Sydney J Risen, Sean W Boland, Sadhana Sharma, Grace M Weisman, Payton M Shirley, Amanda S Latham, Arielle J D Hay, Vincenzo S Gilberto, Amelia D Hines, Stephen Brindley, Jared M Brown, Stephanie McGrath, Anushree Chatterjee, Prashant Nagpal, Julie A Moreno
Neuroinflammation plays a crucial role in the development of neurodegenerative protein misfolding disorders. This category of progressive diseases includes, but is not limited to, Alzheimer's disease, Parkinson's disease, and prion diseases. Shared pathogenesis involves the accumulation of misfolded proteins, chronic neuroinflammation, and synaptic dysfunction, ultimately leading to irreversible neuronal loss, measurable cognitive deficits, and death. Presently, there are few to no effective treatments to halt the advancement of neurodegenerative diseases...
March 20, 2024: ACS Chemical Neuroscience