journal
Journals Clinical Medicine Insights. On...

Clinical Medicine Insights. Oncology

https://read.qxmd.com/read/38152726/cancer-associated-thrombosis-epidemiology-pathophysiological-mechanisms-treatment-and-risk-assessment
#21
REVIEW
Dragica Pavlovic, Danijela Niciforovic, Marina Markovic, Dragana Papic
Cancer patients represent a growing population with drastically difficult care and a lowered quality of life, especially due to the heightened risk of vast complications. Thus, it is well established so far that one of the most prominent complications in individuals with cancer is venous thromboembolism. Since there are various improved methods for screening and diagnosing cancer and its complications, the incidence of cancer-associated thrombosis has been on the rise in recent years. Therefore, the high mortality and morbidity rates among these patients are not a surprise...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38144543/mir-133b-promotes-esophageal-squamous-cell-carcinoma-metastasis
#22
JOURNAL ARTICLE
Cong-Gai Huang, Qing Liu, Shu-Tao Zheng, Tao Liu, Yi-Yi Tan, Tian-Yuan Peng, Jiao Chen, Xiao-Mei Lu
BACKGROUND: Evaluation of biological changes at the molecular level has important clinical implications for improving the survival rate of esophageal squamous cell carcinoma (ESCC). Therefore, we plan to analyze and elucidate the expression of microRNA-133b (miR-133b), M2 pyruvate kinase (PKM2), and signal transducer and activator of transcription 3 (STAT3) in ESCC and their associated clinicopathological significance. METHODS: The 72 patients with ESCC were selected as the experimental study group...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38107371/influence-of-smoking-habits-on-the-efficacy-of-egfr-tki-therapy-in-patients-with-advanced-nsclc-a-systematic-review-and-meta-analysis
#23
JOURNAL ARTICLE
Zexun Mo, Meifeng Ye, Hua He, Xiaomei Huang, Weihong Guo, Ziwen Zhao, Yujun Li, Shuquan Wei
BACKGROUND: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are considered as the first-line treatment for advanced EGFR mutation-positive non-small cell lung cancer (NSCLC). We aimed to analyze the efficacy of EGFR-TKIs treatment in patients with advanced NSCLC of different smoking habits. METHODS: We conducted a search for meta-analyses and systematic reviews on the PubMed, MEDLINE, Embase, and the Cochrane Library to address this knowledge gap...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38090634/a-phase-ii-study-of-131-i-rituximab-for-patients-with-relapsed-or-refractory-marginal-zone-lymphoma
#24
JOURNAL ARTICLE
Yoon Jung Jang, Sang Moo Lim, Inki Lee, Byung Hyun Byun, Ilhan Lim, Byung Il Kim, Chang Woon Choi, Seung-Sook Lee, Sung Hyun Yang, Im Il Na, Hyo-Rak Lee, Dong-Yeop Shin, Hye Jin Kang
BACKGROUND: Radioimmunotherapy (RIT) is a rare treatment option for relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL). We investigated the safety and efficacy of 131 I-rituximab in patients with relapsed or refractory marginal zone lymphomas. METHODS: Patients with pathologically confirmed marginal zone lymphoma who relapsed or were resistant to prior therapy were enrolled. The patients received 250 mg/m2 of unlabeled rituximab immediately before receiving a therapeutic 131 I-rituximab dose...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38058602/-bcl11b-mutations-are-associated-with-higher-cd8-t-cell-percentage-and-favorable-clinical-outcomes-in-patients-with-t-cell-acute-lymphoblastic-leukemia
#25
JOURNAL ARTICLE
Cunte Chen, Yuping Zhang, Xiangbo Zeng, Chengwu Zeng, Grzegorz K Przybylski, Yangqiu Li
No abstract text is available yet for this article.
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38033743/circadian-clock-dysregulation-and-prostate-cancer-a-molecular-and-clinical-overview
#26
REVIEW
Dalia Kaakour, Bridget Fortin, Selma Masri, Arash Rezazadeh
Circadian clock dysregulation has been implicated in various types of cancer and represents an area of growing research. However, the role of the circadian clock in prostate cancer has been relatively unexplored. This literature review will highlight the potential role of circadian clock dysregulation in prostate cancer by examining molecular, epidemiologic, and clinical data. The influence of melatonin, light, night shift work, chronotherapy, and androgen independence are discussed as they relate to the existing literature on their role in prostate cancer...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38033742/clinical-pathological-characteristics-and-prognosis-of-multigene-co-mutations-in-elderly-patients-with-non-small-cell-lung-cancer-a-retrospective-analysis
#27
JOURNAL ARTICLE
Wanjing Li, Fangqun Chang, Hao Zhang, Furong Meng, Zhangyan Ke, Yanbei Zhang
BACKGROUND: With the development and wide application of next-generation sequencing (NGS), multiple-gene mutations related to lung cancer are detected using this technology. Notably, even multigene concomitant mutations (co-mutations), which occur at a relatively low incidence, can be detected more effectively using NGS. It is well-known that the percentages of non-small cell lung cancer (NSCLC) in the elderly lung cancer population are also gradually increasing, while its prognosis is hard and the quality of long-term survival is poor...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38033741/a-systematic-review-of-clinical-practice-guidelines-for-managing-pulmonary-toxicities-caused-by-immune-checkpoint-inhibitors-quality-of-treatment-recommendations-and-differences-in-management-strategies-between-guidelines
#28
REVIEW
Kofi N Donkor, Hyeree Jang, Reena Sail
BACKGROUND: Pulmonary toxicities caused by immune checkpoint inhibitors are a prominent concern for clinicians. Clinical Practice Guidelines (CPGs) are critical for managing these toxicities. METHODS: A systematic search of CPGs on checkpoint-associated pulmonary toxicities (ca-PT) was conducted in October 2022. PubMed, Embase, Cochrane Library, CINAHL, and Web of Science were searched. AGREE II and AGREE-REX were used to appraise CPGs and recommendations quality, respectively...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38023290/is-the-urinary-and-gut-microbiome-associated-with-bladder-cancer
#29
JOURNAL ARTICLE
Joanna Chorbińska, Wojciech Krajewski, Łukasz Nowak, Klaudia Bardowska, Paulina Żebrowska-Różańska, Łukasz Łaczmański, Katarzyna Pacyga-Prus, Sabina Górska, Bartosz Małkiewicz, Tomasz Szydełko
BACKGROUND: Microbiome dysbiosis plays a role in the pathogenesis of many urological diseases, including bladder cancer (BC). The aim of the study was to compare the urinary and gut microbiota of patients with BC with a healthy control (HC) group. METHODS: The study group included patients hospitalized in 2020 to 2021 with diagnosed BC and HC. Prior to the transurethral resection of bladder tumor, patients collected their urine and stool which was then subjected to 16S rRNA gene sequencing...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38023289/clinicopathologic-features-and-prognosis-of-female-early-breast-cancer-with-her2-low-expression-a-propensity-score-matched-analysis
#30
JOURNAL ARTICLE
Lanyi Dai, Qiyuan Huang, Rong Guo, Keying Zhu, Yiyin Tang, Dedian Chen, Sheng Huang
BACKGROUND: Metastatic breast cancer (MBC) patients with low expression of human epidermal growth factor 2 (HER2) have been proven to benefit from HER2 targeted therapy. We aimed to determine how HER2-low status affected survival and metastatic risk as well as how it affected pathological complete response (pCR) in neoadjuvant chemotherapy (NAC) patients. METHODS: According to the results of immunohistochemistry (IHC) and in situ hybridization (ISH) testing, 321 female patients were sorted into HER2-low (IHC 1+/2+ with ISH negative) and HER2-zero (IHC 0) groups using propensity score matching (PSM)...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38023288/-fast-first-and-then-slowly-steroid-tapering-regimen-in-managing-corticoid-sensitive-patients-with-severe-immunotherapy-complications-after-anti-pd-l-1-therapy-for-cancer
#31
JOURNAL ARTICLE
Qi Gui, Liping Xie, Shaoqi Cheng, Chengcheng Xu
BACKGROUND: We aimed to assess the efficacy of the "fast first and then slowly" steroid-tapering regimen used in managing corticoid-sensitive patients with severe irAE after anti-PD-(L)1 therapy. Corticosteroids are the primary therapy for severe immune-related adverse events (irAEs). Less is known about the standard steroid-tapering regimen for corticoid-sensitive patients. METHODS: This study was a single-center, retrospective medical record review of patients with severe irAE after anti-PD-(L)1 treatment for cancer from October 13, 2021 to October 20, 2022...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38023287/improving-treatment-outcome-for-cervical-cancer-using-2-point-assessment-of-quality-of-life-among-nigerian-women-a-protocol-for-a-multi-center-study
#32
JOURNAL ARTICLE
Maureen Uche Umemmuo, George Uchenna Eleje, Timothy A Oluwasola, Michael Ezeanochie, Hadiza Abdullahi Usman, Jawhara Shehu Galadanci, Chiemezie Mac-Kingsley Agbanu, Ayyuba Rabiu
BACKGROUND: Cervical cancer is the fourth most common cancer among women globally, with quality of life (QOL) being a major concern for patients with cervical cancer, especially in low- and middle-income countries (LMICs). This is largely due to the advanced nature of the disease at presentation. Although there are a higher number of studies focusing on the QOL of high-income countries, the QOL of cervical cancer patients in LMICs is not available. The aim of this study is to evaluate QOL among women with cervical cancer in Nigeria using a 2-point assessment...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38023286/the-antitumor-impact-of-combining-hepatic-artery-ligation-with-copper-chelators-for-liver-cancer
#33
JOURNAL ARTICLE
Ni Zeng, Ye Wang, Yuan Wan, Hongyu Wang, Nan Li
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the main cancer-related mortality worldwide. Thus, there is a constant search for improvement in treatment strategies to enhance the prognosis of this malignancy. The study aims to investigate the combined antitumor activity of ammonium tetrathiomolybdate (TM, copper chelator) combined with hepatic artery ligation (HAL) for liver cancer. METHODS: A total of 40 Sprague-Dawley (SD) rats bearing hepatic tumors were randomly divided into four groups: the control group without any treatment (control), HAL only (HAL), given TM by gavage (TM), and given TM combined with HAL (HAL + TM)...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38023285/contrast-enhanced-mri-in-women-with-endometrial-cancer-dynamic-versus-single-phase-acquisitions
#34
JOURNAL ARTICLE
Myoung Seok Lee, Min Hoan Moon, Taek Min Kim, Siwon Jang, Sohee Oh, Jeong Yeon Cho
BACKGROUND: The 2019 European Society of Urogenital Radiology (ESUR) guidelines for endometrial cancer recommend performing either dynamic contrast-enhanced magnetic resonance imaging (CE MRI) or single-phase CE MRI. However, no study has directly compared these options. Therefore, this study compared dynamic versus single-phase CE MRI for the evaluation of myometrial invasion in women with endometrial cancer. METHODS: This retrospective, single-institution comparative study was conducted among women with surgically proven endometrial cancer, including 30 consecutive women with single-phase CE MRI and 30 age- and pathologic stage-matched women with dynamic CE MRI...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/37928452/comparison-of-sentinel-lymph-node-biopsy-by-blue-dye-conjunction-with-indocyanine-green-or-radioisotope-in-early-stage-breast-cancer-a-prospective-single-center-observational-study
#35
JOURNAL ARTICLE
Yanmei Wang, Qing Peng, Pengcheng Sun, Xuesha Li, Yilong Dong
BACKGROUND: Although radioisotope (RI) combined with blue dye (BD) is the standard technique for sentinel lymph node (SLN) biopsy in breast cancer, the use of RI is limited at some institutions due to the specific equipment needed. Indocyanine green (ICG) fluorescence detection has been developed as a potential substitute for RI method. However, reports on the sensitivity of ICG and RI techniques in detecting SLN are inconsistent; hence, the present study was designed to compare the clinical efficacy between the combined method of ICG + BD (ICG-B) and RI + BD (RI-B)...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/37928451/the-investigation-of-the-association-between-the-bcl-2-3-utr-rs1564483-polymorphism-and-mir-296-3p-in-the-development-of-breast-and-gastric-cancers
#36
JOURNAL ARTICLE
Mehrnoush Azadeh Jouneghani, Fatemeh Keshavarzi, Nahid Haghnazari, Zahra Hooshmandi, Sabrieh Amini
BACKGROUND: B-cell leukemia/lymphoma 2 ( Bcl-2) gene regulates carcinogenesis by inhibiting apoptosis. This study evaluated the association of Bcl-2 3'-untranslated regions (3' UTR) rs1564483 polymorphism and miR-296-3p with the development of breast and gastric cancers. METHODS: A microarray analysis was performed on the Genomic Spatial Event (GSE)29431 and GSE161533 datasets for breast and gastric cancers. Blood samples were taken from 222 (111 patients and 111 controls) and 210 (84 patients and 126 controls) individuals for breast and gastric cancers, respectively...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/37915530/the-riddle-of-the-sphinx-progress-in-leptomeningeal-metastasis-of-non-small-cell-lung-cancer
#37
REVIEW
Yuhua Zhao, Limeng Yu, Lili Wang, Yingxi Wu, Haiyang Chen, Qiming Wang, Yufeng Wu
Leptomeningeal metastasis (LM) is a serious complication of advanced non-small cell lung cancer (NSCLC), and the incidence of LM has been increasing yearly in recent times. There is no consensus on the best treatment modality for LM, which underscores a difficult problem in the management of advanced NSCLC patients. The existing treatments include molecular targeted therapy, systemic chemotherapy, local radiotherapy, antivascular tumor therapy, intrathecal chemotherapy, and immunotherapy, but their efficacy is not satisfactory...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/37905234/clinical-features-and-outcomes-of-primary-breast-diffuse-large-b-cell-lymphoma-a-matched-pair-study
#38
JOURNAL ARTICLE
Ling-Chiao Teng, Yu-Min Liao, Jyh-Pyng Gau, Tzu-Hung Hsiao, Tsung-Chih Chen, Mei-Hui Chen, Su-Peng Yeh, Chieh-Lin Jerry Teng
BACKGROUND: The influence of the breast as the primary site on the outcome of diffuse large B-cell lymphoma (DLBCL) and further changes in therapeutic strategies remain unclear. We aimed to compare the outcomes between primary breast and non-breast DLBCL and analyze the genetic profiles of some of the study cohorts using next-generation sequencing. METHODS: This matched-pair study reviewed the medical records of 19 patients with stage I and II primary breast DLBCL diagnosed between January 2005 and December 2021 on the basis of the Wiseman and Liao criteria, and we used 1:4 propensity score matching to identify patients with non-breast DLBCL as the control group...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/37905233/relationships-of-braf-v600e-gene-mutation-with-some-immunohistochemical-markers-and-recurrence-rate-in-patients-with-thyroid-carcinoma
#39
JOURNAL ARTICLE
Tri Bui Dang Minh, Thuan Nghiem Duc, Van Phan Nguyen Thanh, Tuan Dinh Le, Minh Duc Tong, Trung Hoang Nguyen, Anh Le Tuan, Kien Xuan Nguyen, Tien Tran Viet, Thang Ba Ta, Son Tien Nguyen, Hai Anh Vu, Ba Van Nguyen, Dung Nguyen Thi Ngoc, Viet Tran Quoc, Thanh Bui Duc
BACKGROUND: The B-type rafkinase (BRAF) V600E gene mutation plays an important role in the pathogenesis, diagnosis, and prognosis of thyroid carcinoma. This study was conducted to investigate the rate of the BRAF V600E mutation, the relationships between the BRAF V600E gene mutation and some immunohistochemical markers, and recurrence rate in patients with differentiated thyroid cancer. METHOD: The study was conducted by a descriptive and longitudinal follow-up method on 102 thyroid carcinoma patients at 103 Military Hospital, Hanoi, Vietnam...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/37901254/the-rna-m6a-binding-protein-ythdc1-is-downregulated-and-associated-with-m2-macrophage-infiltration-in-muscle-invasive-bladder-cancer
#40
JOURNAL ARTICLE
Lamei Zhao, Dongyan Han, Jianghua Zhu, Dexi Bi, Tingting Ding, Xingchen Zhu, Dengfeng Huang, Youhua Zhang, Ling Lu, Weijun Wu, Yaohui Gao, Hu Liu, Qiongyi Huang, Qing Wei, Xudong Yao
BACKGROUND: Dysregulation of RNA N6-methyladenosine (m6A) modification is indispensable in tumorigenesis. However, in muscle-invasive bladder cancer (MIBC), the key regulators and mechanisms involved in this process remain largely unknown. This study aimed to screen the key m6A regulators and explore its possible role in MIBC. METHODS: Aberrantly expressed m6A regulator genes were screened in The Cancer Genome Atlas (TCGA) MIBC cohort (n = 408) and validated using fresh-frozen and formalin-fixed paraffin-embedded (FFPE) specimens collected during this study...
2023: Clinical Medicine Insights. Oncology
journal
journal
42907
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.