Li Zhang, Dawei Fu, Pavel V Belichenko, Chunhong Liu, Alexander M Kleschevnikov, Annie Pao, Ping Liang, Steven J Clapcote, William C Mobley, Y Eugene Yu
Human trisomy 21 is the most frequent live-born human aneuploidy and causes a constellation of disease phenotypes classified as Down syndrome, which include heart defects, myeloproliferative disorder, cognitive disabilities and Alzheimer-type neurodegeneration. Because these phenotypes are associated with an extra copy of a human chromosome, the genetic analysis of Down syndrome has been a major challenge. To complement human genetic approaches, mouse models have been generated and analyzed based on evolutionary conservation between the human and mouse genomes...
January 1, 2012: Bioengineered Bugs