Cognitive Neuroscience

Learning regularities in the environment is a fundamental of human cognition that is supported by a network of brain regions that include the hippocampus. In two experiments, we assessed the effects of selective bilateral damage to human hippocampal subregion CA3, which was associated with autobiographical episodic amnesia extending ~50 years prior to the damage, on the ability to recognize complex, deterministic event sequences presented either in a spatial or a non-spatial configuration. In contrast to findings from related paradigms, modalities, and homologue species, hippocampal damage did not preclude recognition memory for an event sequence studied and tested at four spatial locations, whereas recognition memory for an event sequence presented at single location was at chance...

According to the traditional memory-systems view, the hippocampus is critical during explicit (conscious) long-term memory, whereas other brain regions support implicit (nonconscious) memory. In the last two decades, some fMRI studies have reported hippocampal activity during implicit memory tasks. The aim of the present discussion paper was to identify whether any implicit memory fMRI studies have provided convincing evidence that the hippocampus is associated with nonconscious processes without being confounded by conscious processes...

Imagined events can be misremembered as experienced, leading to memory distortions. However, less is known regarding how imagining counterfactual versions of past events can impair existing memories. We addressed this issue, and used EEG to investigate the neurocognitive processes involved when retrieving memories of true events that are associated with a competing imagined event. Participants first performed simple actions with everyday objects (e.g., rolling dice). A week later, they were shown pictures of some of the objects and either imagined the same action they had originally performed, or imagined a counterfactual action (e...

Previous research has suggested that the perception of emotional images may also activate brain regions related to the preparation of motoric plans. However, little research has investigated whether these emotion-movement interactions occur at early or later stages of visual perception. In the current research, event-related potentials (ERPs) were used to examine the time course of the independent - and combined - effects of perceiving emotions and implied movement. Twenty-five participants viewed images from four categories: 1) emotional with implied movement, 2) emotional with no implied movement, 3) neutral with implied movement, and 4) neutral with no implied movement...

This study aimed to investigate the intra-/inter-hemispheric interactions during visual word processing, by manipulating stimulus onset asynchrony (SOA) in a primed-lateralized lexical decision task. To assess intra-/inter-hemispheric priming effects, identical prime-target pairs were presented in the same or opposite unilateral visual fields. The study found that the right visual field advantage (RVFA) was observed when Korean words were presented sequentially within hemispheres, indicating that the inherent characteristics of the two hemispheres, rather than differences in memory or linguistic aspects of lexical processing, contributed to the hemispheric asymmetry...

Selective attention and conflict monitoring are daily human phenomena, yet the spatial and temporal neurological underpinnings of these processes are not fully understood. Current literature suggests these executive functions are thought to occur via diverse and highly interconnected neural networks, including top-down and bottom-up processing, as well as conflict-control loops. To investigate the spatiotemporal activity of these processes, we collected neuromagnetic data using magnetoencephalography (MEG) in 28 healthy adults (age 19-36) while they performed a computerized Stroop task based on color naming, an experiment used for decades to understand cognitive interference...

Transcranial magnetic stimulation (TMS) can modulate a targeted brain region to assess whether that region is involved in a cognitive process. When TMS is employed in cognitive neuroscience, participants are typically healthy volunteers, and the technique is described as noninvasive. However, TMS parameters can be set such that stimulation produces long-lasting effects. Critically, TMS effects that have any possibility of lasting beyond a participant's time in the lab are potentially harmful. In this editorial, evidence is considered that indicates a 20-Hz multi-day TMS protocol has long-lasting effects, and a continuous theta-burst stimulation protocol needs further testing before it is deemed noninvasive...

Midfrontal theta activity is crucial for attentional and cognitive control. However, its causal role in facilitating visual search, particularly from the perspective of distractor inhibition, is yet to be discovered. We applied theta band transcranial alternate current stimulation (tACS) over frontocentral regions when participants searched for targets among heterogeneous distractors with foreknowledge of distractor features. The results demonstrated improved visual search performance in the theta stimulation group compared to the active sham group...

Language comprehension must require some degree of attentional focus, but how do periods of inattention and/or split attention impact how language is processed? Here EEG was recorded while participants listened to full-length stories, and were periodically asked about whether they were fully attentive, were completely inattentive, or felt that they were in a split attention state. The ERP response to the words immediately preceding these attention questions was examined as a function of participant response, which allowed for the comparison of word processing in each of these attentional states...

Few studies have examined the specific contribution of focal damage of the prefrontal cortex and executive dysfunction to emotion recognition deficits, with results reporting controversial findings. This study investigated the performance of 30 patients with prefrontal cortex damage and 30 matched controls on a battery of executive measures assessing processes of inhibition, flexibility, and planning and a task of emotion recognition with also a particular attention to the examination of the association between these domains...

This commentary makes three suggestions on Willems' neurocognitive model for understanding mixed and ambiguous emotions and morality. First, it proposes that his atheoretical approach risks unwittingly adopting theoretical and conceptual limitations implicit in reigning paradigms and overlooking the need for theoretical impetus and constraints in the development of valid constructs of targeted emotions. Second, it suggests that a dynamical systems approach to emotions provides a fruitful theory and neuro-phenomenology as a corresponding methodology...

The use of naturalistic stimuli in cognitive neuroscience experiments inspires and requires theoretical foundations that bring together different cognitive domains, such as emotion, language, and morality. By zooming in on the digital environments in which we often perceive emotional messages today, and inspired by the Mixed and Ambiguous Emotions and Morality model, we here argue that successfully processing emotional information in the twenty-first century will often have to rely not only on simulation and/or mentalizing, but also on executive control and attention regulation...

Willems (this issue) proposes a neurocognitive model with a central role allotted to ambiguity in perceived morality and emotion in driving involvement of reflective/mentalizing processes. We argue that abstractness of representation has more explanatory power in this respect. We illustrate this with examples from the verbal and non-verbal domain showing a) concrete-ambiguous emotions processed through reflexive systems and b) abstract-unambiguous emotions processed through the mentalizing system, counter to MA-EM model predictions...

In this commentary we draw attention to a context involving mixed and ambiguous emotions: verbal irony. Irony is frequently used, evokes mixed emotional responses (e.g., criticism and amusement), and has been the focus of recent cognitive neuroscience research. Yet, irony has primarily been studied as a linguistic device, and has rarely been considered by emotion researchers. Similarly, linguistics has not considered mixed and ambiguous emotion when studying verbal irony. We argue that verbal irony offers rich opportunities to evoke and study mixed and ambiguous emotions, and might provide advantages for testing the MA-EM model...

Over the past decades, the emerging and ever-growing body of studies in empirical aesthetics has made one thing abundantly clear: our current models and conceptualizations of emotional experiences have outlived their usefulness. How do we go from here?

In a previous discussion paper , twenty-six working memory fMRI studies that reported activity in the hippocampus were systematically analyzed. None of these studies provided convincing evidence that the hippocampus was active during the late delay phase, the only period in which working memory can be isolated from long-term memory processes. Based on these results, it was concluded that working memory does not activate the hippocampus. Six commentaries on the discussion paper were received from Courtney (2022), Kessels and Bergmann (2022), Peters and Reithler (2022), Rose and Chao (2022), Stern and Hasselmo (2022), and Wood et al...

The neurocognitive model of Mixed and Ambiguous Emotions and Morality (MA-EM) makes a relevant case for putting non-unidimensional emotions and morality more prominently on the research agenda. However, existing research challenges its assumptions about the distinction between mixed and ambiguous emotions and morality, and how they relate to reflective versus simulative processing routes, in three respects. First, the emotional state of being moved is generally conceptualized as a non-ambiguous rather than an ambiguous emotion...

It is important for mental health to be able to control unwanted intrusive memories. Previous studies suggest that middle frontal gyrus (MFG) down regulates pathways underlie the suppression of retrieval of general memories. However, the neural basis of motivated forgetting of autobiographical memories is unclear. Therefore, this study used two samples to explore the neural mechanisms of motivated forgetting of self-referential memories. Every participant provided 40 life events (20 negative and 20 neutral) from their past personal experience, and then completed the Think/No-Think task while undergoing functional magnetic resonance imaging (fMRI)...

Understanding emotions and moral intentions of other people is integral to being human. Humanities scholars have long recognized the complex and ambiguous nature of emotions and morality. People are rarely 'just' happy, or sad. Neither are they 'just' good or bad people. Despite this, most knowledge about the psychological and neural basis of emotions and moral understanding comes from experiments investigating unidimensional and non-ambiguous emotions and morality. The goal of this paper is twofold. First I want to point out why mixed and ambiguous emotions and morality are a promising research topic for cognitive neuroscientists...

In this commentary, we highlight the role of the hippocampus as a binding device that may explain its recruitment during associative working-memory paradigms. Furthermore, we argue that both functional neuroimaging research, as presented in Slotnick (this issue), and carefully designed lesion studies in patients with selective bilateral hippocampal damage are crucial for advancing our understanding of the neural structures and processing involved in human memory in general and disentangling the role of the hippocampus proper and other medial temporal lobe structures in working-memory function and long-term encoding specifically...