journal
https://read.qxmd.com/read/39015406/recalcitrant-basal-cell-carcinoma-after-grenz-ray-therapy-introduction-of-high-intensity-focused-ultrasound-for-minimally-invasive-management
#1
JOURNAL ARTICLE
Jørgen Serup, Tomasz Zawada, Torsten Bove
INTRODUCTION: Grenz ray therapy popular in dermatology decades ago causes multiple and recalcitrant skin cancer in the treated field many years later. The treatment of choice is surgical excision, but limitations especially disfiguring scarring are a major challenge. We introduce 20 MHz high-intensity focused ultrasound (HIFU) as a new therapy overcoming the limitations of excisional surgery. CASE PRESENTATION: A 66-year-old female, who in the 1980s had received several grenz ray treatments of the scalp, developed multiple basal cell carcinomas in the field...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015405/a-challenging-case-of-reactive-angioendotheliomatosis
#2
JOURNAL ARTICLE
Georgios Kravvas, Lola Meghoma, Victoria Vilenchik, Jon Oxley, Daniel J Keith
INTRODUCTION: Reactive angioendotheliomatosis (RAE) is a rare, benign, angioproliferative disorder with poorly understood aetiopathogenesis. It is characterised by vascular occlusion that occurs in patients with coexistent systemic or autoimmune disease. CASE PRESENTATION: A 60-year-old female presented with an 8-week history of a painful, non-healing, and non-traumatic ulcer on the left thigh. Her past medical history included smoking, peripheral vascular disease (PVD) and previously treated rectal squamous cell carcinoma...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015404/lupus-erythematosus-tumidus-misdiagnosed-as-erythema-nodosum-from-coccidioidomycosis
#3
JOURNAL ARTICLE
Brianae Garcia, Anis Hasnaoui, Prakash V A K Ramdass
INTRODUCTION: Lupus erythematosus tumidus (LET) is a rare photosensitive dermatosis that is categorized as intermittent cutaneous lupus erythematosus. It shares clinical similarities and histopathological features with other skin disorders, such as erythema nodosum, lymphocytic infiltrate of Jessner, and reticular erythematous mucinosis, thus making diagnosis quite challenging. We present a patient with LET whose diagnosis was confirmed after seeing several doctors. CASE PRESENTATION: A 52-year-old Hispanic female presented with tender erythematous nodules on her thighs for approximately 1 month...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015403/multisystem-langerhans-cell-histiocytosis-following-treatment-of-initially-presumed-atopic-dermatitis-with-dupilumab-a-case-report-of-an-extremely-confusing-scenario
#4
JOURNAL ARTICLE
Wenhao Cheng, Hong Ren, Wenlong Hu
INTRODUCTION: Atopic dermatitis (AD) is a common chronic, recurrent, and non-infectious inflammatory skin disease. Dupilumab is a human monoclonal antibody with clinical efficacy in severe AD and has a good safety profile. CASE PRESENTATION: We hereby describe a previously unreported case of multisystem Langerhans cell histiocytosis (MS-LCH) that is associated with a history of AD treatment using dupilumab. CONCLUSION: A single case of MS-LCH with a history of dupilumab treatment for AD was described for the first time...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015402/recurrence-of-quadruple-extramammary-paget-s-disease-after-12-years-a-case-report-and-literature-review
#5
JOURNAL ARTICLE
Akihiro Ishiguro, Nobuhiko Iwashita, Michihiro Abe, Akina Ogawa, Tomohiro Takeo, Daisuke Watanabe
INTRODUCTION: Extramammary Paget's disease (EMPD) is a rare skin cancer that tends to be multicentric, with quadruple EMPD cases being scarcely reported. CASE PRESENTATION: We report the case of an 81-year-old man with heterochronous quadruple EMPD. Twelve years after total resection of vulvar EMPD, the patient developed erythematous lesions on the resection margin in the lower abdomen, umbilical region, and both axillae. Histological examination revealed that all lesions were in situ EMPD...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015401/porocarcinoma-of-the-groin-a-case-report
#6
JOURNAL ARTICLE
Hannah E Myers, Keith Pennycook, Joshua Hammel
INTRODUCTION: Porocarcinoma is a rare skin cancer that arises from the intraepidermal ducts of sweat glands. It is classically found in the 60-70-year-old age group, and lesions are most commonly reported on the head and neck or lower extremities. CASE PRESENTATION: This case focuses on a 49-year-old man who presented to an outpatient dermatology clinic with a growing, painful nodule in his right groin. A shave biopsy was conducted and resulted in a diagnosis of a porocarcinoma...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015400/pityriasis-lichenoides-et-varioliformis-acuta-developing-during-pembrolizumab-treatment-for-bladder-cancer
#7
JOURNAL ARTICLE
Yuki Mizutani, Ena Noda, Makoto Kondo, Akinobu Hayashi, Keiichi Yamanaka
INTRODUCTION: Anti-PD-1 immunotherapies enhance T-cell responses against tumor cells by blocking the interaction between PD-1 and its ligand, PD-L1. While these therapies offer significant benefits in treating various malignancies, they can also lead to several immune-related adverse events (irAEs), most notably manifesting in the skin. Lichenoid reactions, eczema, and vitiligo are the three most prevalent forms of cutaneous irAE. CASE PRESENTATION: Here, we report a rare case of a pityriasis lichenoides et varioliformis acuta (PLEVA) that developed during pembrolizumab treatment for invasive bladder cancer...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015399/hedgehog-pathway-and-programmed-cell-death-protein-1-inhibitors-for-advanced-basal-cell-carcinoma
#8
JOURNAL ARTICLE
Babette J A Verkouteren, An K L Reyners, Maureen J B Aarts, Klara Mosterd
INTRODUCTION: Basal cell carcinoma (BCC) is treated with local surgery or noninvasive treatment modalities. If a BCC remains untreated, it can develop into a locally advanced BCC or a metastatic BCC. CASE PRESENTATION: Here we report in detail the management of three complex advanced BCC (aBCC) after treatment failure with vismodegib. On all tumors, next generation DNA sequencing in the Center for Personalized Cancer Treatment-02 (CPCT-02) study was performed; subsequently, patients were included in the Drug Rediscovery Protocol (DRUP) trial, in which treatment was started with commercially available targeted anticancer drugs based on the molecular tumor profile...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015398/characteristic-skin-eruptions-with-a-distinct-histological-pattern-allow-early-diagnosis-of-vitamin-c-deficiency
#9
JOURNAL ARTICLE
Goran Mirkovic, Markus Reinhold Mutke, Beda Muehleisen
INTRODUCTION: Scurvy has become a rare disease in western countries with potentially high morbidity. Early diagnosis is crucial and can be challenging. CASE PRESENTATION: We present the case of a 56-year-old male patient who developed hemorrhagic diathesis after trivial impact trauma. Previously, the patient suffered from fatigue and loss of appetite. Characteristic skin eruptions and a distinct skin histology along with a decreased serum vitamin C level led to the diagnosis of scurvy...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015397/janus-kinase-inhibitors-as-successful-treatment-alternative-in-dupilumab-induced-psoriasis
#10
JOURNAL ARTICLE
Lina Weiss, Corinne Punsap Marbet, Lorenzo Barino Branca, Beda Mühleisen, Alexander Navarini
INTRODUCTION: After the introduction of dupilumab as systemic treatment for atopic dermatitis, an increasing number of patients have been successfully treated. However, reports of patients developing psoriasis as a secondary skin condition have been accumulating. The most likely reason is assumed to be an immune shift from Th2- to Th1-mediated auto-inflammatory processes. CASE PRESENTATION: Our patient is a 38-year-old male suffering from head-neck type atopic dermatitis since childhood...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015396/the-first-case-of-eruptive-pyogenic-granuloma-following-covid-19-vaccination
#11
JOURNAL ARTICLE
Saman Al-Zahawi, Alireza Ghanadan, Fatema Saberi, Kamran Balighi, Zahra Razavi
INTRODUCTION: Pyogenic granuloma presents clinically as a rapidly growing, friable, red papule of skin or mucosa, commonly measuring less than 10 mm with frequent bleeding due to ulceration. Angioproliferative diseases including pyogenic granuloma and cherry angioma have been reported during COVID-19 infection or following COVID-19 vaccination. CASE PRESENTATION: Here, we report a 52-year-old female patient who developed diffuse skin eruptions 3 weeks after the second dose of COVID-19 vaccination...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/39015395/pilomatrix-carcinoma-a-benign-mimic-with-malignant-consequences-a-case-report-and-review-of-the-current-literature
#12
JOURNAL ARTICLE
Cedar A Slovacek, Yang Li, Maria Hurley, Ramona Beshad, Michael L Bernstein
INTRODUCTION: Pilomatrix carcinomas (PMXCs) are uncommon, locally aggressive tumors with high recurrence rates, metastatic potential, and fewer than 130 cases reported in the literature. Typically, they present as an unassuming, firm, dermal swelling and therefore are frequently mistaken for more common, benign masses, leading to undertreatment which can cause local invasion and metastatic spread. Diagnosis relies on excision with pathologic analysis; however once diagnosed, there are no current recommendations to guide treatment or surveillance for recurrence or metastases...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38831934/eruptive-melanocytic-nevi-in-the-setting-of-encorafenib-cetuximab-and-binimetinib-combination-therapy-a-case-report
#13
Karen Lam, Gregory A Gates, Daniel Q Bach, Kyle Cheng
INTRODUCTION: The development of new and changing melanocytic lesions has been increasingly reported as an adverse dermatologic toxicity of BRAF inhibitor therapy. Melanocytic lesions and melanomas induced by BRAF inhibitor therapy that lack BRAF V600E expression have been less commonly described. One mechanism that has been proposed for the development of BRAF inhibitor-induced melanocytic lesions, including those lacking BRAF V600E expression, is the paradoxical activation of the MAPK signaling pathway in BRAF wild-type ( BRAF WT ) cells...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38650914/successful-removal-of-17-tattoos-self-administered-using-black-eyeliner-ink-with-quality-switched-neodymium-doped-yttrium-aluminum-garnet-1-064-nm-laser-a-case-report
#14
S Morteza Seyed Jafari, Simon Bossart, Maurice Adatto, Laurence Feldmeyer, Nikhil Yawalkar, Kristine Heidemeyer
INTRODUCTION: Tattooing has a rich historical presence in various human civilizations, with the earliest physical evidence dating back to around 3258 BC. While acceptance of tattoos is increasing in the Western world, negative associations remain. Short-pulsed lasers, such as Q-Switched (QS) or picosecond lasers, are the gold standard for tattoo removal. CASE PRESENTATION: This case report discusses the successful removal of 17 amateur tattoos, which were self-administered by a 19-year-old female patient using black eyeliner ink and sewing needles...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38601048/thoracocervicofacial-purpura-as-a-presenting-symptom-of-seizure-disorder-a-case-report
#15
Waseem Alhawsawi, Khalid Al Hawsawi, Alhusain Alshareef, Rama Halabi, Ammar Baksh, Basant Alzubaidy
INTRODUCTION: Postictal thoracocervicofacial purpura (PTP) is a rare clinical sign after a seizure episode and may be the only objective sign seen in patients who are unaware of their own seizure disorder. Moreover, it can be the only reason a patient seeks medical care after a seizure activity. CASE PRESENTATION: Herein, we report a 23-year-old, living alone and not known to have any medical illnesses, who presented to our emergency department complaining of asymptomatic purpuric facial rash extending to his neck and upper chest that started suddenly when he woke up that morning...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38590388/efficacy-of-siltuximab-and-1-927-nm-fractional-laser-for-the-treatment-of-cutaneous-manifestations-in-castleman-s-disease-the-role-of-dermoscopy-and-reflectance-confocal-microscopy-for-lesion-evaluation
#16
Giovanni Paolino, Marco Ardigò, Emanuel Della-Torre, Luca Moroni, Nathalie Rizzo, Matteo Riccardo Di Nicola, Vittoria Giulia Bianchi, Lorenzo Dagna, Giuseppe Alvise Ramirez, Santo Raffaele Mercuri
INTRODUCTION: Multicentric Castleman's disease (MCD) with cutaneous involvement has rarely been discussed in dermatologic literature, with few reports. Cutaneous lesions in MCD may induce deep scars, causing a significant impact in the daily life of the patients. The treatment of Castleman's disease (CD) is usually a challenge, especially in case of cutaneous involvement. CASE PRESENTATION: We report the case of a 35-year-old Caucasian man with a 3-year-old history of MCD with cutaneous involvement that we treated with a combined therapy characterized by siltuximab and 1,927 nm fractional laser...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38567034/the-cystic-sponge-anus
#17
Hessel H van der Zee, Pim Aarts
INTRODUCTION: A peculiar spongy appearance of the perianal skin was observed in a patient who underwent wide excision surgery for inguinal and gluteal hidradenitis suppurativa (HS). CASE PRESENTATION: This peculiar appearance was observed in a 62-year-old male patient. It included multiple orifices and cavities forming the spongy aspect of the perianal skin with multiple cysts and giant comedones. The perianal lesions were asymptomatic and the patient had never received any perianal treatment for the comedones or cysts...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38550795/expanding-the-differential-diagnosis-of-the-painful-nail-a-case-of-an-onychopapilloma-with-neuroma
#18
Jade Conway, Cynthia M Magro, Shari R Lipner
INTRODUCTION: Onychopapilloma most commonly presents as longitudinal erythronychia, but diagnosis may be challenging in some cases due to varied clinical presentations. Most patients with onychopapillomas do not report associated pain but instead more commonly report functional interference. CASE REPORT: We present a case of a 74-year-old female with a 5-year history of splitting and lifting of the right thumbnail, accompanied by nail sensitivity and intermittent painful throbbing...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38529513/diffuse-lichen-planopilaris-masquerading-as-diffuse-alopecia-areata
#19
Li Jie Helena Yoo, Nekma Meah, Dmitri Wall, Ian McDonald
INTRODUCTION: Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia that represents a form of follicular lichen planus. CASE PRESENTATION: We describe a case of coexisting diffuse LPP and female pattern hair loss masquerading as diffuse alopecia areata in a 32-year-old female. DISCUSSION: In complex cases such as this, dermoscopy-guided vertical and horizontal biopsies from androgen sensitive and insensitive areas are helpful in increasing diagnostic yield...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38481563/repair-of-a-large-nasal-ala-and-medial-cheek-defect-case-report
#20
Hannah E Myers, Ashley A Kessler, Michael Roberts, Christopher Buckley
INTRODUCTION: Mohs micrographic surgery is a complex but essential aspect of functional and cosmetic skin cancer removal. It allows for skin cancers to be removed from cosmetically challenging areas in the most efficient and effective possible method; however, closure of these lesions can be difficult. CASE: An 80-year-old male presented for Mohs surgery of a basal cell carcinoma on the right nasal sidewall that measured 3.4 cm. The patient underwent seven stages of Mohs surgery, and the final defect measured 6...
2024: Case Reports in Dermatology
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