journal
https://read.qxmd.com/read/38529362/efficacy-and-predictive-factors-of-oral-spironolactone-treatment-in-chronic-central-serous-chorioretinopathy
#1
JOURNAL ARTICLE
Sheng Gao, Yun Zhang, Meixia Zhang
PURPOSE: To evaluate the efficacy of spironolactone in the treatment of chronic central serous chorioretinopathy (CSC) and identify imaging characteristics that can predict the benefit of spironolactone treatment. METHODS: Patients with chronic CSC were treated with spironolactone (20 mg/tid) and followed for 6 months. The primary outcome measure was complete resolution of the subretinal fluid (SRF), and the best-corrected visual acuity (BCVA), the SRF area, the central macular thickness (CMT), the subfoveal choroidal thickness (SFCT), and the density of the choriocapillaris vessel and adverse events were secondary outcome measures...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38500553/correlations-between-steady-state-pattern-electroretinogram-and-humphrey-visual-field-analyzer-global-indices-and-their-associations-with-retinal-ganglion-cell-layer-inner-plexiform-layer-thickness-in-glaucoma-suspects
#2
JOURNAL ARTICLE
Andrew Tirsi, Vasiliki Gliagias, Daniel Zhu, Benny Wong, Rohun Gupta, Sung Chul Park, Stephen Obstbaum, Celso Tello
PURPOSE: The purpose of this study was to investigate the utility of steady state pattern electroretinogram (ss-PERG) in detecting retinal ganglion cell (RGC) dysfunction in glaucoma suspects (GS) who had normal 24-2 Humphrey Visual Fields (HFA). MATERIALS AND METHODS: This was a prospective cohort study of GS patients who were identified based on optic disc appearance with normal HFAs. Patients received a complete eye examination, standard automated perimetry (SAP), optical coherence tomography (OCT), and ss-PERG measurements...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38495222/microsurgical-vitrectomy-with-pars-plana-incision-for-the-removal-of-posterior-segment-intraocular-foreign-bodies
#3
JOURNAL ARTICLE
Xin Liu, Meng Meng Ji, Ling Jin, Ai Ping Zeng
This study describes a pars plana incision surgical technique combined with 23 or 25-gauge vitrectomy in the management of intraocular foreign bodies (IOFBs) and to assess its anatomical and functional results. Sixteen patients with ocular trauma complicated with IOFB were enrolled in our study. The mean preoperative visual acuity was 2.01 ± 0.55 LogMAR, and the mean postoperative visual acuity at the final visit was improved to 0.91 ± 0.58 LogMAR ( p < 0.001). Until the last follow-up, all IOFBs were successfully removed and anatomic success was obtained...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38468717/mutational-profile-and-retinal-phenotypes-of-pcare-related-cone-rod-dystrophies-in-a-mexican-cohort
#4
JOURNAL ARTICLE
Víctor R López-Rodríguez, Rocío Arce-González, Alan Martínez-Aguilar, Carlos E Rodríguez-López, Sergio Groman-Lupa, M Isabel Neria-González, Genaro Rodríguez-Uribe, Juan C Zenteno
PURPOSE: The aim of the study is to describe the genotype and phenotype of a Mexican cohort with PCARE -related retinal disease. METHODS: The study included 14 patients from 11 unrelated pedigrees with retinal dystrophies who were demonstrated to carry biallelic pathogenic variants in PCARE . Visual assessment methods included best corrected visual acuity, color fundus photography, Goldmann visual field test, kinetic perimetry, dark/light adapted chromatic perimetry, full-field electroretinography, autofluorescence imaging, and spectral domain-optical coherence tomography imaging...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38456099/advanced-periocular-basal-cell-carcinoma-with-orbital-invasion-update-on-management-and-treatment-advances
#5
JOURNAL ARTICLE
Alvaro Bengoa-González, Enrique Mencía-Gutiérrez, María Garrido, Elena Salvador, María-Dolores Lago-Llinás
PURPOSE: Basal cell carcinoma (BCC) is the most frequent malignant periocular tumor. It is associated with exposure to ultraviolet radiation, and its incidence is gradually increasing. It may occasionally display more aggressive behavior and result in orbital or intracranial invasion. Mortality from periocular BBC with orbital invasion is very low, but the associated morbidity can be significant, from disfigurement to blindness. Traditionally, these cases have been treated with orbital exenteration or with radiotherapy (RT), but in recent years, hedgehog pathway inhibitors (HPIs) have emerged, are effective in more serious cases, and are used primarily or combined with surgery, changing our perspective on the management of these patients...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38449717/association-between-axial-length-to-corneal-curvature-radius-ratio-and-myopia-in-adult-patients
#6
JOURNAL ARTICLE
Yanyun Fan, Yikeng Huang, Xionggao Huang
PURPOSE: To analyze the distribution characteristics of axial length to corneal curvature radius ratio (AL/CR) and other ocular biometric parameters in adult myopia patients and their association with myopia. METHODS: A cross-sectional study was conducted among patients with no eye diseases except ametropia who attended the optometry clinic of the First Affiliated Hospital of Hainan Medical College from January 2022 to June 2022. In total, 187 eyes (right eye) of 187 myopic patients aged 18-35 years were selected by random sampling...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38445101/longitudinal-rates-of-change-in-structural-parameters-of-optical-coherence-tomography-in-primary-angle-closure-glaucoma-following-laser-iridotomy-along-with-peripheral-iridoplasty
#7
JOURNAL ARTICLE
Hyun-Kyung Cho, Changwon Kee
BACKGROUND: This study aimed to investigate longitudinal rates of change (LRCs) of structural parameters from optical coherence tomography (OCT) in patients with primary angle closure glaucoma (PACG) after laser iridotomy (LI) along with laser peripheral iridoplasty (PI). METHODS: Among 146 patients diagnosed with PACG, thirty-two subjects (32 eyes) who underwent LI plus PI and accomplished more than five times of reliable OCT tests were included in the current retrospective study...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38379662/transcanthal-canthopexy-for-involutional-lower-eyelid-entropion-corrects-horizontal-laxity
#8
JOURNAL ARTICLE
Shinjiro Kono, Motohiro Kamei
In this prospective observational study, we aimed to examine improvements in horizontal laxity after lower eyelid retractor advancement and transcanthal canthopexy for involutional lower eyelid entropion. The study included 19 sides in 15 patients with involutional entropion who underwent transcanthal canthopexy with the advancement of the lower eyelid retractor. Using the pinch test, the distance from the lowest part of the corneal limbus to the eyelid margin was measured using callipers. All measurements were performed preoperatively and at postoperative 3 and 6 months...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38370869/clinical-and-imaging-characteristics-of-metastatic-orbital-tumours-in-north-china
#9
JOURNAL ARTICLE
Yun Zhao, Shasha Yu, Mengxia Mu, Jiagen Li, Hongxun Li, Hong Zhao
PURPOSE: This study was designed to review the primary sites, clinical manifestations, imaging features, treatments, and outcomes of 36 patients with orbital metastasis in North China. METHODS: This was a retrospective review of 36 patients with orbital metastasis at Tianjin Eye Hospital between January 2010 and December 2020 in North China as well as a review of the literature. RESULTS: Thirty-six patients were included in the study; 17 were male, and 19 were female, with an age range of 1-82 years (average 54...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38333732/efficacy-of-2-hydroxypropyl-methylcellulose-and-bandage-contact-lens-for-the-management-of-dry-eye-disease-after-cataract-surgery
#10
JOURNAL ARTICLE
Tianyao Zhao, Xiaodan Jiang, Ran Hao, Yi Ding, Dalan Jing, Xuemin Li
OBJECTIVES: To investigate the effect of 2% hydroxypropyl methylcellulose (HPMC) and bandage contact lens (BCL) on dry eye disease after cataract surgery. METHODS: This prospective randomized controlled trial included 63 eyes which were divided into the balanced salt solution (BSS), HPMC, BCL, and combined HPMC and BCL (H&B) groups. The Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), and average tear break-up time were measured before cataract surgery and 30 days postoperatively...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38322501/the-effect-of-a-loading-dose-regimen-in-the-switch-to-brolucizumab-for-patients-with-aflibercept-resistant-namd
#11
JOURNAL ARTICLE
Hiroyuki Kamao, Erika Mitsui, Yuto Date, Katsutoshi Goto, Kenichi Mizukawa, Atsushi Miki
PURPOSE: To evaluate the one-year outcomes of switching to brolucizumab with and without a loading dose regimen (three monthly injections) in eyes with aflibercept-resistant neovascular age-related macular degeneration (nAMD). METHODS: We retrospectively studied nAMD patients who had retinal exudate under bimonthly injections of aflibercept and were switched to brolucizumab from aflibercept. Patients were grouped into intravitreal brolucizumab injection (IVBr) with a loading dose regimen (loading group) and without a loading dose regimen (nonloading group)...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38322500/congenital-malformations-of-the-eye-a-pictorial-review-and-clinico-radiological-correlations
#12
REVIEW
Alessia Guarnera, Paola Valente, Luca Pasquini, Giulia Moltoni, Francesco Randisi, Chiara Carducci, Alessia Carboni, Giulia Lucignani, Antonio Napolitano, Antonino Romanzo, Daniela Longo, Carlo Gandolfo, Maria Camilla Rossi-Espagnet
Congenital malformations of the eye represent a wide and heterogeneous spectrum of abnormalities that may be part of a complex syndrome or be isolated. Ocular malformation severity depends on the timing of the causative event during eye formation, ranging from the complete absence of the eye if injury occurs during the first weeks of gestation, to subtle abnormalities if the cause occurs later on. Knowledge of ocular malformations is crucial to performing a tailored imaging protocol and correctly reporting imaging findings...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38304290/long-term-surgical-outcomes-of-glaucoma-drainage-implants-in-eyes-with-preoperative-intraocular-pressure-less-than-19%C3%A2-mmhg
#13
JOURNAL ARTICLE
Shahin Hallaj, Jae-Chiang Wong, Lauren E Hock, Natasha Nayak Kolomeyer, Aakriti G Shukla, Michael J Pro, Marlene R Moster, Jonathan S Myers, Reza Razeghinejad, Daniel Lee
BACKGROUND: This retrospective review reports on patients who underwent glaucoma drainage implant (GDI) surgery and had baseline intraocular pressure (IOP) of ≤18 mmHg with at least one year of follow-up. METHODS: Clinical data of 67 eyes of 67 patients were collected from patients' charts, and the outcomes of GDI were evaluated until 7 years. GDI failure was defined as IOP reduction of less than 20% from the baseline at two consecutive visits three months after surgery, decline to no light perception, or if additional glaucoma surgery was performed...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38282962/long-term-visual-quality-and-pupil-changes-after-small-incision-lenticule-extraction-for-eyes-without-preoperative-cylinder-refraction
#14
JOURNAL ARTICLE
Xiaonan Yang, Qiting Feng, Quan Liu, Jianhui Chen, Pengxia Wan
PURPOSE: To investigate the long-term changes in visual quality and pupil size after small incision lenticule extraction (SMILE) for eyes without preoperative cylinder refraction. METHODS: Thirty-three myopic eyes (33 patients) without preoperative cylinder refraction were corrected using SMILE. Refractive outcomes, corneal curvature, aberrations, contrast sensitivity (CS), and pupil diameter were evaluated preoperatively, and 30 months postoperatively. RESULTS: The 30-month postoperative uncorrected and corrected distance visual acuity (UDVA and CDVA, LogMAR) were -0...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38282961/mir-26a-5p-attenuates-oxidative-stress-and-inflammation-in-diabetic-retinopathy-through-the-usp14-nf-%C3%AE%C2%BA-b-signaling-pathway
#15
JOURNAL ARTICLE
Jie Bian, Weizhong Ge, Zhengmei Jiang
PURPOSE: Diabetic retinopathy (DR) is an ocular disease caused by diabetes and may lead to vision impairment and even blindness. Oxidative stress and inflammation are two key pathogenic factors of DR. Recently, regulatory roles of different microRNAs (miRNAs) in DR have been widely verified. miR-26a-5p has been confirmed to be a potential biomarker of DR. Nevertheless, the specific functions of miR-26a-5p in DR are still unclear. METHODS: Primary cultured mouse retinal Müller cells in exposure to high glucose (HG) were used to establish an in vitro DR model...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38264273/accommodation-and-binocular-vision-in-children-with-myopic-anisometropia
#16
JOURNAL ARTICLE
Chu-Chu Zhuang, Ling Zhang, Shan-Shan Pan, Yi-Ning Wang, Jian-Xin Guo
PURPOSE: To assess the differences in accommodation and binocular vision in children with myopic anisometropia and determine the correlation with anisometropia. METHOD: A total of 110 patients with myopia aged 8-15 years were recruited from June 2021 to February 2022 from the Affiliated Hospital of Xuzhou Medical University. Based on the interocular differences of spherical equivalent refraction, patients were divided into the isometropia (35 children), low anisometropia (LA group, 42 children), and high anisometropia (HA group, 33 children)...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38250183/changes-in-corneal-higher-order-aberrations-and-ocular-biometric-measurements-after-phacoemulsification-combined-with-goniosynechialysis-in-primary-angle-closure-glaucoma-patients
#17
JOURNAL ARTICLE
Jiali Xia, Siqi Guo, Fei Hu, Liqi Fan, Ling Yu, Jian Ye
PURPOSE: To compare corneal higher-order aberrations (HOAs), refractive error, and ocular biological parameters before and after phacoemulsification combined with goniosynechialysis (Phaco-GSL) in primary angle closure/glaucoma (PAC/PACG) patients with different axial lengths (ALs). METHODS: In this prospective study, cataract patients diagnosed with PAC/PACG were categorized into two groups based on their ALs: the short AL group (AL ≤ 22.5 mm) and the normal AL group (22...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38205100/the-relationship-between-complements-and-age-related-macular-degeneration-and-its-pathogenesis
#18
REVIEW
Liyuan Chu, Chaoran Bi, Caiming Wang, Hongyan Zhou
Age-related macular degeneration is a retinal disease that causes permanent loss of central vision in people over the age of 65. Its pathogenesis may be related to mitochondrial dysfunction, inflammation, apoptosis, autophagy, complement, intestinal flora, and lipid disorders. In addition, the patient's genes, age, gender, cardiovascular disease, unhealthy diet, and living habits may also be risk factors for this disease. Complement proteins are widely distributed in serum and tissue fluid. In the early 21st century, a connection was found between the complement cascade and age-related macular degeneration...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38205099/corneal-epithelial-thickness-mapping-a-major-review
#19
REVIEW
Mohammad-Ali Abtahi, Amir Hushang Beheshtnejad, Golshan Latifi, Marjan Akbari-Kamrani, Sadegh Ghafarian, Ahmad Masoomi, Seyed Ali Sonbolastan, Hamidreaza Jahanbani-Ardakani, Mehrnaz Atighechian, Laleh Banan, Hosein Nouri, Seyed-Hossein Abtahi
The corneal epithelium (CE) is the outermost layer of the cornea with constant turnover, relative stability, remarkable plasticity, and compensatory properties to mask alterations in the underlying stroma. The advent of quantitative imaging modalities capable of producing epithelial thickness mapping (ETM) has made it possible to characterize better the different patterns of epithelial remodeling. In this comprehensive synthesis, we reviewed all available data on ETM with different methods, including very high-frequency ultrasound (VHF-US) and spectral-domain optical coherence tomography (SD-OCT) in normal individuals, corneal or systemic diseases, and corneal surgical scenarios...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38187496/modulation-of-hypoxia-inducible-factors-and-vascular-endothelial-growth-factor-expressions-by-superfood-camu-camu-myrciaria-dubia-treatment-in-arpe-19-and-fetal-human-rpe-cells
#20
JOURNAL ARTICLE
Ayaka Nakai, Deokho Lee, Chiho Shoda, Kazuno Negishi, Hiroyuki Nakashizuka, Satoru Yamagami, Toshihide Kurihara
BACKGROUND: Anti-vascular endothelial growth factor (anti-VEGF) therapy via intravitreal injection is an effective treatment for patients with abnormal ocular neovascularization, such as age-related macular degeneration (AMD) and diabetic macular edema (DME). However, prolonged and frequent anti-VEGF treatment is associated with a risk of local and systemic adverse events, including geographic atrophy, cerebrovascular disease, and death. Furthermore, some patients do not adequately respond to anti-VEGF therapy...
2023: Journal of Ophthalmology
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