journal
Journals Journal of Developmental Origi...

Journal of Developmental Origins of Health and Disease

https://read.qxmd.com/read/38500346/-epicatechin-treatment-did-not-modify-the-thermogenic-pathway-in-the-gastrocnemius-muscle-of-male-rat-offspring-obeses-by-programming
#1
JOURNAL ARTICLE
María Elena Tejeda, Sergio De Los Santos, Ramón Mauricio Coral-Vázquez, Ana Álvarez-Chávez, Carlos Palma Flores, Elena Zambrano, Juan Pablo Méndez, Patricia Canto
The aim of this study was to analyse the expression of genes related to the regulation of energy metabolism in skeletal muscle tissue by comparing male offspring in two age groups [at 110 and 245 postnatal days (pnd)] from a mother with obesity induced by a high-fat diet and (-)-epicatechin (Epi) administration. Four groups of six male offspring from different litters were randomly selected for the control groups [C and offspring of mothers with maternal obesity (MO)] or Epi intervention groups. We evaluated the effect of Epi on gastrocnemius tissue by analysing the mRNA and protein expression levels of Fndc5/irisin, Pgc-1α, Ucp3, and Sln...
March 19, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38487898/breastfeeding-moderates-the-association-of-maternal-pre-pregnancy-nutritional-status-with-offspring-body-composition-at-30-years
#2
JOURNAL ARTICLE
Bernardo L Horta, Kelly P Coca, Mina Desai, Mariane S Dias, Manoella B Jaccottet, Michael G Ross
Maternal pre-pregnancy body mass index is positively associated with offspring obesity, even at adulthood, whereas breastfeeding decreases the risk of obesity. The present study was aimed at assessing whether breastfeeding moderates the association of maternal pre-pregnancy body mass index with offspring body composition at adulthood, using data from 3439 subjects enrolled in a southern Brazilian birth cohort. At 30 years of age, maternal pre-pregnancy body mass index was positively associated with offspring prevalence of obesity, abdominal obesity, as well as body mass index and fat and lean mass index...
March 15, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38450456/anaesthesia-and-brain-development-a-review-of-propofol-induced-neurotoxicity-in-pediatric-populations
#3
REVIEW
Weixin Zhang, Qi Liu, Junli Wang, Li Liu
With the advancement of medical technology, there are increasing opportunities for new-borns, infants, and pregnant women to be exposed to general anaesthesia. Propofol is commonly used for the induction of anaesthesia, maintenance of general intravenous anaesthesia and sedation of intensive-care children. Many previous studies have found that propofol has organ-protective effects, but growing evidence suggests that propofol interferes with brain development, affecting learning and cognitive function. The purpose of this review is to summarize the latest progress in understanding the neurotoxicity of propofol...
March 7, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38450455/the-developmental-origins-of-health-and-disease-and-intergenerational-inheritance-a-scoping-review-of-multigenerational-cohort-studies
#4
REVIEW
Jie Tan, Zifang Zhang, Lijing L Yan, Xiaolin Xu
Epidemiologic research has increasingly acknowledged the importance of developmental origins of health and disease (DOHaD) and suggests that prior exposures can be transferred across generations. Multigenerational cohorts are crucial to verify the intergenerational inheritance among human subjects. We carried out this scoping review aims to summarize multigenerational cohort studies' characteristics, issues, and implications and hence provide evidence to the DOHaD and intergenerational inheritance. We adopted a comprehensive search strategy to identify multigenerational cohorts, searching PubMed, EMBASE, and Web of Science databases from the inception of each dataset to June 20th, 2022, to retrieve relevant articles...
March 7, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38345286/supplementation-of-the-maternal-diet-with-brazil-nut-bertholletia-excelsa-h-b-k-prevents-cognitive-impairment-in-the-offspring-of-obese-mothers
#5
JOURNAL ARTICLE
Lilian Fioravanso Apolinário, Amanda Tais Silva, Andrielli Pompermayer Rosa, Cleber da Silva Oliveira, Cleberson Lira, João Pedro Costa Dos Santos Guerra, Júlia Furtado Friedrich, Letícia Queiroz Rosa, Rodrigo Chelegão, Sílvia de Carvalho Campos Botelho, Valéria Dornelles Gindri Sinhorin, Júlio Cezar de Oliveira, Nádia Aléssio Velloso
Maternal obesity may trigger long-term neurodevelopmental disorders in offspring. Considering the benefits of the Brazil nut ( Bertholletia excelsa H.B.K.), a rich source of nutrients such as selenium, this study aimed to evaluate its effect on the behavior of obese rat offspring and its relationship with oxidative stress. From 60 days of age until weaning, female Wistar rats were fed a high-fat diet (mHF) or an HF diet supplemented with 5% Brazil nut (mHF/BN), while control mothers (mCTL) were fed a standard diet or a standard diet supplemented with 5% Brazil nut (mBN)...
February 12, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38327072/maternal-prenatal-and-postnatal-psychological-distress-trajectories-and-impact-on-cognitive-development-in-4-year-old-children-the-japan-environment-and-children-s-study
#6
JOURNAL ARTICLE
Hidekazu Nishigori, Toshie Nishigori, Taeko Suzuki, Miyuki Mori, Mika Yamada, Hirotaka Isogami, Tsuyoshi Murata, Hyo Kyozuka, Yuka Ogata, Akiko Sato, Hirohito Metoki, Kosei Shinoki, Seiji Yasumura, Mitsuaki Hosoya, Koichi Hashimoto, Keiya Fujimori
Maternal prenatal and postnatal psychological distress, including depression and anxiety, may affect children's cognitive development. However, the findings have been inconsistent. We aimed to use the dataset from the Japan Environment and Children's Study, a nationwide prospective birth cohort study, to examine this association. We evaluated the relationship between the maternal six-item version of the Kessler Psychological Distress Scale (K6) scores and cognitive development among children aged 4 years. K6 was administered twice during pregnancy (M-T1; first half of pregnancy, M-T2; second half of pregnancy) and 1 year postpartum (C-1y)...
February 8, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38258455/a-systematic-review-exploring-evidence-for-adolescent-understanding-of-concepts-related-to-the-developmental-origins-of-health-and-disease
#7
REVIEW
M Tohi, S Tu'akoi, M H Vickers
The developmental origins of health and disease (DOHaD) framework has highlighted the importance of the early life period on disease risk in later life with impacts that can span generations. A primary focus to date has been around maternal health and the 'First Thousand Days' as a key developmental window whereby an adverse environment can have lasting impacts on both mother and offspring. More recently, the impact of paternal health has gathered increasing traction as a key window for early life developmental programming...
January 23, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38254258/association-between-vitamin-levels-and-obesity-in-the-national-health-and-nutrition-examination-surveys-2017-to-2018
#8
JOURNAL ARTICLE
Xiaomin Lu, Zhongyou Sun
In recent years, the rapidly increasing incidence of obesity is becoming a worldwide public health problem. Obesity is a chronic disease which may have a major negative effect on the people's quality of life. Previous studies on the comprehensive effects of multivitamins on central obesity and general obesity are relatively few. The aim of this study was to evaluate association of vitamins exposure with obesity risk and obesity-related indicators. We fitted three statistical models (linear regression model, logistic regression model, and Bayesian kernel machine regression model) to evaluate the correlation between vitamin levels and obesity in the study population...
January 23, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38254254/human-milk-polyunsaturated-fatty-acids-are-related-to-neurodevelopmental-anthropometric-and-allergic-outcomes-in-early-life-a-systematic-review
#9
JOURNAL ARTICLE
Saori Mitguard, Olivia Doucette, John Miklavcic
Polyunsaturated fatty acids are critically important for newborn nutrition and in the trajectory of growth and developmental processes throughout early life. This systematic review (PROSPERO ID: CRD42023400059) critically analyzes literature pertaining to how omega-3 and omega-6 fatty acids in human milk are related to health outcomes in early life. Literature selected for the review were published between 2005 and 2020 and included assessments in healthy term children between 0 and 5 years of age. The studies reported the relation between human milk fatty acids docosahexaenoic acid (C22:6 n -3, DHA), eicosapentaenoic acid (C20:5 n -3, EPA), alpha-linolenic acid (C18:3 n -3, ALA), arachidonic acid (C20:4 n -6, AA), and linoleic acid (C18:2 n -6, LA) with three domains of health outcomes: neurodevelopment, body composition, and allergy, skin & eczema...
January 23, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38247363/the-impact-of-maternal-and-paternal-birth-weights-on-infant-birth-weights-the-japan-environment-and-children-s-study
#10
JOURNAL ARTICLE
Hasumi Tomita, Noriyuki Iwama, Hirotaka Hamada, Rie Kudo, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi
This study aimed to evaluate the association between parental and infant birth weights in Japan. In total, 37,504 pregnant Japanese women and their partners were included in this birth cohort study. A multinomial logistic regression model was used to evaluate the associations of parental birth weights with small-for-gestational-age (SGA) or large-for-gestational-age (LGA) infants. Associations between parental birth weight and low birth weight (LBW) infants or macrosomia were also examined, and linear associations between parental birth weight and SGA or LGA were found...
January 22, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38234128/maternal-pea-fiber-supplementation-to-a-high-calorie-diet-in-obese-pregnancies-protects-male-offspring-from-metabolic-dysfunction-in-adulthood
#11
JOURNAL ARTICLE
Gabriella A Andreani, Saleh Mahmood, Mulchand S Patel, Todd C Rideout
We investigated the influence of maternal yellow-pea fiber supplementation in obese pregnancies on offspring metabolic health in adulthood. Sixty newly-weaned female Sprague-Dawley rats were randomized to either a low-calorie control diet (CON) or high calorie obesogenic diet (HC) for 6-weeks. Obese animals were then fed either the HC diet alone or the HC diet supplemented with yellow-pea fiber (HC + FBR) for an additional 4-weeks prior to breeding and throughout gestation and lactation. On postnatal day (PND) 21, 1 male and 1 female offspring from each dam were weaned onto the CON diet until adulthood (PND 120) for metabolic phenotyping...
January 18, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38224025/association-of-birthweight-with-diabetes-hypertension-and-ischemic-heart-disease-in-young-adulthood-a-retrospective-cohort-study
#12
JOURNAL ARTICLE
Yulika Yoshida-Montezuma, Charles D G Keown-Stoneman, Catherine S Birken, Jonathon L Maguire, Hilary K Brown, Laura N Anderson
Birthweight has been associated with diabetes in a reverse J-shape (highest risk at low birthweight and moderately high risk at high birthweight) and inversely associated with hypertension in adulthood with inconsistent evidence for cardiovascular disease. There is a lack of population-based studies examining the incidence of cardiometabolic outcomes in young adults born with low and high birthweights. To evaluate the association between birthweight and diabetes, hypertension, and ischemic heart disease (IHD) in young adulthood, we conducted a retrospective cohort study of 874,904 singletons born in Ontario, Canada, from 1994 to 2002, identified from population-based health administrative data...
January 15, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38196328/empirical-evidence-of-predictive-adaptive-response-in-humans-systematic-review-and-meta-analysis-of-migrant-populations
#13
JOURNAL ARTICLE
Clara Bueno López, Guillermo Gómez Moreno, Alberto Palloni
Meta-analysis is used to test a variant of a Developmental Origins of Adult Health and Disease (DOHaD)'s conjecture known as predictive adaptive response (PAR). According to it, individuals who are exposed to mismatches between adverse or constrained in utero conditions, on the one hand, and postnatal obesogenic environments, on the other, are at higher risk of developing adult chronic conditions, including obesity, type 2 diabetes (T2D), hypertension and cardiovascular disease. We argue that migrant populations from low and middle to high-income countries offer a unique opportunity to test the conjecture...
January 10, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38192014/associations-of-offspring-birthweight-and-placental-weight-with-subsequent-parental-coronary-heart-disease-survival-regression-using-the-walker-cohort
#14
JOURNAL ARTICLE
Carlos Sánchez-Soriano, Ewan R Pearson, Rebecca M Reynolds
Low birth weight (BW) is consistently correlated with increased parental risk of subsequent cardiovascular disease, but the links with offspring placental weight (PW) are mostly unexplored. We have investigated the associations between parental coronary heart disease (CHD) and offspring BW and PW using the Walker cohort, a collection of 48,000 birth records from Dundee, Scotland, from the 1950s and 1960s. We linked the medical history of 13,866 mothers and 8,092 fathers to their offspring's records and performed Cox survival analyses modelling maternal and paternal CHD risk by their offspring's BW, PW, and the ratio between both measurements...
January 9, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38186328/involuntary-tobacco-smoke-exposures-from-conception-to-18-years-increase-midlife-cardiometabolic-disease-risk-a-40-year-longitudinal-study
#15
JOURNAL ARTICLE
Zhongzheng Niu, Lina Mu, Stephen L Buka, Eric B Loucks, Meng Wang, Lili Tian, Xiaozhong Wen
Few population studies have sufficient follow-up period to examine early-life exposures with later life diseases. A critical question is whether involuntary exposure to tobacco smoke from conception to adulthood increases the risk of cardiometabolic diseases (CMD) in midlife. In the Collaborative Perinatal Project, serum-validated maternal smoking during pregnancy (MSP) was assessed in the 1960s. At a mean age of 39 years, 1623 offspring were followed-up for the age at first physician-diagnoses of any CMDs, including diabetes, heart disease, hypertension, or hyperlipidemia...
January 8, 2024: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38073570/upregulation-of-mir-21-5p-rescues-the-inhibition-of-cardiomyocyte-proliferation-induced-by-high-glucose-through-negative-regulation-of-rhob
#16
JOURNAL ARTICLE
Fang Wu, Feng Wang, Qian Yang, Yawen Zhang, Ke Cai, Jialing Zhang, Min Xia, Youhua Wang, Xu Wang, Yonghao Gui, Qiang Li
Increasing evidence shows that maternal hyperglycemia inhibits cardiomyocyte (CM) proliferation and promotes cell apoptosis during fetal heart development, which leads to cardiac dysplasia. Accumulating evidence suggests that the overexpression of miR-21 in CMs has a protective role in cardiac function. Therefore, we investigated whether miR-21 can rescue CM injury caused by high glucose. First, we performed biological function analysis of miR-21-5p overexpression in H9c2 cells treated with high glucose. We found that the proliferation of H9c2 cells treated with high glucose decreased significantly and was rescued after overexpression of miR-21-5p...
December 11, 2023: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38044700/associations-between-epigenome-wide-dna-methylation-and-height-related-traits-among-sub-saharan-africans-the-rodam-study
#17
JOURNAL ARTICLE
Galatea Swart, Karlijn Meeks, Felix Chilunga, Andrea Venema, Charles Agyemang, Eva van der Linden, Peter Henneman
Human height and related traits are highly complex, and extensively research has shown that these traits are determined by both genetic and environmental factors. Such factors may partially affect these traits through epigenetic programing. Epigenetic programing is dynamic and plays an important role in controlling gene expression and cell differentiation during (early) development. DNA methylation (DNAm) is the most commonly studied epigenetic feature. In this study we conducted an epigenome-wide DNAm association analysis on height-related traits in a Sub-Saharan African population, in order to detect DNAm biomarkers across four height-related traits...
December 4, 2023: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38037831/neonatal-nicotine-exposure-affects-adult-rat-hepatic-pathways-involved-in-endoplasmic-reticulum-stress-and-macroautophagy-in-a-sex-dependent-manner
#18
JOURNAL ARTICLE
Luana Lopes Souza, Camila Lüdke Rossetti, Thamara Cherem Peixoto, Alex Christian Manhães, Egberto Gaspar de Moura, Patrícia Cristina Lisboa
Nonalcoholic fatty liver disease (NAFLD) involves changes in hepatic pathways, as lipogenesis, oxidative stress, endoplasmic reticulum (ER) stress, and macroautophagy. Maternal nicotine exposure exclusively during lactation leads to fatty liver (steatosis) only in the adult male offspring, not in females. Therefore, our hypothesis is that neonatal exposure to nicotine sex-dependently affects the signaling pathways involved in hepatic homeostasis of the offspring, explaining the hepatic lipid accumulation phenotype only in males...
December 1, 2023: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38017690/associations-between-early-infections-and-childhood-cognition-in-the-newcastle-thousand-families-study-birth-cohort
#19
JOURNAL ARTICLE
Erin Pennock, Emma L Slack, Jess A Grebby, Lara N Forster, Mark S Pearce
Childhood infections have been shown to stunt growth, contribute to malnutrition and reduce cognition in early adulthood. This study aimed to assess relationships between early life infections and childhood cognition at age 11 years in the Newcastle Thousand Families Study (NTFS). The analysis included 741 members from the NTFS who had complete data for infections between birth and 5 years, and the 11-plus examinations. School records from the 11-plus examinations showed cognitive (IQ), English (EQ) and arithmetic (AQ) abilities...
November 29, 2023: Journal of Developmental Origins of Health and Disease
https://read.qxmd.com/read/38017666/stress-response-abnormalities-transgenerationally-inherited-via-mir-23-downregulation-are-restored-by-a-methyl-modulator-during-the-lactation-period
#20
JOURNAL ARTICLE
Takahiro Nemoto, Yuki Morita, Yoshihiko Kakinuma
Low birthweight rats due to fetal undernutrition sustain higher corticosterone levels when exposed to stress. This is due to the upregulated expression of the pituitary-specific Gas5, a long noncoding RNA (lncRNA) that acts as a glucocorticoid receptor decoy and then competitively inhibiting the binding of glucocorticoids to DNA. However, the mechanism of Gas5 lncRNA upregulation remains unclear. Therefore, using the fetal undernourished model, we identified the factors that regulated Gas5 lncRNA expression and examined their effect on subsequent generations...
November 29, 2023: Journal of Developmental Origins of Health and Disease
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