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Journals Neurodegenerative Disease Mana...

Neurodegenerative Disease Management

https://read.qxmd.com/read/38501760/measuring-fatigue-in-people-with-multiple-sclerosis-which-questionnaire-should-be-used-a-plain-language-summary-of-publication
#1
REVIEW
Paul Kamudoni, Jeffrey Johns, Karon F Cook, Rana Salem, Sam Salek, Jana Raab, Rod Middleton, Christian Henke, Dagmar Amtmann
WHAT IS THIS SUMMARY ABOUT?: This summary explains the findings of a recent study that compared different questionnaires used by doctors to measure levels of fatigue in people with multiple sclerosis (MS). The aim of the study was to find out which questionnaire doctors should use to measure fatigue in people with MS in the future. Fatigue, which can be described as the overwhelming feeling of tiredness or exhaustion, is a very common symptom of MS. For the majority of people with MS, fatigue is one of the worst symptoms of MS, so it is essential that doctors can measure it accurately...
March 19, 2024: Neurodegenerative Disease Management
https://read.qxmd.com/read/38420948/welcome-to-volume-14-of-neurodegenerative-disease-management
#2
JOURNAL ARTICLE
Afra Paleel
No abstract text is available yet for this article.
February 29, 2024: Neurodegenerative Disease Management
https://read.qxmd.com/read/38318862/patient-reported-benefits-from-nabiximols-treatment-in-multiple-sclerosis-related-spasticity-exceed-conventional-measures
#3
JOURNAL ARTICLE
Michael R Haupts, Ute Essner, Mathias Mäurer
Aim: This prospective, multicenter, open-label, noninterventional 12-week study investigated the effectiveness and tolerability of add-on nabiximols oromucosal spray (Sativex® ) in the real-world setting in Germany. Patients & methods: The main analysis set comprised 51 adult patients (49 nabiximols responders) with multiple sclerosis (MS) spasticity. Results: The mean overall goal attainment scale score (primary outcome measure) increased by 46% from baseline to week 12 (35.2 vs 51.4; p < 0...
February 6, 2024: Neurodegenerative Disease Management
https://read.qxmd.com/read/38357803/a-review-on-nonviral-nonbacterial-infectious-agents-toxicity-involved-in-neurodegenerative-diseases
#4
REVIEW
Mohammad Taheri, Ali Bahrami, Kiana Kimiaei Asadi, Mojdeh Mohammadi, Pejman Molaei, Mehrdad Hashemi, Fatemeh Nouri
Neuronal death, decreased activity or dysfunction of neurotransmitters are some of the pathophysiological reasons for neurodegenerative diseases like Alzheimer's, Parkinson's and multiple sclerosis. Also, there is evidence for the role of infections and infectious agents in neurodegenerative diseases and the effect of some metabolites in microorganisms in the pathophysiology of these diseases. In this study, we intend to evaluate the existing studies on the role of infectious agents and their metabolites on the pathophysiology of neurodegenerative diseases...
December 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/38305913/an-overview-of-the-worldwide-distribution-of-lrrk2-mutations-in-parkinson-s-disease
#5
REVIEW
Hicham El Otmani, Mohamed Daghi, Nadia Tahiri Jouti, Suzanne Lesage
Parkinson's disease (PD) is a neurodegenerative disorder with significant genetic influence. The LRRK2 gene is a major genetic contributor, particularly the Gly2019Ser mutation. This focused review investigates the global distribution of LRRK2 mutations, with emphasis on Gly2019Ser and other pathogenic variants. Prevalence rates of Gly2019Ser are highest in North Africa and the Ashkenazi-Jewish population, indicating a potential common ancestor and founder effect. Other LRRK2 mutations, including Asn1437His, Arg1441Gly/Cys/His, Tyr1699Cys and Ile2020Thr, exhibit varying global prevalences...
December 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/38284385/an-innovative-approach-to-recruiting-participants-for-dementia-research-primary-care-and-researcher-perspectives
#6
JOURNAL ARTICLE
Linda Lee, Loretta M Hillier, Tejal Patel, Stephanie K Lu, Michael Lee, Catherine Lee
Aim: To describe clinician and researcher perceptions of a new, patient preference focused approach to recruiting patients for research from primary care-based memory clinics. Methods: Memory clinic clinicians completed a survey and key informants completed an individual interview to gather their perceptions of this new program. Results: The majority of clinicians were 'satisfied' or 'very satisfied' with this recruitment approach and indicated that this approach would have minimal negative impact on patient care or create conflict of interest...
December 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/38264968/free-cog-revisited-the-diagnostic-contribution-of-cognitive-and-executive-function
#7
JOURNAL ARTICLE
Andrew J Larner, Alistair Burns
Aim: To examine Free-Cog, a recently described, hybrid screening instrument, as separate tests of cognitive (Free-Cog-Cog) and executive function (Free-Cog-Exec) to see if this improved screening accuracy for cognitive impairment compared with standard Free-Cog. Materials & methods: Free-Cog-Cog and Free-Cog-Exec were combined using Boolean logical 'AND' and 'OR' operators (serial and parallel combination), and also used to construct a stepwise decision tree. Results: Serial combination improved specificity and positive predictive value whereas parallel combination improved sensitivity, typical findings with these operators...
December 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/38084603/piecing-together-the-alzheimer-s-puzzle-lecanemab-s-role-in-treatment
#8
EDITORIAL
Danish Ali Ashraf, Hassan Tariq, Fathimath Shahaa Hassan, Farooq Kamran, Warda Mushtaq Khosa, Maha Mushtaq Khosa
No abstract text is available yet for this article.
October 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/38078426/people-with-neuromuscular-diseases-and-their-relatives-perspectives-on-challenges-in-everyday-life-and-healthcare
#9
JOURNAL ARTICLE
Charlotte Handberg, Ulla Werlauff
Objective: People with a neuromuscular disease (NMD) often experience challenges in everyday life and healthcare. Aim: To investigate experiences of and perspectives on challenges in everyday life and healthcare of people with NMDs and their relatives to gain new insights into how life-long rehabilitation can be tailored. Patients & methods: The design was qualitative using the interpretive description methodology and the Sense of Coherence theory. An ethnographic fieldwork was conducted where 45 persons with NMD and their relatives were included for interviews and participant observations...
October 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/38063885/comparison-of-diagnostic-routines-for-suspected-alzheimer-s-disease-patients-in-us-american-and-german-primary-care
#10
JOURNAL ARTICLE
Felix Menne, Timo Grimmer, Carola G Schipke
Aim: Thorough diagnostics are a prerequisite for the optimal treatment of Alzheimer's disease (AD). Biomarker-based diagnostics are standard in academia, data on practitioners' diagnostic workups is scarce. Materials & methods: Surveys in German and US healthcare providers (HCP) were conducted regarding diagnostics in presumed AD patients. A subsample of 153 German and 88 US professionals was analyzed in detail. Results: Fewer German physicians conduct AD diagnostics themselves compared with US colleagues (67% vs 99%; p < 0...
October 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37909320/satisfaction-and-practicality-of-a-prefilled-glatiramer-acetate-pen-in-relapsing-remitting-multiple-sclerosis-patients
#11
MULTICENTER STUDY
Herbert Schreiber, Joachim Hipp, Fabian Roßnagel, Christiane Moritz
Aim: Evaluation of practicality and patient satisfaction of a glatiramer acetate (GA) prefilled pen in patients with relapsing-remitting multiple sclerosis (RRMS). Patients & methods: A cross-sectional, multicenter, observational study evaluating patients' experiences with the GA-pen 3 months after its first use by means of self-reporting questionnaires. Primary end point was the proportion of patients who were satisfied with the pen. Results: 80 patients participated in the study. The majority (83...
October 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37671720/a-study-of-once-a-week-donepezil-transdermal-system-s-bioequivalence-to-oral-donepezil-in-healthy-volunteers-a-plain-language-summary
#12
REVIEW
Rene Braeckman, Charles Oh
WHAT IS THIS SUMMARY ABOUT?: This is a plain language summary of an article published in the Journal of Alzheimer's Disease . It describes an adhesive patch placed on the skin's surface, also referred to as a transdermal delivery system (or TDS), that delivers donepezil (called donepezil TDS going forward) through the skin of patients with mild, moderate, and severe dementia of the Alzheimer's type. This summary focuses on how fast and how much of the medication donepezil enters the body through the skin, and how it compares with taking a pill form of donepezil by mouth (oral donepezil)...
September 6, 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37535336/a-plain-language-summary-on-assessing-the-long-term-effectiveness-of-cladribine-tablets-in-people-living-with-relapsing-multiple-sclerosis-the-classic-ms-study
#13
REVIEW
Gavin Giovannoni, Alexey Boyko, Jorge Correale, Gilles Edan, Mark S Freedman, Xavier Montalban, Kottil Rammohan, Dusan Stefoski, Bassem Yamout, Thomas Leist, Aida Aydemir, Laszlo Borsi, Elisabetta Verdun di Cantogno
WHAT IS THIS SUMMARY ABOUT?: Previous studies have shown that people living with multiple sclerosis (MS) treated with cladribine tablets have fewer relapses (where new symptoms occur or existing symptoms get worse for 24 hours or more) and delayed disability progression (slowing down of the disease getting worse). The CLASSIC-MS study looked at the long-term effectiveness of treatment with cladribine tablets in people living with MS who had taken part in the original CLARITY and CLARITY Extension clinical studies...
August 3, 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37345645/a-plain-language-summary-of-what-clinical-studies-can-tell-us-about-the-safety-of-evobrutinib-a-potential-treatment-for-multiple-sclerosis
#14
REVIEW
Xavier Montalban, Daniel Wallace, Mark C Genovese, Davorka Tomic, Dana Parsons-Rich, Claire Le Bolay, Amy H Kao, Hans Guehring
WHAT IS THIS SUMMARY ABOUT?: This summary explains the findings from a recent investigation that combined the results of over 1000 people from three clinical studies to understand the safety of evobrutinib. Evobrutinib is an oral medication (taken by mouth), being researched as a potential treatment for multiple sclerosis (MS). This medication was also investigated in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Over 1000 people have taken evobrutinib as part of three separate phase 2 clinical studies...
August 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37395172/impact-of-a-7-day-retreat-for-people-with-parkinson-s-disease-a-phenomenological-study
#15
JOURNAL ARTICLE
Lori M Bordenave, Corrine Fritcher Nelson, Becky G Farley, Tara L McIsaac
Aim: Early and ongoing access to rehabilitation and exercise may preserve functional mobility and quality of life for persons with Parkinson disease (PwP). The aim of the current study was to describe the experience of PwP who participated in a 7-day retreat. Materials & methods: A phenomenological approach was used to describe the lived experience of PwP. Results: Three themes emerged from interviews: a community of shared information where participants discussed exercising and learning with other PwP; improved control of Parkinson's disease symptoms, including performing physical tasks more easily and renewed motivation for their long-term plans for exercise because of the retreat...
July 3, 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37382065/glatiramer-acetate-or-ifn-%C3%AE-bridging-therapy-in-women-with-relapsing-multiple-sclerosis-planning-a-pregnancy
#16
JOURNAL ARTICLE
Kerstin Hellwig, Sandra Thiel, Sabrina Haben, Andrea I Ciplea, Anna Kurzeja
Aim: To assess bridging glatiramer acetate (GA) or IFN-β for relapse prevention in women with relapsing multiple sclerosis planning pregnancy. Materials & methods: Participants discontinued disease-modifying therapies (DMTs) and received GA/IFN (early- or delayed-start) or no DMT (control) until pregnancy. Results: Annualized relapse rate was lower in delayed-start GA/IFN cohort versus control during washout/bridging. During washout/bridging, bridging with GA/IFN in this cohort reduced clinical activity, while disease activity increased in controls versus baseline...
June 29, 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37317956/wearable-activity-monitors-to-support-physical-activity-interventions-in-neurodegenerative-disease-a-feasibility-study
#17
JOURNAL ARTICLE
Hai-Jung Steffi Shih, Lori Quinn, Philippa Morgan-Jones, Katrina Long, Abigail R Schreier, Ciaran P Friel
Aim: To evaluate the feasibility of using activity monitors in a physical activity (PA) intervention in people with Parkinson's (PD) and Huntington's disease (HD). Materials & methods: People with early-stage PD (n = 13) and HD (n = 14) enrolled in a 4-month coaching program, wore a Fitbit, and were guided through a behavioral intervention to facilitate PA uptake. Wear time, wear habits and activity metrics (e.g., steps) were analyzed. Results: Retention rate was 85% and participants had an average 92...
June 15, 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37306283/targeting-metabotropic-glutamate-receptors-for-the-treatment-of-parkinson-s-disease
#18
EDITORIAL
Philippe Huot
No abstract text is available yet for this article.
June 12, 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37287269/a-plain-language-summary-on-the-effectiveness-of-cladribine-tablets-compared-with-other-oral-treatments-for-multiple-sclerosis-results-from-the-msbase-registry
#19
REVIEW
Tim Spelman, Serkan Ozakbas, Raed Alroughani, Murat Terzi, Suzanne Hodgkinson, Guy Laureys, Tomas Kalincik, Anneke Van Der Walt, Bassem Yamout, Jeannette Lechner-Scott, Aysun Soysal, Jens Kuhle, Jose Luis Sanchez-Menoyo, Yolanda Blanco Morgado, Daniele LA Spitaleri, Vincent van Pesch, Dana Horakova, Radek Ampapa, Francesco Patti, Richard Macdonell, Abdullah Al-Asmi, Oliver Gerlach, Jiwon Oh, Ayse Altintas, Namita Tundia, Schiffon L Wong, Helmut Butzkueven
WHAT IS THIS SUMMARY ABOUT?: Patient registries contain anonymous data from people who share the same medical condition. The MSBase registry contains information from over 80,000 people living with multiple sclerosis (MS) across 41 countries. Using information from the MSBase registry, the GLIMPSE (Generating Learnings In MultiPle SclErosis) study looked at real-life outcomes in 3475 people living with MS who were treated with cladribine tablets (Mavenclad® ) compared with other oral treatments...
June 7, 2023: Neurodegenerative Disease Management
https://read.qxmd.com/read/37278296/computerized-cognitive-testing-in-patients-with-parkinson-s-disease-an-indian-perspective
#20
JOURNAL ARTICLE
Moulika Mandal, Kashish Srivastava
Aim: This study investigates perspectives on computer-based assessments among elderly individuals with Parkinson's disease (PD) in India for more efficient usability of digital assessments for this population. Materials & methods: Content analysis was conducted on 30 participants diagnosed with PD, who were interviewed for their preferences and perspectives on integrating technology in healthcare assessments. Results: Elderly individuals with PD in India favored paper-pencil assessments over computer-based alternatives due to limited technological familiarity, resistance to change, lack of trust in healthcare technology and PD related motor challenges...
June 6, 2023: Neurodegenerative Disease Management
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