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Journal of Tropical Medicine

Artitaya Thiengsusuk, Phunuch Muhamad, Wanna Chaijaroenkul, Kesara Na-Bangchang
Malaria remains a public health problem in tropical and subtropical regions. Resistance of Plasmodium falciparum to artemisinins in Southeast Asia is a great concern for disease control and research on discovery and development of new alternative antimalarial drugs is urgently required. In a previous study, the fruit of Piper chaba Hunt. was demonstrated to exhibit promising antimalarial activity against the asexual stage of 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) P. falciparum clones. The aim of the present study was to further investigate the antimalarial activity of piperine, the major isolated constituent of Piper chaba Hunt...
2018: Journal of Tropical Medicine
Otchere Addai-Mensah, Max Efui Annani-Akollor, Linda Ahenkorah Fondjo, Kwadwo Sarbeng, Enoch Odame Anto, Eddie-Williams Owiredu, Shanice Nglokie Arthur
Background: The World Health Organization (WHO) recommends the use of Insecticide Treated Bed-Nets and Intermittent Preventive Treatment (IPT) with Sulphadoxine-Pyrimethamine (SP) as interventions in curbing malaria during pregnancy. However, increasing evidence shows a gap in coverage where not all pregnant women receive the recommended SP dose. This study evaluated the factors influencing uptake of IPTp-SP among pregnant women in Kumasi, Ghana. Methodology: This cross-sectional study was conducted among 280 pregnant women attending the Kwame Nkrumah University of Science and Technology Hospital in Kumasi, Ghana...
2018: Journal of Tropical Medicine
C L Fonseka, S Lekamwasam
Introduction: Leptospirosis is an emerging infectious disease associated with multiorgan involvement and significant morbidity and mortality. Although pulmonary hemorrhage due to leptospirosis has a high fatality, specific treatment options are limited and their efficacy is not adequately proven. We opted to find out the current evidence on plasmapheresis and extracorporeal membrane oxygenation (ECMO) in pulmonary hemorrhages due to leptospirosis. Methods: The first search was conducted in PubMed, OVID, Google Scholar, and Cochrane clinical trial registry using keywords "leptospirosis" OR "Leptospira" OR "Weil's disease" AND "plasmapheresis" OR "plasma exchange" AND "pulmonary hemorrhage" OR "alveolar hemorrhage" OR "lung hemorrhage" and the second search was done using keyword "leptospirosis" OR "Leptospira" OR "Weil's disease" AND "ECMO" OR "Extracorporeal membrane oxygenation...
2018: Journal of Tropical Medicine
El Hadji Amadou Niang, Hubert Bassene, Florence Fenollar, Oleg Mediannikov
People living in the tropical and subtropical regions of the world face an enormous health burden due to mosquito-borne diseases such as malaria, dengue fever, and filariasis. Historically and today, targeting mosquito vectors with, primarily, insecticide-based control strategies have been a key control strategy against major mosquito-borne diseases. However, the success to date of such approaches is under threat from multiple insecticide resistance mechanisms while vector control (VC) options are still limited...
2018: Journal of Tropical Medicine
Lilian Da Silva Santos, Hans Wolff, François Chappuis, Pedro Albajar-Viñas, Marco Vitoria, Nguyen-Toan Tran, Stéphanie Baggio, Giuseppe Togni, Nicolas Vuilleumier, François Girardin, Francesco Negro, Laurent Gétaz
In Swiss prisons, more than 70% of detained people are foreigners and over one-third originate from sub-Saharan Africa or Latin America. These two regions are endemic for various tropical diseases and viral infections, which persist after migration to nonendemic countries. Parasitic infections (schistosomiasis; strongyloidiasis) and cooccurrent viral infections (HIV, hepatitis B (HBV), and hepatitis C (HCV)) are especially of concern for clinical care but have been neglected in empirical research. These diseases often remain silent for years before causing complications, especially if they occur concomitantly...
2018: Journal of Tropical Medicine
Michael Buenor Adinortey, Charles Ansah, Cynthia Ayefoumi Adinortey, Ansumana Sandy Bockarie, Martin Tangnaa Morna, Damian H Amewowor
Helicobacter pylori ( H. pylori ) is a gram-negative bacterium that colonizes the human stomach. Infection with this microaerophilic bacterium causes gastric and duodenal ulcer. This study sought to isolate H. pylori , from gastric biopsy samples of dyspeptic patients in Ghana using a 2,3,5-triphenyltetrazolium chloride (TTC) dye incorporated medium method. This TTC dye method was further used in an antimicrobial susceptibility assay involving Dissotis rotundifolia extract (DRE). H. pylori were successfully isolated from gastric biopsy of dyspeptic patients...
2018: Journal of Tropical Medicine
Aline Maria de Oliveira Rocha, Maria Julia Gonçalves de Mello, Juliane Roberta Dias Torres, Natalia de Oliveira Valença, Alessandra Costa de Azevedo Maia, Nara Vasconcelos Cavalcanti
Background: Congenital syndrome of Zika virus (CSZV) is associated with neuromotor and cognitive developmental disorders, limiting the independence and autonomy of affected children and high susceptibility to complications, so palliative care needs to be discussed and applied. Aim: To identify factors associated with emergency visits and hospitalizations of patients with CSZV and clinical interventions performed from the perspective of palliative care. Design: This is a cross-sectional study with bidirectional longitudinal component...
2018: Journal of Tropical Medicine
John Tetteh, Wisdom Kwami Takramah, Martin Amogre Ayanore, Augustine Adoliba Ayanore, Elijah Bisung, Josiah Alamu
About 22% of childhood deaths in developing countries are attributable to diarrhea. In poor resource settings, diarrhea morbidities are correlated with poverty and socio-contextual factors. Diarrhea rates in Ghana are reported to be high, with cases estimated at 113,786 among children under-five years in 2011. This study analyzed the trends of diarrhea morbidity outcomes in the Jasikan District of Ghana. A retrospective analysis of records on diarrhea data for a five years' period (January 2012 to December 2016) was undertaken...
2018: Journal of Tropical Medicine
Pryanka Relan, Kristy C Y Yiu, Henry C Lin, Lawrence C Loh
The global health development community is increasingly examining the phenomenon of short-term experiences in global health (STEGH), with an aim to mitigate the negative impacts of such activities on host communities. Appropriate supervision is one strategy, but various barriers (e.g., institutional requirements) limit the availability of qualified supervisors. Remote supervision represents one potential model to provide supervision that may mitigate the negative impacts of STEGH. This paper reports observed outcomes from a description of a pilot remote supervision program employed in a global health program for Canadian undergraduate students...
2018: Journal of Tropical Medicine
Mpumelelo Casper Rikhotso, Jean Pierre Kabue, Solanka Ellen Ledwaba, Afsatou Ndama Traoré, Natasha Potgieter
Background: Human Bocavirus (HBoV) is an emerging virus discovered in 2005 from individuals suffering gastroenteritis and respiratory tract infections. Numerous studies related to the epidemiology and pathogenesis of HBoV have been conducted worldwide. This review reports on HBoV studies in individuals with acute gastroenteritis, with and without respiratory tract infections in Africa between 2005 and 2016. Material and Method: The search engines of PubMed, Google Scholar, and Embase database for published articles of HBoV were used to obtain data between 2005 and 2016...
2018: Journal of Tropical Medicine
Chalachew Genet Akal, Tesfaye Andualem
Role of laboratory service in patient care is well recognized in developed compared to developing countries like Ethiopia where most medical decisions are based on clinical judgment. Laboratory based medical decisions save life and resources. Thus, health facilities (HFs) having capacitated laboratories provide better health care service. Thus, this study assessed capacity of laboratories found in all nine HFs in zone one of Afar region, Ethiopia. Cross-sectional study was conducted from January to May 2015...
2018: Journal of Tropical Medicine
Boniphace Sylvester, Dinah B Gasarasi, Said Aboud, Donath Tarimo, Siriel Masawe, Rose Mpembeni, Göte Swedberg
Background: Infants born to mothers with placental malaria are prenatally exposed to Plasmodium falciparum antigens. However, the effect of that exposure to subsequent immune responses has not been fully elucidated. This study aimed at determining the effect of prenatal exposure to P. falciparum on Interleukin-10 and Interferon- γ responses during clinical malaria episodes in the first 24 months of life. Methods: This prospective cohort study involved 215 infants aged 0-2 years born to mothers with or without placental malaria...
2018: Journal of Tropical Medicine
Tommaso C Bulfone, Stephen P Samuel, Philip E Bickler, Matthew R Lewin
The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge. Small molecule therapeutics (SMTs) have been proposed as potential prereferral treatments for snakebite to help address this gap. Herein, we discuss the characteristics, potential uses, and development of SMTs as potential treatments for snakebite envenomation...
2018: Journal of Tropical Medicine
T Kumanan, V Sujanitha, S Balakumar, N Sreeharan
Amoebic liver abscess (ALA) seen commonly in the tropics is predominantly confined to adult males, especially those who consume locally brewed alcohol, although intestinal amoebiasis occurs in all age groups and in both genders. Whether the role of alcohol in the development of ALA is incidental and casual or whether alcohol is causally implicated has been debated. It has been argued that socioeconomic factors and poor sanitary conditions are the primary culprits that casually link alcohol to ALA. However, there has emerged an abundance of data that implicates alcohol in a more causal role in facilitating the extraintestinal invasion of the infective protozoan and the subsequent development of ALA...
2018: Journal of Tropical Medicine
Simon Peter Inyimai, Mosses Ocan, Benjamin Wabwire, Peter Olupot-Olupot
Background: There is a paucity of data on asymptomatic carriage of Plasmodium parasite among adult population in Eastern Uganda, an area of perennial high transmission of malaria. In this study, we estimated the prevalence of Plasmodium parasites in donor blood units at Mbale Regional Blood Bank (Mbale RBB), a satellite centre of the Uganda Blood Transfusion Service (UBTS). Method: This was a cross-sectional descriptive study in which 380 screened donor blood units were examined for the presence of Plasmodium parasites...
2018: Journal of Tropical Medicine
Alexandre Pessoa Dias, Deiviane Calegar, Filipe Anibal Carvalho-Costa, Maria de Fátima Leal Alencar, Caroline Ferraz Ignacio, Milena Enderson Chagas da Silva, Antonio Henrique Almeida de Moraes Neto
Introduction: The drought in the Brazilian semiarid region has affected the quality of water. This study assessed the relationships between enteric parasitoses, water management, and water quality, correlating them with pluviometric seasonality. Methods: Cross-sectional surveys were carried out in four rural communities at the beginning of the dry season (n=151), at the end of the dry season (n=184), and in the rainy season (n=199), in order to collect sociodemographic data, human fecal samples, and samples of the water used for human consumption for physicochemical and microbiological analyses...
2018: Journal of Tropical Medicine
Agani Afaya, Solomon Mohammed Salia, Peter Adatara, Richard Adongo Afaya, Solomon Suglo, Milipaak Japiong
Despite increased support from government and other stakeholders for malaria control over the past decade, malaria burden remains high in many endemic countries, particularly in Sub-Saharan Africa. This study aimed to assess patients' knowledge of antimalarial treatment (ACT) and its association with patient adherence. A descriptive cross-sectional study design was employed in this study. Data were collected from April to May 2017. Both descriptive and inferential statistics in the form of frequencies, percentages, mean values, standard deviations, and Pearson's chi-square test were generated by use of Microsoft excel spreadsheet and IBM Statistical Package for Social Sciences (SPSS) version 23...
2018: Journal of Tropical Medicine
Carolina Rodríguez Vásquez, Sebastián Barrera Escobar, Alberto Tobón-Castaño
Background: A screening for malaria parasites was conducted with asymptomatic residents in Colombia. Methods: A descriptive study was carried out in December 2012 in four municipalities of Urabá region in Colombia. A convenience sample of 400 subjects was selected. Participants responded to a survey regarding epidemiological data and blood samples were taken from capillary blood obtained by finger prick for thick smear, rapid diagnostic test (RDT), and polymerase chain reaction (PCR)...
2018: Journal of Tropical Medicine
Boakye-Yiadom Adomako, Frank Baiden, Samuel Sackey, Donne Kofi Ameme, Fred Wurapa, Kofi Mensah Nyarko, Ernest Kenu, Edwin Afari
Background: A One-Health approach is advocated to ensure effective rabies surveillance in sub-Saharan Africa. Information is needed to assess the current state of dog bites and rabies in Ghana. We analyzed data on reported events in the Eastern Region of Ghana from 2013 to 2015 to generate information that can be used for rabies elimination in Ghana through the One-Health approach. Method: We extracted data on dog bites and rabies from the database of the regional health service and performed descriptive analysis using Epi Info version 7™...
2018: Journal of Tropical Medicine
N D B Ehelepola, W M C M Wijesinghe
Reports on dengue outbreaks at hospitals are extremely rare. Here the authors analyze a dengue outbreak at the Teaching Hospital-Kandy (THK), Sri Lanka. Our hypothesis was that the present outbreak of dengue was due to nosocomial infections. Our objectives were to illustrate epidemiological evidence for nosocomial dengue infections among THK workers and comparison of dengue incidence of hospital workers of wards that treat dengue patients with workers of other wards, to ascertain whether most nosocomial dengue incidences occur closer to where dengue patients are treated and vector larvae were detected, and to draw the attention of the medical community to the significance of hospital outbreaks, making suggestions on how to improve dengue preventive work at the THK...
2018: Journal of Tropical Medicine
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