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Journal of Diabetes Investigation

Wataru Ogawa, Yushi Hirota
Sodium-glucose cotransporter 2 (SGLT2) inhibitors, the newest class of oral antidiabetes drugs for type 2 diabetes, ameliorate hyperglycemia primarily by preventing the reabsorption of urinary glucose in the kidneys. Within less than 5 years, abundant evidence for favorable characteristics of SGLT2 inhibitors has accumulated. Of note, large-scale clinical trials have revealed that these drugs prevent cardiovascular events, at least in cohorts at high risk for such events, and that they slow the decline in renal function...
February 15, 2019: Journal of Diabetes Investigation
Krzysztof Tucholski, Magdalena Sokołowska, Dagmara Tucholska, Halla Kamińska, Przemysława Jarosz-Chobot
OBJECTIVE: Assessment of postprandial glucose concentration after carbohydrates rich meals using continuous glucose monitoring in 30 children with type 1 diabetes treated using continuous subcutaneous insulin infusion with a rapid-acting analogs insulin. METHODS: During 3 days, participants administering simple boluses with different delay time between insulin administration and beginning of carbohydrates rich meals consumption (meal №1 containing - 197 kcal, №2 - 247 kcal and meal №3 - 323 kcal; practically not containing protein and fat)...
February 15, 2019: Journal of Diabetes Investigation
Yusuke Mine, Tatsuhiko Urakami, Daisuke Matsuura
We present the case of an 8-year old girl with type 1 diabetes, who developed severe allergic contact dermatitis by using FreeStyle® Libre. A patch test was performed by a piece of the adhesive part of the sensor of the FreeStyle® Libre, and subsequently by using the potential contact allergens in the sensor, isobornyl acrylate (IBOA). She reacted positively to the adhesive part of the sensor, and also reacted positively to IBOA with three different concentrations, 0.1%, 0.05% and 0.01%, over a 48-hour, 72-hour, and 7-day periods...
February 13, 2019: Journal of Diabetes Investigation
Takumi Nishi, Akira Babazono, Toshiki Maeda
BACKGROUND: This study aimed to evaluate the effects of income levels on physician visit patterns and to quantify the consequent impact of irregular physician visits on glycemic control, among employees' health insurance beneficiaries in Japan. METHOD: We obtained specific health check-up data on untreated diabetes patients from the Fukuoka branch of the Japanese Health Insurance Association. We selected 2,981 insurance beneficiaries, and classified 650 and 2,331 patients into, respectively, the regular visit and irregular visit group...
February 13, 2019: Journal of Diabetes Investigation
Huanhuan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Hiroko Okazaki, Makoto Yamamoto, Toshiaki Miyamoto, Masafumi Eguchi, Takeshi Kochi, Makiko Shimizu, Taizo Murakami, Kentaro Tomita, Takayuki Ogasawara, Naoko Sasaki, Akihiko Uehara, Keisuke Kuwahara, Isamu Kabe, Tetsuya Mizoue, Tomofumi Sone, Seitaro Dohi
AIMS/INTRODUCTION: We examined a prospective association between serum creatinine levels and diabetes. MATERIALS AND METHODS: This study included 31,343 male workers without diabetes and aged between 20 and 64 years old at baseline. We calculated the cumulative average of their serum creatinine over the study period. We defined diabetes as either HbA1c levels ≥6.5%, random glucose levels ≥200 mg/dL, fasting glucose levels ≥126 mg/dL, or receiving antidiabetic treatment...
February 12, 2019: Journal of Diabetes Investigation
Yui Shibayama, Hiraku Kameda, Shoichiro Ota, Kazuhisa Tsuchida, Kyu Yong Cho, Akinobu Nakamura, Hideaki Miyoshi, Tatsuya Atsumi
With the expansive use of immune checkpoint inhibitors (ICIs), the frequency of immune-related adverse events, including autoimmune type 1 diabetes, have been exponentially increased. The anti-programmed death-ligand 1 antibody, avelumab, has recently been approved for metastatic Merkel cell carcinoma (MCC) therapy. Herein, we report a patient that developed fulminant type 1 diabetes during avelumab treatment. An 81-year-old woman with no history of diabetes received avelumab for metastatic MCC. Elevated plasma glucose level (483 mg/dL), hemoglobin A1c level (7...
February 9, 2019: Journal of Diabetes Investigation
Kazuyuki Tobe, Hiroshi Maegawa, Hiromi Tabuchi, Ichiro Nakamura, Satoshi Uno
AIMS/INTRODUCTION: STELLA-LONG TERM is an ongoing post-marketing study of ipragliflozin for long-term use in Japanese patients with type 2 diabetes mellitus. A subgroup analysis of data from the study was carried out to investigate the impact of obesity on the efficacy and safety of ipragliflozin in this population. MATERIALS AND METHODS: Patients were divided into the following subgroups according to their body mass index (BMI): <22.0, 22.0 to <25.0, 25.0 to <30...
February 4, 2019: Journal of Diabetes Investigation
K Sugimoto, H Murakami, T Deguchi, A Arimura, M Daimon, S Suzuki, T Shimbo, S Yagihashi
AIM: To examine the three-dimensional morphology and vascular endothelial growth factor (VEGF) expression of skin microvasculature in patients with type 2 diabetes in relation to neuropathy, retinopathy and nephropathy. METHODS: This study enrolled 17 individuals with type 2 diabetes and 16 without. Skin sections were double-immunostained for type IV collagen and VEGF-A or protein gene product (PGP)9.5. Projected images from confocal microscopy served for quantification of the occupancy rate of subepidermal type IV collagen-immunoreactive microvascular basement membrane area (OR-T4MBM), subepidermal VEGF-A-immunoreactive area, and the VEGF/T4MBM ratio as well as the PGP9...
February 4, 2019: Journal of Diabetes Investigation
Tohid Vahdatpour, Ali Nokhodchi, Parvin Zakeri-Milani, Mehran Mesgari-Abbasi, Naser Ahmadi-Asl, Hadi Valizadeh
AIMS/INTRODUCTION: Peptides are considered as quasi-hormones and effective molecules for regulation of the cells function and metabolic disorders prevention. Di- and tripeptides with the ability to gastrointestinal absorption have been proposed to prevent diabetes progression. MATERIALS AND METHODS: Small peptides with different sequences of specific amino acids were synthesized based on a solid phase peptide synthesis (SPPS) protocol as well as carnosine (A) and glutathione (B) were examined for the prevention of diabetes induced by multiple low-dose of streptozotocin (MLDS) in mice...
February 2, 2019: Journal of Diabetes Investigation
Kazunori Utsunomiya, Masayuki Senda, Seigo Kakiuchi, Hiroyuki Kameda, Masahiro Tamura, Yuji Kurihara, Ryoji Gunji, Shoko Fujii, Hisataka Fujiwara, Kohei Kaku
AIMS/INTRODUCTION: This study analysis was conducted to evaluate the safety and efficacy of tofogliflozin, a sodium-glucose co-transporter (SGLT) 2 inhibitor in Japanese patients with type 2 diabetes mellitus (T2DM) in real-world clinical practice. MATERIALS AND METHODS: This was a 3-year non-interventional observational study in patients with T2DM newly administered tofogliflozin uncontrolled on current therapy. We conducted a 12-week interim analysis of tofogliflozin as a part of 3-year post-marketing surveillance study...
January 31, 2019: Journal of Diabetes Investigation
Hiroshi Miura, Kazuhiko Sakaguchi, Yuko Okada, Tomoko Yamada, Natsu Otowa, Anna Sou, Hisako Komada, Yushi Hirota, Takeshi Ohara, Yasuo Kuroki, Kenta Hara, Tomokazu Matsuda, Minoru Kishi, Akihiko Takeda, Kazuki Yokota, Yoshikazu Tamori, Wataru Ogawa
AIMS: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors improve blood glucose control as well as reduce body weight by promoting urinary glucose excretion. The weight loss is less than expected from urinary glucose loss, however, likely because of an increase in food intake. To investigate whether SGLT-2 inhibitors might increase appetite by affecting related hormones, we examined the effects of the SGLT-2 inhibitor ipragliflozin, including those on appetite-regulating hormones, in individuals with suboptimally controlled type 2 diabetes...
January 28, 2019: Journal of Diabetes Investigation
Daisuke Sato, Katsutaro Morino, Seiichiro Ogaku, Akiko Tsuji, Kimihiro Nishimura, Osamu Sekine, Satoshi Ugi, Hiroshi Maegawa
AIMS/INTRODUCTION: Preprandial metformin administration significantly reduces postprandial plasma triglyceride levels in animal studies by reducing intestinal absorption through delayed gastric emptying. However, this effect has not been shown in a clinical study. Therefore, we planned to investigate the efficacy of preprandial metformin administration on postprandial hypertriglyceridemia and the related gastrointestinal effects in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Eleven patients taking single-dose metformin at 500-1000 mg, with non-fasting plasma triglyceride levels of 150-1000 mg/dL were recruited at a single university hospital...
January 28, 2019: Journal of Diabetes Investigation
Hiroyasu Mori, Akio Kuroda, Masashi Ishizu, Mami Ohishi, Yuichi Takashi, Yinhua Otsuka, Satoshi Taniguchi, Motoyuki Tamaki, Kiyoe Kurahashi, Sumiko Yoshida, Itsuro Endo, Ken-Ichi Aihara, Makoto Funaki, Yuko Akehi, Munehide Matsuhisa
AIMS: Advanced glycation end products (AGEs), which are major cause of diabetic vascular complications, are accumulated in various tissues with chronic hyperglycemia as well as aging in patients with diabetes. The loss of muscle mass and strength, so called sarcopenia and dynapenia, has recently been recognized as a diabetic complication. However, the influence of accumulated AGEs on muscle mass and strength remains unclear. The present study aimed to evaluate the association of sarcopenia and dynapenia with accumulated AGEs in patients with type 2 diabetes...
January 24, 2019: Journal of Diabetes Investigation
Masayuki Baba, Norimitsu Matsui, Masanori Kuroha, Yosuke Wasaki, Shoichi Ohwada
OBJECTIVE: This study evaluated the efficacy and safety of mirogabalin, a novel, potent, selective ligand of the α2 δ subunit of voltage-dependent Ca2+ channels, for the treatment of diabetic peripheral neuropathic pain (DPNP). RESEARCH DESIGN AND METHODS: During this double-blind, multisite, placebo-controlled phase 3 study, Asian patients aged ≥20 years with type 1 or 2 diabetes and DPNP were randomized 2:1:1:1 to placebo, mirogabalin 15, 20, or 30 mg/day for up to 14 weeks, with a 1- to 2-week titration (NCT02318706)...
January 23, 2019: Journal of Diabetes Investigation
Soulmaz Fazeli Farsani, Atsushi Taniguchi, Rie Ikeda, Kimberly G Brodovicz, Dorothee B Bartels
AIMS/INTRODUCTION: To evaluate linagliptin prescribing in type 2 diabetes mellitus patients with different comorbidities, an expanded Japanese post-marketing surveillance also collected baseline data for patients initiating other glucose-lowering drugs. MATERIALS AND METHODS: Patients initiating linagliptin monotherapy were enrolled, then the next patient starting monotherapy with another glucose-lowering drug was enrolled (2012-2014). Baseline data were collected and analyzed by Medical Dictionary for Regulatory Activities system organ class...
January 22, 2019: Journal of Diabetes Investigation
Zonglin He, Huatao Xie, Shangqiang Liang, Yuan Tang, Wenjing Ding, Yanxin Wu, Wai-Kit Ming
AIMS: To summarize the development of the criteria for diagnosing gestational diabetes mellitus (GDM) in China and investigate how different GDM diagnostic criteria influence the national prevalence of GDM, the national health system, and the economic burden of GDM in China. METHOD: Retrospectively using data from women undergoing a 2-h, 75-g oral glucose tolerance test at 24-28 gestational weeks in the First Affiliated Hospital of Jinan University (Guangzhou, Guangdong, China) from January 2011 to December 2017, the prevalence rate of GDM and its impacts on the national health system were evaluated using different criteria (the 7th edition textbook criteria, NDDG 1979, WHO 1985, EASD 1996, Japan 2002, ADA 2011 (IADPSG), and NICE 2015)...
January 21, 2019: Journal of Diabetes Investigation
Yukishige Kimura, Atsushi Kuno, Masaya Tanno, Tatsuya Sato, Kouhei Ohno, Satoru Shibata, Kei Nakata, Hirohito Sugawara, Koki Abe, Yusuke Igaki, Toshiyuki Yano, Takayuki Miki, Tetsuji Miura
INTRODUCTION: Type 2 diabetes mellitus (T2DM) is a risk factor of acute kidney injury (AKI) after myocardial infarction (MI), a form of cardiorenal syndrome (CRS). Recent clinical trials have shown that an SGLT2 inhibitor improved both cardiac and renal outcomes in patients with T2DM, but effects of an SGLT2 inhibitor on CRS remain unclear. MATERIALS AND METHODS: T2DM (OLETF) and control (LETO) rats were treated with canagliflozin, an SGLT2 inhibitor, for 2 weeks...
January 21, 2019: Journal of Diabetes Investigation
Masayuki Kato, Akiko Toda, Ritsuko Yamamoto-Honda, Yasuji Arase, Hirohito Sone
AIMS/INTRODUCTION: It is suspected that Helicobacter pylori (H. pylori) is associated with extra-digestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, the results were conflicting. The aim of this study was to examine the association between H. pylori infection, eradication and diabetes. MATERIALS AND METHODS: This cross-sectional study was conducted using data from annual health check-up performed in the Toranomon Hospital Health Management Center...
January 21, 2019: Journal of Diabetes Investigation
Takafumi Sugihiro, Masayasu Yoneda, Haruya Ohno, Kenji Oki, Noboru Hattori
INTRODUCTION: Our previous survey of two Japanese populations, with different lifestyles but identical genetic dispositions, revealed that Japanese-Americans had different dietary intakes and higher prevalences of obesity and diabetes mellitus, compared to the native Japanese population. This study examined whether Westernized dietary habits could affect the development of obesity or diabetes. MATERIALS AND METHODS: This study included 765 individuals with normal glucose tolerance at baseline medical examinations (1986 or 1989 in Los Angeles and in 1988 or 1992 in Hawaii) who subsequently completed follow-up medical examinations several years later...
January 21, 2019: Journal of Diabetes Investigation
Yuka Shibata, Tatsuhito Himeno, Taeko Kamiya, Hiroya Tani, Takayuki Nakayama, Chika Kojima, Yukako Sugiura-Roth, Ena Naito, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya
AIMS/INTRODUCTION: Although nerve conduction study using a standard electromyography system is considered to be the gold standard in evaluating diabetic polyneuropathy, this examination requires expensive equipment and well-trained technicians. We aimed to validate a point-of-care device, NC-stat/DPNCheckTM , that has been developed for widespread use of nerve conduction study in diabetic polyneuropathy. MATERIALS AND METHODS: Diabetic patients underwent two kinds of nerve conduction study: DPNCheck and electromyography system...
January 19, 2019: Journal of Diabetes Investigation
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