journal
https://read.qxmd.com/read/38533131/progerin-inhibits-the-proliferation-and-migration-of-melanoma-cells-by-regulating-the-expression-of-paxillin
#1
JOURNAL ARTICLE
Weixian Liu, Xinxian Huang, Weizhao Luo, Xinguang Liu, Weichun Chen
OBJECTIVE: Progerin, the underlying cause of Hutchinson-Gilford Progeria Syndrome (HGPS), has been extensively studied for its impact on normal cells and premature aging patients. However, there is a lack of research on its specific effects on tumor cells. Melanoma is one of the most common malignant tumors with high morbidity and mortality. This study aimed to elucidate the potential therapeutic role of progerin in melanoma. MATERIALS AND METHODS: We constructed the melanoma A375 cell line and M14 cell line with stable expression of progerin...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38523659/apolipoprotein-e-is-a-potential-biomarker-for-predicting-cancer-prognosis-and-is-correlated-with-immune-infiltration
#2
JOURNAL ARTICLE
Jinji Chen, Herong Zhu, Shaohua Chen, Hua Mi
BACKGROUND: Apolipoprotein E (APOE) is a polymorphic protein that plays a role in lipoprotein transformation and metabolism. It is involved in numerous physiological processes within the body and is closely associated with tumor growth and metastasis. However, the role of APOE in pan-cancer has yet to be evaluated. Therefore, studying the association between APOE and various cancer types is crucial for providing a basis for individualized treatment strategies and clinical prognosis assessment...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38476309/tsc22d2-regulates-acot8-to-delay-the-malignant-progression-of-colorectal-cancer
#3
JOURNAL ARTICLE
Nana Zhou, Chaoqin Guo, Jingyang Du, Xu Zhang, Qiuran Xu, Xiaoliang Zheng, Linglan Tu
PURPOSE: Colorectal cancer (CRC) is one of the cancers with high incidence and mortality rates worldwide. In China, there are approximately 400,000 new CRC cases each year, seriously endangering people's life and health. Transforming growth factor β-stimulated clone 22 domain family, member 2 (TSC22D2) is widely expression in cancers, but the role of TSC22D2 in CRC are still unknown. METHODS: Real‑time quantitative PCR (qRT-PCR) and Western blot were applied to determine the TSC22D2 levels...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38476308/taking-the-next-step-in-double-refractory-disease-current-and-future-treatment-strategies-for-chronic-lymphocytic-leukemia
#4
REVIEW
Manabu Hayama, John C Riches
Chronic lymphocytic leukemia (CLL) is a monoclonal B-cell lymphoproliferative disease with a high annual incidence in Western countries. As B-cell receptor (BCR) signaling and intrinsic apoptotic resistance play critical roles in the development and survival of CLL cells, therapeutic approaches targeting these pathways have been extensively investigated to tackle this incurable disease. Over the last decade, several Phase 3 trials have confirmed the superior efficacy of covalent Bruton tyrosine kinase inhibitors (cBTKis) and venetoclax, a selective B-cell lymphoma 2 (BCL2) inhibitor, over chemoimmunotherapy...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38435840/treatment-of-abdominal-desmoplastic-small-round-cell-tumor-induces-acute-myeloid-leukemia-m5-a-case-report-and-literature-review
#5
Lan Liu, Meizuo Zhong, Xuan Zhou, Fanhua Kang, Yong Long, Junfeng Li
Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive malignancy. Most patients are diagnosed at a late stage with poor prognosis. The treatment usually includes combined intensive chemotherapy, cytoreductive surgery, radiotherapy, and targeted therapy. Due to the low incidence rate and dismal survival, there is currently a lack of case reports on DSRCT with concurrent leukemia. We report a case of a young patient who achieved disease stabilization for 14 months after receiving 6 cycles of chemotherapy and whole abdominal radiation therapy (WART), followed by consolidation treatment with anlotinib...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38426082/sirt6-overexpression-induces-apoptosis-of-nasopharyngeal-carcinoma-by-inhibiting-nf-%C3%AE%C2%BAb-signaling-retraction
#6
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S179866.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38420288/the-lncrna-linc01194-mir-486-5p-axis-facilitates-malignancy-in-non-small-cell-lung-cancer-via-regulating-cdk4-retraction
#7
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S235037.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38414760/coronin-3-promotes-the-development-of-oncogenic-properties-in-glioma-through-the-wnt-%C3%AE-catenin-signaling-pathway-retraction
#8
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S257001.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38414759/applications-of-yttrium-90-90-y-in-hepatocellular-carcinoma
#9
REVIEW
ZhongHao Jiang, Fan Yang, WanXiang Wang
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, affecting millions of people worldwide. Due to the lack of systemic radiation therapy in hepatocellular carcinoma, researchers have been investigating the use of yttrium-90 (90 Y) radioembolization for local-regional tumor control since the 1960s. With the development of glass and resin 90 Y microspheres and the durable local control, good long-term efficacy, and equivalent tumor responsiveness and tolerability of 90 Y-selective internal irradiation compared with alternative therapies such as transarterial chemoembolization (TACE) and sorafenib, 90 Y radioembolization has gradually been applied in the treatment of hepatocellular carcinoma of all stages...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38414758/lncrna-hcp5-promotes-cell-invasion-and-migration-by-sponging-mir-29b-3p-in-human-bladder-cancer-retraction
#10
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S249770.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38405177/microrna-126-inhibit-viability-of-colorectal-cancer-cell-by-repressing-mtor-induced-apoptosis-and-autophagy-retraction
#11
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S238348.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38405176/prognostic-factors-and-construction-of-nomogram-prediction-model-of-lung-cancer-patients-using-clinical-and-blood-laboratory-parameters
#12
JOURNAL ARTICLE
Yamin Zhang, Wei Wan, Rui Shen, Bohao Zhang, Li Wang, Hongyi Zhang, Xiaoyue Ren, Jie Cui, Jinpeng Liu
OBJECTIVE: This work aimed to explore the prognostic risk factors of lung cancer (LC) patients and establish a line chart prediction model. METHODS: A total of 322 LC patients were taken as the study subjects. They were randomly divided into a training set (n = 202) and a validation set (n = 120). Basic information and laboratory indicators were collected, and the progression-free survival (PFS) and overall survival (OS) were followed up. Single-factor and cyclooxygenase (COX) multivariate analyses were performed on the training set to construct a Nomogram prediction model, which was validated with 120 patients in the validation set, and Harrell's consistency was analyzed...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38384996/exosome-delivered-egfr-induced-by-acidic-bile-salts-regulates-macrophage-m2-polarization-to-promote-esophageal-adenocarcinoma-cell-proliferation
#13
JOURNAL ARTICLE
Chuangui Chen, Jinsheng Ding, Zhao Ma, Yongjie Xie, Linhua Zhang, Dunwan Zhu
PURPOSE: Chronic gastroesophageal reflux disease (GERD) causes the abnormal reflux of acid and bile salts, which would induce Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). EGFR, as one of main components of the exosome, plays an important role in cancer progression. Here, we investigated the role of acidic bile salts (ABS)-induced exosomal EGFR in EAC cell proliferation. METHODS: Electronic microscopic examination and Western blot were used to identify exosomes...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38375328/mir-136-targets-mien1-and-involves-the-metastasis-of-colon-cancer-by-suppressing-epithelial-to-mesenchymal-transition-retraction
#14
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S113359.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38375327/thyroid-metastases-from-triple-negative-breast-cancer-with-high-pd-l1-expression-a-rare-presentation
#15
Wenjuan Meng, Qingxia Guo, Gaoyan Tang, Guiyan Han, Guikai Ma, Qingyun Zhang, Rui Li, Shuzhen Liu, Guohua Yu
Thyroid metastases secondary to triple-negative breast cancer are sporadic. Diagnosis usually requires fine needle aspiration biopsy (FNAB) and immunohistochemistry. There are no treatment guidelines for this type of cancer, and to date, reports of chemotherapy combined with immunotherapy in thyroid metastases are very rare. Here, we first report the effectiveness of anti-PD-1 inhibitor in combination with chemotherapy for the treatment of metastatic thyroid cancer secondary to advanced triple-negative breast cancer with high expression of programmed cell death ligand 1 (PD-L1)...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38375326/mst1-hippo-pathway-triggers-breast-cancer-apoptosis-via-inducing-mitochondrial-fragmentation-in-a-manner-dependent-on-jnk-drp1-axis-retraction
#16
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S193787.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38371879/mir-182-promotes-tumor-growth-and-increases-chemoresistance-of-human-anaplastic-thyroid-cancer-by-targeting-tripartite-motif-8-retraction
#17
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S110468.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38371878/kanglaite-reverses-multidrug-resistance-of-hcc-by-inducing-apoptosis-and-cell-cycle-arrest-via-pi3k-akt-pathway-retraction
#18
(no author information available yet)
[This retracts the article DOI: 10.2147/OTT.S153814.].
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38348427/mettl3-malat1-elavl1-axis-promotes-tumor-growth-in-ovarian-cancer
#19
JOURNAL ARTICLE
Jian Xiong, Wenqin Lian, Rui Zhao, Kefei Gao
BACKGROUND: Studies increasingly recognize the role of N6-methyladenosine ( m6A ) modification in cancer occurrence and development. METTL3 is a core catalytic subunit of m6A-modified methyltransferases complex, but its regulatory mechanism in ovarian cancer (OC) is not clear. METHODS: In this study, GEPIA 2.0 database was applied for expression analysis, survival analysis and correlation analysis for OC. Additionally, in vitro and in vivo assays were conducted to explore regulatory mechanisms of METTL3 in OC...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38313386/amplifying-curcumin-s-antitumor-potential-a-heat-driven-approach-for-colorectal-cancer-treatment
#20
JOURNAL ARTICLE
Janviere Kabagwira, Ryan N Fuller, Paul A Vallejos, Chase S Sugiono, Vola-Masoandro Andrianarijaona, Jazmine Brianna Chism, Michael P O'Leary, David Caba Molina, William Langridge, Maheswari Senthil, Nathan R Wall
INTRODUCTION: Peritoneal metastases from colorectal cancer (CRC) present a significant clinical challenge with poor prognosis, often unresponsive to systemic chemotherapy. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment approach for select patients. The use of curcumin, a natural compound with antitumor properties, in HIPEC is of interest due to its lower side effects compared to conventional drugs and potential for increased efficacy through direct delivery to the peritoneal cavity...
2024: OncoTargets and Therapy
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