journal
https://read.qxmd.com/read/31884578/elevated-free-thyroxine-levels-are-associated-with-poorer-overall-survival-in-patients-with-gastroesophageal-cancer-a-retrospective-single-center-analysis
#21
JOURNAL ARTICLE
H C Puhr, P Wolf, A S Berghoff, S F Schoppmann, M Preusser, Aysegul Ilhan-Mutlu
As endocrinological parameters such as thyroid hormones modulate proliferative, metabolic, and angiogenic pathways, it is surmised that their levels can be associated with cancer development and progression. Most patients with gastroesophageal cancer are diagnosed very late and have a poor prognosis, yet the association with endocrinological parameters has not been addressed so far. The aim of this study was to correlate hormones with the outcome, so new prognostic and potentially therapeutic markers can be defined...
December 28, 2019: Hormones & Cancer
https://read.qxmd.com/read/31865591/the-thyroid-hormone-receptor-runx2-axis-a-novel-tumor-suppressive-pathway-in-breast-cancer
#22
JOURNAL ARTICLE
Eric L Bolf, Noelle E Gillis, Michael S Barnum, Caitlin M Beaudet, Grace Y Yu, Jennifer A Tomczak, Janet L Stein, Jane B Lian, Gary S Stein, Frances E Carr
Metastatic breast cancer is refractory to conventional therapies and is an end-stage disease. RUNX2 is a transcription factor that becomes oncogenic when aberrantly expressed in multiple tumor types, including breast cancer, supporting tumor progression and metastases. Our previous work demonstrated that the thyroid hormone receptor beta (TRβ) inhibits RUNX2 expression and tumorigenic characteristics in thyroid cells. As TRβ is a tumor suppressor, we investigated the compelling question whether TRβ also regulates RUNX2 in breast cancer...
December 21, 2019: Hormones & Cancer
https://read.qxmd.com/read/31858384/a-computational-statistics-approach-to-evaluate-blood-biomarkers-for-breast-cancer-risk-stratification
#23
JOURNAL ARTICLE
Kaan Oktay, Ashlie Santaliz-Casiano, Meera Patel, Natascia Marino, Anna Maria V Storniolo, Hamdi Torun, Burak Acar, Zeynep Madak Erdogan
Breast cancer is the second leading cause of cancer mortality among women. Mammography and tumor biopsy followed by histopathological analysis are the current methods to diagnose breast cancer. Mammography does not detect all breast tumor subtypes, especially those that arise in younger women or women with dense breast tissue, and are more aggressive. There is an urgent need to find circulating prognostic molecules and liquid biopsy methods for breast cancer diagnosis and reducing the mortality rate. In this study, we systematically evaluated metabolites and proteins in blood to develop a pipeline to identify potential circulating biomarkers for breast cancer risk...
December 19, 2019: Hormones & Cancer
https://read.qxmd.com/read/31838715/platelet-atp-thyroid-hormone-receptor-on-integrin-%C3%AE-v%C3%AE-3-and-cancer-metastasis
#24
REVIEW
Paul J Davis, Shaker A Mousa, Geraldine P Schechter, Hung-Yun Lin
Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin αvβ3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor...
December 14, 2019: Hormones & Cancer
https://read.qxmd.com/read/31468469/metastatic-adrenocortical-carcinoma-a-single-institutional-experience
#25
JOURNAL ARTICLE
Dwight H Owen, Sandipkumar Patel, Lai Wei, John E Phay, Lawrence A Shirley, Lawrence S Kirschner, Carl Schmidt, Sherif Abdel-Misih, Pamela Brock, Manisha H Shah, Bhavana Konda
Adrenocortical carcinoma (ACC) is a rare malignancy with limited data to guide the management of metastatic disease. The optimal treatment strategies and outcomes of patients with metastatic ACC remain areas of active interest. We retrospectively reviewed patients with ACC who were treated with systemic therapy between January 1997 and October 2016 at The Ohio State University Comprehensive Cancer Center. Kaplan-Meier and Cox proportional hazards regression models were used for survival analysis. We identified 65 patients diagnosed with ACC during the given time period, and 36 patients received systemic therapy for distant metastatic disease...
December 2019: Hormones & Cancer
https://read.qxmd.com/read/31713780/downregulation-of-mir-196-5p-induced-by-hypoxia-drives-tumorigenesis-and-metastasis-in-hepatocellular-carcinoma
#26
JOURNAL ARTICLE
Hao Zheng, Feng-Rui Bi, Yuan Yang, Yong-Gang Hong, Jun-Sheng Ni, Long Ma, Ming-Hua Liu, Li-Qiang Hao, Wei-Ping Zhou, Li-Hua Song, Hong-Li Yan
In hepatocellular carcinoma (HCC), the hypoxic tumor microenvironment can drive enhance tumor malignancy and recurrence. The microRNA (miRNA) miR-196-5p has been shown to modulate the progression of several cancer types, but its roles in HCC remain uncertain. In the present report we observed significant miR-196-5p downregulation in HCC tissues and cells, and we found that the expression of this miRNA significantly impaired the proliferation and metastatic potential of HCC in vitro and in vivo. We identified high-mobility group AT-hook 2 (HMGA2) as a miR-196-5p target gene that was associated with the ability of miR-196-5p to modulate the progression of HCC...
November 12, 2019: Hormones & Cancer
https://read.qxmd.com/read/31631239/collagen-and-papp-a-in-the-etiology-of-postpartum-breast-cancer
#27
REVIEW
Elizabeth Slocum, Doris Germain
Pregnancy has a dual effect on the risk of breast cancer. On one hand, pregnancy at a young age is known to be protective. However, pregnancy is also associated with a transient increased risk of breast cancer. For women that have children after the age of 30, the risk remains higher than women who never had children for decades. Involution of the breast has been identified as a window of mammary development associated with the adverse effect of pregnancy. In this review, we summarize the current understanding of the role of involution and describe the role of collagen in this setting...
October 20, 2019: Hormones & Cancer
https://read.qxmd.com/read/31621000/association-of-long-term-dynamics-in-circulating-testosterone-with-serum-psa-in-prostate-cancer-free-men-with-initial-psa-4-ng-ml
#28
JOURNAL ARTICLE
Kai Wang, Xinguang Chen, Ting-Yuan David Cheng, Peihua Qiu, Victoria Y Bird, Mattia Prosperi
We previously reported that an accelerated decline in circulating testosterone level is associated with a higher risk of prostate cancer (PCa). This study is to examine whether testosterone change rate is related to serum prostate-specific antigen (PSA) concentration among PCa-free men. Longitudinal data were derived from electronic medical records at a tertiary hospital in the Southeastern USA. PCa-free men with initial-PSA < 4 ng/mL and ≥ 2 testosterone measurements were included (n = 632). Three PSA measures (peak, the most recent, and average PSA) during the study period (from first testosterone measurement to the most recent hospital visit) were examined using multivariable-adjusted geometric means and were compared across quintiles of testosterone change rate (ng/dL/month) and current testosterone level (cross-sectional)...
October 16, 2019: Hormones & Cancer
https://read.qxmd.com/read/31317324/mir-4500-regulates-plxnc1-and-inhibits-papillary-thyroid-cancer-progression
#29
JOURNAL ARTICLE
Rui Li, Xin Teng, Haicheng Zhu, Tongliang Han, Qingwei Liu
Although most patients with papillary thyroid cancer (PTC) are curable, there are still a few patients showing poor outcomes and increased risk of secondary cancers after therapies. In this study, we aimed to investigate the correlation between miR-4500 and PTC and to explore its molecular functions. A total of 50 patients were included, and sonography and histological examinations were used for diagnosis. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied for detection of mRNA levels while Western blotting was used for measuring protein expression...
July 17, 2019: Hormones & Cancer
https://read.qxmd.com/read/31254251/assessing-the-effect-of-vitamin-d-replacement-on-basal-cell-carcinoma-occurrence-and-recurrence-rates-in-patients-with-vitamin-d-deficiency
#30
JOURNAL ARTICLE
Bilsev Ince, Mehmet Emin Cem Yildirim, Mehmet Dadaci
The study aimed to determine whether 25-OH vitamin D3 deficiency is present in patients with diagnosed BCC, and the effect of vitamin D replacement on the rates of BCC recurrence in patients with 25-OH vitamin D3 deficiency. In this prospective study, between 2012 and 2017, in the first stage, 25-OH vitamin D3 levels of all patients diagnosed with BCC between 2012 and 2013 were evaluated. In the second stage between 2014 and 2015, we evaluated the 25-OH vitamin D3 level of patients who had 25-OH vitamin D3 level < 25 ng/mL...
June 28, 2019: Hormones & Cancer
https://read.qxmd.com/read/31102172/effects-of-ketoconazole-on-acth-producing-and-non-acth-producing-neuroendocrine-tumor-cells
#31
JOURNAL ARTICLE
Aura D Herrera-Martínez, Richard A Feelders, Wouter W de Herder, Justo P Castaño, María Ángeles Gálvez Moreno, Fadime Dogan, Rosanna van Dungen, Peter van Koetsveld, Leo J Hofland
Prolonged remission of hypercortisolism with steroidogenesis inhibitors has been described in patients with ectopic adrenocorticotropic hormone (ACTH) syndrome. The anti-proliferative and pro-apoptotic effect of ketoconazole in human cancer cells was previously suggested. The aim of this study was to explore the effects of ketoconazole on ACTH-producing and non-ACTH-producing neuroendocrine tumor (NET) cell lines. The effects of ketoconazole alone, and in combination with somatostatin analogs, were evaluated in two human cell lines: DMS-79 (ectopic ACTH-producing small cell lung carcinoma) and BON-1 (human pancreatic NET)...
June 2019: Hormones & Cancer
https://read.qxmd.com/read/31001736/cabergoline-withdrawal-before-and-after-menopause-outcomes-in-microprolactinomas
#32
JOURNAL ARTICLE
Rita Indirli, Emanuele Ferrante, Elisa Sala, Claudia Giavoli, Giovanna Mantovani, Maura Arosio
Natural course of prolactinomas after menopause is not fully elucidated. The aim of this study was to compare recurrence rate after cabergoline withdrawal in premenopausal vs. postmenopausal women with microprolactinoma. Sixty-two women with microprolactinoma treated with cabergoline for at least 1 year and followed for 2 years after drug withdrawal were retrospectively selected. Patients were divided into two groups: 48 patients stopped cabergoline before menopause ("PRE" group), while 14 after menopause ("POST" group)...
June 2019: Hormones & Cancer
https://read.qxmd.com/read/30656558/nuclear-erbb-2-a-novel-therapeutic-target-in-erbb-2-positive-breast-cancer
#33
REVIEW
Rosalía I Cordo Russo, María F Chervo, Santiago Madera, Eduardo H Charreau, Patricia V Elizalde
Membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbB family of receptor tyrosine kinases, occurs in 15-20% of breast cancers (BC) and constitutes a therapeutic target in this BC subtype (ErbB-2-positive). Although MErbB-2-targeted therapies have significantly improved patients' clinical outcome, resistance to available drugs is still a major issue in the clinic. Lack of accurate biomarkers for predicting responses to anti-ErbB-2 drugs at the time of diagnosis is also an important unresolved issue...
June 2019: Hormones & Cancer
https://read.qxmd.com/read/31093954/exploratory-analysis-of-plasma-neurotensin-as-a-novel-biomarker-for-early-detection-of-colorectal-polyp-and-cancer
#34
JOURNAL ARTICLE
Shengyang Qiu, Stella Nikolaou, Francesca Fiorentino, Shahnawaz Rasheed, Ara Darzi, David Cunningham, Paris Tekkis, Christos Kontovounisios
Earlier detection of colorectal cancer (CRC) results in improved survival. Existing non-invasive biomarkers have suboptimal accuracy. Neurotensin (NTS) is involved in CRC carcinogenesis. This study evaluated the diagnostic potential of plasma NTS for colorectal polyps and cancers. Participants were selected based on national CRC referral guidelines. All subjects underwent colonoscopy. Average plasma concentrations were compared across different diagnostic groups. Predictors for detecting colorectal neoplasia were identified...
May 15, 2019: Hormones & Cancer
https://read.qxmd.com/read/30989580/recent-use-of-oral-contraceptives-and-risk-of-luminal-b-triple-negative-and-her2-overexpressing-breast-cancer
#35
JOURNAL ARTICLE
Nicole C Lorona, Linda S Cook, Mei-Tzu C Tang, Deirdre A Hill, Charles L Wiggins, Christopher I Li
Oral contraceptive use is a well-established risk factor for breast cancer and is common among reproductive-aged women in the USA. Its relationship with less common, more aggressive, molecular subtypes is less clear. A population-based case-case analysis was conducted comparing three less common molecular subtypes to luminal A breast cancer among 1701 premenopausal cases aged 21-49 diagnosed with a first primary invasive breast cancer between 2004 and 2015. Medical record reviews and structured interviewer-administered questionnaires were used to collect data on oral contraceptive use...
April 15, 2019: Hormones & Cancer
https://read.qxmd.com/read/30903583/the-combination-of-ret-braf-and-demographic-data-identifies-subsets-of-patients-with-aggressive-papillary-thyroid-cancer
#36
JOURNAL ARTICLE
Jose R W Martínez, Sergio Vargas-Salas, Soledad Urra Gamboa, Estefanía Muñoz, José Miguel Domínguez, Augusto León, Nicolás Droppelmann, Antonieta Solar, Mark Zafereo, F Christopher Holsinger, Hernán E González
The use of BRAFV600E and RET/PTC1 as biomarkers to guide the extent of surgery in patients with papillary thyroid cancer (PTC) remains controversial. We assessed the combined use of demographic data (sex and age) with mRNA expression levels and/or mutational status (BRAFV600E and RET/PTC1) to identify potential subsets of patients with aggressive histopathological features (lymph node metastases and extrathyroidal extension). In a cohort of 126 consecutive patients, BRAFV600E and RET/PTC1 mutations were found in 52 and 18%, respectively...
March 22, 2019: Hormones & Cancer
https://read.qxmd.com/read/30877616/role-of-estrogen-in-androgen-induced-prostate-carcinogenesis-in-nbl-rats
#37
JOURNAL ARTICLE
Nur Ozten, Katherine Vega, Joachim Liehr, Xi Huang, Lori Horton, Ercole L Cavalieri, Eleanor G Rogan, Maarten C Bosland
Androgens are thought to cause prostate cancer, but the underlying mechanisms are unclear. Data from animal studies suggest that for androgens to cause prostate cancer, they must be aromatized to estrogen and act in concert with estrogen metabolites. We tested the hypothesis that androgen-receptor and estrogen receptor-mediated effects of androgen and estrogen are necessary, as well as genotoxicity of estrogen metabolites. NBL rats were treated with androgenic and estrogenic compounds for 16-75 weeks through slow-release silastic implants or pellets...
March 16, 2019: Hormones & Cancer
https://read.qxmd.com/read/30712080/estrogen-signaling-in-endometrial-cancer-a-key-oncogenic-pathway-with-several-open-questions
#38
REVIEW
Adriana C Rodriguez, Zannel Blanchard, Kathryn A Maurer, Jason Gertz
Endometrial cancer is the most common gynecological cancer in the developed world, and it is one of the few cancer types that is becoming more prevalent and leading to more deaths in the USA each year. The majority of endometrial tumors are considered to be hormonally driven, where estrogen signaling through estrogen receptor α (ER) acts as an oncogenic signal. The major risk factors and some treatment options for endometrial cancer patients emphasize a key role for estrogen signaling in the disease. Despite the strong connections between estrogen signaling and endometrial cancer, important molecular aspects of ER function remain poorly understood; however, progress is being made in our understanding of estrogen signaling in endometrial cancer...
February 2, 2019: Hormones & Cancer
https://read.qxmd.com/read/30565014/a-targeted-bivalent-androgen-receptor-binding-compound-for-prostate-cancer-therapy
#39
JOURNAL ARTICLE
Shafinaz Chowdhury, Lenore K Beitel, Rose Lumbroso, Enrico O Purisima, Miltiadis Paliouras, Mark Trifiro
The androgen-directed treatment of prostate cancer (PCa) is fraught with the recurrent profile of failed treatment due to drug resistance and must be addressed if we are to provide an effective therapeutic option. The most singular difficulty in the treatment of PCa is the failure to respond to classical androgen withdrawal or androgen blockade therapy, which often develops as the malignancy incurs genetic alterations and gain-of-function somatic mutations in the androgen receptor (AR). Physical cellular damaging therapeutic agents, such as radiation or activatable heat-generating transducers would circumvent classical "anti-functional" biological resistance, but to become ultimately effective would require directed application modalities...
February 2019: Hormones & Cancer
https://read.qxmd.com/read/30293206/aggressiveness-of-localized-prostate-cancer-the-key-value-of-testosterone-deficiency-evaluated-by-both-total-and-bioavailable-testosterone-androcan-study-results
#40
JOURNAL ARTICLE
Yann Neuzillet, Jean-Pierre Raynaud, Jean-François Dreyfus, Camélia Radulescu, Mathieu Rouanne, Marc Schneider, Sylvie Krish, Morgan Rouprêt, Sarah J Drouin, Eva Comperat, Marc Galiano, Xavier Cathelineau, Pierre Validire, Vincent Molinié, Jean Fiet, Franck Giton, Thierry Lebret, Henry Botto
Failure rates after first-line treatment of localized prostate cancer (PCa) treatment remain high. Improvements to patient selection and identification of at-risk patients are central to reducing mortality. We aimed to determine if cancer aggressiveness correlates with androgen levels in patients undergoing radical prostatectomy for localized PCa. We performed a prospective, multicenter cohort study between June 2013 and June 2016, involving men with localized PCa scheduled to undergo radical prostatectomy...
February 2019: Hormones & Cancer
journal
journal
42676
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.