journal
https://read.qxmd.com/read/23984187/upregulation-of-serum-vascular-endothelial-growth-factor-in-patients-with-salivary-gland-tumor
#61
JOURNAL ARTICLE
Azadeh Andisheh Tadbir, Bijan Khademi, Mahyar Malekzadeh, Maryam Mardani, Bahar Khademi
Neoangiogenesis is essential for tumor development, invasion, and dissemination. The most potent of the cytokines associated with angiogenesis is vascular endothelial growth factor (VEGF). The aim of the present study was to determine VEGF serum level in patients with salivary gland tumor. Using an ELISA kit, the circulating levels of VEGF in sera from 58 patients with salivary gland tumor and 30 healthy controls were assessed. Mean VEGF levels in sera of patients with salivary gland tumors (574.9 ± 414.3) were significantly higher than those in controls (263...
2013: Pathology Research International
https://read.qxmd.com/read/23970998/a-naturally-occurring-feline-model-of-head-and-neck-squamous-cell-carcinoma
#62
JOURNAL ARTICLE
Jackie M Wypij
Despite advances in understanding cancer at the molecular level, timely and effective translation to clinical application of novel therapeutics in human cancer patients is lacking. Cancer drug failure is often a result of toxicity or inefficacy not predicted by preclinical models, emphasizing the need for alternative animal tumor models with improved biologic relevancy. Companion animals (dogs and cats) provide an opportunity to capitalize on an underutilized and biologically relevant translational research model which allows spontaneous disease modeling of human cancer...
2013: Pathology Research International
https://read.qxmd.com/read/23509667/outcomes-in-ovarian-cancer-among-hispanic-women-living-in-the-united-states-a-population-based-analysis
#63
JOURNAL ARTICLE
Okechukwu A Ibeanu, Teresa P Díaz-Montes
Introduction. Ovarian cancer is the deadliest gynecologic cancer in the United States. There is limited data on presentation and outcomes among Hispanic women with ovarian cancer. Objective. To investigate how ovarian cancer presents among Hispanic women in the USA and to analyze differences in presentation, staging, and survival between Hispanic and non-Hispanic women with ovarian cancer. Methods. Data from January 1, 2000 to December 31, 2004 were extracted from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) database...
2013: Pathology Research International
https://read.qxmd.com/read/23431500/plasmin-activation-of-glial-cells-through-protease-activated-receptor-1
#64
JOURNAL ARTICLE
André R Greenidge, Kiana R Hall, Ian R Hambleton, Richelle Thomas, Dougald M Monroe, R Clive Landis
The objective of this study was to determine whether plasmin could induce morphological changes in human glial cells via PAR1. Human glioblastoma A172 cells were cultured in the presence of plasmin or the PAR1 specific activating hexapeptide, SFLLRN. Cells were monitored by flow cytometry to detect proteolytic activation of PAR1 receptor. Morphological changes were recorded by photomicroscopy and apoptosis was measured by annexinV staining. Plasmin cleaved the PAR1 receptor on glial cells at 5 minutes (P = 0...
2013: Pathology Research International
https://read.qxmd.com/read/23320251/met-hgf-signaling-pathway-in-ovarian-carcinoma-clinical-implications-and-future-direction
#65
JOURNAL ARTICLE
Paulette Mhawech-Fauceglia, Michelle Afkhami, Tanja Pejovic
The HGF/MET signaling pathway is abnormal in numerous cancers including ovarian cancer. MET is expressed in 70% of human cancer and it is overexpressed in 30% of ovarian cases and cancer cell lines. The HGF/MET pathway plays a role in the initiation and progression of ovarian cancer through the most distinctive biologic program known as "invasive growth" which is accomplished through a coordinated activation of cell motility, invasiveness, degradation of extracellular matrix, survival, and proliferation. Because of its ubiquitous role in cancer, the MET axis seems to be an attractive target for cancer therapy...
2012: Pathology Research International
https://read.qxmd.com/read/23304639/neuroinflammation-as-the-proximate-cause-of-signature-pathogenic-pattern-progression-in-amyotrophic-lateral-sclerosis-aids-and-multiple-sclerosis
#66
JOURNAL ARTICLE
Lawrence M Agius
The realization of injury to large motor neurons is embedded within contextual reference to the parallel pathways of apoptosis and necrosis of system-patterned evolution. A widespread loss of cell components occurs intracellularly and involves a reactive participation to a neuroinflammation that potentially is immunologically definable. In such terms, sporadic and hereditary forms of amyotrophic sclerosis are paralleled by the components of a reactive nature that involve the aggregation of proteins and conformational misfolding on the one hand and a powerful oxidative degradation that overwhelms the proteasome clearance mechanisms...
2012: Pathology Research International
https://read.qxmd.com/read/23227427/false-negative-results-of-endoscopic-biopsy-in-the-diagnosis-of-gastrointestinal-kaposi-s-sarcoma-in-hiv-infected-patients
#67
JOURNAL ARTICLE
Naoyoshi Nagata, Katsunori Sekine, Toru Igari, Yohei Hamada, Hirohisa Yazaki, Norio Ohmagari, Junichi Akiyama, Takuro Shimbo, Katsuji Teruya, Shinichi Oka, Naomi Uemura
Kaposi's sarcoma (KS) is a rare endothelial neoplasm mainly involving the skin, but it is often associated with AIDS. Diagnosis of gastrointestinal (GI) tract KS, a common site of visceral involvement in AIDS, is important, but endoscopic biopsy carries a risk of false-negative results (FNRs) due to its submucosal appearance. This study sought to determine the rate and causes of FNR for endoscopic biopsy of GI-KS lesions. Endoscopic biopsy samples of 116 GI-KS lesions were reviewed retrospectively. All GI-KS lesions were confirmed to be resolved following KS therapy...
2012: Pathology Research International
https://read.qxmd.com/read/23213624/the-role-of-molecular-pathology-in-the-diagnosis-of-cutaneous-lymphomas
#68
JOURNAL ARTICLE
Philipp W Raess, Adam Bagg
Primary cutaneous lymphomas can be difficult to be distinguished from reactive mimics, even when integrating histologic, immunophenotypic, and clinical findings. Molecular studies, especially PCR-based antigen receptor gene rearrangement (ARGR) analysis, are frequently useful ancillary studies in the evaluation of cutaneous lymphoproliferations. The biologic basis of ARGR studies is discussed, as well as a comparison of various current protocols. The pitfalls and limitations of ARGR analysis are also highlighted...
2012: Pathology Research International
https://read.qxmd.com/read/23213623/clear-cell-carcinomas-of-the-mullerian-system-does-the-pathogenesis-vary-depending-on-their-nuclear-grade-and-their-association-with-endometriosis-an-immunohistochemical-analysis
#69
JOURNAL ARTICLE
Ahmad Alduaij, Katrine Hansen, Tahreem A Karim, Cunxian Zhang, Michelle M Lomme, C James Sung, W Dwayne Lawrence, M Ruhul Quddus
UNLABELLED: Clear cell carcinomas (CCC) of the mullerian system are considered high grade tumors, but morphologically, the cells of CCC show both low and high grade features. The aims of the current study were to categorize CCC into low and high nuclear grade types, correlate their association with endometriosis, and then observe possible variations in pathogenesis based on their expression of p53 and Ki-67. We studied 41 pure mullerian CCCs and designated each as either a high (HNG) or low (LNG) nuclear grade tumor...
2012: Pathology Research International
https://read.qxmd.com/read/23094199/immunohistochemical-expression-of-platelet-derived-growth-factor-receptors-in-ovarian-cancer-patients-with-long-term-follow-up
#70
JOURNAL ARTICLE
Christine Vestergaard Madsen, Karina Dahl Steffensen, Marianne Waldstrøm, Anders Jakobsen
Introduction. The well-documented role of the PDGF system in tumor growth and angiogenesis has prompted the development of new biological agents targeting the PDGF system. The aim of the present study was to analyze the expression of the PDGF-receptors in ovarian cancer and to investigate its relation to histopathological parameters and long-term overall survival. Methods. The immunohistochemical expression of PDGFR-α and PDGFR-β was investigated in tumor and stromal cells in 170 patients with histologically verified epithelial ovarian cancer...
2012: Pathology Research International
https://read.qxmd.com/read/23094198/the-prognostic-value-of-lymph-node-cross-sectional-cancer-area-in-node-positive-breast-cancer-a-comparison-with-n-stage-and-lymph-node-ratio
#71
JOURNAL ARTICLE
Yanxia Li, Earle Holmes, Karan Shah, Kevin Albuquerque, Anna Szpaderska, Cağatay Erşahin
The number of positive axillary lymph nodes (LNs) is the only node-related factor for prognostic evaluation of breast cancer recognized by AJCC (TNM staging). However, N staging may not completely reflect LN tumor involvement due to the erroneous count of LNs in the presence of matted LNs and different tumor volume in LNs. Additionally, the positive/total LN ratio (LNR) has been shown to outperform N staging in survival prediction. In our study, to better quantify the tumor involvement of axillary LNs, we measured the cross-sectional cancer area (CSCA) of the positive LNs in 292 breast cancer patients diagnosed between 1998 and 2000 in our institution and compared its prognostic value to that of number of positive LNs (metLN)/N stage and LNR...
2012: Pathology Research International
https://read.qxmd.com/read/22997602/molecular-events-in-primary-and-metastatic-colorectal-carcinoma-a-review
#72
JOURNAL ARTICLE
Rani Kanthan, Jenna-Lynn Senger, Selliah Chandra Kanthan
Colorectal cancer (CRC) is a heterogeneous disease, developing through a multipathway sequence of events guided by clonal selections. Pathways included in the development of CRC may be broadly categorized into (a) genomic instability, including chromosomal instability (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP), (b) genomic mutations including suppression of tumour suppressor genes and activation of tumour oncogenes, (c) microRNA, and (d) epigenetic changes. As cancer becomes more advanced, invasion and metastases are facilitated through the epithelial-mesenchymal transition (EMT), with additional genetic alterations...
2012: Pathology Research International
https://read.qxmd.com/read/22888469/genetic-and-epigenetic-events-generate-multiple-pathways-in-colorectal-cancer-progression
#73
JOURNAL ARTICLE
Massimo Pancione, Andrea Remo, Vittorio Colantuoni
Colorectal cancer (CRC) is one of the most common causes of death, despite decades of research. Initially considered as a disease due to genetic mutations, it is now viewed as a complex malignancy because of the involvement of epigenetic abnormalities. A functional equivalence between genetic and epigenetic mechanisms has been suggested in CRC initiation and progression. A hallmark of CRC is its pathogenetic heterogeneity attained through at least three distinct pathways: a traditional (adenoma-carcinoma sequence), an alternative, and more recently the so-called serrated pathway...
2012: Pathology Research International
https://read.qxmd.com/read/22848863/malignant-mixed-mullerian-tumor-an-immunohistochemical-study
#74
JOURNAL ARTICLE
Zhanyong Bing, Theresa Pasha, Li-Ping Wang, Paul J Zhang
Malignant mixed Mullerian tumor (MMMT) is an uncommon aggressive neoplasm composed of both malignant epithelial and mesenchymal components. In this study, immunohistochemical stains of germ cell markers, including SALL4, OCT3/4, glypican-3, and alpha-fetal protein (AFP), and CDX2 were performed in a series of MMMTs. SALL4 nuclear immunoreactivity was detected in 6 out of 19 cases (33%). The staining extent ranged from focal to extensive. The staining intensity was usually intermediate to strong (the score ranged from 1...
2012: Pathology Research International
https://read.qxmd.com/read/22848862/retrospective-case-control-study-of-apolipoprotein-j-clusterin-protein-expression-in-early-liveborn-neonatal-deaths-with-and-without-pontosubicular-necrosis
#75
JOURNAL ARTICLE
Kathreena M Kurian, Declan McGuone
Aims. Our objective was to examine Apo J protein expression in a total of 27 early liveborn neonatal deaths (less than 7 days of age) selected from the Scottish Perinatal Study (gestation of 25-42 weeks) comparing a group with histological pontosubicular necrosis (PSN) (n = 12) to a control group lacking PSN (n = 15). Methods. Using immunohistochemistry we evaluated postmortem pons and hippocampus from patients with PSN versus controls. Results. In the group with PSN, 11/12 (92%) cases showed positive Apo J neurones in the hippocampus/pons compared with 6/15 (40%) cases without PSN (P = 0...
2012: Pathology Research International
https://read.qxmd.com/read/22792510/role-of-multiparameter-analysis-of-agnors-in-fna-smears-of-thyroid-swellings-in-differentiating-benign-and-malignant-lesions
#76
JOURNAL ARTICLE
Mohammad Ismail Hossain, Md Quamrul Hassan, Pradip Bhattacharjee, M Shahab Uddin Ahamad, Zillur Rahman
Background. The aim of this study is to assess the role of multiparameter analysis of silver (Ag)-stained nucleolar organizer regions (AgNORs) technique on aspiration smears of thyroid swellings to distinguish between benign and malignant lesions. Materials and Methods. Aspiration smears from 166 cases of thyroid swellings were examined. Diagnosis was confirmed by histology in 61 cases. AgNOR staining was done on FNA smears according to silver-staining protocol proposed by the International Committee for AgNOR quantification...
2012: Pathology Research International
https://read.qxmd.com/read/22701813/fibroblast-growth-factor-receptor-2-expression-roles-and-potential-as-a-novel-molecular-target-for-colorectal-cancer
#77
JOURNAL ARTICLE
Yoko Matsuda, Junji Ueda, Toshiyuki Ishiwata
The fibroblast growth factor receptor (FGFR) family consists of four members, named FGFR1, 2, 3, and 4. All 4 FGFRs and their ligands, fibroblast growth factors (FGFs), are expressed in colorectal cancer (CRC). Recent studies have shown that FGFR2 plays important roles in cancer progression; therefore, it is of great interest as a novel target for cancers. Expression of FGFR2 regulates migration, invasion, and growth in CRC. Expression of the FGFR2 isoform FGFR2 IIIb was associated with well-differentiated histological types, and its specific ligand, FGF7, enhanced angiogenesis and adhesion to type-IV collagen via FGFR2 IIIb in CRC...
2012: Pathology Research International
https://read.qxmd.com/read/22701199/barrett-s-esophagus-emerging-knowledge-and-management-strategies
#78
JOURNAL ARTICLE
Atul Bhardwaj, Thomas J McGarrity, Douglas B Stairs, Haresh Mani
The incidence of esophageal adenocarcinoma (EAC) has increased exponentially in the last 3 decades. Barrett's esophagus (BE) is the only known precursor of EAC. Patients with BE have a greater than 40 folds higher risk of EAC compared with the general population. Recent years have witnessed a revolution in the clinical and molecular research related to BE. However, several aspects of this condition remain controversial. Data regarding the true prevalence of BE have varied widely. Recent studies have suggested a lower incidence of EAC in nondysplastic BE (NDBE) than previously reported...
2012: Pathology Research International
https://read.qxmd.com/read/22693682/diagnosis-of-b-cell-non-hodgkin-lymphomas-with-small-intermediate-sized-cells-in-cytopathology
#79
JOURNAL ARTICLE
Joerg Schwock, William R Geddie
Fine needle sampling is a fast, safe, and potentially cost-effective method of obtaining tissue for cytomorphologic assessment aimed at both initial triage and, in some cases, complete diagnosis of patients that present clinically with lymphadenopathy. The cytologic diagnosis of B-cell non-Hodgkin lymphomas composed of small-/intermediate-sized cells, however, has been seen as an area of great difficulty even for experienced observers due to the morphologic overlap between lymphoma and reactive lymphadenopathies as well as between the lymphoma entities themselves...
2012: Pathology Research International
https://read.qxmd.com/read/22666633/endoscopic-ultrasound-guided-fine-needle-aspiration-and-the-role-of-the-cytopathologist-in-solid-pancreatic-lesion-diagnosis
#80
JOURNAL ARTICLE
Shahzad Iqbal, David Friedel, Mala Gupta, Lorna Ogden, Stavros N Stavropoulos
Endoscopic ultrasound (EUS) is the most sensitive imaging modality for solid pancreatic lesions. The specificity, however, is low (about 75%). It can be increased to 100% with an accuracy of 95% by the addition of fine-needle aspiration (FNA). Cytopathology plays an important role. The final diagnosis is based upon the correlation of clinical, EUS, and cytologic features. A close interaction with the cytopathologist is required in improving the diagnostic yield. In this paper, we present an overview of the role of EUS-guided FNA and importance of close interaction with the cytopathologist...
2012: Pathology Research International
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