Yvonne J Rosenberg, Tracy Ordonez, Urjeet S Khanwalkar, Philip Barnette, Shilpi Pandey, Iara M Backes, Claire E Otero, Benjamin S Goldberg, Andrew R Crowley, David A Leib, Mariya B Shapiro, Xiaoming Jiang, Lori A Urban, Jonathan Lees, Ann J Hessell, Sallie Permar, Nancy L Haigwood, Margaret E Ackerman
Transplacental transfer of maternal antibodies provides the fetus and newborn with passive protection against infectious diseases. While the role of the highly conserved neonatal Fc receptor (FcRn) in transfer of IgG in mammals is undisputed, recent reports have suggested that a second receptor may contribute to transport in humans. We report poor transfer efficiency of plant-expressed recombinant HIV-specific antibodies, including engineered variants with high FcRn affinity, following subcutaneous infusion into rhesus macaques close to parturition...
March 22, 2023: MBio