early identification and treatment under the finest medical guidance. One of the best methods to find this sort of malignancy is by looking at a Pap smear image. For automated detection of cervical cancer, the available datasets often have missing values, which can significantly affect the performance of machine learning models...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686691/differences-in-the-clinical-and-molecular-profiles-of-subungual-melanoma-and-acral-melanoma-in-asian-patients
#9
JOURNAL ARTICLE
So-Young Ahn, Go-Eun Bae, Seung-Yeol Park, Min-Kyung Yeo
Subungual melanoma (SUM) is a rare type of malignant melanoma that arises beneath the nails. SUM is categorized as a type of acral melanoma (AM), which occurs on the hands and feet. SUM is an aggressive type of cutaneous melanoma that is most common among Asian patients. Recent studies reveal that SUM and AM might have different molecular characteristics. Treatment of melanoma relies on analysis of both clinical and molecular data. Therefore, the clinical and molecular characteristics of SUM need to be established, especially during metastasis...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686690/radiomics-based-prediction-of-tert-promotor-mutations-in-intracranial-high-grade-meningiomas
#10
JOURNAL ARTICLE
Burak Han Akkurt, Dorothee Cäcilia Spille, Susanne Peetz-Dienhart, Nora Maren Kiolbassa, Christian Mawrin, Manfred Musigmann, Walter Leonhard Heindel, Werner Paulus, Walter Stummer, Manoj Mannil, Benjamin Brokinkel
PURPOSE: In meningiomas, TERT promotor mutations are rare but qualify the diagnosis of anaplasia, directly impacting adjuvant therapy. Effective screening for patients at risk for promotor mutations could enable more targeted molecular analyses and improve diagnosis and treatment. METHODS: Semiautomatic segmentation of intracranial grade 2/3 meningiomas was performed on preoperative magnetic resonance imaging. Discriminatory power to predict TERT promoter mutations was analyzed using a random forest algorithm with an increasing number of radiomic features...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686689/depression-inflammation-and-intestinal-permeability-associations-with-subjective-and-objective-cognitive-functioning-throughout-breast-cancer-survivorship
#11
JOURNAL ARTICLE
Annelise A Madison, Rebecca Andridge, Anthony H Kantaras, Megan E Renna, Jeanette M Bennett, Catherine M Alfano, Stephen P Povoski, Doreen M Agnese, Maryam Lustberg, Robert Wesolowski, William E Carson, Nicole O Williams, Raquel E Reinbolt, Sagar D Sardesai, Anne M Noonan, Daniel G Stover, Mathew A Cherian, William B Malarkey, Janice K Kiecolt-Glaser
About one-in-three breast cancer survivors have lingering cognitive complaints and objective cognitive impairment. Chronic inflammation and intestinal permeability (i.e., leaky gut), two risk factors for cognitive decline, can also fuel depression-another vulnerability for cognitive decline. The current study tested whether depression accompanied by high levels of inflammation or intestinal permeability predicted lower subjective and objective cognitive function in breast cancer survivors. We combined data from four breast cancer survivor studies ( n = 613); some had repeated measurements for a total of 1015 study visits...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686688/can-high-frequency-intraoral-ultrasound-predict-histological-risk-factors-in-oral-squamous-cell-carcinoma-a-preliminary-experience
#12
JOURNAL ARTICLE
Simone Caprioli, Giorgio-Gregory Giordano, Alessia Pennacchi, Valentina Campagnari, Andrea Iandelli, Giampiero Parrinello, Cristina Conforti, Riccardo Gili, Edoardo Giannini, Elisa Marabotto, Stefano Kayali, Bernardo Bianchi, Giorgio Peretti, Giuseppe Cittadini, Filippo Marchi
Despite advancements in multidisciplinary care, oncologic outcomes of oral cavity squamous cell carcinoma (OSCC) have not substantially improved: still, one-third of patients affected by stage I and II can develop locoregional recurrences. Imaging plays a pivotal role in preoperative staging of OSCC, providing depth of invasion (DOI) measurements. However, locoregional recurrences have a strong association with adverse histopathological factors not included in the staging system, and any imaging features linked to them have been lacking...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686687/genetic-regulation-of-human-isomir-biogenesis
#13
JOURNAL ARTICLE
Guanglong Jiang, Jill L Reiter, Chuanpeng Dong, Yue Wang, Fang Fang, Zhaoyang Jiang, Yunlong Liu
MicroRNAs play a critical role in regulating gene expression post-transcriptionally. Variations in mature microRNA sequences, known as isomiRs, arise from imprecise cleavage and nucleotide substitution or addition. These isomiRs can target different mRNAs or compete with their canonical counterparts, thereby expanding the scope of miRNA post-transcriptional regulation. Our study investigated the relationship between cis-acting single-nucleotide polymorphisms (SNPs) in precursor miRNA regions and isomiR composition, represented by the ratio of a specific 5'-isomiR subtype to all isomiRs identified for a particular mature miRNA...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686686/changes-in-the-number-of-gastrointestinal-cancers-and-stage-at-diagnosis-with-covid-19-pandemic-in-japan-a-multicenter-cohort-study
#14
JOURNAL ARTICLE
Kento Kuzuu, Noboru Misawa, Keiichi Ashikari, Shigeki Tamura, Shingo Kato, Kunihiro Hosono, Masato Yoneda, Takashi Nonaka, Shozo Matsushima, Tatsuji Komatsu, Atsushi Nakajima, Takuma Higurashi
This retrospective cohort study compared the number of newly diagnosed patients, stage at diagnosis, and detection process of gastrointestinal cancers based on hospital-based cancer registry data at two tertiary Japanese hospitals. The pre-COVID-19 period was from January 2017 to February 2020, with phase 1 (midst of COVID-19 pandemic) from March to December 2020 and phase 2 (the transition period to the "new normal") from January to December 2021. Each month, the number of patients diagnosed with esophageal, gastric, colorectal, pancreatic, liver, and biliary tract cancers were aggregated, classified by stage and detection process, and compared, including a total of 6453 patients...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686685/an-overview-of-head-and-neck-tumor-reirradiation-what-has-been-achieved-so-far
#15
REVIEW
Konstantin Gordon, Daniil Smyk, Igor Gulidov, Kirill Golubev, Timur Fatkhudinov
The recurrence rate of head and neck cancers (HNCs) after initial treatment may reach 70%, and poor prognosis is reported in most cases. Curative options for recurrent HNCs mainly depend on the treatment history and the recurrent tumor localization. Reirradiation for HNCs is effective and has been included in most guidelines. However, the option remains clinically challenging due to high incidence of severe toxicity, especially in cases of quick infield recurrence. Recent technical advances in radiation therapy (RT) provide the means for upgrade in reirradiation protocols...
September 4, 2023: Cancers
https://read.qxmd.com/read/37686684/high-throughput-drug-screening-revealed-that-ciclopirox-olamine-can-engender-gastric-cancer-stem-like-cells
#16
JOURNAL ARTICLE
Diana Pádua, Paula Figueira, Mariana Pinto, André Filipe Maia, Joana Peixoto, Raquel T Lima, António Pombinho, Carlos Filipe Pereira, Raquel Almeida, Patrícia Mesquita
Cancer stem cells (CSCs) are relevant therapeutic targets for cancer treatment. Still, the molecular circuits behind CSC characteristics are not fully understood. The low number of CSCs can sometimes be an obstacle to carrying out assays that explore their properties. Thus, increasing CSC numbers via small molecule-mediated cellular reprogramming appears to be a valid alternative tool. Using the SORE6-GFP reporter system embedded in gastric non-CSCs (SORE6-), we performed a high-throughput image-based drug screen with 1200 small molecules to identify compounds capable of converting SORE6- to SORE6+ (CSCs)...
September 3, 2023: Cancers
https://read.qxmd.com/read/37686683/association-of-fibrinolytic-potential-and-risk-of-mortality-in-cancer-patients
#17
JOURNAL ARTICLE
Gabriele Silva Souza Gois, Silmara Aparecida Lima Montalvão, Thaizy Ramires Alencar Anhaia, Millene Evelyn Alves Almeida, Beatriz Moraes Martinelli, Maria Carmen Gonçalves Lopes Fernandes, Stephany Cares Hubers, Monique R M Ferreira, Daniel Dias Ribeiro, Júlio César Teixeira, José Barreto Campello Carvalheira, Carmen Silvia Passos Lima, Nelson Adami Andreollo, Maurício Etchebehere, Lair Zambon, Ubirajara Ferreira, Alfio José Tincani, Antônio Santos Martins, Cláudio Saddy Rodrigues Coy, José Cláudio Teixeira Seabra, Ricardo Kalaf Mussi, Helder Tedeschi, Joyce Maria Anninchino-Bizzacchi, Adventh Cancer Group
Cancer is a leading cause of death, and the fibrinolytic system shows cooperative effects that facilitate the growth of tumors and the appearance of metastases. This prospective study aimed to evaluate the fibrinolytic potential in cancer patients and its association with mortality outcomes using the fluorometric method of simultaneous thrombin and plasmin generation. The study included 323 cancer patients and 148 healthy individuals. During the 12-month follow-up, 68 patients died. Compared to the control group, cancer patients showed alterations in thrombin production consistent with a hypercoagulability profile, and an increase in plasmin generation...
September 3, 2023: Cancers
https://read.qxmd.com/read/37686682/multi-omics-characterization-of-response-to-pd-1-inhibitors-in-advanced-melanoma
#18
JOURNAL ARTICLE
Lucía Trilla-Fuertes, Angelo Gámez-Pozo, Guillermo Prado-Vázquez, Rocío López-Vacas, Virtudes Soriano, Fernando Garicano, M José Lecumberri, María Rodríguez de la Borbolla, Margarita Majem, Elisabeth Pérez-Ruiz, María González-Cao, Juana Oramas, Alejandra Magdaleno, Joaquín Fra, Alfonso Martín-Carnicero, Mónica Corral, Teresa Puértolas, Ricardo Ramos-Ruiz, Antje Dittmann, Paolo Nanni, Juan Ángel Fresno Vara, Enrique Espinosa
Immunotherapy improves the survival of patients with advanced melanoma, 40% of whom become long-term responders. However, not all patients respond to immunotherapy. Further knowledge of the processes involved in the response and resistance to immunotherapy is still needed. In this study, clinical paraffin samples from fifty-two advanced melanoma patients treated with anti-PD-1 inhibitors were assessed via high-throughput proteomics and RNA-seq. The obtained proteomics and transcriptomics data were analyzed using multi-omics network analyses based on probabilistic graphical models to identify those biological processes involved in the response to immunotherapy...
September 3, 2023: Cancers
https://read.qxmd.com/read/37686681/squamous-cell-carcinoma-of-the-oral-cavity-oropharynx-and-larynx-a-scoping-review-of-treatment-guidelines-worldwide
#19
REVIEW
Lady Paola Aristizabal Arboleda, Genival Barbosa de Carvalho, Alan Roger Santos-Silva, Gisele Aparecida Fernandes, Jose Guilherme Vartanian, David I Conway, Shama Virani, Paul Brennan, Luiz Paulo Kowalski, Maria Paula Curado
Head and neck cancer (HNC) treatments have been based on single or multimodal therapies with surgery, radiotherapy (RT), chemotherapy, and immunotherapy. However, treatment recommendations among countries may differ due to technological/human resources and usual local practices. This scoping review aims to identify, compare, and map the clinical practice guidelines (CPGs) for treating squamous cell carcinoma (SCC) of the oral cavity, oropharynx, and larynx worldwide. A search strategy on global CPGs for HNC was performed by using five electronic databases and grey literature...
September 3, 2023: Cancers
https://read.qxmd.com/read/37686680/pet-ct-and-conventional-imaging-for-the-assessment-of-neuroendocrine-prostate-cancer-a-systematic-review
#20
REVIEW
Francesco Dondi, Alessandro Antonelli, Nazareno Suardi, Andrea Emanuele Guerini, Domenico Albano, Silvia Lucchini, Luca Camoni, Giorgio Treglia, Francesco Bertagna
BACKGROUND: Neuroendocrine prostate cancer (NEPC) is a rare neoplasm, and the role of both conventional imaging (CI) and positron emission tomography/computed tomography (PET/CT) for its assessment has not been clearly evaluated and demonstrated. The aim of this systematic review was to analyze the diagnostic performances of these imaging modalities in this setting. METHODS: A wide literature search of the PubMed/MEDLINE, Scopus, and Web of Science databases was made to find relevant published articles about the role of CI and PET/CT for the evaluation of NEPC...
September 3, 2023: Cancers
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