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International Journal of Endocrinology

G Simi, A R Genazzani, M E R Obino, F Papini, S Pinelli, V Cela, P G Artini
[This corrects the article DOI: 10.1155/2017/5469409.].
2019: International Journal of Endocrinology
Wei Xu, Jun Liang, H F Geng, Jun Lu, Rui Li, X L Wang, Qian Lv, Ying Liu, Jie Wang, X K Liu, Peter M Jones, Zl Sun
Background: Emerging evidence suggests that T2DM is attributable to the dysfunction of β -cells and the activation of islet stellate cells (ISCs). The wingless-type MMTV integration site family member 5a (Wnt5a)/frizzled 5 (Fzd5) signalling pathway might take part in this process. Our study is aimed at defining the status of ISCs during β -cell insulin secretion homeostasis by determining the role of the Wnt5a protein in the regulation of insulin production. We examined the effects of the status of ISCs on β -cell insulin secretion in normoglycemic db/m and hyperglycaemic db/db mice...
2019: International Journal of Endocrinology
Manting Choy, Yan Guo, Hai Li, Guohong Wei, Runyi Ye, Weiwei Liang, Haipeng Xiao, Yanbing Li, Hongyu Guan
Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs), a class of noncoding RNAs (ncRNAs) longer than 200 nucleotides, are aberrantly expressed in malignant diseases, including PTC. Here, we identified a novel isoform of LOC100129940 and designated it as LOC100129940-N...
2019: International Journal of Endocrinology
Ewa Matuszczak, Marta Diana Komarowska, Wojciech Debek, Adam Hermanowicz
Bisphenol A (BPA) has been used since the 1950s, in food packaging, industrial materials, dental sealants, and personal hygiene products. Everyone is exposed to BPA through skin, inhalation, and digestive system. BPA disrupts endocrine pathways, because it has weak estrogenic, antiandrogenic, and antithyroid activities. Despite the rapid metabolism, BPA can accumulate in different tissues. Many researchers proved the impact of BPA on human development, metabolism, and finally reproductive system. There is increasing evidence that BPA has impact on human fertility and is responsible for the reproductive pathologies, e...
2019: International Journal of Endocrinology
Andrea Repaci, Valentina Vicennati, Alexandro Paccapelo, Ottavio Cavicchi, Nicola Salituro, Fabio Monari, Dario de Biase, Giovanni Tallini, Annalisa Altimari, Elisa Gruppioni, Michelangelo Fiorentino, Uberto Pagotto
Background: Stimulated thyroglobulin levels measured at the time of remnant ablation (A-hTg) and BRAFV600E mutation had shown prognostic value in predicting persistent disease in differentiated thyroid cancer (DTC). The aim of this study was to evaluate the prognostic role of A-hTg combined with the BRAFV600E status in association with the revised American Thyroid Association (ATA) risk stratification. Material and Methods: 620 patients treated for a DTC were included in this study with a median follow-up duration of 6...
2019: International Journal of Endocrinology
Tingting Bao, Liuting Zeng, Kailin Yang, Yuehua Li, Fengying Ren, Yulong Zhang, Ziren Gao
Objective: To assess the effectiveness and safety of melatonin for perimenopausal and postmenopausal women with osteopenia. Methods: In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of melatonin versus placebo or western medicine in perimenopausal and postmenopausal women with osteopenia. The study's registration number is CRD42018086238. The primary outcomes included bone mineral density (BMD) and T-score. Result: From 551 articles retrieved, three trials involving 121 patients were included...
2019: International Journal of Endocrinology
Jun Jiang, Hui Lu
For high-risk papillary thyroid microcarcinomas (PTMCs), immediate surgery is recommended. This study aimed to evaluate the location of PTMCs in the thyroid lobe and determine whether location is associated with an aggressive biology and the necessity of immediate surgery. This retrospective study included 288 patients who underwent initial surgery for PTMC. Clinical data were extracted. Subcapsular thyroid microcarcinomas (STMs) and nonsubcapsular thyroid microcarcinomas (NSTMs), distinguished by ultrasound, were compared in terms of tumour size, extrathyroidal extension, cervical lymph node metastasis, and multifocality...
2019: International Journal of Endocrinology
Qiaojing Qin, Yingjun Qian, Guanghua Zhu, Weifeng Fan, Jianying Niu, Yong Gu
Objective: The elder diabetic patients increases rapidly in China and often accompany with hyperuricemia. Recently evidences show that renal function has been impaired in part of diabetic patients with normoalbuminuria. Therefore, we investigated the relationship between serum uric acid (SUA) and renal function in Chinese elder diabetes with normoalbuminuria. Methods: The physical examination data from 1052 cases of diabetic residents with normoalbuminuria aged 70 years and over in the Jiangchuan community of Minhang District, Shanghai, from October 2011 to September 2014 was analyzed retrospectively...
2019: International Journal of Endocrinology
Cunfu Li, Jun Xiang, Yunjun Wang
Objective: To evaluate the risk factors for predicting lymph nodes (LN) posterior to right recurrent laryngeal nerve metastasis in thyroid papillary carcinoma. Methods: PubMed, PMC, EMBASE, and the Cochrane Library were systematically searched for articles published spanning 30/06/2009-30/8/2018 using multiple search terms. Thirteen articles involving 10,014 patients were reviewed in our meta-analysis. Stata 15.1 software was used for the meta-analysis. Results: The rate of LN posterior to right recurrent laryngeal nerve (LN-prRLN) metastasis was 8...
2019: International Journal of Endocrinology
Dragan Manojlović, Ana Stupin, Anita Matić, Zrinka Mihaljević, Sanja Novak, Ines Drenjančević
Aim: The present study was aimed at determining if type 1 diabetes mellitus (DM) affects vascular function and at elucidating the mechanisms mediating vasorelaxation in both nonovariectomized and ovariectomized Sprague-Dawley (SD) rats. Materials and Methods: Eighty female SD rats were divided into four groups: nonovariectomized healthy (non-OVX-CTR) and diabetic (non-OVX-DM) rats and ovariectomized healthy (OVX-CTR) and diabetic (OVX-DM) rats. Bilateral ovariectomy was performed at the age of 5 weeks, and type 1 DM was induced by streptozotocin at the age of 6 weeks...
2019: International Journal of Endocrinology
Wendong Liu, Jing Hou, Xiuqin Liu, Limin Wang, Guimei Li
Objective: To identify the causes of central diabetes insipidus (CDI) by evaluating the values of magnetic resonance imaging (MRI) in the diagnosis of pediatric CDI, providing evidence for the clinical diagnosis and treatment of CDI. Methods: Seventy-nine patients with CDI (CDI group) hospitalized from July 2012 to March 2017 and 43 healthy children (control group) were enrolled in this study. All cases underwent MRI examination including T1-weighted three-dimensional magnetization-prepared rapid gradient-echo (T1WI-3D-MP RAGE) imaging sequences...
2019: International Journal of Endocrinology
Kader Ugur, Suleyman Aydin
Background: The aim was to investigate the amounts of saliva and serum asprosin in order to determine whether it is related to obesity and whether salivary glands synthesize asprosin or not. Methods: A total of 116 underweight, normal weight, overweight, and obese (class I, class II, and class III) volunteers participated in the study. Saliva and blood samples were collected simultaneously from the participants. The amounts of asprosin in saliva, salivary gland tissue supernatants, and bloods were determined by ELISA, whereas asprosin synthesis sites of salivary gland tissues were determined immunohistochemically...
2019: International Journal of Endocrinology
Carlo Cappelli, Ilenia Pirola, Elena Gandossi, Fiorella Marini, Alessandra Cristiano, Claudio Casella, Davide Lombardi, Barbara Agosti, Alberto Ferlin, Maurizio Castellano
Background: Toshiba Medical System has developed a new Doppler technique [Superb Microvascular Imaging (SMI)] that has improved microvascular flow imaging. SMI depicts perinodular and intranodular thyroid microvascular flow in higher detail compared to standard colour Doppler (CD) and power Doppler (PD) imaging. Objective: Assess the nodular microvascular architecture by SMI compared to CD and PD features in a series of thyroid nodules submitted to fine needle aspiration cytology, in order to evaluate the potential of SMI in detecting thyroid cancer...
2019: International Journal of Endocrinology
Mining Liang, Beibei Zhang, Lu Deng, Rong Xu, Haishan Wu, Jindong Chen
Aim: To explore whether olanzapine alters bone mineral density (BMD), glucose, and lipid metabolism in schizophrenia patients. Methods: This study enrolled 150 patients diagnosed with schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) , including 101 patients who had over 6-month history of olanzapine use (olanzapine-treated group) and 49 patients who had no history of antipsychotic use (first episode drug-naïve group). 71 subjects with age- and gender-matched healthy volunteers (healthy control group) were also enrolled...
2019: International Journal of Endocrinology
Chuyan Wu, Feng Jiang, Ke Wei, Feng Lin, Zhongli Jiang
Exercise can reduce androgen and insulin levels in polycystic ovary syndrome (PCOS) patients. Finasteride is also presumed to improve the developing follicle environment. Therefore, the aim of this study was to observe the effects of the combination of exercise and finasteride therapy on hormone levels and ovarian morphology in rats with polycystic ovary syndrome. Forty female rats were randomly divided into five groups ( n = 8 each group): the PCOS sedentary group (P-Sed), PCOS exercise group (P-Ex), PCOS finasteride and sedentary group (P-FSed), and PCOS finasteride and exercise group (P-FEx), and healthy, age-matched rats were used as controls (CO)...
2019: International Journal of Endocrinology
Ting-Ting Shi, Lin Hua, Zhong Xin, Yu Li, Wei Liu, Yi-Lin Yang
Aim: This study investigated the association of DNA methylation with Graves' orbitopathy (GO) incidence through a combined analysis in the context of biological network to identify and validate potential genes for Chinese patients with GO. Methods: A genome-scale screening of DNA methylation was performed on the peripheral blood sample of six patients with GO and six controls. After extracting differentially methylated regions (DMRs), the study focused on two classes of genes with obviously different methylation levels: low methylated genes (LMGs) and high methylated genes (HMGs)...
2019: International Journal of Endocrinology
Minh Tam Le, Dac Nguyen Nguyen, Jessica Zolton, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Alan Decherney, Micah J Hill
This study is aimed at comparing clinical pregnancy rates (CPRs) in patients who are administered either gonadotropin-releasing hormone agonist (GnRHa) or human chorionic gonadotropin (hCG) for ovulation trigger in intrauterine insemination (IUI) cycles. A prospective randomized comparative study was conducted at Hue University Hospital in Vietnam. A total of 197 infertile women were randomly assigned to receive either GnRHa trigger ( n = 98 cycles) or hCG trigger ( n = 99 cycles) for ovulation trigger. Patients returned for ultrasound monitoring 24 hours after IUI to confirm ovulation...
2019: International Journal of Endocrinology
Rosângela C Rodrigues, Flávia Schechtman Belham, Ana Garcia, Corina Satler, Carlos Tomaz, Maria Clotilde H Tavares
This study aimed at evaluating the availability of the primate Sapajus libidinosus as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female S. libidinosus from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment...
2019: International Journal of Endocrinology
John F Tierney, Jennifer Poirier, Sitaram Chivukula, Sam G Pappas, Martin Hertl, Erik Schadde, Xavier Keutgen
Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly present with metastatic disease, and the liver is the most frequent metastatic site. Herein, we studied whether primary tumor site affects survival in patients with GEP-NETs and liver metastases (NELM). As a secondary endpoint, we studied whether extrahepatic disease and surgical resection impact survival in this patient population. Methods: Patients with NELM diagnosed from 2006 to 2014 were identified from the National Cancer Database...
2019: International Journal of Endocrinology
Mingsheng Yang, Yixin Liu, Hengchang Xie, Zhengzheng Wen, Yunxia Zhang, Changjing Wu, Li Huang, Jie Wu, Chensheng Xie, Tao Wang, Weifeng Peng, Shangqi Liu, Long Chen, Xiaomeng Liu
Introduction: Gut microbiota is involved in the progression of metabolic diseases such as obesity and type 2 diabetes. The ob/ob and db/db mice are extensively used as models in studies on the pathogenesis of these diseases. The goal of this study is to characterize the composition and structure of gut microbiota in these model mice at different ages. Materials and methods: High-throughput sequencing was used to obtain the sequences of the highly variable 16S rRNA V3-V4 region from fecal samples...
2019: International Journal of Endocrinology
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