journal
https://read.qxmd.com/read/38730739/expression-of-potential-antibody-drug-conjugate-targets-in-cervical-cancer
#1
JOURNAL ARTICLE
Michael R Mallmann, Sina Tamir, Katharina Alfter, Dominik Ratiu, Alexander Quaas, Christian M Domroese
(1) Background: There is a huge unmet clinical need for novel treatment strategies in advanced and recurrent cervical cancer. Several cell membrane-bound molecules are up-regulated in cancer cells as compared to normal tissue and have revived interest with the introduction of antibody-drug conjugates (ADCs). (2) Methods: In this study, we characterize the expression of 10 potential ADC targets, TROP2, mesotheline, CEACAM5, DLL3, folate receptor alpha, guanylatcyclase, glycoprotein NMB, CD56, CD70 and CD138, on the gene expression level...
May 6, 2024: Cancers
https://read.qxmd.com/read/38730738/phytochemical-modulation-of-ion-channels-in-oncologic-symptomatology-and-treatment
#2
REVIEW
Rohan Rao, Caroline Mohammed, Lise Alschuler, Daniel A Pomeranz Krummel, Soma Sengupta
Modern chemotherapies offer a broad approach to cancer treatment but eliminate both cancer and non-cancer cells indiscriminately and, thus, are associated with a host of side effects. Advances in precision oncology have brought about new targeted therapeutics, albeit mostly limited to a subset of patients with an actionable mutation. They too come with side effects and, ultimately, 'self-resistance' to the treatment. There is recent interest in the modulation of ion channels, transmembrane proteins that regulate the flow of electrically charged molecules in and out of cells, as an approach to aid treatment of cancer...
May 6, 2024: Cancers
https://read.qxmd.com/read/38730737/programmed-death-ligand-1-expression-in-circulating-tumor-cells-as-a-predictor-and-monitor-of-response-to-atezolizumab-plus-bevacizumab-treatment-in-patients-with-hepatocellular-carcinoma
#3
JOURNAL ARTICLE
Takuto Nosaka, Yosuke Murata, Yu Akazawa, Tomoko Tanaka, Kazuto Takahashi, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Yoshiaki Imamura, Yasunari Nakamoto
There remains no reliable biomarker of therapeutic efficacy in hepatocellular carcinoma (HCC) for the PD-L1 inhibitor atezolizumab and bevacizumab (Atezo/Bev). Circulating tumor cells (CTCs) enable the serial collection of living tumor cells. Pre-treatment and serial CTC gene expression changes and tumor histology were evaluated to identify predictors of response to Atezo/Bev. Peripheral blood from 22 patients with HCC treated with Atezo/Bev and 24 patients treated with lenvatinib was serially collected. The RNA expression in CTCs was analyzed using qRT-PCR...
May 6, 2024: Cancers
https://read.qxmd.com/read/38730736/hypnosis-assisted-awake-craniotomy-for-eloquent-brain-tumors-advantages-and-pitfalls
#4
JOURNAL ARTICLE
Giulia Cossu, Alberto Vandenbulcke, Sonia Zaccarini, John G Gaudet, Andreas F Hottinger, Nina Rimorini, Arnaud Potie, Valerie Beaud, Ursula Guerra-Lopez, Roy T Daniel, Chantal Berna, Mahmoud Messerer
BACKGROUND: Awake craniotomy (AC) is recommended for the resection of tumors in eloquent areas. It is traditionally performed under monitored anesthesia care (MAC), which relies on hypnotics and opioids. Hypnosis-assisted AC (HAAC) is an emerging technique that aims to provide psychological support while reducing the need for pharmacological sedation and analgesia. We aimed to compare the characteristics and outcomes of patients who underwent AC under HAAC or MAC. METHODS: We retrospectively analyzed the clinical, anesthetic, surgical, and neuropsychological data of patients who underwent awake surgical resection of eloquent brain tumors under HAAC or MAC...
May 5, 2024: Cancers
https://read.qxmd.com/read/38730735/two-year-span-breast-cancer-screening-uptake-in-japan-after-the-covid-19-pandemic-and-its-association-with-the-covid-19-vaccination
#5
JOURNAL ARTICLE
Aminu Kende Abubakar, Yudai Kaneda, Akihiko Ozaki, Hiroaki Saito, Michio Murakami, Daisuke Hori, Kenji Gonda, Masaharu Tsubokura, Takahiro Tabuchi
There is limited information on whether the COVID-19 pandemic was associated with decreased breast cancer screening uptake and if COVID-19 vaccination was associated with an increase in screening uptake. Our study explored the uptake of breast cancer screening in Japan after the COVID-19 pandemic and assessed its association with the COVID-19 vaccination. We analyzed data from the Japan COVID-19 and Society Internet Survey (JACSIS), a web-based prospective cohort survey, and we included 6110 women without cancer history who were aged 40 to 74 years that participated in the 2012 and 2022 surveys...
May 5, 2024: Cancers
https://read.qxmd.com/read/38730734/spinal-intradural-tumor-resection-via-long-segment-approaches-and-clinical-long-term-follow-up
#6
JOURNAL ARTICLE
Laura Dieringer, Lea Baumgart, Laura Schwieren, Jens Gempt, Maria Wostrack, Bernhard Meyer, Vicki M Butenschoen
INTRODUCTION: Spinal intradural tumors account for 15% of all CNS tumors. Typical tumor entities include ependymomas, astrocytomas, meningiomas, and neurinomas. In cases of multiple affected segments, extensive approaches may be necessary to achieve the gold standard of complete tumor resection. METHODS: We performed a bicentric, retrospective cohort study of all patients equal to or older than 14 years who underwent multi-segment surgical treatment for spinal intradural tumors between 2007 and 2023 with approaches longer than four segments without instrumentation...
May 5, 2024: Cancers
https://read.qxmd.com/read/38730733/amplification-of-hippo-signaling-pathway-genes-is-governed-and-implicated-in-the-serous-subtype-specific-ovarian-carcino-genesis
#7
JOURNAL ARTICLE
Karthik Balakrishnan, Yuanhong Chen, Jixin Dong
Among women, ovarian cancer ranks as the fifth most common cause of cancer-related deaths. This study examined the impact of Hippo signaling pathway on ovarian carcinogenesis. Therefore, the signatures related to Hippo signaling pathway were derived from the molecular signatures database (MSigDB) and were used for further analysis. The Z score-based pathway activation scoring method was employed to investigate the expression patterns of these signatures in the mRNA expression profiles of ovarian cancer cohorts...
May 5, 2024: Cancers
https://read.qxmd.com/read/38730732/how-immunotherapy-has-redefined-the-treatment-paradigm-of-metastatic-or-locally-advanced-muscle-invasive-urothelial-bladder-carcinoma
#8
REVIEW
Mathieu Larroquette, Félix Lefort, Charlotte Domblides, Luc Héraudet, Grégoire Robert, Alain Ravaud, Marine Gross-Goupil
In the past decade, the therapeutic arsenal for metastatic bladder cancer has expanded considerably, with the development of immune checkpoint inhibitors (ICIs), antibody-drug conjugates such as enfortumab vedotin, and anti-fibroblast growth factor receptor agents. Clinical trials evaluating ICIs as neoadjuvants, adjuvants, or first- or second-line treatments have produced conflicting results. However, first-line therapeutic strategies have been redefined by the recent publication of results from two clinical trials: CheckMate-901, which demonstrated the superiority of combined treatment with nivolumab and chemotherapy in extending overall survival, and EV-302, which demonstrated that combined treatment with pembrolizumab and enfortumab vedotin reduced the risk of death by 53%...
May 5, 2024: Cancers
https://read.qxmd.com/read/38730731/opaganib-downregulates-n-myc-expression-and-suppresses-in-vitro-and-in-vivo-growth-of-neuroblastoma-cells
#9
JOURNAL ARTICLE
Lynn W Maines, Staci N Keller, Ryan A Smith, Randy S Schrecengost, Charles D Smith
Neuroblastoma (NB), the most common cancer in infants and the most common solid tumor outside the brain in children, grows aggressively and responds poorly to current therapies. We have identified a new drug (opaganib, also known as ABC294640) that modulates sphingolipid metabolism by inhibiting the synthesis of sphingosine 1-phosphate (S1P) by sphingosine kinase-2 and elevating dihydroceramides by inhibition of dihydroceramide desaturase. The present studies sought to determine the potential therapeutic activity of opaganib in cell culture and xenograft models of NB...
May 5, 2024: Cancers
https://read.qxmd.com/read/38730730/the-diagnostic-performance-of-2-18-f-fdg-pet-ct-in-identifying-richter-transformation-in-chronic-lymphocytic-leukemia-an-updated-systematic-review-and-bivariate-meta-analysis
#10
REVIEW
Domenico Albano, Alessio Rizzo, Manuela Racca, Barbara Muoio, Francesco Bertagna, Giorgio Treglia
Richter transformation is a rare phenomenon characterized by the transformation of cell chronic lymphocytic leukemia (CLL) into a more aggressive lymphoma variant. The early identification of CLLs with a high risk of RT is fundamental. In this field, 2-deoxy-2-[18 F]-fluoro-D-glucose positron emission tomography/computed tomography (2-[18 F]FDG PET/CT) has been shown to be a non-invasive and promising tool, but apparently, unclear data seem to be present in the literature. This systematic review and bivariate meta-analysis aimed to investigate the diagnostic performance of 2-[18 F]FDG PET/CT and its parameters in predicting RT...
May 5, 2024: Cancers
https://read.qxmd.com/read/38730729/-seeing-is-believing-additive-utility-of-68-ga-psma-11-pet-ct-in-prostate-cancer-diagnosis
#11
JOURNAL ARTICLE
Joel Chin, Yu Guang Tan, Alvin Lee, Tze Kiat Ng, Ruoyu Shi, Charlene Yu Lin Tang, Sue Ping Thang, Jeffrey Kit Loong Tuan, Christopher Wai Sam Cheng, Kae Jack Tay, Henry Sun Sien Ho, Hung-Jen Wang, Peter Ka-Fung Chiu, Jeremy Yuen-Chun Teoh, Winnie Wing-Chuen Lam, Yan Mee Law, John Shyi Peng Yuen, Kenneth Chen
Widespread adoption of mpMRI has led to a decrease in the number of patients requiring prostate biopsies. 68 Ga-PSMA-11 PET/CT has demonstrated added benefits in identifying csPCa. Integrating the use of these imaging techniques may hold promise for predicting the presence of csPCa without invasive biopsy. A retrospective analysis of 42 consecutive patients who underwent mpMRI, 68 Ga-PSMA-11 PET/CT, prostatic biopsy, and radical prostatectomy (RP) was carried out. A lesion-based model ( n = 122) using prostatectomy histopathology as reference standard was used to analyze the accuracy of 68 Ga-PSMA-11 PET/CT, mpMRI alone, and both in combination to identify ISUP-grade group ≥ 2 lesions...
May 5, 2024: Cancers
https://read.qxmd.com/read/38730728/the-current-role-of-radiation-in-the-management-of-cholangiocarcinoma-a-narrative-review
#12
REVIEW
Saurav Verma, Natalie Grindrod, Daniel Breadner, Michael Lock
Cholangiocarcinoma (CCA) is a rare cancer of bile ducts. It is associated with a poor prognosis. The incidence of CCA is rising worldwide. Anatomical subgroups have been used to classify patients for treatment and prognosis. There is a growing understanding of clinically important distinctions based on underlying genetic differences that lead to different treatment options and outcomes. Its management is further complicated by a heterogeneous population and relative rarity, which limits the conduct of large trials to guide management...
May 4, 2024: Cancers
https://read.qxmd.com/read/38730727/artificial-intelligence-in-urologic-robotic-oncologic-surgery-a-narrative-review
#13
REVIEW
Themistoklis Bellos, Ioannis Manolitsis, Stamatios Katsimperis, Patrick Juliebø-Jones, Georgios Feretzakis, Iraklis Mitsogiannis, Ioannis Varkarakis, Bhaskar K Somani, Lazaros Tzelves
With the rapid increase in computer processing capacity over the past two decades, machine learning techniques have been applied in many sectors of daily life. Machine learning in therapeutic settings is also gaining popularity. We analysed current studies on machine learning in robotic urologic surgery. We searched PubMed/Medline and Google Scholar up to December 2023. Search terms included "urologic surgery", "artificial intelligence", "machine learning", "neural network", "automation", and "robotic surgery"...
May 4, 2024: Cancers
https://read.qxmd.com/read/38730726/effects-on-the-physical-functioning-of-two-exercise-interventions-in-patients-with-multiple-myeloma-a-pilot-feasibility-study
#14
JOURNAL ARTICLE
Jens Hillengass, Michaela Hillengass, Janine M Joseph, Kristopher Attwood, Rikki Cannioto, Hillary Jacobson, Carolyn Miller, Bryan Wittmeyer, Kirsten Moysich
Because of the high prevalence of bone destruction in patients with multiple myeloma (MM), physical exercise is oftentimes discouraged by healthcare providers. The goal of this prospective trial was to investigate the feasibility of two six-month exercise interventions in patients with MM ( N = 42): a remotely prompted home-based walking intervention or a supervised strength training intervention. Physical function and pain were assessed with the Activity Measure for Post-Acute Care (AM-PAC) Basic Mobility Short Form raw score, a six-minute walk test (6 MWT), a 30-second sit-to-stand test (30 SST), a timed up-and-go (TUG) test, a visual analog scale (VAS) for pain, handheld dynamometer tests, heart rate at rest, blood oxygen saturation at rest, and body mass index...
May 4, 2024: Cancers
https://read.qxmd.com/read/38730725/mif-and-cd74-as-emerging-biomarkers-for-immune-checkpoint-blockade-therapy
#15
REVIEW
Rosalyn M Fey, Rebecca A Nichols, Thuy T Tran, Arthur A Vandenbark, Rajan P Kulkarni
Immune checkpoint blockade (ICB) therapy is used to treat a wide range of cancers; however, some patients are at risk of developing treatment resistance and/or immune-related adverse events (irAEs). Thus, there is a great need for the identification of reliable predictive biomarkers for response and toxicity. The cytokine MIF (macrophage migration inhibitory factor) and its cognate receptor CD74 are intimately connected with cancer progression and have previously been proposed as prognostic biomarkers for patient outcome in various cancers, including solid tumors such as malignant melanoma...
May 4, 2024: Cancers
https://read.qxmd.com/read/38730724/macrophages-orchestrate-the-liver-tumor-microenvironment
#16
REVIEW
Valeria Quaranta, Costanza Ballarò, Gianluigi Giannelli
Liver cancer is one of the leading causes of cancer-related mortality. Hepatocellular carcinoma and cholangiocarcinoma are the most common types, and despite numerous advances, therapeutic options still remain poor for these cancer patients. Tumor development and progression strictly depend on a supportive tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the most abundant immune cells population within a tumorigenic liver; they sustain cancer cells' growth and invasiveness, and their presence is correlated with a poor prognosis...
May 4, 2024: Cancers
https://read.qxmd.com/read/38730723/sex-differences-in-odds-of-brain-metastasis-and-outcomes-by-brain-metastasis-status-after-advanced-melanoma-diagnosis
#17
JOURNAL ARTICLE
Gino Cioffi, Mustafa S Ascha, Kristin A Waite, Mantas Dmukauskas, Xiaoliang Wang, Trevor J Royce, Gregory S Calip, Timothy Waxweiler, Chad G Rusthoven, Brian D Kavanagh, Jill S Barnholtz-Sloan
Sex differences in cancer are well-established. However, less is known about sex differences in diagnosis of brain metastasis and outcomes among patients with advanced melanoma. Using a United States nationwide electronic health record-derived de-identified database, we evaluated patients diagnosed with advanced melanoma from 1 January 2011-30 July 2022 who received an oncologist-defined rule-based first line of therapy ( n = 7969, 33% female according to EHR, 35% w/documentation of brain metastases). The odds of documented brain metastasis diagnosis were calculated using multivariable logistic regression adjusted for age, practice type, diagnosis period (pre/post-2017), ECOG performance status, anatomic site of melanoma, group stage, documentation of non-brain metastases prior to first-line of treatment, and BRAF positive status...
May 3, 2024: Cancers
https://read.qxmd.com/read/38730722/detection-of-oncogene-hotspot-mutations-in-female-nsclc-tumor-dna-and-cell-free-dna
#18
JOURNAL ARTICLE
Ieva Drejeriene, Saulius Cicenas, Diana Stanciute, Arnoldas Krasauskas, Jurate Gruode
Non-small-cell lung cancer (NSCLC) is the most prevalent type of lung cancer, with extensively characterized mutational spectra. Several biomarkers (such as EGFR , BRAF , KRAS gene mutations, etc.) have emerged as predictive and prognostic markers for NSCLC. Unfortunately, the quality of the available tumor biopsy and/or cytology material is not always adequate to perform the necessary molecular testing, prompting the search for alternatives. Cell-free DNA (cfDNA) found in plasma is emerging as a highly promising avenue or a supplementary method for assessing the efficacy of cancer treatments...
May 3, 2024: Cancers
https://read.qxmd.com/read/38730721/gynecological-cancer-and-venous-thromboembolism-a-narrative-review-to-increase-awareness-and-improve-risk-assessment-and-prevention
#19
REVIEW
Anna Falanga, Domenica Lorusso, Nicoletta Colombo, Gennaro Cormio, Benilde Cosmi, Giuseppa Scandurra, Vanna Zanagnolo, Marco Marietta
The prevention and appropriate management of venous thromboembolism in cancer patients is of paramount importance. However, the literature data report an underestimation of this major problem in patients with gynecological cancers, with an inconsistent venous thromboembolism risk assessment and prophylaxis in this patient setting. This narrative review provides a comprehensive overview of the available evidence regarding the management of venous thromboembolism in cancer patients, focusing on the specific context of gynecological tumors, exploring the literature discussing risk factors, risk assessment, and pharmacological prophylaxis...
May 3, 2024: Cancers
https://read.qxmd.com/read/38730720/a-tumor-specific-molecular-network-promotes-tumor-growth-in-drosophila-by-enforcing-a-jun-n-terminal-kinase-yorkie-feedforward-loop
#20
JOURNAL ARTICLE
Indrayani Waghmare, Karishma Gangwani, Arushi Rai, Amit Singh, Madhuri Kango-Singh
Cancer cells expand rapidly in response to altered intercellular and signaling interactions to achieve the hallmarks of cancer. Impaired cell polarity combined with activated oncogenes is known to promote several hallmarks of cancer, e.g., activating invasion by increased activity of Jun N-terminal kinase (JNK) and sustained proliferative signaling by increased activity of Hippo effector Yorkie (Yki). Thus, JNK, Yki, and their downstream transcription factors have emerged as synergistic drivers of tumor growth through pro-tumor signaling and intercellular interactions like cell competition...
May 2, 2024: Cancers
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