journal
https://read.qxmd.com/read/38711598/editorial-the-3-s-s-sex-stress-and-sleep-as-risk-factors-for-dementias
#21
EDITORIAL
Qunxing Ding
No abstract text is available yet for this article.
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38711597/detection-of-elevated-levels-of-pink1-in-plasma-from-patients-with-idiopathic-parkinson-s-disease
#22
JOURNAL ARTICLE
Xianchai Hong, Yi Zheng, Jialong Hou, Tao Jiang, Yao Lu, Wenwen Wang, Shuoting Zhou, Qianqian Ye, Chenglong Xie, Jia Li
BACKGROUNDS: Numerous lines of evidence support the intricate interplay between Parkinson's disease (PD) and the PINK1-dependent mitophagy process. This study aimed to evaluate differences in plasma PINK1 levels among idiopathic PD, PD syndromes (PDs), and healthy controls. METHODS: A total of 354 participants were included, consisting of 197 PD patients, 50 PDs patients, and 107 healthy controls were divided into two cohorts, namely the modeling cohort (cohort 1) and the validated cohort (cohort 2)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38711596/genetic-markers-associated-with-ferroptosis-in-alzheimer-s-disease
#23
JOURNAL ARTICLE
Yuting Sun, Yu Xiao, Qin Tang, Wei Chen, Lu Lin
OBJECTIVE: Ferroptosis is implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and vascular dementia, implying that it may have a regulatory effect on the progression of these diseases. However, the specific role of ferroptosis-related genes (FRGs) in Alzheimer's disease (AD) is not yet fully understood. The aim of the study was to detect ferroptosis related genes with regulatory functions in the disease and explore potential mechanisms in AD...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38706458/incidence-and-risk-factors-of-age-related-macular-degeneration-in-patients-with-parkinson-s-disease-a-population-based-study
#24
JOURNAL ARTICLE
Bora Yoon, Ho-Seok Sa, Hwa Jung Kim
BACKGROUND AND OBJECTIVE: The association between age-related macular degeneration (AMD) and Parkinson' disease (PD) remains unclear. The aim of the present study was to assess the incidence of AMD in patients with PD, elucidate differences by age and sex, and investigate potential risk factors for AMD. METHODS: Data were extracted from the Korean National Health Insurance System database, which covers 97% of the Korean population (2002 through 2019). We calculated the incidence of newly diagnosed AMD in patients with PD and used Cox proportional-hazards models to estimate risk factors for AMD, presenting adjusted hazard ratios (aHR) with 95% confidence intervals (CI)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38706457/neuroanatomical-correlates-of-distracted-straight-driving-performance-a-driving-simulator-mri-study-across-the-lifespan
#25
JOURNAL ARTICLE
Dylan X Guan, Nathan W Churchill, Corinne E Fischer, Simon J Graham, Tom A Schweizer
BACKGROUND: Driving is the preferred mode of transportation for adults across the healthy age span. However, motor vehicle crashes are among the leading causes of injury and death, especially for older adults, and under distracted driving conditions. Understanding the neuroanatomical basis of driving may inform interventions that minimize crashes. This exploratory study examined the neuroanatomical correlates of undistracted and distracted simulated straight driving. METHODS: One-hundred-and-thirty-eight participants (40...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38699560/sv2a-pet-imaging-in-human-neurodegenerative-diseases
#26
REVIEW
Mahsa Shanaki Bavarsad, Lea T Grinberg
This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a biomarker for synaptic integrity using Positron Emission Tomography (PET) in neurodegenerative diseases. Synaptic pathology, characterized by synaptic loss, has been linked to various brain diseases. Therefore, there is a need for a minimally invasive approach to measuring synaptic density in living human patients. Several radiotracers targeting synaptic vesicle protein 2A (SV2A) have been created and effectively adapted for use in human subjects through PET scans...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38699559/causal-relationship-between-circulating-insulin-like-growth-factor-1-and-parkinson-s-disease-a-two-sample-mendelian-randomization-study
#27
JOURNAL ARTICLE
Jiahao Xu, Peidong Fan, Jiacheng Yang, Mingjuan Yin, Jun Wu, Chao Chen, Jindong Ni
BACKGROUND: Linear associations between circulating insulin-like growth factor-1 (IGF-1) levels and Parkinson's disease (PD) have been evidenced in observational studies. Yet, the causal relationship between IGF-1 levels and PD remains obscure. We conducted Mendelian randomization to examine the correlation between genetically predicted IGF-1 levels and PD. METHODS: By reviewing genome-wide association studies (GWAS) that are publicly accessible, we uncovered SNPs linked to both serum concentrations of IGF-1 and PD...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38694261/the-relationship-between-gender-differences-in-dietary-habits-neuroinflammation-and-alzheimer-s-disease
#28
REVIEW
Alison Warren
Neurocognitive decline is one of the foremost dire issues in medicine today. The mechanisms by which dementia pathogenesis ensues are complicated and multifactorial, particularly in the case of Alzheimer's disease (AD). One irrefutable, yet unexplained factor is the gender disparity in AD, in which women are disproportionately affected by AD, both in the rate and severity of the disease. Examining the multifaceted contributing causes along with unique gender dynamics in modifiable risk factors, such as diet, may lend some insight into why this disparity exists and potential paths forward...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38694260/application-and-progress-of-advanced-eye-movement-examinations-in-cognitive-impairment
#29
REVIEW
Qi Leng, Bo Deng, Yi Ju
The worldwide incidence of cognitive impairment is escalating, yet no effective solutions for these afflictions have been discovered. Consequently, the importance of early identification and immediate intervention is heightened. Advanced eye movements-a form of voluntary eye movements that includes anti-saccades, memory-guided saccades, predictive saccades, pro-saccades and gap/overlap saccades, mediated by the cerebral cortex and subcortical pathways reflect cognitive levels and functions across different domains...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38694259/trends-in-cause-specific-mortality-among-persons-with-alzheimer-s-disease-in-south-carolina-2014-to-2019
#30
JOURNAL ARTICLE
Candace S Brown, Xi Ning, Amy Money, Mauriah Alford, Yinghao Pan, Margaret Miller, Matthew Lohman
INTRODUCTION: Inconsistencies of reports contributes to the underreporting of Alzheimer's disease (AD) on death certificates. Whether underreporting exists within South Carolina has not been studied. METHODS: We conducted a prospective, population-based study on a cohort of persons ( N  = 78,534) previously diagnosed with AD and died between 2014-2019. We linked vital records with the South Carolina Alzheimer's Disease and Related Dementias Registry to investigate their cause of death and survival rates...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38694258/morphological-changes-in-the-cerebellum-during-aging-evidence-from-convolutional-neural-networks-and-shape-analysis
#31
JOURNAL ARTICLE
Yu Wang, Ye Teng, Tianci Liu, Yuchun Tang, Wenjia Liang, Wenjun Wang, Zhuoran Li, Qing Xia, Feifei Xu, Shuwei Liu
The morphology and function of the cerebellum are associated with various developmental disorders and healthy aging. Changes in cerebellar morphology during the aging process have been extensively investigated, with most studies focusing on changes in cerebellar regional volume. The volumetric method has been used to quantitatively demonstrate the decrease in the cerebellar volume with age, but it has certain limitations in visually presenting the morphological changes of cerebellar atrophy from a three-dimensional perspective...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38694257/clathrin-mediated-endocytosis-in-alzheimer-s-disease-cell-type-specific-involvement-in-amyloid-beta-pathology
#32
REVIEW
Sierra Jaye, Ursula S Sandau, Julie A Saugstad
This review provides a comprehensive examination of the role of clathrin-mediated endocytosis (CME) in Alzheimer's disease (AD) pathogenesis, emphasizing its impact across various cellular contexts beyond neuronal dysfunction. In neurons, dysregulated CME contributes to synaptic dysfunction, amyloid beta (Aβ) processing, and Tau pathology, highlighting its involvement in early AD pathogenesis. Furthermore, CME alterations extend to non-neuronal cell types, including astrocytes and microglia, which play crucial roles in Aβ clearance and neuroinflammation...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38685909/distance-based-novelty-detection-model-for-identifying-individuals-at-risk-of-developing-alzheimer-s-disease
#33
JOURNAL ARTICLE
Hongqin Yang, Jiangbing Mao, Qinyong Ye, Magda Bucholc, Shuo Liu, Wenzhao Gao, Jie Pan, Jiawei Xin, Xuemei Ding
INTRODUCTION: Novelty detection (ND, also known as one-class classification) is a machine learning technique used to identify patterns that are typical of the majority class and can discriminate deviations as novelties. In the context of Alzheimer's disease (AD), ND could be employed to detect abnormal or atypical behavior that may indicate early signs of cognitive decline or the presence of the disease. To date, few research studies have used ND to discriminate the risk of developing AD and mild cognitive impairment (MCI) from healthy controls (HC)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38685908/comparison-between-morphometry-and-radiomics-detecting-normal-brain-aging-based-on-grey-matter
#34
JOURNAL ARTICLE
Yuting Yan, Xiaodong He, Yuyun Xu, Jiaxuan Peng, Fanfan Zhao, Yuan Shao
OBJECTIVE: Voxel-based morphometry (VBM), surface-based morphometry (SBM), and radiomics are widely used in the field of neuroimage analysis, while it is still unclear that the performance comparison between traditional morphometry and emerging radiomics methods in diagnosing brain aging. In this study, we aimed to develop a VBM-SBM model and a radiomics model for brain aging based on cognitively normal (CN) individuals and compare their performance to explore both methods' strengths, weaknesses, and relationships...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38681668/associations-of-vitamin-d-receptor-polymorphisms-with-risk-of-alzheimer-s-disease-parkinson-s-disease-and-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#35
Yanjun Du, Peizhen Geng, Qunqun Chen, Laixi Han, Lu Liu, Maoquan Yang, Mingzhu Tan, Jun Meng, Xiaojuan Sun, Lidan Feng
Vitamin D is a lipid soluble steroid hormone, which plays a critical role in the calcium homeostasis, neuronal development, cellular differentiation, and growth by binding to vitamin D receptor (VDR). Associations between VDR gene polymorphism and Alzheimer's disease (AD), Parkinson's disease (PD), and mild cognitive impairment (MCI) risk has been investigated extensively, but the results remain ambiguous. The aim of this study was to comprehensively assess the correlations between four VDR polymorphisms ( Fok I, Bsm I, Taq I, and Apa I) and susceptibility to AD, PD, and MCI...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38681667/association-of-genetically-predicted-486-blood-metabolites-on-the-risk-of-alzheimer-s-disease-a-mendelian-randomization-study
#36
JOURNAL ARTICLE
Qiqi Yang, Xinyu Han, Min Ye, Tianxin Jiang, Baoguo Wang, Zhenfeng Zhang, Fei Li
BACKGROUND: Studies have reported that metabolic disturbance exhibits in patients with Alzheimer's disease (AD). Still, the presence of definitive evidence concerning the genetic effect of metabolites on AD risk remains insufficient. A systematic exploration of the genetic association between blood metabolites and AD would contribute to the identification of new targets for AD screening and prevention. METHODS: We conducted an exploratory two-sample Mendelian randomization (MR) study aiming to preliminarily identify the potential metabolites involved in AD development...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38681666/the-role-of-neuroinflammation-in-neurodegenerative-diseases-current-understanding-and-future-therapeutic-targets
#37
REVIEW
Alhamdu Adamu, Shuo Li, Fankai Gao, Guofang Xue
Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory mediators are liberated and reactive oxygen and nitrogen species are synthesized. Neuroinflammation is a key process that helps protect the brain from pathogens, but inappropriate, or protracted inflammation yields pathological states such as Parkinson's disease, Alzheimer's, Multiple Sclerosis, and other neurodegenerative disorders that showcase various pathways of neurodegeneration distributed in various parts of the CNS...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38681665/cognitive-reserve-over-the-life-course-and-risk-of-dementia-a-systematic-review-and-meta-analysis
#38
REVIEW
Yulu Liu, Guangyu Lu, Lin Liu, Yuhang He, Weijuan Gong
BACKGROUND: The number of people with dementia is soaring. Cognitive reserve has been thought to be associated with dementia risk. It is not clear at which period in the life course and which cognitive reserve proxies contribute to the reduced risk of dementia. METHODS: By scanning four databases (PubMed, Embase, Web of Science, and MEDLINE) up to Jun 3, 2023, longitudinal studies of life-course cognitive reserve and risk of dementia were found. The HRs and 95% CIs for each study were summarized using random effects models...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38665900/corrigendum-effectiveness-of-a-multicomponent-exercise-intervention-in-community-dwelling-older-chinese-people-with-cognitive-frailty-protocol-for-a-mixed-methods-research
#39
Hongting Ning, Fenghui Chen, Junxin Li, Yan Du, Xi Chen, Shuang Wu, Abigael Joseph, Yinyan Gao, Zeng Cao, Hui Feng
[This corrects the article DOI: 10.3389/fnagi.2024.1282263.].
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38665899/older-and-younger-adults-differ-in-time-course-of-skill-acquisition-but-not-in-overall-improvement-in-a-bimanual-visuomotor-tracking-task
#40
JOURNAL ARTICLE
Ana Zvornik, Keenie Ayla Andersen, Andreas Deigaard Petersen, Mikael Novén, Hartwig Roman Siebner, Jesper Lundbye-Jensen, Anke Ninija Karabanov
Manual motor performance declines with age, but the extent to which age influences the acquisition of new skills remains a topic of debate. Here, we examined whether older healthy adults show less training-dependent performance improvements during a single session of a bimanual pinch task than younger adults. We also explored whether physical and cognitive factors, such as grip strength or motor-cognitive ability, are associated with performance improvements. Healthy younger ( n  = 16) and older ( n  = 20) adults performed three training blocks separated by short breaks...
2024: Frontiers in Aging Neuroscience
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