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Journals Clinical Medicine Insights. Ca...

Clinical Medicine Insights. Cardiology

https://read.qxmd.com/read/38328472/metagenomic-analysis-of-bacterial-microflora-in-dental-and-atherosclerotic-plaques-of-patients-with-internal-carotid-artery-stenosis
#1
JOURNAL ARTICLE
Ayako Sato, Shintaro Arai, Kenji Sumi, Haruka Fukamachi, Satoko Miyake, Manami Ozawa, Mie Myers, Yasubumi Maruoka, Katsuyoshi Shimizu, Tohru Mizutani, Hirotaka Kuwata
BACKGROUND: Internal carotid artery stenosis is primarily attributed to atherosclerosis in the carotid artery bifurcation. Previous studies have detected oral bacteria in atherosclerotic lesions, suggesting an association between oral bacteria and atherosclerosis. In this study, we compared the bacterial flora of the atherosclerotic plaque in the carotid artery and dental plaque of patients with internal carotid artery stenosis using 16S ribosomal RNA (16S rRNA) metagenomic sequencing...
2024: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/38249317/is-there-a-causal-link-between-acute-myocarditis-and-covid-19-vaccination-an-umbrella-review-of-published-systematic-reviews-and-meta-analyses
#2
REVIEW
Amine Bouchlarhem, Soumia Boulouiz, Zakaria Bazid, Nabila Ismaili, Noha El Ouafi
INTRODUCTION: A few months after the beginning of the coronavirus disease of 2019 (COVID-19) vaccination, several reports of myocarditis secondary to the vaccines were published, sometimes with fulminant cases, but until today there is no proven causal link between these 2 events, but with many hypotheses proposed. METHODS: A systematic review of current evidence regarding myocarditis after COVID-19 vaccination was performed by searching several databases including PubMed/Medline and Web of Science...
2024: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/38192356/the-risk-of-left-atrial-appendage-thrombus-in-patients-with-atrial-flutter-versus-atrial-fibrillation
#3
JOURNAL ARTICLE
Gassan Moady, Gal Rubinstein, Loai Mobarki, Alexander Shturman, Tsafrir Or, Shaul Atar
OBJECTIVE: Patients with atrial fibrillation (AF) are at increased risk of thromboembolic events originating mainly from left atrial appendage thrombus (LAAT). Patients with atrial flutter (AFL) are treated with anticoagulation based on the same criteria as patients with AF. However, whether patients with AFL have similar thromboembolic risk as AF is unclear. In the current study we aimed to estimate the prevalence of LAAT in patients with AFL undergoing trans-esophageal echocardiography (TEE)...
2024: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/38143929/comparison-of-inotropes-for-use-with-the-impella-device-in-cardiogenic-shock
#4
JOURNAL ARTICLE
Essilvo Sulejmani, Nathaniel Wayne, Laura Provost, Aaron Chase, Andrea Sikora Newsome
No abstract text is available yet for this article.
2023: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/37637260/a-case-of-pericarditis-and-pericardial-masses-associated-with-mycobacterium-paragordonae
#5
Rehman Jinah, Tammy Ryan, Matthew Sibbald
Tuberculosis is a common cause of pericarditis worldwide and has been associated with pericardial masses. Non-tuberculous mycobacteria are uncommonly associated with cardiac disease, having primarily been described in cases of endocarditis. Here we describe a case of an immunocompetent patient with Mycobacterium paragordonae infection causing pericarditis with a large effusion containing pericardial masses. The patient presented with chest pain, hypoxia and biochemical evidence of inflammation (CRP 216.1 mg/L)...
2023: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/37529084/sex-differences-define-the-vulnerability-to-atherosclerosis
#6
REVIEW
Anastasia V Poznyak, Vasiliy N Sukhorukov, Shuzhen Guo, Anton Y Postnov, Alexander N Orekhov
For several decades, atherosclerosis has attracted the attention of researchers around the world. Even being a major cause of serious cardiovascular disease and events, atherosclerosis is still not fully understood. Despite the fact that the main players in the pathogenesis of atherosclerosis are well known, many mechanisms of their implementation and interactions remain unknown. The same can be said about the risk factors for atherosclerosis. Many of them are known, but exactly how they work remains to be seen...
2023: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/37434790/salt-sensitive-hypertension-mediation-by-salt-induced-hypervolemia-and-phosphate-induced-vascular-calcification
#7
JOURNAL ARTICLE
Ronald B Brown
Preventing hypertension by restricting dietary salt intake, sodium chloride, is well established in public health policy, but a pathophysiological mechanism has yet to explain the controversial clinical finding that some individuals have a greater risk of hypertension from exposure to salt intake, termed salt-sensitive hypertension. The present perspective paper synthesizes interdisciplinary findings from the research literature and offers novel insights proposing that the pathogenesis of salt-sensitive hypertension is mediated by interaction of salt-induced hypervolemia and phosphate-induced vascular calcification...
2023: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/37377539/massive-biventricular-thrombi-in-a-patient-with-endometrial-adenocarcinoma-diagnosed-on-computed-tomography-angiography
#8
Shiva Barforoshi, Justin Sharim, Matthew J Budoff
Biventricular thrombi are a rare clinical entity and only reported in several case reports. Given ventricular thrombi are high risk for cardioembolic events, accurate detection and therapeutic management has an important influence on clinical outcomes. We present a case of a patient with biventricular thrombi that was initially diagnosed on computed tomography angiography, emphasizing its clinical utility as a rapid, non-invasive imaging modality for early detection.
2023: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/37312974/reverse-mcconnell-s-a-sign-of-acute-pulmonary-embolism
#9
Andrew Sagalov, Mukul Bhattarai, Ashley Eggert, Shruti Hegde
Regional right ventricular dysfunction with akinesia of the mid-free wall with normal apical motion known as McConnell's sign is an under-reported echocardiographic finding in the setting of pulmonary embolism. We conducted a literature review and systematic analysis, while describing 2 cases of pulmonary embolism with findings of reverse McConnell's sign.
2023: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/37153696/oxidative-stress-underpins-clinical-social-and-genetic-risk-factors-for-atherosclerotic-cardiovascular-disease
#10
JOURNAL ARTICLE
Emily Mewborn, Ansley Stanfill
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide and is poorly predicted with current risk estimation tools. The biological mechanisms relating ASCVD risk factors to oxidative stress (OS) and how this accumulates ASCVD risk are misunderstood. PURPOSE: To develop a comprehensive conceptual model explaining how expanded clinical, social, and genetic ASCVD risk factors accumulate ASCVD risk through OS. CONCLUSIONS: OS (primarily from excess reactive oxygen species) and inflammation are present along the entire ASCVD pathophysiologic continuum...
2023: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36727115/cardiothyreosis-epidemiological-clinical-and-therapeutic-approach
#11
JOURNAL ARTICLE
Elleuch Mouna, Ben Bnina Molka, Ben Teber Sawssan, Ben Salah Dhoha, Boujelbene Khouloud, Charfi Nadia, Mnif Fatma, Mnif Fatma, Mnif Mouna, Rekik Nabila, Hadj Kacem Faten, Abid Mohamed
INTRODUCTION: Cardiothyreosis corresponds to the cellular effects of free thyroid hormones on the vascular wall and the myocardium. We aim to describe the clinical, para-clinical and therapeutic aspects of cardiothyreosis and to detail prognostic factors. METHODS: We conducted a descriptive retrospective study at the Endocrinology-Diabetology Department of the Hedi Chaker University Hospital in Sfax-Tunisia. We collected medical records of 100 patients with cardiothyreosis between January 1999 and December 2019...
2023: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36601071/a-peek-at-lvads-pumping-to-recovery
#12
JOURNAL ARTICLE
Samiullah Arshad, Rachel D Cutting, Daniel J Stephens, Ythan H Goldberg, Claudius Mahr, Mahender Vyasabattu, Ahmed H Abdelfattah, Gaurang N Vaidya
Left ventricular assist devices (LVADs) have revolutionized the management of patients with advanced heart failure refractory to medical therapy. Current indications of LVADs include Bridge to Transplantation (BTT), Destination Therapy (DT) for long-term use, Bridge to the Decision (BTD) used as a temporary measure, and lastly Bridge to Recovery (BTR). Here, we briefly review the clinical evidence and the molecular mechanisms behind myocardial recovery following LVAD placement. We also share institutional protocols used at 2 major medical centers in the USA...
2022: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36505229/myxedema-coma-a-rare-case-of-shock-post-pericardial-window-procedure
#13
Blerina Asllanaj, Mark Olson, Yi McWhorter
The clinical features of severe hypothyroidism vary in presentation, ranging from subclinical symptoms to multiorgan failure referred to as myxedema coma. The cornerstone treatments of myxedema coma include aggressive thyroid hormone replacement combined with excellent supportive care in the intensive care unit. We report a rare case of a 56-year-old female with history of hypothyroidism treated with levothyroxine, who developed myxedema coma post-pericardial window surgery for a large pericardial effusion...
2022: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36386406/implementing-a-machine-learning-adapted-algorithm-to-identify-possible-transthyretin-amyloid-cardiomyopathy-at-an-academic-medical-center
#14
JOURNAL ARTICLE
Joshua D Mitchell, Daniel J Lenihan, Casey Reed, Ahsan Huda, Kim Nolen, Marianna Bruno, Thomas Kannampallil
BACKGROUND: Wild-type transthyretin amyloid cardiomyopathy (ATTR-CM) is a frequently under-recognized cause of heart failure (HF) in older patients. To improve identification of patients at risk for the disease, we initiated a pilot program in which 9 cardiac/non-cardiac phenotypes and 20 high-performing phenotype combinations predictive of wild-type ATTR-CM were operationalized in electronic health record (EHR) configurations at a large academic medical center. METHODS: Inclusion criteria were age >50 years and HF; exclusion criteria were end-stage renal disease and prior amyloidosis diagnoses...
2022: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36386405/xgboost-a-novel-explainable-ai-technique-in-the-prediction-of-myocardial-infarction-a-uk-biobank-cohort-study
#15
JOURNAL ARTICLE
Alexander Moore, Max Bell
We wanted to assess if "Explainable AI" in the form of extreme gradient boosting (XGBoost) could outperform traditional logistic regression in predicting myocardial infarction (MI) in a large cohort. Two machine learning methods, XGBoost and logistic regression, were compared in predicting risk of MI. The UK Biobank is a population-based prospective cohort including 502 506 volunteers with active consent, aged 40 to 69 years at recruitment from 2006 to 2010. These subjects were followed until end of 2019 and the primary outcome was myocardial infarction...
2022: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36329805/-a-missed-therapeutic-opportunity-sglt-2-inhibitor-use-in-general-medicine-patients-with-heart-failure-a-retrospective-audit-of-admissions-to-a-tertiary-health-service
#16
JOURNAL ARTICLE
Padeepa Perera, Ronan O'Donnabhain, Timothy Fazio, Douglas Johnson, Peter Lange
OBJECTIVE: Sodium-glucose co-transporter-2 inhibitors (SGLT2-I's) are novel oral hypoglycaemic agents, with proven decreased MACE and re-hospitalisation risk in type 2 diabetic patients with concomitant heart failure. This study aimed to assess the current practice in the use of SGLT2-I's in general medical units at a large metropolitan health service. METHODS/RESULTS: A retrospective audit was conducted of patients admitted to general medicine over a 12 month period (between April 2018 and 2019)...
2022: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36187466/heterotaxy-syndrome-with-polysplenia-fused-adrenal-glands-and-diabetes-mellitus
#17
Abid M Sadiq, Adnan M Sadiq
Heterotaxy syndrome is a rare congenital heart disease with a disarrangement of the heart and abdominal organs. We present a young African female with features of heart failure, diffuse irregular cardiac murmurs, and palpable, tender epigastric mass. A chest and abdominal computed tomography (CT) identified heterotaxy syndrome with left isomerism and fused adrenal glands. This case highlights the feature of fused adrenal glands in a patient with polysplenia.
2022: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36060113/prevalence-of-hypertension-in-ghana-analysis-of-an-awareness-and-screening-campaign-in-2019
#18
JOURNAL ARTICLE
Elliot Koranteng Tannor, Obed Ofori Nyarko, Yaw Adu-Boakye, Saabea Owusu Konadu, Gilda Opoku, Frank Ankobea-Kokroe, Mercy Opare-Addo, Lambert Tetteh Appiah, Evans Xorse Amuzu, Gilgal Justice Ansah, Kate Appiah-Boateng, Emmanuel Ofori, Daniel Ansong
Introduction: Hypertension is an important public health menace globally and in sub-Saharan Africa. The prevalence of hypertension is on the rise in low- and lower-middle-income countries (LMIC) such as Ghana. This rise led to the adoption of the May Measurement Month (MMM) initiative, a global blood pressure screening campaign. We aimed to create awareness and present the findings of the 2019 MMM screening campaign in the Ashanti region of Ghana. Methods: Ghana was 1 of 92 countries that participated in this global community-based cross-sectional study in May 2019...
2022: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36046183/vasoactive-biomarkers-in-patients-with-vasovagal-syncope-during-head-up-tilt-test-a-case-control-study
#19
JOURNAL ARTICLE
Cláudia Madeira Miranda, Rose Mary Ferreira Lisboa da Silva, Vanessa Peruhybe-Magalhães, Josep Brugada
BACKGROUND: Vasovagal syncope (VVS) is the most common cause of syncope. Some stages of its pathophysiological mechanisms remain unclear. Vasoactive substances such as nitric oxide metabolites (NOx) and endothelin (ET) may be involved during acute orthostatic stress. OBJECTIVE: To analyze plasma changes in NOx and ET and heart rate variability (HRV) in the supine positions (T1) and during the head-up tilt test (HUTT) (T2), in patients with VVS (case group) and control group...
2022: Clinical Medicine Insights. Cardiology
https://read.qxmd.com/read/36046182/correlation-of-walking-activity-and-cardiac-hospitalizations-in-coronary-patients-for-1%C3%A2-year-post-cardiac-rehabilitation-the-more-steps-the-better
#20
JOURNAL ARTICLE
Sinann Al Najem, Andreas Groll, Axel Schmermund, Bernd Nowak, Thomas Voigtländer, Ulrike Kaltenbach, Peter Dohmann, Dietrich Andresen, Jürgen Scharhag
PROBLEM: Reducing risk by improving fitness is one of the main objectives of cardiac rehabilitation (CR). To estimate how the number of steps/day post-CR affects coronary patients' prognosis, we analyzed its correlation with the occurrence of death, hospitalizations, and heart complaints, and if and how other variables (ejection fraction (EF), gender, age) relate to those. METHODS: One hundred eleven patients (male = 91, female = 20; average age ± standard deviation (SD): 61 ± 11 years) who had been in CR due to recent coronary revascularization or chronic coronary syndrome could be enrolled...
2022: Clinical Medicine Insights. Cardiology
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