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Journals Pharmacogenomics and Personali...

Pharmacogenomics and Personalized Medicine

https://read.qxmd.com/read/38370334/natural-language-processing-for-radiation-oncology-personalizing-treatment-pathways
#1
REVIEW
Hui Lin, Lisa Ni, Christina Phuong, Julian C Hong
Natural language processing (NLP), a technology that translates human language into machine-readable data, is revolutionizing numerous sectors, including cancer care. This review outlines the evolution of NLP and its potential for crafting personalized treatment pathways for cancer patients. Leveraging NLP's ability to transform unstructured medical data into structured learnable formats, researchers can tap into the potential of big data for clinical and research applications. Significant advancements in NLP have spurred interest in developing tools that automate information extraction from clinical text, potentially transforming medical research and clinical practices in radiation oncology...
2024: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38332855/pharmacogenomic-analysis-of-cyp3a5-3-and-tacrolimus-trough-concentrations-in-vietnamese-renal-transplant-outcomes
#2
JOURNAL ARTICLE
Thi Van Anh Nguyen, Ba Hai Le, Minh Thanh Nguyen, Viet Thang Le, Viet Tien Tran, Dinh Tuan Le, Duong Anh Minh Vu, Quy Kien Truong, Trong Hieu Le, Huong Thi Lien Nguyen
PURPOSE: CYP3A5 polymorphisms have been associated with variations in the pharmacokinetics of tacrolimus (Tac) in kidney transplant patients. Our study aims to quantify how the CYP3A5 genotype influences tacrolimus trough concentrations (C0 ) in a Vietnamese outpatient population by selecting an appropriate population pharmacokinetic model of Tac for our patients. PATIENTS AND METHODS: The external dataset was obtained prospectively from 54 data of adult kidney transplant recipients treated at the 103 Military Hospital...
2024: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38313795/response-to-challenges-in-dpyd-test-implementation-in-patients-treated-with-fluoropyirimidines-is-dpyd-genotype-arriving-on-time-response-to-letter
#3
COMMENT
Cristina Montrasio, Stefania Cheli, Emilio Clementi
No abstract text is available yet for this article.
2024: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38313794/the-impact-of-opioid-receptor-gene-polymorphism-on-fentanyl-and-alfentanil-s-analgesic-effects-in-the-pediatric-perioperative-period
#4
JOURNAL ARTICLE
Jelena Lilic, Vesna G Marjanovic, Ivana Budic, Nikola Stefanovic, Dragana Stokanovic, Goran T Marjanovic, Tatjana Jevtovic-Stoimenov, Mladjan Golubovic, Maja Zecevic, Radmila Velickovic-Radovanovic
INTRODUCTION: The polymorphism of the gene coding mu-opioid receptor ( OPRM1 ) is one of the factors contributing to the variability in the response to opioid analgesics in children. The goal of this study is to investigate its role in association with postoperative acute pain in children of various ages. METHODS: This prospective study analyzed 110 pediatric patients, after plastic or orthopedic surgery, who were genotyped and randomly assigned to receive fentanyl or alfentanil...
2024: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38264064/fbln5-as-one-presumably-prognostic-gene-potentially-modulating-tumor-immune-microenvironment-for-renal-clear-cell-carcinoma-in-children-and-young-adults
#5
JOURNAL ARTICLE
Ming Zhang, Feng Chen, Shaoguang Feng, Xu Liu, Zhen Wang, Nan Shen, Lingjian Meng, Dongsheng Zhu, Zhitao Zhu
OBJECTIVE: To investigate the role of FBLN5in renal clear cell carcinoma (KIRC), in particular on the tumor's immune microenvironment, including children and young adults. METHODS: FBLN5 expression in tumor and normal samples was explored using SangerBox, TIMER2.0, GEPIA, UALCAN, HPA databases. The Linkedomics database was used to obtain FBLN5 co-expressed genes in KIRC tissue. SangerBox was also used to estimate immune infiltration of FBLN5 in KIRC. The Kaplan-Meier plotter was used to investigate the survival effects of FBLN5 expression in the presence of immune infiltration...
2024: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38222291/maternally-inherited-essential-hypertension-may-be-associated-with-the-mutations-in-mitochondrial-trna-glu-gene
#6
JOURNAL ARTICLE
Chun Wang, Xin Deng, Lei Li, Mei Li
BACKGROUND: Mitochondrial DNA (mtDNA) mutations are associated with essential hypertension (EH), but the molecular mechanism remains largely unknown. OBJECTIVE: The aim of this study is to explore the association between mtDNA mutations and EH. METHODS: Two maternally inherited families with EH are underwent clinical, genetic and biochemical assessments. mtDNA mutations are screened by PCR-Sanger sequencing and phylogenetic, and bioinformatics analyses are performed to evaluate the pathogenicity of mtDNA mutations...
2024: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38204802/circpvt1-inhibits-the-proliferation-and-aids-in-prediction-of-the-prognosis-of-bladder-cancer
#7
JOURNAL ARTICLE
Hongyi Zhou, Xueping Cui, Leilei Zhu, Zhuoqun Xu, Zhuo Wang, Jianfeng Shao
BACKGROUND: Circular RNA PVT1 (circPVT1) is aberrantly expressed in several cancers, but its functional role and clinical relevance in bladder urothelial carcinoma (BLCA) remain unknown. This study aimed to identify the expression level of circPVT1 in BLCA and investigated its functional relevance with BLCA progression both in vitro and in vivo. METHODS: GEPIA, UALCAN, and OncoLnc were referred to presented data. Quantitative real-time PCR (qPCR) was used for the measurement of transnational expression of genes in BLCA specimens and cell lines...
2024: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38170144/erratum-identification-of-novel-prognostic-biomarkers-that-are-associated-with-immune-microenvironment-based-on-gaba-related-molecular-subtypes-in-gastric-cancer-corrigendum
#8
(no author information available yet)
[This corrects the article DOI: 10.2147/PGPM.S411862.].
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38164443/challenges-in-dpyd-test-implementation-in-patients-treated-with-fluoropyrimidines-are-dpyd-genotype-arriving-on-time-letter
#9
JOURNAL ARTICLE
Marta López López-Cepero, Antonia Obrador de Hevia, Mónica Guillot Morales
No abstract text is available yet for this article.
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38152411/heme-metabolism-related-gene-tent5c-is-a-prognostic-marker-and-investigating-its-immunological-role-in-colon-cancer
#10
JOURNAL ARTICLE
Wei Han, Cheng Li, Yongheng Wang, Binliang Huo, Wenhan Li, Wen Shi
BACKGROUND: There is a strong correlation between consuming high amounts of heme and an elevated risk of developing various types of cancer, including colorectal cancer. However, the role of heme metabolism-related genes (HRGs) in colorectal cancer remains unclear. Our study aimed to identify prognostic markers for colorectal cancer patients based on these genes. METHODS: The heme metabolism score was assessed using gene set variation analysis (GSVA). Potential prognostic HRGs were identified from the TCGA-COAD dataset using LASSO and COX regression analyses...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38149287/bicdl1-predicts-poor-prognosis-and-is-correlated-with-methylation-and-immune-infiltration-in-colorectal-cancer
#11
JOURNAL ARTICLE
Hongbiao Luo, Ji Luo, Ning Ding, Tao Zhang, Yongheng He
BACKGROUND: Bicaudal-D (BICD) Family Like Cargo Adaptor 1 (BICDL1) is an essential component of the molecular mechanism during neuronal development. However, BICDL1 has not been reported in cancer. Using bioinformatics analysis, we systematically evaluated the potential role of BICDL1 in CRC. METHODS: Colorectal cancer (CRC) and normal tissue samples were retrieved from the Gene Expression Omnibus (GEO), Genotype-Tissue Expression (GTEx), and Cancer Genome Atlas (TCGA) databases...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38146514/olanzapine-pharmacokinetics-a-clinical-review-of-current-insights-and-remaining-questions
#12
REVIEW
Priyanka Kolli, Grace Kelley, Marianela Rosales, Justin Faden, Ryan Serdenes
Olanzapine is one of the most widely used antipsychotics since its initial approval by the US Food and Drug Administration in 1996 and has undergone extensive pharmacokinetic study. Despite being utilized in clinical psychiatry for decades, there remain questions regarding the variety of available formulations, the utility of therapeutic drug monitoring, altered kinetic properties in special populations/medical illnesses, the use of high-dose olanzapine, and drug interactions, among many others. We performed a narrative literature review of olanzapine pharmacokinetics in June 2023 using the US National Library of Medicine's PubMed...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38116086/a-case-of-floating-harbor-syndrome-with-growth-and-language-development-delay-as-its-clinical-manifestation
#13
Yi-Can Yang, Qiong Tang, Li-Juan Yan, Shi-Bin Zhang, Xiao-Min Ye, Dai Gong, Li Zou, Xiang-Lan Wen
BACKGROUND: Floating-Harbor syndrome (FHS) is a rare autosomal dominant inherited disease characterized primarily by short stature, delayed language development, and typical facial features. There are currently few case reports, diagnoses and treatments for these syndromes at home and abroad. CASE DESCRIPTION: This study reports a case of a boy with "growth and language development delay" as the predominant clinical manifestation. FHS was clinically diagnosed based on his growth hormone (GH) deficiency, significant bone age delay, left testicular hydrocele, and the whole exon gene in peripheral blood, which indicated heterozygous mutation of SRCAP gene...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38105907/circ_0000140-alters-mir-527-slc7a11-mediated-ferroptosis-to-influence-oral-squamous-cell-carcinoma-cell-resistance-to-ddp
#14
JOURNAL ARTICLE
Yu Ma, Jinbo Gao, Hongning Guo
BACKGROUND: While there is prior evidence for the ability of circular RNAs (circRNAs) to shape the cisplatin (DDP) resistance of cancers in human patients, there has been relatively little research to date focused on the interplay between circRNAs and DDP resistance in the context of OSCC progression to date. In the present analysis, the functional role that circ_0000140 plays as a mediator of chemoresistance to DDP was thus explored in greater detail. METHODS: Both qPCR and Western immunoblotting were employed as appropriate to detect circ_0000140, miR-527, and SLC7A11 levels, while interactions among these factors were detected through RNA immunoprecipitation, RNA pull-down, and dual luciferase report assays...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38084311/a-review-on-probable-causes-of-cardiotoxicity-caused-by-common-cancer-drugs-and-the-role-of-traditional-chinese-medicine-in-prevention-and-treatment
#15
REVIEW
Miao Zhou, Wenyan Wang, Jiahao Weng, Zhikun Lai
Cancer is a widespread disease in our nation, characterized by a high occurrence rate. The use of tumor medications has been linked to an increased chance of cardiovascular complications, including a notable occurrence of heart toxicity. This has caused significant concern among healthcare professionals. This article provides a comprehensive compilation of drugs recognized for their potential to cause heart toxicity. Furthermore, extensive research has been conducted to investigate and categorize the effects of heart toxicity, with the purpose of promoting awareness, facilitating early intervention, and ultimately reducing the occurrence of heart toxicity...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38073713/novel-autophagy-related-blood-biomarkers-associated-with-immune-cell-infiltration-in-ankylosing-spondylitis
#16
JOURNAL ARTICLE
Hanbing Song, Hongpeng Liu, XiaoDong Li, Bing Lv, Zonghan Tang, Qipeng Chen, Danqi Zhang, Fei Wang
BACKGROUND: This study aims to identify new therapeutic targets and explore the molecular mechanism of ankylosing spondylitis (AS), a rheumatic immune disease that mainly affects the sacroiliac and spinal joints. Despite extensive research, the exact cause of AS is still unknown. The research team utilized a bioinformatics approach to achieve their objectives. METHODS: The GSE73754 dataset was downloaded from GEO database. Autophagy-related genes (ARGs) were collected from the Human Autophagy-dedicated Database...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38058295/identification-of-p3h1-as-a-predictive-prognostic-biomarker-for-bladder-urothelial-carcinoma-based-on-the-cancer-genome-atlas-database
#17
JOURNAL ARTICLE
Yuanfeng Zhang, Yang Chen, Zhiming Chen, Xinye Zhou, Shaochuan Chen, Kaijian Lan, Zhiping Wang, Yonghai Zhang
PURPOSE: The extracellular matrix in the tumor microenvironment are closely related to the development of tumors. This study's primary aim is to study the association between prolyl 3-hydroxylase 1 (P3H1) which mainly expresses collagen in extracellular matrix and the progression and prognosis of bladder cancer (BC). METHODS: The clinical and transcriptome data were acquired from the cancer genome atlas database. BLCAsubtyping is used to evaluate tissue subtypes of BC...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38046381/implication-of-kdr-polymorphism-rs2071559-on-therapeutic-outcomes-and-safety-of-postoperative-patients-with-gastric-cancer-who-received-s-1-based-adjuvant-chemotherapy-a-real-world-exploratory-study
#18
JOURNAL ARTICLE
Lei Meng, Jun Cao, Li Kang, Gang Xu, Da-Wei Yuan, Kang Li, Kun Zhu
OBJECTIVE: Regimens of S-1-based adjuvant chemotherapy are of great significance in attenuating recurrence risk in postoperative patients with gastric cancer (GC). Kinase insert-domain receptor (KDR) gene plays an essential role in tumor growth and metastasis. This study aimed to investigate the implication of KDR genotyping on the therapeutic outcomes of patients with gastric cancer (GC) who received S-1-based adjuvant chemotherapy. METHODS: A total of 169 postoperative GC with pathological staging of II and III and no metastasis who received S-1-based adjuvant chemotherapy were included retrospectively...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38023824/identification-of-a-prognostic-gene-signature-based-on-lipid-metabolism-related-genes-in-esophageal-squamous-cell-carcinoma
#19
JOURNAL ARTICLE
Guo-Yi Shen, Peng-Jie Yang, Wen-Shan Zhang, Jun-Biao Chen, Qin-Yong Tian, Yi Zhang, Bater Han
BACKGROUND: Dysregulation of lipid metabolism is common in cancer. However, the molecular mechanism underlying lipid metabolism in esophageal squamous cell carcinoma (ESCC) and its effect on patient prognosis are not well understood. The objective of our study was to construct a lipid metabolism-related prognostic model to improve prognosis prediction in ESCC. METHODS: We downloaded the mRNA expression profiles and corresponding survival data of patients with ESCC from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases...
2023: Pharmacogenomics and Personalized Medicine
https://read.qxmd.com/read/38023823/clinical-characteristics-and-prognosis-of-acute-myeloid-leukemia-patients-with-protein-tyrosine-phosphatase-non-receptor-type-11-gene-mutation
#20
JOURNAL ARTICLE
Rui Huang, Yi-Ting Zhang, Yu Lin, Ru-Li Pang, Zhi Yang, Wei-Hua Zhao
OBJECTIVE: The purpose of our study was to investigate the clinical characteristics, molecular biological characteristics and prognosis of acute myeloid leukemia (AML) patients with protein tyrosine phosphatase non-receptor type 11 (PTPN11) gene mutation. METHODS: The clinical data of 30 newly diagnosed adult AML patients with PTPN11 gene mutation were analyzed retrospectively. Kaplan-Meier and Cox proportional risk regression model were examined for prognostic analysis and prognostic factor screening...
2023: Pharmacogenomics and Personalized Medicine
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