Claudia Lugo-Candelas, Le Chang, Jordan D Dworkin, Natalie Aw, Andrea Fields, Hannah Reed, Marisa Spann, Michelle A Gilchrist, Walter Hinds, Rachel Marsh, William P Fifer, Myrna Weissman, Bernd Uwe Foerster, Marina Giorgi Manin, Ivaldo Silva, Bradley Peterson, Ana Carolina Coelho Milani, Jay Gingrich, Catherine Monk, Cristiane S Duarte, Andrea Jackowski, Jonathan Posner
The deleterious effects of adversity are likely intergenerational, such that one generation's adverse experiences can affect the next. Epidemiological studies link maternal adversity to offspring depression and anxiety, possibly via transmission mechanisms that influence offspring fronto-limbic connectivity. However, studies have not thoroughly disassociated postnatal exposure effects nor considered the role of offspring sex. We utilized infant neuroimaging to test the hypothesis that maternal childhood maltreatment (CM) would be associated with increased fronto-limbic connectivity in infancy and tested brain-behavior associations in childhood...
September 21, 2023: Journal of Developmental Origins of Health and Disease