journal
https://read.qxmd.com/read/38592819/a-convenient-protonated-strategy-for-constructing-nanodrugs-from-hydrophobic-drug-inhibitor-conjugates-to-reverse-tumor-multidrug-resistance
#21
JOURNAL ARTICLE
Penghui Wang, Yuling Wang, Xuelin Xia, Jingchun Wu, Jintang Lin, Wei Huang, Deyue Yan
Combination therapy has proven effective in counteracting tumor multidrug resistance (MDR). However, the pharmacokinetic differences among various drugs and inherent water insolubility for most small molecule agents greatly hinder their synergistic effects, which makes the delivery of drugs for combination therapy in vivo a key problem. Herein, we propose a protonated strategy to transform a water-insoluble small molecule drug-inhibitor conjugate into an amphiphilic one, which then self-assembles into nanoparticles for co-delivery in vivo to overcome tumor MDR...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38592744/genetically-engineered-cell-derived-nanovesicles-for-cancer-immunotherapy
#22
REVIEW
Shan He, Zongmin Zhao
The emergence of immunotherapy has marked a new epoch in cancer treatment, presenting substantial clinical benefits. Extracellular vesicles (EVs), as natural nanocarriers, can deliver biologically active agents in cancer therapy with their inherent biocompatibility and negligible immunogenicity. However, natural EVs have limitations such as inadequate targeting capability, low loading efficacy, and unpredictable side effects. Through progress in genetic engineering, EVs have been modified for enhanced delivery of immunomodulatory agents and antigen presentation with specific cancer targeting ability, deepening the role of EVs in cancer immunotherapy...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38592739/self-assembly-of-water-filled-molecular-saddles-to-generate-diverse-morphologies-and-high-proton-conductivity
#23
JOURNAL ARTICLE
Nyaya Prakash Pradhan, Sweety Gupta, Swapnendu Narayan Ghosh, Amit Paul, Santanu Talukder, Aasheesh Srivastava
The design of single-component organic compounds acting as efficient solid-state proton conduction (SSPC) materials has been gaining significant traction in recent times. Molecular design and controlled self-assembly are critical components in achieving highly efficient SSPC. In this work, we report the design, synthesis, and self-assembly of an organic macrocyclic aza-crown-type compound, P2Mac, which complements synthetic ease with efficient SSPC. P2Mac is derived from the pyridine-2,6-dicarboxamide (PDC) framework and contains polar amide and amine residues in its inner region, while aromatic residues occupy the periphery of the macrocycle...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38592716/optical-color-routing-enabled-by-deep-learning
#24
REVIEW
Shijie Xiong, Xianguang Yang
Nano-color routing has emerged as an immensely popular and widely discussed subject in the realms of light field manipulation, image sensing, and the integration of deep learning. The conventional dye filters employed in commercial applications have long been hampered by several limitations, including subpar signal-to-noise ratio, restricted upper bounds on optical efficiency, and challenges associated with miniaturization. Nonetheless, the advent of bandpass-free color routing has opened up unprecedented avenues for achieving remarkable optical spectral efficiency and operation at sub-wavelength scales within the area of image sensing applications...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38592692/role-of-the-zno-electron-transport-layer-in-pbs-colloidal-quantum-dot-solar-cell-yield
#25
REVIEW
Arlene Chiu, Chengchangfeng Lu, Dana E Kachman, Eric Rong, Sreyas M Chintapalli, Yida Lin, Daniel Khurgin, Susanna M Thon
The development of lead sulfide (PbS) colloidal quantum dot (CQD) solar cells has led to significant power conversion efficiency (PCE) improvements in recent years, with record efficiencies now over 15%. Many of the recent advances in improving PCE have focused on improving the interface between the PbS CQD active layer and the zinc oxide (ZnO) electron transport layer (ETL). Proper optimization of the ZnO ETL also increases yield, or the percentage of functioning devices per fabrication run. Simultaneous improvements in both PCE and yield will be critical as the field approaches commercialization...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38591730/origami-nanogap-electrodes-for-reversible-nanoparticle-trapping
#26
JOURNAL ARTICLE
Itir Bakis Dogru-Yuksel, Allard P Mosk, Sanli Faez
We present a facile desktop fabrication method for origami-based nanogap indium tin oxide (ITO) electrokinetic particle traps, providing a simplified approach compared to traditional lithographic techniques and effective trapping of nanoparticles. Our approach involves bending ITO thin films on optically transparent polyethylene terephthalate (PET), creating an array of parallel nanogaps. By strategically introducing weak points through cut-sharp edges, we successfully controlled the spread of nanocracks. A single crack spanning the constriction width and splitting the conductive layers forms a nanogap that can effectively trap small nanoparticles after applying an alternating electric potential across the nanogap...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38591642/blue-sensitive-sub-band-gap-negative-photoconductance-in-sno-2-tio-2-np-bilayer-oxide-transistor
#27
JOURNAL ARTICLE
Utkarsh Pandey, Nila Pal, Arpan Ghosh, Swati Suman, Sajal Biring, Bhola N Pal
Large negative photoconductance (NPC) of SnO2 /TiO2 nanoparticles (NPs) heterostructure has been observed with thin film transistor (TFT) geometry and has been investigated using sub-bandgap light (blue) illumination. This negative photoconduction has been detected both in accumulation and depletion mode operation, which effectively reduces the carrier mobility ( μ ) of the TFT. Moreover, the threshold voltage ( V th ) widely shifted in the positive direction under illumination. The combined effects of the reduction of mobility and V th shifting led to a faster reduction of On (or Off) state current under illumination...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38591601/nanoscale-assembly-of-enantiomeric-supramolecular-gels-driven-by-the-nature-of-solvents
#28
JOURNAL ARTICLE
Tómas A Gudmundsson, Geethanjali Kuppadakkath, Dipankar Ghosh, Manuel Ruether, Annela Seddon, Rebecca E Ginesi, James Doutch, Dave J Adams, Thorfinnur Gunnlaugsson, Krishna K Damodaran
Understanding the key parameters that control the self-assembly process is critical to predict self-assembly modes in multi-component systems, which will lead to the development of nanofibrous materials with tuneable properties. Enantiomeric amino acid-based low-molecular-weight gelators (LMWGs) were mixed in polar (polar protic) and aromatic apolar (aromatic) solvents and compared to their individual counterparts to probe the effect of solvent polarity on the self-assembly process. Scanning electron microscopy (SEM) reveals that xerogels of individual components display hollow needles in polar protic solvents, while chiral coils are observed in aromatic solvents...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38591112/synthesis-of-tunable-thickness-to-diameter-ratio-microcapsules-via-a-diffusion-controlled-process-for-temperature-responsive-release
#29
JOURNAL ARTICLE
Jinshun Zhao, Chun Li, Jiayang Sui, Tong Feng, Chonghui Li, Lifei Liu, Huimin Xue, Weizhen Zhao, Xuhuang Chen
Designing microcapsules with a complicated functionalized shell to respond to an external stimulus has attracted much attention for triggered release; however, simplifying the synthesis process remains a significant challenge. Herein, we initially propose a novel, simple synthesis strategy that utilizes a mixed solvent as the organic phase to control the diffusion of common monomers during interfacial polymerization, resulting in the successful preparation of microcapsules with tunable thickness-to-diameter ratios ( T / D )...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38591110/a-photo-responsive-self-healing-hydrogel-loaded-with-immunoadjuvants-and-mos-2-nanosheets-for-combating-post-resection-breast-cancer-recurrence
#30
JOURNAL ARTICLE
Siyu Wang, Zhuoping Qian, Huaxin Xiao, Guangwen Yang, Ziyi Zhu, Yubin Gu, Junjie Song, Xin Zhang, Xinxuan Huang, Lixing Weng, Yu Gao, Wenjing Yang, Lianhui Wang
Tumor recurrence after surgical resection remains a significant challenge in breast cancer treatment. Immune checkpoint blockade therapy, as a promising alternative therapy, faces limitations in combating tumor recurrence due to the low immune response rate. In this study, we developed an implantable photo-responsive self-healing hydrogel loaded with MoS2 nanosheets and the immunoadjuvant R837 (PVA-MoS2 -R837, PMR hydrogel) for in situ generation of tumor-associated antigens at the post-surgical site of the primary tumor, enabling sustained and effective activation of the immune response...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38591108/light-driven-dynamical-tuning-of-the-thermal-conductivity-in-ferroelectrics
#31
JOURNAL ARTICLE
Claudio Cazorla, Sebastian Bichelmaier, Carlos Escorihuela-Sayalero, Jorge Íñiguez, Jesús Carrete, Riccardo Rurali
Dynamical tuning of the thermal conductivity in crystals, κ , is critical for thermal management applications, as well as for energy harvesting and the development of novel phononic devices able to perform logic operations with phonons. Such a desired κ control can be achieved in functional materials that experience large structural and phonon variations as a result of field-induced phase transformations. However, this approach is only practical within reduced temperature intervals containing zero-bias phase transition points, since otherwise the necessary driving fields become excessively large and the materials' performances are detrimentally affected...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38590267/morphology-does-not-matter-wse-2-luminescence-nanothermometry-unravelled
#32
JOURNAL ARTICLE
Paloma Martínez-Merino, Miguel A Hernández-Rodríguez, José C Piñero, Carlos D S Brites, Rodrigo Alcántara, Javier Navas
Transition metal dichalcogenides, including WSe2 , have gained significant attention as promising nanomaterials for various applications due to their unique properties. In this study, we explore the temperature-dependent photoluminescent properties of WSe2 nanomaterials to investigate their potential as luminescent nanothermometers. We compare the performance of WSe2 quantum dots and nanorods synthesized using sonication synthesis and hot injection methods. Our results show a distinct temperature dependence of the photoluminescence, and conventional ratiometric luminescence thermometry demonstrates comparable relative thermal sensitivity (0...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38590261/a-ros-storm-generating-nanocomposite-for-enhanced-chemodynamic-therapy-through-h-2-o-2-self-supply-gsh-depletion-and-calcium-overload
#33
JOURNAL ARTICLE
Yong Li, Jing Wang, Tao Zhu, Ying Zhan, Xiaoli Tang, Jianying Xi, Xiaohui Zhu, Yong Zhang, Jinliang Liu
Catalytic generation of toxic hydroxyl radicals (˙OH) from hydrogen peroxide (H2 O2 ) is an effective strategy for tumor treatment in chemodynamic therapy (CDT). However, the intrinsic features of the microenvironment in solid tumors, characterized by limited H2 O2 and overexpressed glutathione (GSH), severely impede the accumulation of intracellular ˙OH, posing significant challenges. To circumvent these critical issues, in this work, a CaO2 -based multifunctional nanocomposite with a surface coating of Cu2+ and L-buthionine sulfoximine (BSO) (named CaO2 @Cu-BSO) is designed for enhanced CDT...
April 9, 2024: Nanoscale
https://read.qxmd.com/read/38587499/high-entropy-based-nano-materials-for-sustainable-environmental-applications
#34
REVIEW
Shubhasikha Das, Shamik Chowdhury, Chandra Sekhar Tiwary
High entropy materials (HEMs), epitomized by high entropy alloys (HEAs), have sparked immense interest for a range of clean energy and environmental applications due to their remarkable structural versatility and adjustable characteristics. In the face of environmental challenges, HEMs have emerged as valuable tools for addressing issues ranging from wastewater remediation to energy conversion and storage. This review provides a comprehensive exploration of HEMs, spotlighting their catalytic capabilities in diverse redox reactions, such as carbon dioxide reduction to value-added products, degradation of organic pollutants, oxygen reduction, hydrogen evolution, and ammonia decomposition using electrocatalytic and photocatalytic pathways...
April 8, 2024: Nanoscale
https://read.qxmd.com/read/38584466/cell-membrane-coated-nanoparticles-cutting-edge-drug-delivery-systems-for-osteoporosis-therapy
#35
REVIEW
Jiewen Liao, Li Lu, Xiangyu Chu, Yuan Xiong, Wu Zhou, Faqi Cao, Peng Cheng, Mohammad-Ali Shahbazi, Guohui Liu, Bobin Mi
Osteoporosis, characterized by a reduction in bone mineral density, represents a prevalent skeletal disorder with substantial global health implications. Conventional therapeutic strategies, exemplified by bisphosphonates and hormone replacement regimens, though effective, encounter inherent limitations and challenges. Recent years have witnessed the surge of cell-membrane-coated nanoparticles (CMNPs) as a promising intervention for osteoporosis, leveraging their distinct attributes including refined biocompatibility, heightened pharmaceutical payload capacity, as well as targeted drug release kinetics...
April 8, 2024: Nanoscale
https://read.qxmd.com/read/38578632/bamboo-like-nitrogen-doped-carbon-supported-chlorine-doped-fe-2-p-as-an-antibacterial-oxygen-reduction-catalyst
#36
JOURNAL ARTICLE
Kai Cheng, Demin Jiang, Sainan Cai, Shikuo Li, Yuqiao Wang
Bio-inspiration and biomimetics offer guidance for designing and synthesizing advanced catalysts for the oxygen reduction reaction (ORR) in microbial fuel cells (MFCs). Herein, a chlorine-doped Fe2 P supported by nitrogen-doped carbon (Cl-Fe2 P/NC) catalyst was designed and prepared based on imitating the bamboo structure. The electronegative chlorine captured the electron transfer from Fe2 P and transferred it to NC through carbon nanotubes (CNTs). The antibacterial chlorine inhibited the cathode biofilm formation to enhance the ion transport...
April 5, 2024: Nanoscale
https://read.qxmd.com/read/38577747/research-on-the-energy-storage-performance-of-laminated-composites-based-on-multidimensional-co-design-in-a-broad-temperature-range
#37
JOURNAL ARTICLE
Yipeng Tan, Jiayu Deng, Hang Gao, Ziwen Feng, Linfei Lu, Jiheng Wang, Zhongbin Pan, Lingmin Yao, Qinglin Deng
Polymer dielectrics play an irreplaceable role in electronic power systems because of their high power density and fast charge-discharge capability, but it is limited by their low stability in the temperature range of 25-200 °C. Rather than the introduction of one-dimensional fillers in polymers, we used a kind of multidimensional synergistic design to prepare Al2 O3 -TiO2 -Al2 O3 /PI composites with layered structures by introducing multi-dimensional materials in polyimide (PI). In fact, the composite achieves much higher temperature stability than the pure PI film...
April 5, 2024: Nanoscale
https://read.qxmd.com/read/38577736/optical-gain-and-entanglement-through-dielectric-confinement-and-electric-field-in-inp-quantum-dots
#38
JOURNAL ARTICLE
Christos S Garoufalis, David B Hayrapetyan, Hayk A Sarkisyan, Paytsar A Mantashyan, Zaiping Zeng, Iosif Galanakis, Gabriel Bester, Torben Steenbock, Sotirios Baskoutas
Quantum dots are widely recognized for their advantageous light-emitting properties. Their excitonic fine structure along with the high quantum yields offers a wide range of possibilities for technological applications. However, especially for the case of colloidal QDs, there are still characteristics and properties which are not adequately controlled and downgrade their performance for applications which go far beyond the simple light emission. Such a challenging task is the ability to manipulate the energetic ordering of exciton and biexciton emission and subsequently control phenomena such as Auger recombination, optical gain and photon entanglement...
April 5, 2024: Nanoscale
https://read.qxmd.com/read/38572999/orientation-and-morphology-control-in-acid-catalyzed-covalent-organic-framework-thin-films
#39
JOURNAL ARTICLE
Dayanni D Bhagwandin, Kirt A Page, Ly D Tran, Yao Yao, Alexander Reidell, Christopher Muratore, Qiyi Fang, Aleksey Ruditskiy, Cheri M Hampton, W Joshua Kennedy, Lawrence F Drummy, Yu Zhong, Tobin J Marks, Antonio Facchetti, Jun Lou, Hilmar Koerner, Luke A Baldwin, Nicholas R Glavin
As thin films of semiconducting covalent organic frameworks (COFs) are demonstrating utility for ambipolar electronics, channel materials in organic electrochemical transistors (OECTs), and broadband photodetectors, control and modulation of their thin film properties is paramount. In this work, an interfacial growth technique is utilized to synthesize imine TAPB-PDA COF films at both the liquid-liquid interface as well as at the liquid-solid interface on a Si/SiO2 substrate. The concentration of acetic acid catalyst in the aqueous phase is shown to significantly influence the thin film morphology of the liquid-solid growth, with concentrations below 1 M resulting in no film nucleation, concentrations of 1-4 M enabling smooth film formation, and concentrations greater than 4 M resulting in films with a higher density of particulates on the surface...
April 4, 2024: Nanoscale
https://read.qxmd.com/read/38572762/enzyme-mimic-catalytic-activities-and-biomedical-applications-of-noble-metal-nanoclusters
#40
REVIEW
Xinxin Pan, Yidan Yao, Manxi Zhang, Xun Yuan, Qiaofeng Yao, Wenping Hu
Noble metal ( e.g. , Au and Ag) nanoclusters (NCs), which exhibit structural complexity and hierarchy comparable to those of natural proteins, have been increasingly pursued in artificial enzyme research. The protein-like structure of metal NCs not only ensures enzyme-mimic catalytic activity, including peroxidase-, catalase-, and superoxide dismutase-mimic activities, but also affords an unprecedented opportunity to correlate the catalytic performance with the cluster structure at the molecular or atomic levels...
April 4, 2024: Nanoscale
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