journal
https://read.qxmd.com/read/38800612/corrigendum-normative-mice-retinal-thickness-16-month-longitudinal-characterization-of-wild-type-mice-and-changes-in-a-model-of-alzheimer-s-disease
#41
Ana Batista, Pedro Guimarães, João Martins, Paula I Moreira, António Francisco Ambrósio, Miguel Castelo-Branco, Pedro Serranho, Rui Bernardes
[This corrects the article DOI: 10.3389/fnagi.2023.1161847.].
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38800611/global-trends-and-hotspots-in-research-on-acupuncture-for-neurodegenerative-diseases-over-the-last-decade-a-bibliometric-and-visualization-analysis
#42
REVIEW
Qian Tan, Xinyuan Liu, Shuyu Xu, Jiangmin Chen, Weixian Li, Shuai Zhang, Yanjun Du
OBJECTIVES: This study aimed to explore the current status and trends of acupuncture for neurodegenerative diseases (NDs) in the last decade and provide new insights for researchers in future studies. METHODS: The publications concerning acupuncture treatment for NDs published between 2014 and 2023 were extracted from the Web of Science Core Collection. We used CiteSpace and VOSviewer to analyze data on numbers of annual publications, countries, institutions, cited journals, cited authors, cited references, keywords, and citation bursts about acupuncture for NDs...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38784446/the-pursuit-for-markers-of-disease-progression-in-behavioral-variant-frontotemporal-dementia-a-scoping-review-to-optimize-outcome-measures-for-clinical-trials
#43
Jay L P Fieldhouse, Dirk N van Paassen, Marie-Paule E van Engelen, Sterre C M De Boer, Willem L Hartog, Simon Braak, Linda J Schoonmade, Sigfried N T M Schouws, Welmoed A Krudop, Mardien L Oudega, Henk J M M Mutsaerts, Charlotte E Teunissen, Everard G B Vijverberg, Yolande A L Pijnenburg
Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder characterized by diverse and prominent changes in behavior and personality. One of the greatest challenges in bvFTD is to capture, measure and predict its disease progression, due to clinical, pathological and genetic heterogeneity. Availability of reliable outcome measures is pivotal for future clinical trials and disease monitoring. Detection of change should be objective, clinically meaningful and easily assessed, preferably associated with a biological process...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38784445/a-comprehensive-bibliometric-analysis-of-global-research-on-the-role-of-acrolein-in-alzheimer-s-disease-pathogenesis-involvement-of-amyloid-beta
#44
JOURNAL ARTICLE
Amadou Wurry Jallow, Doan Phuong Quy Nguyen, Monika Renuka Sanotra, Chun-Hsien Hsu, Yi-Fang Lin, Yung-Feng Lin
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive and behavioral decline. Acrolein, an environmental pollutant and endogenous compound, is implicated in AD development. This research employs bibliometric analysis to assess current trends and key areas concerning acrolein-AD interaction. METHODS: The Web of Science was used to extensively review literature on acrolein and AD. Relevant data were systematically gathered and analyzed using VOSviewer, CiteSpace, and an online bibliometric tool...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38784444/integrative-analysis-of-plasma-and-substantia-nigra-in-parkinson-s-disease-unraveling-biomarkers-and-insights-from-the-lncrna-mirna-mrna-cerna-network
#45
JOURNAL ARTICLE
Ka-Yoon Chun, Seung-Nam Kim
INTRODUCTION: Parkinson's disease (PD) is a rapidly growing neurological disorder characterized by diverse movement symptoms. However, the underlying causes have not been clearly identified, and accurate diagnosis is challenging. This study aimed to identify potential biomarkers suitable for PD diagnosis and present an integrative perspective on the disease. METHODS: We screened the GSE7621, GSE8397-GPL96, GSE8397-GPL97, GSE20163, and GSE20164 datasets in the NCBI GEO database to identify differentially expressed (DE) mRNAs in the substantia nigra (SN)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38778863/cardiovascular-disease-risk-exacerbates-brain-aging-among-hispanic-latino-adults-in-the-sol-inca-mri-study
#46
JOURNAL ARTICLE
Ariana M Stickel, Wassim Tarraf, Kevin A Gonzalez, Alejandra Morlett Paredes, Donglin Zeng, Jianwen Cai, Carmen R Isasi, Robert Kaplan, Richard B Lipton, Martha L Daviglus, Fernando D Testai, Melissa Lamar, Linda C Gallo, Gregory A Talavera, Marc D Gellman, Alberto R Ramos, Vladimir Ivanovic, Stephan Seiler, Hector M González, Charles DeCarli
BACKGROUND: Cardiovascular disease (CVD) risk factors are highly prevalent among Hispanic/Latino adults, while the prevalence of MRI infarcts is not well-documented. We, therefore, sought to examine the relationships between CVD risk factors and infarcts with brain structure among Hispanic/Latino individuals. METHODS: Participants included 1,886 Hispanic/Latino adults (50-85 years) who underwent magnetic resonance imaging (MRI) as part of the Study of Latinos-Investigation of Neurocognitive Aging-MRI (SOL-INCA-MRI) study...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38774266/in-sickness-and-in-health-type-i-interferon-and-the-brain
#47
REVIEW
Wei Cao
Type I interferons (IFN-I) represent a group of pleiotropic cytokines renowned for their antiviral activity and immune regulatory functions. A multitude of studies have unveiled a critical role of IFN-I in the brain, influencing various neurological processes and diseases. In this mini-review, I highlight recent findings on IFN-I's effects on brain aging, Alzheimer's disease (AD) progression, and central nervous system (CNS) homeostasis. The multifaceted influence of IFN-I on brain health and disease sheds light on the complex interplay between immune responses and neurological processes...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38774265/alzheimer-s-disease-manifests-abnormal-sphingolipid-metabolism
#48
JOURNAL ARTICLE
Baasanjav Uranbileg, Hideaki Isago, Eri Sakai, Masayuki Kubota, Yuko Saito, Makoto Kurano
INTRODUCTION: Alzheimer's disease (AD) is associated with disturbed metabolism, prompting investigations into specific metabolic pathways that may contribute to its pathogenesis and pathology. Sphingolipids have garnered attention due to their known physiological impact on various diseases. METHODS: We conducted comprehensive profiling of sphingolipids to understand their possible role in AD. Sphingolipid levels were measured in AD brains, Cerad score B brains, and controls, as well as in induced pluripotent stem (iPS) cells (AD, PS, and control), using liquid chromatography mass spectrometry...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38765774/using-sustained-vowels-to-identify-patients-with-mild-parkinson-s-disease-in-a-chinese-dataset
#49
JOURNAL ARTICLE
Miao Wang, Xingli Zhao, Fengzhu Li, Lingyu Wu, Yifan Li, Ruonan Tang, Jiarui Yao, Shinuan Lin, Yuan Zheng, Yun Ling, Kang Ren, Zhonglue Chen, Xi Yin, Zhenfu Wang, Zhongbao Gao, Xi Zhang
INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disease and affects millions of people. Accurate diagnosis and subsequent treatment in the early stages can slow down disease progression. However, making an accurate diagnosis of PD at an early stage is challenging. Previous studies have revealed that even for movement disorder specialists, it was difficult to differentiate patients with PD from healthy individuals until the average modified Hoehn-Yahr staging (mH&Y) reached 1...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38765773/modeling-of-age-related-neurological-disease-utility-of-zebrafish
#50
REVIEW
Tohgo Kanoh, Takamasa Mizoguchi, Ayako Tonoki, Motoyuki Itoh
Many age-related neurological diseases still lack effective treatments, making their understanding a critical and urgent issue in the globally aging society. To overcome this challenge, an animal model that accurately mimics these diseases is essential. To date, many mouse models have been developed to induce age-related neurological diseases through genetic manipulation or drug administration. These models help in understanding disease mechanisms and finding potential therapeutic targets. However, some age-related neurological diseases cannot be fully replicated in human pathology due to the different aspects between humans and mice...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38765772/a-bibliometric-analysis-on-the-health-behaviors-related-to-mild-cognitive-impairment
#51
Liping Xiao, Chunyi Zhou, Shibo Zhang, Yuncui Wang
BACKGROUND: Mild cognitive impairment (MCI) is commonly defined as a transitional subclinical state between normal aging and dementia. A growing body of research indicates that health behaviors may play a protective role against cognitive decline and could potentially slow down the progression from MCI to dementia. The aim of this study is to conduct a bibliometric analysis of literature focusing on health behaviors and MCI to summarize the factors and evidence regarding the influence of health behaviors on MCI...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38765771/prefrontal-cortical-activity-during-uneven-terrain-walking-in-younger-and-older-adults
#52
JOURNAL ARTICLE
Jungyun Hwang, Chang Liu, Steven P Winesett, Sudeshna A Chatterjee, Anthony D Gruber, Clayton W Swanson, Todd M Manini, Chris J Hass, Rachael D Seidler, Daniel P Ferris, Arkaprava Roy, David J Clark
INTRODUCTION: Walking in complex environments increases the cognitive demand of locomotor control; however, our understanding of the neural mechanisms contributing to walking on uneven terrain is limited. We used a novel method for altering terrain unevenness on a treadmill to investigate the association between terrain unevenness and cortical activity in the prefrontal cortex, a region known to be involved in various cognitive functions. METHODS: Prefrontal cortical activity was measured with functional near infrared spectroscopy while participants walked on a novel custom-made terrain treadmill surface across four different terrains: flat, low, medium, and high levels of unevenness...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38756536/real-world-chinese-herbal-medicine-for-parkinson-s-disease-a-hospital-based-retrospective-analysis-of-electronic-medical-records
#53
JOURNAL ARTICLE
Shaohua Lyu, Claire Shuiqing Zhang, Zhenhui Mao, Xinfeng Guo, Zhe Li, Xiaodong Luo, Jingbo Sun, Qiaozhen Su
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative condition. Chinese medicine therapies have demonstrated effectiveness for PD in controlled settings. However, the utilization of Chinese medicine therapies for PD in real-world clinical practice and the characteristics of patients seeking these therapies have not been thoroughly summarized. METHOD: The study retrospectively analyzed initial patient encounters (PEs) with a first-listed diagnosis of PD, based on electronic medical records from Guangdong Provincial Hospital of Chinese Medicine between July 2018 and July 2023...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38756535/three-major-effects-of-apoe-%C3%AE%C2%B54-on-a%C3%AE-immunotherapy-induced-aria
#54
REVIEW
Kate E Foley, Donna M Wilcock
The targeting of amyloid-beta (Aβ) plaques therapeutically as one of the primary causes of Alzheimer's disease (AD) dementia has been an ongoing effort spanning decades. While some antibodies are extremely promising and have been moved out of clinical trials and into the clinic, most of these treatments show similar adverse effects in the form of cerebrovascular damage known as amyloid-related imaging abnormalities (ARIA). The two categories of ARIA are of major concern for patients, families, and prescribing physicians, with ARIA-E presenting as cerebral edema, and ARIA-H as cerebral hemorrhages (micro- and macro-)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38756534/moderating-effect-of-education-on-glymphatic-function-and-cognitive-performance-in-mild-cognitive-impairment
#55
JOURNAL ARTICLE
Liang Zhou, Wenxia Yang, Yang Liu, Yu Zheng, Xin Ge, Kai Ai, Guangyao Liu, Jing Zhang
OBJECTIVE: This research aims to investigate putative mechanisms between glymphatic activity and cognition in mild cognitive impairment (MCI) and analyzes whether the relationship between cognitive reserve (CR) and cognition was mediated by glymphatic activity. METHODS: 54 MCI patients and 31 NCs were enrolled to evaluate the bilateral diffusivity along the perivascular spaces and to acquire an index for diffusivity along the perivascular space (ALPS-index) on diffusion tensor imaging (DTI)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38756533/cerebrospinal-fluid-serum-albumin-ratio-in-patients-with-lewy-body-disease-a-systematic-review-and-meta-analysis
#56
REVIEW
Moyu Li, Jinghuan Gan, Xia Yang, Shuai Liu, Yong Ji
BACKGROUND: Abnormal cerebrospinal fluid (CSF)/serum albumin ratio (Qalb) levels have been observed in patients with cognitive impairment. Few studies have specifically focused on Lewy Body Disease (LBD), and the results were controversial. Thus, we conducted this systematic review and meta-analysis to investigate Qalb levels in patients with LBD by including data from different studies. METHOD: We systematically searched PubMed, Embase, Cochrane Library, and Web of Science databases for a collection of studies containing studies comparing Qalb levels in patients with LBD and healthy controls (including healthy controls and other dementia subtypes)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38752210/key-developments-and-hotspots-of-exosomes-in-alzheimer-s-disease-a-bibliometric-study-spanning-2003-to-2023
#57
JOURNAL ARTICLE
Siyu Liu, Daoying Geng
BACKGROUND: Alzheimer's disease (AD) is a degenerative illness of the central nervous system that is irreversible and is characterized by gradual behavioral impairment and cognitive dysfunction. Researches on exosomes in AD have gradually gained the attention of scholars in recent years. However, the literatures in this research area do not yet have a comprehensive visualization analysis. The aim of this work is to use bibliometrics to identify the knowledge constructs and investigate the research frontiers and hotspots related to exosomes in AD...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38752209/research-status-and-global-trends-of-late-life-depression-from-2004-to-2023-bibliometric-analysis
#58
JOURNAL ARTICLE
Ruonan Du, Kebing Yang, Wei Li, Zhiren Wang, Haipeng Cai
BACKGROUND: Global research hotspots and future research trends in the neurobiological mechanisms of late-life depression (LLD) as well as its diagnosis and treatment are not yet clear. OBJECTIVES: This study profiled the current state of global research on LLD and predicted future research trends in the field. METHODS: Literature with the subject term LLD was retrieved from the Web of Science Core Collection, and CiteSpace software was used to perform econometric and co-occurrence analyses...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38752208/testosterone-deficiency-worsens-mitochondrial-dysfunction-in-app-ps1-mice
#59
JOURNAL ARTICLE
Tianyun Zhang, Yun Chu, Yue Wang, Yu Wang, Jinyang Wang, Xiaoming Ji, Guoliang Zhang, Geming Shi, Rui Cui, Yunxiao Kang
BACKGROUND: Recent studies show testosterone (T) deficiency worsens cognitive impairment in Alzheimer's disease (AD) patients. Mitochondrial dysfunction, as an early event of AD, is becoming critical hallmark of AD pathogenesis. However, currently, whether T deficiency exacerbates mitochondrial dysfunction of men with AD remains unclear. OBJECTIVE: The purpose of this study is to explore the effects of T deficiency on mitochondrial dysfunction of male AD mouse models and its potential mechanisms...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38746830/multimodal-cognitive-and-behavioral-interventions-for-patients-with-mci-a-systematic-review-and-meta-analysis-on-cognition-and-mood
#60
Gelan Ying, Ambar Perez-Lao, Michael Marsiske, Shellie-Anne Levy, Glenn E Smith
BACKGROUND: Research has increasingly suggested a benefit to combining multiple cognitive or behavioral strategies in a single treatment program for cognitively impaired older adults. Therefore, this systematic review and meta-analysis aimed to summarize results on the effects of multimodal cognitive and behavioral interventions versus control conditions on changes in cognition and mood in patients with mild cognitive impairment (pwMCI). METHODS: The review followed a general PRISMA guideline for systematic literature review with a format consisting of participants, interventions, comparators, and outcomes (PICO)...
2024: Frontiers in Aging Neuroscience
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