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Allergy, Asthma & Immunology Research

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https://read.qxmd.com/read/30661320/higher-binding-affinity-and-in-vitro-potency-of-reslizumab-for-interleukin-5-compared-with-mepolizumab
#1
Mark Liddament, Jean Husten, Tanya Estephan, David Laine, David Mabon, Laurie Pukac, Jacquelyn Lyons, Adam W Clarke, Anthony Doyle
Reslizumab and mepolizumab are recently approved monoclonal antibodies for the treatment of severe (uncontrolled) eosinophilic asthma. Both are effective in neutralizing the function of interleukin-5 (IL-5). This study is the first to compare the binding affinity and in vitro potency of both antibodies in head-to-head assays. Two assays assessed binding affinity (using the equilibrium dissociation constant [KD ]) of each drug for human IL-5. In the Biacore surface plasmon resonance assay, the association constant (kon ) values for human IL-5 for reslizumab and mepolizumab were 3...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661319/prescription-patterns-and-burden-of-pediatric-asthma-in-korea
#2
In Suk Sol, Yoon Hee Kim, Soo Yeon Kim, Sun Ha Choi, Jong Deok Kim, Bo Ok Kim, Ji Eun Moon, Kyung Won Kim, Myung Hyun Sohn
PURPOSE: This study aimed to estimate the prevalence, prescription pattern and burden of pediatric asthma in Korea by analyzing the National Health Insurance (NHI) claims data. METHODS: We retrospectively analyzed the insurance claim records from the Korean NHI claims database from January 2010 to December 2014. Asthmatic patients were defined as children younger than 18 years, with appropriate 10th Revision of the International Classification of Diseases codes (J45 or J46) and a prescription for 1 or more asthma maintenance medications at the same date...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661318/intranasal-treatment-with-1-25-dihydroxyvitamin-d3-alleviates-allergic-rhinitis-symptoms-in-a-mouse-model
#3
Sung Woo Cho, Yu Lian Zhang, Young Kyung Ko, Jae Min Shin, Jun Ho Lee, Chae Seo Rhee, Dong Young Kim
PURPOSE: Vitamin D is a potent immunomodulator. However, its role in the pathogenesis of allergic rhinitis is unclear. METHODS: The aim of this study was to evaluate the antiallergic effect of intranasally applied vitamin D in an allergic rhinitis mouse model. BALB/c mice were intraperitoneally sensitized with ovalbumin (OVA) and alum before they were intranasally challenged with OVA. Then, they were intranasally administered 1, 25-dihydroxyvitamin D3 (0.02 μg) or solvent...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661317/a-fusion-protein-of-derp2-allergen-and-flagellin-suppresses-experimental-allergic-asthma
#4
Wenzhi Tan, Jin Hai Zheng, Tra My Nu Duong, Young Il Koh, Shee Eun Lee, Joon Haeng Rhee
PURPOSE: The house dust mite (HDM) is one of the most important sources of indoor allergens and a significant cause of allergic rhinitis and allergic asthma. Our previous studies demonstrated that Vibrio vulnificus flagellin B (FlaB) plus allergen as a co-treatment mixture improved lung function and inhibited eosinophilic airway inflammation through the Toll-like receptor 5 signaling pathway in an ovalbumin (OVA)- or HDM-induced mouse asthma model. In the present study, we fused the major mite allergen Derp2 to FlaB and compared the therapeutic effects of the Derp2-FlaB fusion protein with those of a mixture of Derp2 and FlaB in a Derp2-induced mouse asthma model...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661316/severe-cutaneous-adverse-reactions-in-korean-pediatric-patients-a-study-from-the-korea-scar-registry
#5
Hea Lin Oh, Dong Yoon Kang, Hye Ryun Kang, Sujeong Kim, Young Il Koh, Sae Hoon Kim, Min Hye Kim, Dong In Suh
PURPOSE: Although severe cutaneous adverse drug reactions (SCARs) are rare, they are associated with high morbidity and mortality, and thus early diagnosis and treatment are critical for improving prognoses. However, few studies have reported the characteristics of SCARs in children. Thus, we aimed to evaluate the clinical characteristics, current management and prognosis of pediatric SCARs. METHODS: We analyzed pediatric data in the Korean SCARs registry, which was built retrospectively in 2016 with SCAR cases treated in 34 tertiary referral university hospitals during 2010-2015...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661315/eperisone-induced-anaphylaxis-pharmacovigilance-data-and-results-of-allergy-testing
#6
Kyung Hee Park, Sang Chul Lee, Ji Eun Yuk, Sung Ryeol Kim, Jae Hyun Lee, Jung Won Park
PURPOSE: Eperisone is an oral muscle relaxant used in musculoskeletal disorders causing muscle spasm and pain. For more effective pain control, eperisone is usually prescribed together with nonsteroidal anti-inflammatory drugs (NSAIDs). As such, eperisone may have been overlooked as the cause of anaphylaxis compared with NSAIDs. This study aimed to analyze the adverse drug reaction (ADR) reported in Korea and suggest an appropriate diagnostic approach for eperisone-induced anaphylaxis...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661314/multicenter-adherence-study-of-asthma-medication-for-children-in-korea
#7
Chang Keun Kim, Zak Callaway, Jungi Choi, Hyo Bin Kim, Eun Mi Kwon, Yoon Seok Chang, Yeong Ho Rha, Soo Jong Hong, Jae Won Oh, Hyun Hee Kim, Dae Hyun Lim, Sung Won Kim, Kang Seo Park, Yong Hoon Cho, Hai Lee Chung, Hee Ju Park, Sang Gun Jung, Im Joo Kang, Myung Chul Hyun, Moo Young Oh, Jin A Jung, Myung Sung Kim, Jung Yeon Shim, Jin Tack Kim, Young Yull Koh
PURPOSE: Adherence is a major component of successful medical treatment. However, non-adherence remains a barrier to effective delivery of healthcare worldwide. METHODS: Twenty healthcare facilities (secondary or tertiary hospitals) belonging to the Korean Academy of Pediatric Allergy and Respiratory Diseases (KAPARD) participated. Questionnaires were given to patients currently receiving treatment in the form of inhalant useor oral intake or transdermal patch for mild to moderate asthma...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661313/phenotypes-of-severe-cutaneous-adverse-reactions-caused-by-nonsteroidal-anti-inflammatory-drugs
#8
Suh Young Lee, Young Hee Nam, Young Il Koh, Sae Hoon Kim, Sujeong Kim, Hye Ryun Kang, Min Hye Kim, Jun Gyu Lee, Jung Won Park, Hye Kyung Park, Hyen O La, Mi Yeong Kim, Seong Ju Park, Yong Eun Kwon, Jae Woo Jung, Sang Hyon Kim, Cheol Woo Kim, Min Seok Yang, Min Gyu Kang, Jin Yong Lee, Joo Hee Kim, Sang Heon Kim, Gyu Young Hur, Young Koo Jee, Hyun Jung Jin, Chan Sun Park, Yi Yeong Jeong, Young Min Ye
PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are common cause of severe cutaneous adverse reactions (SCARs). The present study aimed to investigate the characteristics of SCARs induced by NSAIDs in the Korean SCAR registry. METHODS: A retrospective survey of NSAID-induced SCARs recorded between 2010 and 2015 at 27 university hospitals in Korea was conducted. Clinical phenotypes of SCARs were classified into Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), SJS-TEN overlap syndrome and drug reaction with eosinophilia and systemic symptoms (DRESS)...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661312/comparison-between-signature-cytokines-of-nasal-tissues-in-subtypes-of-chronic-rhinosinusitis
#9
Dong Kyu Kim, Kyoung Mi Eun, Min Kyung Kim, Deuktae Cho, Sun A Han, Sang Yoon Han, Yuju Seo, Dong Han Lee, Seong Ho Cho, Dae Woo Kim
PURPOSE: Endotype in chronic rhinosinusitis (CRS) has been established in the last decade. However, the exact immunologic profile of CRS still has controversy because it has a considerable immunologic heterogeneity. Therefore, we investigated various inflammatory mediators according to different nasal tissues in chronic rhinosinusitis and compared them within the same subject. METHODS: We collected uncinate process mucosa (UP) and nasal polyp (NP) tissues from controls, CRS without NP (CRSsNP) and CRS with NP (CRSwNP)...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661311/update-on-the-management-of-occupational-asthma-and-work-exacerbated-asthma
#10
REVIEW
Ambrose Lau, Susan M Tarlo
Work-related asthma is the most common occupational lung disease encountered in clinical practice. In adult asthmatics, work-relatedness can account for 15%-33% of cases, but delays in diagnosis remain common and lead to worse outcomes. Accurate diagnosis of asthma is the first step to managing occupational asthma, which can be sensitizer-induced or irritant-induced asthma. While latency has traditionally been recognized as a hallmark of sensitizer-induced asthma and rapid-onset a defining feature of irritant-induced asthma (as in Reactive Airway Dysfunction Syndrome), there is epidemiological evidence for irritant-induced asthma with latency from chronic moderate exposure...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661310/lessons-learned-from-gwas-of-asthma
#11
REVIEW
Kyung Won Kim, Carole Ober
Asthma is a common complex disease of the airways. Genome-wide association studies (GWASs) of asthma have identified many risk alleles and loci that have been replicated in worldwide populations. Although the risk alleles identified by GWAS have small effects and explain only a small portion of prevalence, the discovery of asthma loci can provide an understanding of its genetic architecture and the molecular pathways involved in disease pathogenesis. These discoveries can translate into advances in clinical care by identifying therapeutic targets, preventive strategies and ultimately approaches for personalized medicine...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661309/increasing-prevalence-of-allergic-rhinitis-in-china
#12
REVIEW
Yuan Zhang, Luo Zhang
Allergic rhinitis (AR) is a critical public health, medical and economic problem in China. AR is also an important risk factor which will cause many diseases or disorders, especially in children. The trend of AR incidence is still on the rise in recent years and has had a significant effect on the general public. This significant increase is alarming, which highlights an urgent need for better understanding of the prevalence status and characteristics, sensitization patterns, and the associated risk factors of AR in order to improve treatment and develop effective prevention strategies...
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30661308/does-inflammatory-endotype-can-change-in-patients-with-chronic-rhinosinusitis
#13
EDITORIAL
Dong Kyu Kim, Dae Woo Kim
No abstract text is available yet for this article.
March 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30479084/pollen-fruit-syndrome-clinical-relevance-of-the-cypress-pollen-allergenic-gibberellin-regulated-protein
#14
Hélène Sénéchal, Sanaz Keykhosravi, Rémy Couderc, Marie Ange Selva, Youcef Shahali, Tomoyasu Aizawa, Jean Marc Busnel, Rihane Arif, Inna Mercier, Nhan Pham-Thi, Denis André Charpin, Pascal Poncet
A pollen/food-associated syndrome (PFAS) has been described between peach and cypress pollen. Cross-reactive allergens were characterized which belong to the Gibberellin-regulated protein (GRP) family, BP14 in cypress pollen and Pru p 7 in peach. GRP are small cationic protein with anti-microbial properties. A patient suffering from a peach/cypress syndrome was explored clinically and biologically using 2 types of immunoglobulin E (IgE) multiarray microchip, immunoblots and a basophil activation test to assess the clinical relevance of various extracts and purified allergens from fruits or cypress pollen...
January 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30479083/effects-of-ser47-point-mutation-on-conformation-structure-and-allergenicity-of-the-allergen-of-der-p-2-a-major-house-dust-mite-allergen
#15
Bhakkawarat Kulwanich, Sasipa Thanyaratsrisakul, Orathai Jirapongsananuruk, Belinda J Hales, Wayne R Thomas, Surapon Piboonpocanun
PURPOSE: Hypoallergenic recombinant Der p 2 has been produced by various genetic manipulations, but mutation of a naturally polymorphic amino acid residue known to affect IgE binding has not been studied. This study aimed to determine the effect of a point mutation (S47W) of residue 47 of Der p 2 on its structure and immunoglobulin (Ig) E binding. Its ability to induce pro-inflammatory responses and to induce blocking IgG antibody was also determined. METHODS: S47 of recombinant Der p 2...
January 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30479082/mugwort-pollen-related-food-allergy-lipid-transfer-protein-sensitization-and-correlation-with-the-severity-of-allergic-reactions-in-a-chinese-population
#16
Shan Deng, Jia Yin
PURPOSE: Little is known about the importance of lipid transfer protein (LTP) sensitization in China. In this study, we investigated the relationship between LTP sensitization and the severity of clinical symptoms in a population of patients with mugwort pollen-related food allergy. METHODS: Food-induced symptoms were evaluated in 148 patients with mugwort pollen allergy by a standardized questionnaire. Specific immunoglobulin E (IgE) to Art v 1, Art v 3, Pru p 3, Ara h 9 and Cor a 8 were quantified by ImmunoCAP...
January 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30479081/different-biological-pathways-are-up-regulated-in-the-elderly-with-asthma-sputum-transcriptomic-analysis
#17
Byung Keun Kim, Hyun Seung Lee, Kyoung Hee Sohn, Suh Young Lee, Sang Heon Cho, Heung Woo Park
BACKGROUND: Elderly asthma (EA) is increasing, but the pathogenesis is unclear. This study aimed to identify EA-related biological pathways by analyzing genome-wide gene expression profiles in sputum cells. METHODS: A total of 3,156 gene probes with significantly differential expressions between EA and healthy elderly controls were used for a hierarchical clustering of genes to identify gene clusters. Gene set enrichment analysis provided biological information, with replication from Gene Expression Omnibus expression profiles...
January 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30479080/prevalence-and-clinical-features-of-drug-reactions-with-eosinophilia-and-systemic-symptoms-syndrome-caused-by-antituberculosis-drugs-a-retrospective-cohort-study
#18
Ho Yeon Jung, Sunmin Park, Beomsu Shin, Ji Ho Lee, Seok Jeong Lee, Myoung Kyu Lee, Won Yeon Lee, Suk Joong Yong, Sang Ha Kim
PURPOSE: Although there have been reported cases of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome caused by antituberculosis drugs, there has been no research to examine its prevalence. This study assessed the prevalence and clinical characteristics of DRESS syndrome caused by antituberculosis drugs. METHODS: The electronic medical records of a cohort consisting of adult patients diagnosed with tuberculosis between July 2006 and June 2010 were reviewed and retrospectively inspected...
January 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30479079/association-between-epithelial-cytokines-and-clinical-phenotypes-of-elderly-asthma
#19
Bastsetseg Ulambayar, So Hee Lee, Eun Mi Yang, Young Min Ye, Hae Sim Park
PURPOSE: Asthma in the elderly has different clinical features including more severe phenotypes with higher comorbidities. Epithelial cells are known to initiate innate/adaptive immune responses in asthmatic airways. We investigated clinical features and epithelial derived cytokine levels in elderly asthmatics compared to non-elderly asthmatics in a cross-sectional cohort of adult asthmatics in order to further understand its pathogenic mechanisms. METHODS: A total of 1,452 adult asthmatics were enrolled from a single tertiary hospital and were classified into 2 groups: 234 elderly (≥ 60 years at initial diagnosis) and 1,218 non-elderly (< 60 years at initial diagnosis) asthmatics...
January 2019: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/30479078/comparison-of-long-term-efficacy-of-subcutaneous-immunotherapy-in-pediatric-and-adult-patients-with-allergic-rhinitis
#20
Yanran Huang, Chengshuo Wang, Feifei Cao, Yan Zhao, Hongfei Lou, Luo Zhang
PURPOSE: Data comparing the long-term efficacy and safety of subcutaneous immunotherapy (SCIT) using house dust mite (HDM) in children and adults with allergic rhinitis (AR) are limited. This study aimed to compare the long-term effects of HDM-SCIT in a cohort of Chinese pediatric and adult patients with AR. METHODS: A total of 124 pediatric and adult AR patients received HDM-SCIT for 3 years, with 118 patients being followed-up for 2 years. Prior to treatment (baseline), at the end of the 3-year treatment periods (third year) and 2 years after the discontinuation of treatment (fifth year), all patients were evaluated for total nasal symptom scores (TNSS), daily medication score (DMS), total combined score (TCS; symptoms [nasal + ocular] + DMS) and quality of life (QoL)...
January 2019: Allergy, Asthma & Immunology Research
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