journal
https://read.qxmd.com/read/39013911/nop2-facilitates-ezh2-mediated-epithelial-mesenchymal-transition-by-enhancing-ezh2-mrna-stability-via-m5c-methylation-in-lung-cancer-progression
#1
JOURNAL ARTICLE
Ying Yang, Hongzhao Fan, Hongyang Liu, Xueling Lou, Nan Xiao, Chenxing Zhang, Huanxiang Chen, Shuangshuang Chen, Huihui Gu, Hongchun Liu, Junhu Wan
NOP2, a member of the NOL1/NOP2/SUN domain (NSUN) family, is responsible for catalyzing the posttranscriptional modification of RNA through 5-methylcytosine (m5C). Dysregulation of m5C modification has been linked to the pathogenesis of various malignant tumors. Herein, we investigated the expression of NOP2 in lung adenocarcinoma (LUAD) tissues and cells, and found that it was significantly upregulated. Moreover, lentivirus-mediated overexpression of NOP2 in vitro resulted in enhanced migration and invasion capabilities of lung cancer cells, while in vivo experiments demonstrated its ability to promote the growth and metastasis of xenograft tumors...
July 16, 2024: Cell Death & Disease
https://read.qxmd.com/read/39013891/mitophagy-related-regulated-cell-death-molecular-mechanisms-and-disease-implications
#2
REVIEW
Molin Yang, Xiang Wei, Xin Yi, Ding-Sheng Jiang
During oxidative phosphorylation, mitochondria continuously produce reactive oxygen species (ROS), and untimely ROS clearance can subject mitochondria to oxidative stress, ultimately resulting in mitochondrial damage. Mitophagy is essential for maintaining cellular mitochondrial quality control and homeostasis, with activation involving both ubiquitin-dependent and ubiquitin-independent pathways. Over the past decade, numerous studies have indicated that different forms of regulated cell death (RCD) are connected with mitophagy...
July 16, 2024: Cell Death & Disease
https://read.qxmd.com/read/39013845/myeloid-derived-suppressor-cells-induced-exhaustion-of-cd8%C3%A2-%C3%A2-t-cell-participates-in-rejection-after-liver-transplantation
#3
JOURNAL ARTICLE
Liu-Xin Zhou, Yi-Zhou Jiang, Xin-Qiang Li, Jin-Ming Zhang, Shi-Peng Li, Lin Wei, Hai-Ming Zhang, Guang-Peng Zhou, Xiao-Jie Chen, Li-Ying Sun, Zhi-Jun Zhu
Liver transplantation (LT) rejection remains the most pervasive problem associated with this procedure, while the mechanism involved is still complicated and undefined. One promising solution may involve the use of myeloid-derived suppressor cells (MDSC). However, the immunological mechanisms underlying the effects of MDSC after LT remain unclear. This study is meant to clarify the role MDSCs play after liver transplantation. In this study, we collected liver tissue and peripheral blood mononuclear cells (PBMC) from LT patients showing varying degrees of rejection, as well as liver and spleen tissue samples from mice LT models...
July 16, 2024: Cell Death & Disease
https://read.qxmd.com/read/39009589/prmt1-promotes-warburg-effect-by-regulating-the-pkm2-pkm1-ratio-in-non-small-cell-lung-cancer
#4
JOURNAL ARTICLE
Lu Peng, Yujiao Zhao, Jiang Tan, Jingyao Hou, Xin Jin, Dong-Xu Liu, Baiqu Huang, Jun Lu
Abnormal epigenetic modifications are involved in the regulation of Warburg effect in tumor cells. Protein arginine methyltransferases (PRMTs) mediate arginine methylation and have critical functions in cellular responses. PRMTs are deregulated in a variety of cancers, but their precise roles in Warburg effect in cancer is largely unknown. Experiments from the current study showed that PRMT1 was highly expressed under conditions of glucose sufficiency. PRMT1 induced an increase in the PKM2/PKM1 ratio through upregulation of PTBP1, in turn, promoting aerobic glycolysis in non-small cell lung cancer (NSCLC)...
July 15, 2024: Cell Death & Disease
https://read.qxmd.com/read/39003255/the-ubiquitin-like-protein-ubtd1-promotes-colorectal-cancer-progression-by-stabilizing-c-myc-to-upregulate-glycolysis
#5
JOURNAL ARTICLE
Liqin Zhao, Nuoya Yu, Yujia Zhai, Yanan Yang, Yixuan Wang, Yue Yang, Zhe Gong, Yanqiu Zhang, Xiaowei Zhang, Weijian Guo
Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC). Ubiquitin domain containing 1 (UBTD1), a ubiquitin-like protein, regulates UPS-mediated protein degradation and tumor progression in some cancer types. However, the biological function and mechanism of UBTD1 are far from being well elucidated, and its role in CRC has not been explored yet. In our study, we analyzed CRC patients' clinical information and UBTD1 expression data, and found that the expression of UBTD1 in cancer tissue was significantly higher than that in adjacent normal tissue...
July 13, 2024: Cell Death & Disease
https://read.qxmd.com/read/39003253/il-4-il-4r-axis-signaling-drives-resistance-to-immunotherapy-by-inducing-the-upregulation-of-fc%C3%AE-receptor-iib-in-m2-macrophages
#6
JOURNAL ARTICLE
Jiayu Zhang, Yu Dong, Shan Yu, Keshu Hu, Lingyun Zhang, Min Xiong, Mengling Liu, Xun Sun, Suyao Li, Yitao Yuan, Chi Zhang, Mengxuan Zhu, Yichou Wei, Yanjing Zhu, Yiyi Yu, Pengfei Zhang, Tianshu Liu
In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these advances, some patients do not respond well to treatment, highlighting the need to understand resistance mechanisms and develop predictive markers of treatment effectiveness. This study retrospectively analyzed data from 106 patients with stage IV gastric cancer who were treated with first-line immunotherapy in combination with chemotherapy. By comparing plasma cytokine levels between patients resistant and sensitive to PD-1 antibody therapy, the researchers identified elevated IL-4 expression in the resistant patients...
July 13, 2024: Cell Death & Disease
https://read.qxmd.com/read/39003252/preclinical-and-clinical-advances-to-overcome-hypoxia-in-glioblastoma-multiforme
#7
REVIEW
Jolie Bou-Gharios, Georges Noël, Hélène Burckel
Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard clinical treatment of GBM includes a maximal surgical resection followed by concomitant radiotherapy (RT) and chemotherapy sessions with Temozolomide (TMZ) in addition to adjuvant TMZ cycles. Despite the severity of this protocol, GBM is highly resistant and recurs in almost all cases while the protocol remains unchanged since 2005. Limited-diffusion or chronic hypoxia has been identified as one of the major key players driving this aggressive phenotype...
July 13, 2024: Cell Death & Disease
https://read.qxmd.com/read/39003251/the-eef2-kinase-coordinates-the-dna-damage-response-to-cisplatin-by-supporting-p53-activation
#8
JOURNAL ARTICLE
Jonathan K M Lim, Arash Samiei, Alberto Delaidelli, Jessica Oliveira de Santis, Vanessa Brinkmann, Christopher J Carnie, Daniel Radiloff, Laura Hruby, Alisa Kahler, Jordan Cran, Gabriel Leprivier, Poul H Sorensen
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and consequently mRNA translation elongation, in response to hypoxia and nutrient deprivation. EEF2K is also involved in the response to DNA damage but its role in response to DNA crosslinks, as induced by cisplatin, is not known. Here we found that eEF2K is critical to mediate the cellular response to cisplatin. We uncovered that eEF2K deficient cells are more resistant to cisplatin treatment...
July 13, 2024: Cell Death & Disease
https://read.qxmd.com/read/38997297/biological-impact-and-therapeutic-implication-of-tumor-associated-macrophages-in-hepatocellular-carcinoma
#9
REVIEW
Deming Li, Ting Zhang, Ye Guo, Cong Bi, Ming Liu, Gang Wang
The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. The macrophages are considered as the most abundant immune cells in tumor microenvironment and their function in tumorigenesis is interesting. Macrophages can be present as M1 and M2 polarization that show anti-cancer and oncogenic activities, respectively. Tumor-associated macrophages (TAMs) mainly have M2 polarization and they increase tumorigenesis due to secretion of factors, cytokines and affecting molecular pathways...
July 12, 2024: Cell Death & Disease
https://read.qxmd.com/read/38997271/increased-onecut2-induced-by-helicobacter-pylori-promotes-gastric-cancer-cell-stemness-via-an-akt-related-pathway
#10
JOURNAL ARTICLE
Mi Lin, Ru-Hong Tu, Sheng-Ze Wu, Qing Zhong, Kai Weng, Yu-Kai Wu, Guang-Tan Lin, Jia-Bin Wang, Chao-Hui Zheng, Jian-Wei Xie, Jian-Xian Lin, Qi-Yue Chen, Chang-Ming Huang, Long-Long Cao, Ping Li
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2's role and the specific mechanism underlying HP infection-associated gastric carcinogenesis to suggest a basis for targeting ONECUT2 as a therapeutic strategy for gastric cancer (GC). Multidimensional data supported an association between ONECUT2, HP infection, and GC pathogenesis. HP infection upregulated ONECUT2 transcriptional activity via NFκB...
July 12, 2024: Cell Death & Disease
https://read.qxmd.com/read/38997255/axdnd1-is-required-to-balance-spermatogonial-commitment-and-for-sperm-tail-formation-in-mice-and-humans
#11
JOURNAL ARTICLE
Brendan J Houston, Joseph Nguyen, D Jo Merriner, Anne E O'Connor, Alexandra M Lopes, Liina Nagirnaja, Corinna Friedrich, Sabine Kliesch, Frank Tüttelmann, Kenneth I Aston, Donald F Conrad, Robin M Hobbs, Jessica E M Dunleavy, Moira K O'Bryan
Dynein complexes are large, multi-unit assemblies involved in many biological processes via their critical roles in protein transport and axoneme motility. Using next-generation sequencing of infertile men presenting with low or no sperm in their ejaculates, we identified damaging variants in the dynein-related gene AXDND1. We thus hypothesised that AXDND1 is a critical regulator of male fertility. To test this hypothesis, we produced a knockout mouse model. Axdnd1-/- males were sterile at all ages but presented with an evolving testis phenotype wherein they could undergo one round of histologically replete spermatogenesis followed by a rapid depletion of the seminiferous epithelium...
July 12, 2024: Cell Death & Disease
https://read.qxmd.com/read/38992005/biogenesis-of-specialized-lysosomes-in-differentiated-keratinocytes-relies-on-close-apposition-with-the-golgi-apparatus
#12
JOURNAL ARTICLE
Sarmistha Mahanty, Ptissam Bergam, Vivek Belapurkar, Litralson Eluvathingal, Nikita Gupta, Bruno Goud, Deepak Nair, Graça Raposo, Subba Rao Gangi Setty
Intracellular organelles support cellular physiology in diverse conditions. In the skin, epidermal keratinocytes undergo differentiation with gradual changes in cellular physiology, accompanying remodeling of lysosomes and the Golgi apparatus. However, it was not known whether changes in Golgi and lysosome morphology and their redistribution were linked. Here, we show that disassembled Golgi is distributed in close physical apposition to lysosomes in differentiated keratinocytes. This atypical localization requires the Golgi tethering protein GRASP65, which is associated with both the Golgi and lysosome membranes...
July 11, 2024: Cell Death & Disease
https://read.qxmd.com/read/38991998/correction-nsun2-modified-by-sumo-2-3-promotes-gastric-cancer-progression-and-regulates-mrna-m5c-methylation
#13
Yuanbo Hu, Chenbin Chen, Xinya Tong, Sian Chen, Xianjing Hu, Bujian Pan, Xiangwei Sun, Zhiyuan Chen, Xinyu Shi, Yingying Hu, Xian Shen, Xiangyang Xue, Mingdong Lu
No abstract text is available yet for this article.
July 11, 2024: Cell Death & Disease
https://read.qxmd.com/read/38987572/linc01133-promotes-pancreatic-ductal-adenocarcinoma-epithelial-mesenchymal-transition-mediated-by-spp1-through-binding-to-arp3
#14
JOURNAL ARTICLE
Yefan Yang, Yuxi Gong, Ying Ding, Shuning Sun, Rumeng Bai, Shuaishuai Zhuo, Zhihong Zhang
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited treatment methods. Long non-coding RNAs (lncRNAs) have been found involved in tumorigenic and progression. The present study revealed that LINC01133, a fewly reported lncRNA, was one of 16 hub genes that could predict PDAC patients' prognosis. LINC01133 was over-expressed in PDAC tumors compared to adjacent pancreas and could promote PDAC proliferation and metastasis in vitro and in vivo, as well as inhibit PDAC apoptosis. LINC01133 expression positively correlated to secreted phosphoprotein 1 (SPP1) expression, leading to an enhanced epithelial-mesenchymal transition (EMT) process...
July 10, 2024: Cell Death & Disease
https://read.qxmd.com/read/38987564/setd8-inhibits-apoptosis-and-ferroptosis-of-ewing-s-sarcoma-through-ybx1-rac3-axis
#15
JOURNAL ARTICLE
Huimou Chen, Jing Hu, Xilin Xiong, Hongling Chen, Qiaofang Liao, Biaojun Lin, Yusong Chen, Yanting Peng, Yang Li, Di Cheng, Zhihua Li
Ewing's sarcoma (ES) represents a rare yet exceedingly aggressive neoplasm that poses a significant health risk to the pediatric and adolescent population. The clinical outcomes for individuals with relapsed or refractory ES are notably adverse, primarily attributed to the constrained therapeutic alternatives available. Despite significant advancements in the field, molecular pathology-driven therapeutic strategies have yet to achieve a definitive reduction in the mortality rates associated with ES. Consequently, there exists an imperative need to discover innovative therapeutic targets to effectively combat ES...
July 10, 2024: Cell Death & Disease
https://read.qxmd.com/read/38987529/myofibroblasts-derived-type-v-collagen-promoting-tissue-mechanical-stress-and-facilitating-metastasis-and-therapy-resistance-of-lung-adenocarcinoma-cells
#16
JOURNAL ARTICLE
Guangsheng Zhu, Yanan Wang, Yingjie Wang, Hua Huang, Boshi Li, Peijie Chen, Chen Chen, Hongbing Zhang, Yongwen Li, Hongyu Liu, Jun Chen
Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD). Mechanical changes within the tumor microenvironment, such as extracellular matrix (ECM) remodeling and fibroblast activity, play pivotal roles in cancer progression and metastasis. However, the specific impact of the basement membrane (BM) on the mechanical characteristics of LUAD remains unclear. This study aims to identify BM genes influencing internal mechanical stress in tumors, elucidating their effects on LUAD metastasis and therapy resistance, and exploring strategies to counteract these effects...
July 10, 2024: Cell Death & Disease
https://read.qxmd.com/read/38982083/zbp1-condensate-formation-synergizes-z-nas-recognition-and-signal-transduction
#17
JOURNAL ARTICLE
Feiyan Xie, Di Wu, Jing Huang, Xuehe Liu, Yanfang Shen, Jinqing Huang, Zhipeng Su, Jixi Li
Z-DNA binding protein 1 (ZBP1) is a crucial player in the intracellular recognition of Z-form nucleic acids (Z-NAs) through its Zαβ domain, initiating downstream interactions with RIPK1 and RIPK3 via RHIM domains. This engagement leads to the assembly of PANoptosomes, ultimately inducing programmed cell death to curb pathogen dissemination. How Zαβ and RHIM domain cooperate to trigger Z-NAs recognition and signal transduction remains unclear. Here, we show that ZBP1 condensate formation facilitates Z-NAs binding and antiviral signal transduction...
July 9, 2024: Cell Death & Disease
https://read.qxmd.com/read/38982073/correction-the-hdac-inhibitor-mpt0e028-enhances-erlotinib-induced-cell-death-in-egfr-tki-resistant-nsclc-cells
#18
M -C Chen, C -H Chen, J -C Wang, A -C Tsai, J -P Liou, S -L Pan, C -M Teng
No abstract text is available yet for this article.
July 9, 2024: Cell Death & Disease
https://read.qxmd.com/read/38982063/publisher-correction-isgylation-of-drp1-closely-balances-other-post-translational-modifications-to-mediate-mitochondrial-fission
#19
Palamou Das, Oishee Chakrabarti
No abstract text is available yet for this article.
July 9, 2024: Cell Death & Disease
https://read.qxmd.com/read/38982059/correction-recruitment-of-lef1-by-pontin-chromatin-modifier-amplifies-tgfbr2-transcription-and-activates-tgf%C3%AE-smad-signalling-during-gliomagenesis
#20
Xuexia Zhou, Xuebing Li, Run Wang, Dan Hua, Cuiyun Sun, Lin Yu, Cuijuan Shi, Wenjun Luo, Zhendong Jiang, Wenzhe An, Qian Wang, Shizhu Yu
No abstract text is available yet for this article.
July 9, 2024: Cell Death & Disease
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