Daniela Martinez-Chapoy, Francisco J Cruz-Arroyo, Francisco D Ancer-Leal, Regina A Rodriguez-Leal, Bianka D Camacho-Zamora, Daniela A Guzman-Sanchez, Nelly A Espinoza-Gonzalez, Lizeth Martinez-Jacobo, Ivan A Marino-Martinez
Genetics is responsible for 80% of androgenetic alopecia (AGA) predisposition. Several single nucleotide polymorphisms (SNPs) have been linked to AGA risk and the metabolism of its first-line therapies. Genotypic and allelic frequencies have not been described in Mexican individuals; therefore, the aim of this study was to describe the genetic distribution of SNPs associated with AGA predisposition and drug metabolism. Using Real Time-PCR, we genotyped SNPs rs4827528 ( AR ), rs7680591 ( FGF 5), rs1042028, rs1042157, rs788068 and rs6839 ( SULT 1 A 1) and rs776746 ( CYP 3 A 5) in 125 (controls = 60, cases = 65) male volunteers from Northern and Western Mexico...
2022: International Journal of Molecular Epidemiology and Genetics