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Robbie P Miller, Marie E Berlouis, Alan G Hall, A Hamish R W Simpson, Innes D M Smith, Andrew C Hall
OBJECTIVE: Septic arthritis results from joint infection by Staphylococcus aureus, which produces potent α-toxin causing cell death, potentially leading to permanent cartilage damage. Treatment is by joint irrigation and antibiotics, although it is unclear if, following treatment with antibiotics which cause bacterial lysis, there is release of additional stored α-toxin. DESIGN: A rabbit erythrocyte hemolysis assay was optimised to assess biologically-active α-toxin from cultured S...
February 14, 2019: Cartilage
Mylène P Jansen, Nick J Besselink, Ronald J van Heerwaarden, Roel J H Custers, Pieter J Emans, Sander Spruijt, Simon C Mastbergen, Floris P J G Lafeber
OBJECTIVE: Both, knee joint distraction (KJD) and high tibial osteotomy (HTO) are joint-preserving surgeries that postpone total knee arthroplasty (TKA) in younger osteoarthritis (OA) patients. Here we evaluate the 2-year follow-up of KJD versus TKA and KJD versus HTO in 2 noninferiority studies. DESIGN: Knee OA patients indicated for TKA were randomized to KJD ( n = 20; KJDTKA ) or TKA ( n = 40). Medial compartmental knee OA patients considered for HTO were randomized to KJD ( n = 23; KJDHTO ) or HTO ( n = 46)...
February 13, 2019: Cartilage
Oliver D Jungesblut, Josephine Berger-Groch, Norbert M Meenen, Ralf Stuecker, Martin Rupprecht
OBJECTIVE: Magnetic resonance imaging (MRI) is currently the gold standard to diagnose and monitor osteochondritis dissecans (OCD) of the knee. The purpose of this study was to evaluate for the first time if ultrasound imaging can be used to visualize osteochondritis dissecans of the distal femur. DESIGN: From May 2008 to December 2013, 44 children (26 boys and 18 girls) presenting with OCD of the knee in our department were examined and evaluated by ultrasound imaging...
February 1, 2019: Cartilage
Masanari Hamasaki, Mohamad Alaa Terkawi, Tomohiro Onodera, Kentaro Homan, Norimasa Iwasaki
OBJECTIVE: Osteoarthritis is a progressive joint disease characterized by cartilage degradation and synovial inflammation. Presence of cartilage fragments in the joint due to degradation of cartilage is thought to be associated with local inflammatory response and progressive osteoarthritic process. Understanding the mechanism by which cartilage fragments elicit this destructive process should aid in designing novel therapeutic approaches. Therefore, objective of current study is to establish an in vitro model to examine the cross-talk between chondrocytes and cartilage fragments-stimulated macrophages...
February 1, 2019: Cartilage
George Konstantinidis, Michael Mitchell, Gordon Boyd, Catherine Coady, Swagata Ghosh, Ivan Wong
OBJECTIVE: The purpose of this study was to retrospectively assess the frequency and characteristics of acetabular cartilage delamination (CD) in femoroacetabular impingement (FAI) patients and to assess the sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of magnetic resonance arthrography (MRA) in detecting CD based on the radiologist report. DESIGN: This is a single-center retrospective review of consecutive patients operated for symptomatic FAI...
January 23, 2019: Cartilage
Jian Sun, Zixin Min, Wenxiang Zhao, Safdar Hussain, Yitong Zhao, Dongxian Guo, Fujun Zhang, Yuanxu Guo, Mengyao Sun, Huang Huang, Yan Han, Nannan Zhong, Peng Xu, Shemin Lu
OBJECTIVE: Both selenium (Se) deficiency and mycotoxin T2 lead to epiphyseal plate lesions, similar to Kashin-Beck disease (KBD). However, regulation of selenoproteins synthesis mediated by SECISBP2, in response to these 2 environmental factors, remained unclear. The present study proposed to explore the mechanism behind the cartilage degradation resulting from Se deficiency and mycotoxin T2 exposure. DESIGN: Deep chondrocyte necrosis and epiphyseal plate lesions were replicated in Dark Agouti (DA) rats by feeding them T2 toxin/Se deficiency artificial synthetic diet for 2 months...
December 29, 2018: Cartilage
Garima Dwivedi, Anik Chevrier, Mohamad-Gabriel Alameh, Caroline D Hoemann, Michael D Buschmann
OBJECTIVE: Previous studies have shown that intrinsic behavior of subchondral bone marrow stem cells (BMSCs) is influenced by donors and locations. To understand the variability in cartilage repair outcomes following bone marrow stimulation, we tested the hypothesis that in vivo cartilage repair correlates with in vitro biological properties of BMSCs using a rabbit model. METHODS: Full-thickness cartilage defects were created in the trochlea and condyle in one knee of skeletally mature New Zealand White rabbits ( n = 8) followed by microdrilling...
December 20, 2018: Cartilage
Martyn Snow, Richard Williams, Joseph Pagkalos, Liam Grover
OBJECTIVE: The study aims were to determine whether BST-CarGel, a chitosan scaffold for cartilage repair, can be mixed with bone marrow aspirate concentrate (BMAC) to create a cell seeded implant with comparative properties to standard BST-CarGel mixed with blood. DESIGN: Whole blood and bone marrow were harvested from 12 patients who underwent cartilage repair surgery using BMAC after informed consent. A validated in vitro testing model was used to assess the following 6 conditions: (1) BST-CarGel mixed with whole blood (CG-WB), (2) BST-CarGel mixed with bone marrow (CG-BM), (3) BST-CarGel mixed with bone marrow concentrate (CG-BMAC), (4) whole blood (WB), (5) bone marrow (BM), and (6) bone marrow concentrate and batroxobin (BMAC-BTX)...
December 7, 2018: Cartilage
Josephine R Coury, Ryan Nixon, Melinda Collins, John Schwartz, Nadeen O Chahine, Daniel A Grande
OBJECTIVE: To evaluate the effects of TRB-N0224, a chemically modified curcumin (CMC) with zinc binding properties and improved pharmacokinetics, in a rabbit anterior cruciate ligament (ACL) transection injury-induced model of osteoarthritis (OA). DESIGN: Thirty-eight skeletally mature New Zealand white rabbits were studied in 4 groups: a sham with arthrotomy ( n = 6), control with ACL transection ( n = 6), and 2 treatment groups with ACL transection and administration of TRB-N0224 at low (25 mg/kg/day) ( n = 13) and high (50 mg/kg/day) ( n = 13) doses...
November 28, 2018: Cartilage
Brian J Cole, Michael L Redondo, Eric J Cotter
OBJECTIVE: The purpose of this article is to review the orthopedic literature regarding patient understanding of articular cartilage disease, interpret literature reporting patient expectations for surgical management of articular cartilage injuries of the knee, and review patient-reported outcomes and patient satisfaction with management of these injuries. DESIGN: A retrospective review of the current literature using the PubMed database (1980-current) was performed on July 15, 2017...
November 28, 2018: Cartilage
Bincy Jacob, Mia Jüllig, Martin Middleditch, Leo Payne, Neil Broom, Vijayalekshmi Sarojini, Ashvin Thambyah
OBJECTIVE: It was hypothesized that the respective protein profiles of bovine cartilage from sites of localized mild to moderate (GI to GII) degeneration versus adjacent sites of intact tissue would vary in accordance with the tissue microstructural changes associated with a pre-osteoarthritic state. METHODS: A total of 15 bovine patellae were obtained for this study. Paired samples of tissue were collected from the lateral region of each patella. If the patella contained a site of degeneration, a paired tissue set involved taking one sample each from the degenerated site and the intact tissue adjacent to it...
November 28, 2018: Cartilage
Takahiro Ogura, Jakob Ackermann, Alexandre Barbieri Mestriner, Gergo Merkely, Andreas H Gomoll
OBJECTIVE: Little is known regarding the minimal clinically important difference (MCID) and substantial clinical benefit (SCB) with regard to the Knee injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Lysholm score, and Short Form 12 (SF-12) score of patients who undergo osteochondral allograft transplantation (OCA). We aimed to determine the MCID and SCB associated with those patient-reported outcome measures (PROMs) after OCA...
November 22, 2018: Cartilage
David Cinats, Sue Miller, Ziad Abusara, S Mark Heard, Carol Hutchison, Norman Schachar, Scott Timmermann
OBJECTIVE: Osteochondral allograft transplantation is a procedure to treat focal osteochondral lesions (OCLs), but is limited by tissue availability, the quality of transplanted tissue, and inconsistent storage protocols. The objective of this study was to assess the clinical outcomes of a novel tissue procurement, storage, and quality control protocol in treating OCLs. DESIGN: Prospective case series. Donor cadaveric tissue was processed, stored, and the tissue quality analyzed using the unique tissue preservation protocol developed at our institution...
November 22, 2018: Cartilage
Felipe C K Duarte, Derek P Zwambag, Stephen H M Brown, Andrea Clark, Mark Hurtig, John Z Srbely
OBJECTIVE: The present study aimed to investigate whether experimentally induced lumbar facet-joint OA lead to degenerative changes and enhanced SP expression within the ipsilateral neurosegmentally linked tibiofemoral cartilage. METHODS: Adult male Sprague-Dawley rats were assigned to left side L5-L6 facet mechanical compression injury (surgery) ( n = 6), L5-L6 facet exposure with no compression (sham) ( n = 5), or naïve (no surgery) ( n = 4) groups. The morphology of the tibiofemoral articular cartilage was assessed using a modified Mankin scoring system...
November 21, 2018: Cartilage
Gergo Merkely, Tom Minas, Takahiro Ogura, Jakob Ackermann, Alexandre Barbieri Mestriner, Andreas H Gomoll
OBJECTIVE: Takedown of the anterior meniscus to facilitate exposure of the cartilage defects located on the tibial plateau and/or posterior femoral condyle with subsequent reattachment is being performed clinically; however, clinical evidence is lacking to support the safety of this technique. The aim of this study was therefore to investigate whether meniscal extrusion develops after patients undergo meniscus takedown and transosseous refixation during autologous chondrocyte implantation (ACI)...
October 31, 2018: Cartilage
Bryan Michael Saltzman, Michael L Redondo, Adam Beer, Eric J Cotter, Rachel M Frank, Adam B Yanke, Brian J Cole
BACKGROUND: The management of complex cartilage pathology in young, otherwise healthy patients can be difficult. PURPOSE: To determine the nature of the design, endpoints chosen, and rate at which the endpoints were met in published studies and ongoing clinical trials that investigate cartilage repair and restoration procedures. STUDY DESIGN: Systematic review. METHODS: A systematic review of the publicly available level I/II literature and of the publicly listed clinical trials regarding cartilage repair and restoration procedures for the knee was conducted adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
October 31, 2018: Cartilage
Samuel Early, Luís E P Tírico, Pamela A Pulido, Julie C McCauley, William D Bugbee
OBJECTIVE: No studies currently exist with long-term follow-up of use of osteochondral allografting (OCA) for treatment of steroid-associated osteonecrosis of femoral condyles in young, active patients who wish to avoid total knee arthroplasty (TKA). We evaluate the extent to which fresh osteochondral allografts can (1) prevent or postpone need for prosthetic arthroplasty and (2) maintain long-term clinically meaningful decrease in pain and improvement in function at mean 11-year follow-up...
October 31, 2018: Cartilage
Yang Wu, Patrick Kennedy, Nicholas Bonazza, Yin Yu, Aman Dhawan, Ibrahim Ozbolat
OBJECTIVE: Treatment of chondral injury is clinically challenging. Available chondral repair/regeneration techniques have significant shortcomings. A viable and durable tissue engineering strategy for articular cartilage repair remains an unmet need. Our objective was to systematically evaluate the published data on bioprinted articular cartilage with regards to scaffold-based, scaffold-free and in situ cartilage bioprinting. DESIGN: We performed a systematic review of studies using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
October 29, 2018: Cartilage
Thomas J A van Schaik, Florian Gaul, Erik W Dorthé, Emily E Lee, Shawn P Grogan, Darryl D D'Lima
OBJECTIVE: Mouse models are commonly used in research applications due to the relatively low cost, highly characterized strains, as well as the availability of many genetically modified phenotypes. In this study, we characterized an ex vivo murine osteochondral repair model using human infrapatellar fat pad (IPFP) progenitor cells. DESIGN: Femurs from euthanized mice were removed and clamped in a custom multidirectional vise to create cylindrical osteochondral defects 0...
October 29, 2018: Cartilage
Julio Granados-Montiel, Monica Cruz-Lemini, Claudia Rangel-Escareño, Gabriela Martinez-Nava, Carlos Landa-Solis, Ricardo Gomez-Garcia, Alberto Lopez-Reyes, Alejandro Espinosa-Gutierrez, Clemente Ibarra
OBJECTIVE: Human mesenchymal stem cells (hMSCs) are a promising source for regenerative medicine, especially mesodermal lineages. Clinical applications require an understanding of the mechanisms for transcriptional control to maintain the desired cell type. The aim of this study was to identify novel markers for differentiation of hMSCs into bone or cartilage with the use of Kartogenin, by RNA analysis using microarray technology, and explore the role of RhoA-Rho associated protein kinase (ROCK) inhibition in these...
October 29, 2018: Cartilage
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