Vanessa Silva de Souza, Liciane Fernandes Medeiros, Dirson João Stein, Camila Lino de Oliveira, Helouise Richardt Medeiros, Jairo Alberto Dussan-Sarria, Wolnei Caumo, Andressa de Souza, Iraci L S Torres
OBJECTIVES: Despite the fact that fibromyalgia, a widespread disease of the musculoskeletal system, has no specific treatment, patients have shown improvement after pharmacological intervention. Pregabalin has demonstrated efficacy; however, its adverse effects may reduce treatment adherence. In this context, neuromodulatory techniques such as transcranial direct current stimulation (tDCS) may be employed as a complementary pain-relieving method. Consequently, the purpose of this study was to evaluate the effect of pregabalin and tDCS treatments on the behavioral and biomarker parameters of rats submitted to a fibromyalgia-like model...
January 1, 2024: Scandinavian Journal of Pain