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Journal of Clinical Research in Pediatric Endocrinology

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https://read.qxmd.com/read/30859797/antim%C3%A3-llerian-hormone-levels-of-infants-with-premature-thelarche
#1
Nursel Muratoglu Sahin, Elvan Bayramoglu, Hatice Nursun Ozcan, Erdal Kurnaz, Meliksah Keskin, Senay Savas Erdeve, Semra Cetinkaya, Zehra Aycan
Objective: AMH levels in mini puberty are higher than prepubertal period. In this study we investigated AMH levels in infants with premature thelarche who were presumed to have prolonged mini puberty due to inadequate/late suppression of pubertal activation. Methods: Forty five female infants between 1 and 3 years of age with premature thelarche were enrolled in the study and 37 healthy girls in the same age group were included in the study. Bone age, pelvic ultrasonography (USG) findings, LH (luteinizing hormone), FSH (follicle-stimulating hormone ), estradiol and AMH level of the patient group and serum AMH level of the control group were evaluated...
March 12, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30859796/intrauterine-twin-discordancy-followed-by-partial-postnatal-catch-up-growth-in-a-girl-with-a-pathogenic-igf1r-mutation
#2
Paula Ocaranza, Monique Losekoot, Marie J. E. Walenkamp, Christiaan de Bruin, Jan M Wit, Veronica Mericq
Background: IGF-1 is essential for normal human growth in utero and postnatally. It mediates its effects through the IGF-1 receptor (IGF1R), a widely expressed cell surface tyrosine kinase receptor. Objective: The aim of the study was to analyze pre- and postnatal growth, clinical features and laboratory findings of discordant twins: one small for gestational age (SGA) girl and one appropriate for gestational age (AGA) brother in whom discordant postnatal growth persisted...
March 12, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30819016/glucose-metabolism-evaluated-by-glycated-hemoglobin-and-insulin-sensitivity-indexes-in-children-treated-with-recombinant-human-growth-hormone
#3
M C Pellegrin, D Michelon, E Faleschini, C Germani, E Barbi, G Tornese
Objective: To evaluate glucose metabolism and insulin sensitivity in children with idiopathic growth hormone (GH) deficiency treated with recombinant human GH (rhGH) and to identify possible risk factors for the development of glucose abnormalities in this population. Methods: We retrospectively collected data from 101 patients (60 males, median age 10.4 years, 77 prepubertal), with confirmed GH deficiency, enrolled before starting rhGH and followed up for the first three years of treatment...
March 1, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30759963/no-associations-between-serum-lipid-levels-or-homa-ir-and-asthma-in-children-and-adolescents-a-nhanes-analysis
#4
Min Lu, Beirong Wu, Rong Qiao, Haoxiang Gu, Ying Din, Xiaoyan Dong
Objective: Studies have reported inconsistent results of the associations between lipids and insulin resistance (IR) and asthma. The purpose of this study was to examine the associations between abnormal serum lipid levels and homeostatic model assessment-insulin resistance (HOMA-IR) and the presence of current asthma in children and adolescents. Methods: The United States National Health and Nutrition Examination Survey database from 1999 to 2012 was randomly searched for children (aged 3-11 years) and adolescents (aged 12-19 years) with and without asthma and with complete demographic and clinical data of interest...
February 14, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30759962/pitfalls-with-vitamin-d-research-in-musculoskeletal-disorders-and-recommendations-on-how-to-avoid-them
#5
Gary M. Kiebzak, Kevin M. Neal, Pooya Hossienzadeh, Robert C. Olney, Michael A. Levine
Reports suggesting that vitamin D may have extraskeletal roles have renewed interest in vitamin D research and stimulated publication of an increasing number of new studies each year. These studies typically assess vitamin D status by measuring the blood concentration of 25-hydroxyvitamin D (25[OH]D), the principal circulating metabolite of vitamin D. Unfortunately, variations in assay format, inconsistency in interpreting 25(OH)D concentrations, cohort bias (age, BMI, race, season of measurements etc.) and failure to measure critical variables needed to interpret study results, makes interpreting results and comparing studies difficult...
February 14, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30759961/evaluation-of-igf1-igfbp3-molar-ratio-as-an-effective-tool-for-assessing-the-safety-of-gh-therapy-in-small-for-gestational-age-gh-deficient-and-prader-willi-children
#6
Meriem Gaddas, Laurence Périn, Yves Le Bouc
Objective: IGF1 concentration is the most widely used parameter for the monitoring and therapeutic adaptation of recombinant human growth hormone (rGH) treatment. However, more than half the variation of the therapeutic response is accounted for by variability in the serum concentrations of IGF1 and IGFBP3. We therefore compared the use of IGF1/IGFBP3 molar ratio with that of IGF1 concentration alone. Methods: We selected 92 children on rGH for this study and assigned them to three groups on the basis of growth deficiency etiology: small for gestational age (SGA), GH deficient (GHD) and Prader-Willi syndrome (PWS)...
February 14, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30759960/associations-between-serum-uric-acid-levels-and-cardiometabolic-risk-renal-%C3%A4-njury-in-obese-and-overweight-children
#7
Deniz Özalp Kızılay, Semra Şen, Betül Ersoy
Objective: In this study we aimed to assess the association between serum uric acid (SUA) concentration and metabolic syndrome (MetS) parameters and insulin resistance (IR). Our second aim was evaluate whether hyperuricemia is related with renal injury and cardiovascular risk in obese (OB) and overweight(OW) children. Methods: This study was conducted on 128 OB/OW children and adolescents (ages: 8-18 years), of whom 52 (40%) with SUA elevation (SUA persantile>75), 76 with (60%) normal SUA level (SUAL)...
February 14, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30759959/a-case-of-autosomal-dominant-osteopetrosis-type-ii-with-a-clcn7-gene-mutation
#8
Sol Kang, Young Kyung Kang, Jun Ah Lee, Dong Ho Kim, Jung Sub Lim
Osteopetrosis is a rare genetic disease characterized by increased bone density and bone breakage due to defective osteoclast function. Autosomal dominant osteopetrosis type II, Albers-Schonberg disease, is characterized by the sclerosis of bones, predominantly involving the spine, pelvis, and the base of the skull. Here, we report a typical case of osteopetrosis in a 17.7-year-old male who carries a heterozygous c.746C>T mutation in exon 9 in the chloride voltage-gated channel 7 gene. The patient spine showed multiple sclerotic changes including sandwich vertebra...
February 14, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30717585/a-novel-homozygous-mutation-of-the-acid-labile-subunit-igfals-gene-in-a-male-adolescent
#9
Sukran Poyrazoglu, Vivian Hwa, Firdevs Bas, Andrew Dauber, Ron Rosenfeld, Feyza Darendeliler
Acid-labile subunit (ALS) forms ternary complexes with insulin like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) and is essential for normal circulating IGF-1 levels. The IGFALS gene encodes the ALS, and mutations in IGFALS cause ALS deficiency. We describe a patient with ALS deficiency with a novel homozygous frameshift mutation in IGFALS presenting with short stature and delayed puberty but ultimately achieving an adult height (AH) comparable to his target height (TH). A 15 3/12 year old boy presented with short stature (149...
February 5, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30701953/effect-of-education-on-impaired-hypoglycemia-awareness-and-glycemic-variablity-in-children-and-adolescents-with-type-1-diabetes-mellitus
#10
Günay Demir, Samim Özen, Hafize Çetin, Şükran Darcan, Damla Gökşen
Objective: The aim of this study was to determine the prevalence of impaired hypoglycemia awareness (IHA) in children and adolescents with type 1 diabetes mellitus with professional continuous glucose monitoring system and to show the effect of structured education on glycemic variability (GV) in children and adolescents with IHA. Methods: Fourty type 1 diabetic children and adolescents with a diabetes duration of at least 5 years were eligible for inclusion in this prospective, quantitative study...
January 31, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30678423/isolated-growth-hormone-deficiency-type-ii-due-to-a-novel-gh1-mutation-a-case-report
#11
Ahmad Kautsar, Jan M. Wit, Aman Pulungan
Isolated growth hormone deficiency (IGHD) type II is a rare autosomal dominant disorder characterized by severe short stature with low growth hormone level. Timely diagnosis is important for optimal results of recombinant human GH (rhGH) treatment and detection of additional pituitary deficiencies in affected relatives. A male child presented at the age of one year with severe proportionate short stature (-4.9 SDS) with normal Body Mass Index (-1.1 SDS). Physical examination revealed frontal bossing, midfacial hypoplasia, normal external genitalia with no dysmorphic features...
January 25, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30630811/the-evaluation-of-etiological-distribution-and-the-rate-of-congenital-hypothyroidism-among-the-cases-referred-from-national-screening-program
#12
Zeynep Donbaloglu, Şenay Savaş Erdeve, Semra Çetinkaya, Zehra Aycan
OBJECTIVE: The aim of this study was to evaluate cases referred from congenital hypothyroidism screening program. METHODS: Infants referred to Pediatric Endocrinology Polyclinic between 30.09.2015 - 01.04.2018 dates, because of suspected congenital hypothyroidism within the scope of Ministry of Health National Neonatal Screening Program were prospectively evaluated. RESULTS: Of the 109 newborns referred to our clinic, 60 (55%) were diagnosed with CH...
January 11, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30630810/a-novel-nonsense-mutation-of-phf6-in-a-female-with-extended-phenotypes-of-borjeson-forssman-lehmann-syndrome
#13
Xia Zhang, Yanjie Fan, Xiaomin Liu, Ming Ang Zhu, Yu Sun, Hui Yan, Yunjuan He, Xiantao Ye, Xuefan Gu, Yongguo Yu
Borjeson-Forssman-Lehmann syndrome (BFLS) is a rare X-linked disease caused by PHF6 mutations. Classic BFLS is featured by intellectual disability (ID), developmental delay (DD), obesity, epilepsy, characteristic face and anomalies of fingers and toes. Endocrinological phenotypes and relevant outcome of treatment in this condition remains to be delineated. Here we report a patient with presentations beyond the classic BFLS - the patient exhibited complete growth hormone deficiency, and adverse effects were elicited after hormonal treatment...
January 11, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30630809/risk-factors-for-childhood-overweight-and-obesity-in-ukraine-and-germany
#14
Vira Yakovenko, Markus Bettendorf, Natalia Zelinska, Galyna Soloviova, Georg F Hoffmann, Semih Bolu, Juergen Grulich Henn
BACKGROUND: Overweight and obesity in childhood and adolescence are rapidly increasing and influenced by genetic, familial, environmental, socioeconomic and cultural factors. OBJECTIVE: The aim of the study was to compare risk factors for childhood obesity in Ukraine (UA) and Germany (DE) using comparable investigative tools. METHODS: Two groups of children aged 8 to 18 years in DE (93 children) and UA (95 children) were divided into children with overweight and with obesity...
January 11, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30604602/early-menarche-is-a-risk-factor-of-short-stature-in-young-korean-female-epidemiologic-study
#15
Sol Kang, Yoon Mo Kim, Jun Ah Lee, Dong Ho Kim, Jung Sub Lim
Objective: We investigated the association between age at menarche and adult height (and body mass index; BMI) in young Korean female. We also investigated whether early menarche (<12years) is a risk factor of short stature and obesity in young Korean female. Methods: We analyzed data for 1148 female aged 18–30 years (612 pairs of mothers and daughters) from the 6th Korea National Health and Nutrition Examination Survey (KNHANES IV) (2013–2015). Results: Among 1148 female, 256(22...
January 3, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30592192/elevated-random-luteinizing-hormone-is-unreliable-indicator-for-pubertal-suppression-in-girls-treated-with-monthly-leuprolide-for-idiopathic-central-precocious-puberty
#16
Pattara Wiromrat, Ouyporn Panamonta
Objective: Longitudinal data in random luteinizing hormone (LH) concentrations in patients with idiopathic central precocious puberty (ICPP) during treatment are limited. Therefore, we sought to evaluate random LH and estradiol concentrations during monthly leuprolide injection and its associations with pubertal progression and final adult height (FAH) in girls with ICPP. Methods: Medical records of 27 ICPP girls who attained FAH were reviewed. Patients’ height, weight, Tanner stage, growth rate (GR), bone age, random LH, follicular-stimulating hormone (FSH) and estradiol were monitored until FAH...
December 28, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30592191/vitamin-d-deficiency-and-insufficiency-according-to-the-current-criteria-for-children-vitamin-d-status-of-elementary-school-children-in-turkey
#17
F Sinem Hocaoglu-Emre, Devrim Saribal, Osman Oğuz
OBJECTIVE: This study aimed to determine the ratio of seasonal Vitamin D deficiency and insufficiency in elementary school children aged between 6-9 years old, living in one of the largest metropols of Europe, Istanbul. METHODS: Serum 25(OH)D levels of 640 children aged 6-9 years old were scanned retrospectively from the hospital information system records between September 2017-August 2018 period. Vitamin D deficiency was defined as a serum 25(OH)D level less than 12 ng/mL (30 nmol/L) and insufficiency as levels between 12 and 20 ng/mL (30-50 nmol/L)...
December 28, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30582317/evaluation-of-unfavorable-cardiovascular-and-metabolic-risk-factors-in-children-and-young-adults-with-haemophilia
#18
Melek Yıldız, Nihal Özdemir, Hasan Önal, Başak Koç, Beyza Eliuz Tipici, Bülent Zülfikar
Objective: Increased risk of unfavorable cardiovascular risk factors has been defined in the aging population of haemophilia however they were less investigated in young patients. The purpose of this study was to assess obesity, hypertension, metabolic variables, insulin resistance and metabolic syndrome in young patients with haemophilia (PwH). Methods: Forty-eight haemophilia A and B patients and 35 age and sex matched healthy controls were included. Anthropometric measurements, blood pressure, fasting glucose and insulin levels, serum lipids and dietary intakes were evaluated...
December 24, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30799596/erratum
#19
(no author information available yet)
No abstract text is available yet for this article.
February 20, 2019: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30786706/editorial-neonatal-screening-for-congenital-adrenal-hyperplasia-in-turkey
#20
Abdullah Bereket
No abstract text is available yet for this article.
February 20, 2019: Journal of Clinical Research in Pediatric Endocrinology
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