Shotaro Watanabe, Hiroaki Hosokawa, Takuya Sakamoto, Manato Horii, Yoshimasa Ono, Seiji Kimura, Satoshi Yamaguchi, Seiji Ohtori, Takahisa Sasho
OBJECTIVE: Multilineage differentiating stress-enduring (Muse) cells, a pluripotent stem cell subset of mesenchymal stem cells (MSCs), have shown promise for various tissue repairs due to their stress tolerance and multipotent capabilities. We aimed to investigate the differentiation potential in vitro , the dynamics in vivo , and the reparative contribution of Muse cells to osteochondral lesions. DESIGN: Labeled MSCs were cultured and sorted into Muse and non-Muse (MSCs without Muse cells) groups...
June 17, 2024: Cartilage
Jonathan J Bjerre-Bastos, Casper Sejersen, Henning Bay Nielsen, Mikael Boesen, Niels H Secher, Gregorio Distajo, Vincent Flood, Yves Henrotin, Melanie Uebelhoer, Peter Krustrup, Carl-Christian Kitchen, Christian S Thudium, Jeppe R Andersen, Asger R Bihlet
OBJECTIVE: To investigate how running, cycling, and sedentary cardiovascular stress impact biomarkers of cartilage turnover acutely in subjects with knee osteoarthritis (OA). DESIGN: This was a sequential, cross-over, clinical study. Forty subjects with primary knee OA underwent moderate-to-high-intensity cycling, running, and adrenaline infusion on separate days. Blood was sampled before, during, and at 6-time points after intervention. On a control day, similar samples were taken...
June 9, 2024: Cartilage
Dongjie Hou, Ling Lu, Ran Tao
OBJECTIVE: Knee osteoarthritis (KOA) is a complex degenerative joint disease and a major cause of joint dysfunction. This study aimed to explore the function of hsa_circ_0007482 on inflammation, proliferation, differentiation, and apoptosis in KOA. DESIGN: Real-time quantitative polymerase chain reaction (PCR) was performed to detect the expression of circ_0007482, inflammatory factors, and differentiation-related molecules in KOA chondrocytes and interleukin (IL)-1β-stimulated chondrocytes...
May 15, 2024: Cartilage
Anne-Mari Mustonen, Janne Capra, Sanna Oikari, Laura Säisänen, Lauri Karttunen, Petro Julkunen, Petri Lehenkari, Antti Joukainen, Antti Jaroma, Tommi Paakkonen, Tommi Kääriäinen, Heikki Kröger, Petteri Nieminen
OBJECTIVE: Hyaluronic acid (HA) in synovial fluid (SF) contributes to boundary lubrication with altered levels in osteoarthritis (OA) and rheumatoid arthritis (RA). SF extracellular vesicles (EVs) may participate in arthritis by affecting inflammation and cartilage degradation. It remains unknown whether HA and EVs display joint-specific alterations in arthritic SFs. DESIGN: We investigated the numbers and characteristics of HA-particles and large EVs in SF from knees and shoulders of 8 OA and 8 RA patients and 8 trauma controls, and in plasma from 10 healthy controls and 11 knee OA patients...
May 10, 2024: Cartilage
Guan-Ling Lin, Joseph Jordan Keller, Li-Hsuan Wang
OBJECTIVE: To investigate the effect of higher cumulative defined daily dose per year (cDDD/y) compared with lower cDDD/y of statin use in the incidence of any joint osteoarthritis (OA). DESIGN: In this population-based retrospective cohort study, patients who were aged ≥40 years were newly initiated on statin therapy between 2002 and 2011, and had a statin prescription for ≥90 days in the first year of treatment were identified from the 2000 Longitudinal Generation Tracking Database...
May 10, 2024: Cartilage
Luca Andriolo, Theodorakys Marín Fermín, Giulia Marcella Maryse Chiari Gaggia, Andreas Serner, Elizaveta Kon, Emmanuel Papakostas, Andrew Massey, Peter Verdonk, Giuseppe Filardo
OBJECTIVE: To systematically review the literature and analyze clinical outcomes and return-to-sport after surgical management of cartilage injuries in football players. DESIGN: A systematic literature review was performed in August 2023 on PubMed, WebOfScience, and Cochrane Library to collect studies on surgical strategies for cartilage lesions in football players. Methodological quality and risk of bias were assessed with the modified Coleman Methodology score and RoB2 and RoBANS2 tools...
April 23, 2024: Cartilage
R P Suderman, M B Hurtig, M D Grynpas, P R T Kuzyk, A Changoor
OBJECTIVE: The osteochondral allograft procedure uses grafts constructed larger than the recipient site to stabilize the graft, in what is known as the press-fit technique. This research aims to characterize the relationships between press-fit size, insertion forces, and cell viability in ovine and human osteochondral tissue. DESIGN: Human (4 donors) and ovine (5 animals) articular joints were used to harvest osteochondral grafts (4.55 mm diameter, N = 33 Human, N = 35 Ovine) and create recipient sites with grafts constructed to achieve varying degrees of press fit (0...
April 23, 2024: Cartilage
Isabel Guillén-Vicente, Ramón Herros-García, Marta Guillén-Vicente, Borja Ruiz, Juan Manuel Lopez-Alcorocho, Elena Rodríguez-Iñigo, Adrián Barrera, Tomás F Fernández-Jaén, Steve Abelow, Pedro Guillén-García
OBJECTIVE: To investigate intermediate-term clinical results in patients with concomitant anterior cruciate ligament (ACL) reconstruction and chondral defect treated with high-density autologous chondrocyte implantation (HD-ACI) compared to patients without ACL tear but with a chondral lesion and HD-ACI treatment. DESIGN: Forty-eight patients with focal chondral lesions underwent HD-ACI (24 with ACL reconstruction after an ACL injury and 24 with an intact ACL). Follow-up assessments occurred at 6, 12, and 24 months...
April 23, 2024: Cartilage
Beibei Li, Enpu Shen, Zhiwen Wu, Hui Qi, Cheng'ai Wu, Danping Liu, Xu Jiang
OBJECTIVE: Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) may modulate the M1/M2 polarization of macrophages during osteoarthritis (OA). However, the underlying mechanisms of BMSC-Exos in this process still need to be elucidated. In this study, we explored the role of BMSC-Exos in the polarization of macrophages in vitro and the OA rats in vivo . METHODS: The effects of BMSC-Exos on RAW264.7 cells were determined, including the production of reactive oxygen species (ROS) and the protein expression of Akt, PINK1, and Parkin...
April 20, 2024: Cartilage
Yu Jung Kim, Jin Han, Seungwoo Han
OBJECTIVE: Oxidative stress and endoplasmic reticulum (ER) stress play pivotal roles in disrupting the homeostasis of chondrocytes by producing catalytic proteases and enhancing chondrocyte senescence, consequently contributing to the progression of osteoarthritis (OA). Despite their close interaction, the underlying molecular mechanisms remain poorly understood. Here, we show that ER stress and oxidative stress reciprocally modulate each other to promote cartilage degradation. METHODS: Primary chondrocytes were obtained from the articular cartilage of 5-day-old C57BL/6J mice by excising distal femur and proximal tibia...
April 20, 2024: Cartilage
Shaun Kai Kiat Chua, Walter-Soon-Yaw Wong, Don Thong Siang Koh, Rehena Sultana, Junwei Soong, Kong Hwee Lee, Hamid Rahmatullah Bin Abdul Razak
OBJECTIVE: The use of synthetic bone substitute material (BSM) as osteotomy gap fillers have been reported to improve outcomes in medial opening wedge high tibial osteotomy (MOWHTO). This study aims to evaluate the early radiological outcomes (bone union) and complication rates of the novel patient-specific 3D-printed honeycomb-structured polycaprolactone and tricalcium phosphate (PCL-TCP) synthetic graft compared to allogeneic bone grafts as an osteotomy gap filler in MOWHTO. METHODS: A retrospective matched-pair analysis of patients who underwent MOWHTO with either PCL-TCP synthetic graft or allogenic femoral head allograft as osteotomy gap filler was performed...
April 16, 2024: Cartilage
John-Peter Bonello, M Yat Tse, Trevor J G Robinson, Davide D Bardana, Stephen D Waldman, Stephen C Pang
OBJECTIVES: While substantial progress has been made in engineering cartilaginous constructs for animal models, further research is needed to translate these methodologies for human applications. Evidence suggests that cultured autologous chondrocytes undergo changes in phenotype and gene expression, thereby affecting their proliferation and differentiation capacity. This study was designed to evaluate the expression of chondrogenic markers in cultured human articular chondrocytes from passages 3 (P3) and 7 (P7), beyond the current clinical recommendation of P3...
April 14, 2024: Cartilage
Julia S Retzky, Connor Fletcher, Morgan Rizy, Alissa Burge, Sabrina M Strickland
PURPOSE: The primary aim is to evaluate the relationship between MOCART scores and patient satisfaction, as evaluated by achievement of (1) the Patient Acceptable Symptomatic State (PASS) and (2) the minimal clinically important difference (MCID) for Knee Injury and Osteoarthritis Score Quality of Life (KOOS QoL), for patients undergoing autologous chondrocyte implantation (ACI) for focal Grade IV patellofemoral chondral defects. The secondary aim is to determine the threshold MOCART score which predicts the ability to meet the PASS and the MCID for KOOS QoL...
April 13, 2024: Cartilage
Ben Efrima, Agustin Barbero, Camilla Maccario, Cristian Indino, Chiara Nocera, Assaf Albagli, Jari Dahmen, Federico Giuseppe Usuelli
PURPOSE: This study aims to evaluate the clinical outcomes of arthroscopic autologous matrix-induced chondrogenesis (A-AMIC) for osteochondral lesions of the talus (OLT) at 24 months and 60 months of follow-up. The secondary aim was to assess whether age, body mass index (BMI), and lesion surface affect outcomes. DESIGN: Sixty-three patients (32 males, 31 females) with a median age of 37 years [interquartile range (IQR): 25-48] were included. Preoperative and postoperative (24 months and 60 months) clinical outcomes were evaluated using a Visual Analog Score (VAS) for pain during walking, the American Orthopaedic Foot and Ankle Society (AOFAS), Short-Form Survey (SF-12), the Halasi, and the University of California, Los Angeles (UCLA) scores...
March 30, 2024: Cartilage
Junjun Yang, Xin Wang, Yingbo Zhang, Rui He, Zhenlan Fu, Rong Wang, Yanming Ma, Dejie Fu, Shuo Meng, Wang Cai, Yizhao Zhou, Cheng Chen, Guangxing Chen, Xiaoyuan Gong
OBJECTIVE: Cytokines are implicated in the pathogenesis of osteoarthritis (OA), and this study aims to assess the therapeutic potential of an IL-8 neutralizing monoclonal antibody (mAb) for OA intervention. DESIGN: The study employed a rabbit model of OA induced by anterior cruciate ligament transection (ACLT) surgery to investigate the effects of an interleukin (IL)-8 neutralizing mAb, with hyaluronic acid (HA) used as a positive control. Primary outcomes assessed in the rabbits included cartilage repair, synovitis, joint effusion, changes in footprints, and lower limb loading conditions...
March 25, 2024: Cartilage
Youichi Yasui, Wataru Miyamoto, Yoshiharu Shimozono, Keisuke Tsukada, Hirotaka Kawano, Masato Takao
BACKGROUND: Retrograde drilling is an established surgical technique to treat osteochondral lesions of the talus (OLT). It involves non-trans-articular drilling to induce subchondral bone revascularization and bone formation without damaging the overlying articular cartilage. The present study aimed to elucidate the heterogeneity of clinical studies on retrograde drilling for OLT. DESIGN: A systematic search of the MEDLINE, Web of Science, EMBASE, and Cochrane Library databases for studies published between January 1996 and August 27, 2022, was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines by two independent reviewers...
March 20, 2024: Cartilage
Christoph Gaissmaier, Peter Angele, Robert C Spiro, Annette Köhler, Alexandra Kirner, Philipp Niemeyer
OBJECTIVE: To compare substantial clinical benefit (SCB) of a hydrogel-based, matrix-associated autologous chondrocyte implantation (M-ACI) method versus microfracture (MFx) in the treatment of knee cartilage defects. DESIGN: Propensity score matched-pair analysis, using the MFx control group of a phase III study as comparator for M-ACI treatment in a single-arm phase III study, resulting in 144 patients in the matched-pair set. RESULTS: Groups were comparable regarding baseline Knee Injury and Osteoarthritis Outcome Score (KOOS), sex, age, body mass index, symptom duration, smoking status, and previous knee surgeries...
March 19, 2024: Cartilage
Ellen G J Ripmeester, Jessica S J J Steijns, Karolina A P Wijnands, Roderick H M J Stassen, Vasek Pitelka, Laura C W Peeters, Andy Cremers, Nzekui M S A Astryde, Alzbeta Chabronova, Don A M Surtel, Pieter J Emans, Guus G H van den Akker, Bert van Rietbergen, Lodewijk W van Rhijn, Marjolein M J Caron, Tim J M Welting
OBJECTIVE: Osteoarthritis (OA) is characterized by articular cartilage erosion, pathological subchondral bone changes, and signs of synovial inflammation and pain. We previously identified p[63-82], a bone morphogenetic protein 7 (BMP7)-derived bioactive peptide that attenuates structural cartilage degeneration in the rat medial meniscal tear-model for posttraumatic OA. This study aimed to evaluate the cartilage erosion-attenuating activity of p[63-82] in a different preclinical model for OA (anterior cruciate ligament transection-partial medial meniscectomy [anterior cruciate ligament transection (ACLT)-pMMx])...
March 19, 2024: Cartilage
Rimtautas Gudas, Mantas Staškūnas, Justinas Mačiulaitis, Emilė Gudaitė, Ieva Aleknaite-Dambrauskiene
OBJECTIVE: The main objective of this study is to assess the safety and clinical efficacy of a cell-free bilayer scaffold (MaioRegen Chondro+ by Fin-Ceramica) in patients affected by chondral knee lesions of different origin and localization. DESIGN: Thirty-one patients with focal chondral lesions of the knee were arthroscopically treated with MaioRegen Chondro+. All patients were prospectively evaluated for a minimum of 2 years using the International Knee Documentation Committee (IKDC) Questionnaire and the Tegner Activity Scale...
March 19, 2024: Cartilage
Robin P Blom, Danka Rahim, Erik Paardekam, Gino M M J Kerkhoffs, Davide Iannuzzi, Theodoor H Smit
OBJECTIVE: To investigate whether and how a single traumatic impact changes the mechanical properties of talar articular cartilage. DESIGN: A marble was placed on the joint surface and a weight was dropped on both medial and lateral caprine talus to create a well-defined single focal impact. The mechanical properties of intact and impacted talar cartilage were measured with a micro-indenter. Elastic (storage) and viscous (loss) moduli were determined by oscillatory ramp and dynamic mechanical analysis protocols...
March 19, 2024: Cartilage
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